Terminally alkylated polyamine analogues as chemotherapeutic agents

Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2001, Pages 1-26

  Casero, Jr ^a   Woster, P M ^b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,20 (ETHYLAMINO) 5,10,15 TRIAZANONADECANE; 1,8 OCTANEDIAMINE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; BETA ACTIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N,N' BIS(3 BENZYLAMINOPROPYL) 1,7 HEPTANEDIAMINE; N,N' BIS(ETHYL)POLYAMINE; N1 CYCLOBUTYLMETHYL N11 ETHYLNORSPERMINE; N1 CYCLOHEPTYLMETHYL N11 ETHYLNORSPERMINE; N1 CYCLOHEXYMETHYL N11 ETHYLNORSPERMINE; N1 CYCLOPENTYLMETHYL N11 ETHYLNORSPERMINE; N1 CYCLOPROPYLMETHYL N11 ETHYLNORSPERMINE; N1 PROPARGYL N11 ETHYLNORSPERMINE; N1,N11 DIETHYLNORSPERMINE; N1,N11 DIETHYLSPERMINE; N1,N14 DIETHYLHOMOSPERMINE; ORNITHINE DECARBOXYLASE; POLYAMINE DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PUTRESCINE; PYRIDOXAL 5 PHOSPHATE; S ADENOSYLMETHIONINE; SPERMIDINE; SPERMIDINE SYNTHASE; SPERMINE; UNCLASSIFIED DRUG;

ALKYLATION; AMINO ACID SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL; CELL FUNCTION; CELL GROWTH; CLINICAL TRIAL; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SUBSTRATE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR TRANSPORT; MICROTUBULE ASSEMBLY; NONHUMAN; OXIDATIVE STRESS; POLYAMINE METABOLISM; PROTEIN BINDING; PROTEIN ISOLATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REVIEW;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIPARASITIC AGENTS; APOPTOSIS; BIOLOGICAL TRANSPORT; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; OPPORTUNISTIC INFECTIONS; POLYAMINES; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 0035804314     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000084m     Document Type: Review

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