-
1
-
-
10944228465
-
Question: what is the biological function of the polyamines?
-
PID: 15185751
-
Rea G, Bocedi A, Cervelli M (2004) Question: what is the biological function of the polyamines? IUBMB Life 56:167–169
-
(2004)
IUBMB Life
, vol.56
, pp. 167-169
-
-
Rea, G.1
Bocedi, A.2
Cervelli, M.3
-
2
-
-
62549087415
-
Spermine metabolism and anticancer therapy
-
COI: 1:CAS:528:DC%2BD1MXks1Wjsrg%3D, PID: 19275753
-
Amendola R, Cervelli M, Fratini E, Polticelli F, Sallustio DE, Mariottini P (2009) Spermine metabolism and anticancer therapy. Curr Cancer Drug Targets 9:118–130
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 118-130
-
-
Amendola, R.1
Cervelli, M.2
Fratini, E.3
Polticelli, F.4
Sallustio, D.E.5
Mariottini, P.6
-
3
-
-
84880515627
-
Polyamines and cancer: implications for chemotherapy and chemoprevention
-
PID: 23432971
-
Nowotarski SL, Woster PM, Casero RA Jr (2013) Polyamines and cancer: implications for chemotherapy and chemoprevention. Expert Rev Mol Med 15:e3
-
(2013)
Expert Rev Mol Med
, vol.15
, pp. e3
-
-
Nowotarski, S.L.1
Woster, P.M.2
Casero, R.A.3
-
4
-
-
0014323475
-
Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors
-
COI: 1:CAS:528:DyaF1cXltVCltL8%3D, PID: 4299947
-
Russell D, Snyder SH (1968) Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors. Proc Natl Acad Sci USA 60:1420–1427
-
(1968)
Proc Natl Acad Sci USA
, vol.60
, pp. 1420-1427
-
-
Russell, D.1
Snyder, S.H.2
-
5
-
-
0141798673
-
Polyamine metabolism and cancer
-
COI: 1:CAS:528:DC%2BD3sXmvFGjsro%3D, PID: 12927050
-
Thomas T, Thomas TJ (2003) Polyamine metabolism and cancer. J Cell Mol Med 7:113–126
-
(2003)
J Cell Mol Med
, vol.7
, pp. 113-126
-
-
Thomas, T.1
Thomas, T.J.2
-
6
-
-
0033812886
-
Alterations in polyamine catabolic enzymes in human breast cancer tissue
-
COI: 1:CAS:528:DC%2BD3cXntFCisbk%3D, PID: 10999758
-
Wallace HM, Duthie J, Evans DM, Lamond S, Nicoll KM, Heys SD (2000) Alterations in polyamine catabolic enzymes in human breast cancer tissue. Clin Cancer Res 6:3657–3661
-
(2000)
Clin Cancer Res
, vol.6
, pp. 3657-3661
-
-
Wallace, H.M.1
Duthie, J.2
Evans, D.M.3
Lamond, S.4
Nicoll, K.M.5
Heys, S.D.6
-
7
-
-
4944242891
-
Polyamines and cancer: old molecules, new understanding
-
COI: 1:CAS:528:DC%2BD2cXos1ymu70%3D, PID: 15510159
-
Gerner EW, Meyskens FL Jr (2004) Polyamines and cancer: old molecules, new understanding. Nat Rev Cancer 4:781–792
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 781-792
-
-
Gerner, E.W.1
Meyskens, F.L.2
-
8
-
-
34248228763
-
Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases
-
COI: 1:CAS:528:DC%2BD2sXkslyiu7k%3D, PID: 17464296
-
Casero RA Jr, Marton LJ (2007) Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases. Nat Rev Drug Discov 6:373–390
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 373-390
-
-
Casero, R.A.1
Marton, L.J.2
-
9
-
-
84896318843
-
Inflammation, carcinogenesis and neurodegeneration studies in transgenic animal models for polyamine research
-
COI: 1:CAS:528:DC%2BC2cXjt1Wgurk%3D, PID: 23933909
-
Cervelli M, Angelucci E, Germani F, Amendola R, Mariottini P (2014) Inflammation, carcinogenesis and neurodegeneration studies in transgenic animal models for polyamine research. Amino Acids 46:521–530
-
(2014)
Amino Acids
, vol.46
, pp. 521-530
-
-
Cervelli, M.1
Angelucci, E.2
Germani, F.3
Amendola, R.4
Mariottini, P.5
-
10
-
-
79956224419
-
Current status of the polyamine research field
-
COI: 1:CAS:528:DC%2BC3MXlslCjt7g%3D, PID: 21318864
-
Pegg AE, Casero RA (2011) Current status of the polyamine research field. Methods Mol Biol 720:3–35
-
(2011)
Methods Mol Biol
, vol.720
, pp. 3-35
-
-
Pegg, A.E.1
Casero, R.A.2
-
11
-
-
84861664390
-
Spermine oxidase: ten years after
-
COI: 1:CAS:528:DC%2BC38Xhtlyqur8%3D, PID: 21809080
-
Cervelli M, Amendola R, Polticelli F, Mariottini P (2012) Spermine oxidase: ten years after. Amino Acids 42:441–450
-
(2012)
Amino Acids
, vol.42
, pp. 441-450
-
-
Cervelli, M.1
Amendola, R.2
Polticelli, F.3
Mariottini, P.4
-
12
-
-
84878452259
-
A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity
-
COI: 1:CAS:528:DC%2BC3sXhtFyjtrzL, PID: 23665428
-
Capone C, Cervelli M, Angelucci E, Colasanti M, Macone A, Mariottini P, Persichini T (2013) A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity. Free Radic Biol Med 63:99–107
-
(2013)
Free Radic Biol Med
, vol.63
, pp. 99-107
-
-
Capone, C.1
Cervelli, M.2
Angelucci, E.3
Colasanti, M.4
Macone, A.5
Mariottini, P.6
Persichini, T.7
-
13
-
-
84879238849
-
A new transgenic mouse model for studying the neurotoxicity of spermine oxidase dosage in the response to excitotoxic injury
-
COI: 1:CAS:528:DC%2BC3sXhtVKltLrF, PID: 23840306
-
Cervelli M, Bellavia G, D’Amelio M, Cavallucci V, Moreno S, Berger J, Nardacci R, Marcoli M, Maura G, Piacentini M, Amendola R, Cecconi F, Mariottini P (2013) A new transgenic mouse model for studying the neurotoxicity of spermine oxidase dosage in the response to excitotoxic injury. PLoS One 8:e64810
-
(2013)
PLoS One
, vol.8
, pp. e64810
-
-
Cervelli, M.1
Bellavia, G.2
D’Amelio, M.3
Cavallucci, V.4
Moreno, S.5
Berger, J.6
Nardacci, R.7
Marcoli, M.8
Maura, G.9
Piacentini, M.10
Amendola, R.11
Cecconi, F.12
Mariottini, P.13
-
14
-
-
84904094118
-
The Glu216–Ser218 pocket is a major determinant of spermine oxidase substrate specificity
-
Cervelli M, Angelucci E, Stano P, Leboffe L, Federico R, Antonini G, Mariottini P, Polticelli F (2014) The Glu216–Ser218 pocket is a major determinant of spermine oxidase substrate specificity. Biochem J 463:453–459
-
(2014)
Biochem J
, vol.463
, pp. 453-459
-
-
Cervelli, M.1
Angelucci, E.2
Stano, P.3
Leboffe, L.4
Federico, R.5
Antonini, G.6
Mariottini, P.7
Polticelli, F.8
-
15
-
-
0023722389
-
Role of polyamines in the growth of hormone-responsive experimental breast cancer In vivo
-
COI: 1:CAS:528:DyaL1cXls1yitbc%3D, PID: 3139111
-
Manni A, Badger B, Luk G, Wright C, Caplan R, Rockette H, Bartholomew M, Ahmed SR (1988) Role of polyamines in the growth of hormone-responsive experimental breast cancer In vivo. Breast Cancer Res Treat 11:231–240
-
(1988)
Breast Cancer Res Treat
, vol.11
, pp. 231-240
-
-
Manni, A.1
Badger, B.2
Luk, G.3
Wright, C.4
Caplan, R.5
Rockette, H.6
Bartholomew, M.7
Ahmed, S.R.8
-
16
-
-
0025677648
-
Selectivity of polyamine involvement in hormone action on normal and neoplastic target tissues of the rat
-
Manni A, Badger B, Lynch J, Demers L (1990) Selectivity of polyamine involvement in hormone action on normal and neoplastic target tissues of the rat. Breast Cancer Res Treat 17:187–196
-
(1990)
Breast Cancer Res Treat
, vol.17
, pp. 187-196
-
-
Manni, A.1
Badger, B.2
Lynch, J.3
Demers, L.4
-
17
-
-
0024597109
-
Polyamine involvement in the growth of hormone-responsive and -resistant human breast cancer cells in culture
-
COI: 1:CAS:528:DyaL1MXhslWjsLc%3D, PID: 2493979
-
Glikman P, Manni A, Demers L, Bartholomew M (1989) Polyamine involvement in the growth of hormone-responsive and -resistant human breast cancer cells in culture. Cancer Res 49:1371–1376
-
(1989)
Cancer Res
, vol.49
, pp. 1371-1376
-
-
Glikman, P.1
Manni, A.2
Demers, L.3
Bartholomew, M.4
-
18
-
-
0034067454
-
Prognostic value of histologic grade and proliferative activity in axillary node-positive breast cancer: results from the Eastern Cooperative Oncology Group Companion Study, EST 4189
-
COI: 1:STN:280:DC%2BD3c3ntF2qtw%3D%3D, PID: 10811671
-
Simpson JF, Gray R, Dressler LG, Cobau CD, Falkson CI, Gilchrist KW, Pandya KJ, Page DL, Robert NJ (2000) Prognostic value of histologic grade and proliferative activity in axillary node-positive breast cancer: results from the Eastern Cooperative Oncology Group Companion Study, EST 4189. J Clin Oncol 18:2059–2069
-
(2000)
J Clin Oncol
, vol.18
, pp. 2059-2069
-
-
Simpson, J.F.1
Gray, R.2
Dressler, L.G.3
Cobau, C.D.4
Falkson, C.I.5
Gilchrist, K.W.6
Pandya, K.J.7
Page, D.L.8
Robert, N.J.9
-
19
-
-
0029050065
-
Involvement of the polyamine pathway in breast cancer progression
-
COI: 1:CAS:528:DyaK2MXlvVSqsb4%3D, PID: 7757960
-
Manni A, Grove R, Kunselman S, Aldaz CM (1995) Involvement of the polyamine pathway in breast cancer progression. Cancer Lett 92:49–57
-
(1995)
Cancer Lett
, vol.92
, pp. 49-57
-
-
Manni, A.1
Grove, R.2
Kunselman, S.3
Aldaz, C.M.4
-
20
-
-
0024998124
-
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture
-
COI: 1:CAS:528:DyaK3MXitFKqsQ%3D%3D, PID: 2242341
-
Glikman PL, Manni A, Bartholomew M, Demers L (1990) Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture. J Steroid Biochem Mol Biol 37:1–10
-
(1990)
J Steroid Biochem Mol Biol
, vol.37
, pp. 1-10
-
-
Glikman, P.L.1
Manni, A.2
Bartholomew, M.3
Demers, L.4
-
21
-
-
0028265460
-
Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications
-
COI: 1:CAS:528:DyaK2cXksl2ktbg%3D, PID: 8012036
-
Thomas T, Thomas TJ (1994) Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications. Breast Cancer Res Treat 29:189–201
-
(1994)
Breast Cancer Res Treat
, vol.29
, pp. 189-201
-
-
Thomas, T.1
Thomas, T.J.2
-
22
-
-
0033539573
-
Activation of nuclear factor kappaB by polyamines in breast cancer cells
-
COI: 1:CAS:528:DyaK1MXmslClt7k%3D, PID: 10555958
-
Shah N, Thomas T, Shirahata A, Sigal LH, Thomas TJ (1999) Activation of nuclear factor kappaB by polyamines in breast cancer cells. Biochemistry 38:14763–14774
-
(1999)
Biochemistry
, vol.38
, pp. 14763-14774
-
-
Shah, N.1
Thomas, T.2
Shirahata, A.3
Sigal, L.H.4
Thomas, T.J.5
-
23
-
-
21644450924
-
Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells
-
COI: 1:CAS:528:DC%2BD2MXmt1CitA%3D%3D, PID: 15583809
-
Balabhadrapathruni S, Santhakumaran LM, Thomas TJ, Shirahata A, Gallo MA, Thomas T (2005) Bis(ethyl)norspermine potentiates the apoptotic activity of the pure antiestrogen ICI 182780 in breast cancer cells. Oncol Rep 13:101–108
-
(2005)
Oncol Rep
, vol.13
, pp. 101-108
-
-
Balabhadrapathruni, S.1
Santhakumaran, L.M.2
Thomas, T.J.3
Shirahata, A.4
Gallo, M.A.5
Thomas, T.6
-
24
-
-
0033835275
-
Molecular correlates of the action of bis(ethyl)polyamines in breast cancer cell growth inhibition and apoptosis
-
COI: 1:CAS:528:DC%2BD3cXmslGmtr0%3D, PID: 11012080
-
Faaland CA, Thomas TJ, Balabhadrapathruni S, Langer T, Mian S, Shirahata A, Gallo MA, Thomas T (2000) Molecular correlates of the action of bis(ethyl)polyamines in breast cancer cell growth inhibition and apoptosis. Biochem Cell Biol 78:415–426
-
(2000)
Biochem Cell Biol
, vol.78
, pp. 415-426
-
-
Faaland, C.A.1
Thomas, T.J.2
Balabhadrapathruni, S.3
Langer, T.4
Mian, S.5
Shirahata, A.6
Gallo, M.A.7
Thomas, T.8
-
25
-
-
77957788933
-
Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm
-
COI: 1:CAS:528:DC%2BC3cXhtlCnsb%2FP, PID: 20946629
-
Cervelli M, Bellavia G, Fratini E, Amendola R, Polticelli F, Barba M, Federico R, Signore F, Gucciardo G, Grillo R, Woster PM, Casero RA Jr, Mariottini P (2010) Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm. BMC Cancer 10:555
-
(2010)
BMC Cancer
, vol.10
, pp. 555
-
-
Cervelli, M.1
Bellavia, G.2
Fratini, E.3
Amendola, R.4
Polticelli, F.5
Barba, M.6
Federico, R.7
Signore, F.8
Gucciardo, G.9
Grillo, R.10
Woster, P.M.11
Casero, R.A.12
Mariottini, P.13
-
26
-
-
0141633535
-
Thirty Years of Polyamine-Related Approaches to Cancer Therapy. Retrospect and Prospect. Part 1. Selective enzyme inhibitors
-
COI: 1:CAS:528:DC%2BD3sXnsV2htbk%3D, PID: 14535654
-
Seiler N (2003) Thirty Years of Polyamine-Related Approaches to Cancer Therapy. Retrospect and Prospect. Part 1. Selective enzyme inhibitors. Curr Drug Targets 4:537–564
-
(2003)
Curr Drug Targets
, vol.4
, pp. 537-564
-
-
Seiler, N.1
-
27
-
-
84880634377
-
Reactive oxygen species spermine metabolites generated from amine oxidases and radiation represent a therapeutic gain in cancer treatments
-
Amendola R, Cervelli M, Fratini E, Sallustio DE, Tempera G, Ueshima T, Mariottini P, Agostinelli E (2014) Reactive oxygen species spermine metabolites generated from amine oxidases and radiation represent a therapeutic gain in cancer treatments. Int J Oncol 43:813–820
-
(2014)
Int J Oncol
, vol.43
, pp. 813-820
-
-
Amendola, R.1
Cervelli, M.2
Fratini, E.3
Sallustio, D.E.4
Tempera, G.5
Ueshima, T.6
Mariottini, P.7
Agostinelli, E.8
-
28
-
-
84896315445
-
Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response
-
COI: 1:CAS:528:DC%2BC3sXhtlOit7fL, PID: 23999645
-
Amendola R, Cervelli M, Tempera G, Fratini E, Varesio L, Mariottini P, Agostinelli E (2014) Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response. Amino Acids 46:487–498
-
(2014)
Amino Acids
, vol.46
, pp. 487-498
-
-
Amendola, R.1
Cervelli, M.2
Tempera, G.3
Fratini, E.4
Varesio, L.5
Mariottini, P.6
Agostinelli, E.7
-
29
-
-
0034045972
-
Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors?
-
COI: 1:CAS:528:DC%2BD3cXkvFWkt7k%3D, PID: 10888272
-
Schipper RG, Penning LC, Verhofstad AA (2000) Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors? Semin Cancer Biol 10:55–68
-
(2000)
Semin Cancer Biol
, vol.10
, pp. 55-68
-
-
Schipper, R.G.1
Penning, L.C.2
Verhofstad, A.A.3
-
30
-
-
0035099627
-
Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications
-
Thomas T, Thomas TJ (2001) Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cell Mol Life Sci 2:244–258
-
(2001)
Cell Mol Life Sci
, vol.2
, pp. 244-258
-
-
Thomas, T.1
Thomas, T.J.2
-
31
-
-
0024382725
-
Influence of polyamines on membrane functions
-
COI: 1:CAS:528:DyaL1MXit1OhsLY%3D, PID: 2673211
-
Schuber F (1989) Influence of polyamines on membrane functions. Biochem J 260:1–10
-
(1989)
Biochem J
, vol.260
, pp. 1-10
-
-
Schuber, F.1
-
32
-
-
0025752595
-
Implications and concepts of polyamine–nucleic acid interactions
-
COI: 1:CAS:528:DyaK3MXkt1Cnu74%3D, PID: 1874798
-
Feuerstein BG, Williams LD, Basu HS, Marton LJ (1991) Implications and concepts of polyamine–nucleic acid interactions. J Cell Biochem 46:37–47
-
(1991)
J Cell Biochem
, vol.46
, pp. 37-47
-
-
Feuerstein, B.G.1
Williams, L.D.2
Basu, H.S.3
Marton, L.J.4
-
33
-
-
0027643498
-
Polyamines, chromatin structure and transcription
-
COI: 1:CAS:528:DyaK2cXpvFGntg%3D%3D, PID: 8135771
-
Matthews HR (1993) Polyamines, chromatin structure and transcription. BioEssays 15:561–566
-
(1993)
BioEssays
, vol.15
, pp. 561-566
-
-
Matthews, H.R.1
-
34
-
-
70350780368
-
Mammalian polyamine metabolism and function
-
COI: 1:CAS:528:DC%2BD1MXhtFSgtrfN, PID: 19603518
-
Pegg AE (2009) Mammalian polyamine metabolism and function. IUBMB Life 61:880–894
-
(2009)
IUBMB Life
, vol.61
, pp. 880-894
-
-
Pegg, A.E.1
-
35
-
-
0033956687
-
The physiological role of the polyamines
-
COI: 1:CAS:528:DC%2BD3cXptVantg%3D%3D, PID: 10619994
-
Wallace HM (2000) The physiological role of the polyamines. Eur J Clin Invest 30:1–3
-
(2000)
Eur J Clin Invest
, vol.30
, pp. 1-3
-
-
Wallace, H.M.1
-
36
-
-
0023897010
-
Polyamine levels and gastrin receptors in colon cancers
-
COI: 1:CAS:528:DyaL1cXkvFSmsbk%3D, PID: 3389934
-
Upp JR Jr, Saydjari R, Townsend CM Jr, Singh P, Barranco SC, Thompson JC (1988) Polyamine levels and gastrin receptors in colon cancers. Ann Surg 207:662–669
-
(1988)
Ann Surg
, vol.207
, pp. 662-669
-
-
Upp, J.R.1
Saydjari, R.2
Townsend, C.M.3
Singh, P.4
Barranco, S.C.5
Thompson, J.C.6
-
37
-
-
0034665334
-
Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice
-
COI: 1:CAS:528:DC%2BD3cXntVamtbY%3D, PID: 11016639
-
Gupta S, Ahmad N, Marengo SR, MacLennan GT, Greenberg NM, Mukhtar H (2000) Chemoprevention of prostate carcinogenesis by alpha-difluoromethylornithine in TRAMP mice. Cancer Res 60:5125–5133
-
(2000)
Cancer Res
, vol.60
, pp. 5125-5133
-
-
Gupta, S.1
Ahmad, N.2
Marengo, S.R.3
MacLennan, G.T.4
Greenberg, N.M.5
Mukhtar, H.6
-
38
-
-
35348848363
-
Polyamines and nonmelanoma skin cancer
-
COI: 1:CAS:528:DC%2BD2sXhtF2mtL7P, PID: 17234230
-
Gilmour SK (2007) Polyamines and nonmelanoma skin cancer. Toxicol Appl Pharmacol 224:249–256
-
(2007)
Toxicol Appl Pharmacol
, vol.224
, pp. 249-256
-
-
Gilmour, S.K.1
-
39
-
-
0034889749
-
Immunohistochemical detection of ornithine-decarboxylase in primary and metastatic human breast cancer specimens
-
COI: 1:STN:280:DC%2BD3Mvns1ygug%3D%3D, PID: 11519863
-
Manni A, Astrow SH, Gammon S, Thompson J, Mauger D, Washington S (2001) Immunohistochemical detection of ornithine-decarboxylase in primary and metastatic human breast cancer specimens. Breast Cancer Res Treat 67:147–156
-
(2001)
Breast Cancer Res Treat
, vol.67
, pp. 147-156
-
-
Manni, A.1
Astrow, S.H.2
Gammon, S.3
Thompson, J.4
Mauger, D.5
Washington, S.6
-
40
-
-
41049086348
-
Role of ornithine decarboxylase in breast cancer
-
COI: 1:CAS:528:DC%2BD1cXkvFOmu7g%3D
-
Deng W, Jiang X, Mei Y, Sun J, Ma R, Liu X, Sun H, Tian H, Sun X (2008) Role of ornithine decarboxylase in breast cancer. Acta Biochim Biophys 40:235–243
-
(2008)
Acta Biochim Biophys
, vol.40
, pp. 235-243
-
-
Deng, W.1
Jiang, X.2
Mei, Y.3
Sun, J.4
Ma, R.5
Liu, X.6
Sun, H.7
Tian, H.8
Sun, X.9
-
41
-
-
0029832374
-
Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer
-
COI: 1:STN:280:DyaK1M%2FjsFahtQ%3D%3D, PID: 9816147
-
Manni A, Mauger D, Gimotty P, Badger B (1996) Prognostic influence on survival of increased ornithine decarboxylase activity in human breast cancer. Clin Cancer Res 2:1901–1906
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1901-1906
-
-
Manni, A.1
Mauger, D.2
Gimotty, P.3
Badger, B.4
-
42
-
-
0023253208
-
Ornithine decarboxylase activity, prolactin blood levels, and estradiol and progesterone receptors in human breast cancer
-
COI: 1:STN:280:DyaL1c7ltVKkuw%3D%3D, PID: 3440234
-
Glikman P, Vegh I, Pollina MA, Mosto AH, Levy CM (1987) Ornithine decarboxylase activity, prolactin blood levels, and estradiol and progesterone receptors in human breast cancer. Cancer 60:2237–2243
-
(1987)
Cancer
, vol.60
, pp. 2237-2243
-
-
Glikman, P.1
Vegh, I.2
Pollina, M.A.3
Mosto, A.H.4
Levy, C.M.5
-
43
-
-
0024400177
-
Cell kinetics as a prognostic indicator in node-negative breast cancer
-
COI: 1:STN:280:DyaL1Mzls1Oqsg%3D%3D, PID: 2767105
-
Silvestrini R, Daidone MG, Valagussa P, Di Fronzo G, Mezzanotte G, Bonadonna G (1989) Cell kinetics as a prognostic indicator in node-negative breast cancer. Eur J Cancer Clin Oncol 25:1165–1171
-
(1989)
Eur J Cancer Clin Oncol
, vol.25
, pp. 1165-1171
-
-
Silvestrini, R.1
Daidone, M.G.2
Valagussa, P.3
Di Fronzo, G.4
Mezzanotte, G.5
Bonadonna, G.6
-
44
-
-
84867259175
-
Arginase activity in patients with breast cancer: an analysis of plasma, tumors, and its relationship with the presence of the estrogen receptor
-
COI: 1:CAS:528:DC%2BC38XhsVOnt7bL, PID: 23038227
-
Perez G, Olivares IM, Rodriguez MG, Ceballos GM, Garcia Sanchez JR (2012) Arginase activity in patients with breast cancer: an analysis of plasma, tumors, and its relationship with the presence of the estrogen receptor. Onkologie 35:570–574
-
(2012)
Onkologie
, vol.35
, pp. 570-574
-
-
Perez, G.1
Olivares, I.M.2
Rodriguez, M.G.3
Ceballos, G.M.4
Garcia Sanchez, J.R.5
-
45
-
-
28844480406
-
2 in polyamine analogue-treated human breast cancer cell lines
-
COI: 1:CAS:528:DC%2BD2MXht1Gjs77N, PID: 16207710
-
2 in polyamine analogue-treated human breast cancer cell lines. J Biol Chem 280:39843–39851
-
(2005)
J Biol Chem
, vol.280
, pp. 39843-39851
-
-
Pledgie, A.1
Huang, Y.2
Hacker, A.3
Zhang, Z.4
Woster, P.M.5
Davidson, E.6
Casero, R.A.7
-
46
-
-
0027238083
-
1-acetyltransferase—the turning point in polyamine metabolism
-
COI: 1:CAS:528:DyaK3sXks1KitbY%3D, PID: 8500690
-
1-acetyltransferase—the turning point in polyamine metabolism. FASEB J 7:653–661
-
(1993)
FASEB J
, vol.7
, pp. 653-661
-
-
Casero, R.A.1
Pegg, A.E.2
-
47
-
-
79954436519
-
Probing mammalian spermine oxidase enzyme-substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization
-
COI: 1:CAS:528:DC%2BC3MXjsFGjtbw%3D, PID: 20839014
-
Tavladoraki P, Cervelli M, Antonangeli F, Minervini G, Stano P, Federico R, Mariottini P, Polticelli F (2011) Probing mammalian spermine oxidase enzyme-substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization. Amino Acids 40:1115–1126
-
(2011)
Amino Acids
, vol.40
, pp. 1115-1126
-
-
Tavladoraki, P.1
Cervelli, M.2
Antonangeli, F.3
Minervini, G.4
Stano, P.5
Federico, R.6
Mariottini, P.7
Polticelli, F.8
-
48
-
-
0037442525
-
Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine backconversion
-
COI: 1:CAS:528:DC%2BD3sXhtVKkur4%3D, PID: 12477380
-
Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW (2003) Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine backconversion. Biochem J 370(Pt 1):19–28
-
(2003)
Biochem J
, vol.370
, pp. 19-28
-
-
Vujcic, S.1
Liang, P.2
Diegelman, P.3
Kramer, D.L.4
Porter, C.W.5
-
49
-
-
84862305749
-
Molecular evolution of the polyamine oxidase gene family in Metazoa
-
COI: 1:CAS:528:DC%2BC3sXmvFKhug%3D%3D, PID: 22716069
-
Polticelli F, Salvi D, Mariottini P, Amendola R, Cervelli M (2012) Molecular evolution of the polyamine oxidase gene family in Metazoa. BMC Evol Biol 12:90
-
(2012)
BMC Evol Biol
, vol.12
, pp. 90
-
-
Polticelli, F.1
Salvi, D.2
Mariottini, P.3
Amendola, R.4
Cervelli, M.5
-
50
-
-
84881132970
-
Structure–function relationships in the evolutionary framework of spermine oxidase
-
COI: 1:CAS:528:DC%2BC3sXhtFKntLbE, PID: 23828398
-
Cervelli M, Salvi D, Polticelli F, Amendola R, Mariottini P (2013) Structure–function relationships in the evolutionary framework of spermine oxidase. J Mol Evol 76:365–370
-
(2013)
J Mol Evol
, vol.76
, pp. 365-370
-
-
Cervelli, M.1
Salvi, D.2
Polticelli, F.3
Amendola, R.4
Mariottini, P.5
-
51
-
-
0036846756
-
Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin
-
COI: 1:CAS:528:DC%2BD38XotFWlurY%3D, PID: 12141946
-
Vujcic S, Diegelman P, Bacchi CJ, Kramer DL, Porter CW (2002) Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J 367(Pt 3):665–675
-
(2002)
Biochem J
, vol.367
, pp. 665-675
-
-
Vujcic, S.1
Diegelman, P.2
Bacchi, C.J.3
Kramer, D.L.4
Porter, C.W.5
-
52
-
-
0038136943
-
Heterologous expression and characterization of mouse spermine oxidase
-
COI: 1:CAS:528:DC%2BD3sXhtVKltbk%3D, PID: 12458219
-
Cervelli M, Polticelli F, Federico F, Mariottini P (2003) Heterologous expression and characterization of mouse spermine oxidase. J Biol Chem 278:5271–5276
-
(2003)
J Biol Chem
, vol.278
, pp. 5271-5276
-
-
Cervelli, M.1
Polticelli, F.2
Federico, F.3
Mariottini, P.4
-
53
-
-
1342280373
-
Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform
-
COI: 1:CAS:528:DC%2BD2cXhslKqsbo%3D, PID: 14764092
-
Cervelli M, Bellini A, Bianchi M, Marcocci L, Nocera S, Polticelli F, Federico R, Amendola R, Mariottini P (2004) Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform. Eur J Biochem 271:760–770
-
(2004)
Eur J Biochem
, vol.271
, pp. 760-770
-
-
Cervelli, M.1
Bellini, A.2
Bianchi, M.3
Marcocci, L.4
Nocera, S.5
Polticelli, F.6
Federico, R.7
Amendola, R.8
Mariottini, P.9
-
54
-
-
69249245459
-
Polyamine catabolism and disease
-
COI: 1:CAS:528:DC%2BD1MXosV2hur8%3D, PID: 19589128
-
Casero RA Jr, Pegg AE (2009) Polyamine catabolism and disease. Biochem J 421:323–338
-
(2009)
Biochem J
, vol.421
, pp. 323-338
-
-
Casero, R.A.1
Pegg, A.E.2
-
55
-
-
33845730779
-
Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis
-
COI: 1:CAS:528:DC%2BD28Xht1KnsL7M, PID: 17145855
-
Babbar N, Casero RA Jr (2006) Tumor necrosis factor-alpha increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. Cancer Res 66:11125–11130
-
(2006)
Cancer Res
, vol.66
, pp. 11125-11130
-
-
Babbar, N.1
Casero, R.A.2
-
56
-
-
80053079336
-
Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis induced colon tumorigenesis
-
COI: 1:CAS:528:DC%2BC3MXht1Gqt73O, PID: 21876161
-
Goodwin AC, Destefano Shields CE, Wu S, Huso DL, Wu X, Murray-Stewart TR, Hacker-Prietz A, Rabizadeh S, Woster PM, Sears CL, Casero RA Jr (2011) Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis induced colon tumorigenesis. Proc Natl Acad Sci USA 108:15354–15359
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 15354-15359
-
-
Goodwin, A.C.1
Destefano Shields, C.E.2
Wu, S.3
Huso, D.L.4
Wu, X.5
Murray-Stewart, T.R.6
Hacker-Prietz, A.7
Rabizadeh, S.8
Woster, P.M.9
Sears, C.L.10
Casero, R.A.11
-
57
-
-
84962511189
-
In vitro breast cancer models as useful tools in therapeutics?
-
Bana E, Bagrel D (2011) In vitro breast cancer models as useful tools in therapeutics? In: Gunduz M, Gunduz E (eds), Breast cancer focusing tumor microenvironment, stem cells and metastasis, chapter 2. Publisher InTech, pp 21–38
-
(2011)
Breast cancer focusing tumor microenvironment, stem cells and metastasis, chapter 2. Publisher InTech
, pp. 21-38
-
-
Bana, E.1
Bagrel, D.2
Gunduz, M.3
Gunduz, E.4
-
58
-
-
84860992007
-
Choosing the right cell line for breast cancer research
-
PID: 21884641
-
Holliday DL, Speirs V (2011) Choosing the right cell line for breast cancer research. Breast Cancer Res 13:215
-
(2011)
Breast Cancer Res
, vol.13
, pp. 215
-
-
Holliday, D.L.1
Speirs, V.2
-
59
-
-
36749012914
-
Persistent use of “false” cell lines
-
COI: 1:CAS:528:DC%2BD2sXhsVSgtb7L, PID: 17960586
-
Lacroix M (2008) Persistent use of “false” cell lines. Int J Cancer 122:1–4
-
(2008)
Int J Cancer
, vol.122
, pp. 1-4
-
-
Lacroix, M.1
-
60
-
-
0024212339
-
Involvement of the polyamine pathway in antiestrogen-induced growth inhibition of human breast cancer
-
COI: 1:CAS:528:DyaL1MXhvVahsQ%3D%3D, PID: 3180091
-
Cohen FJ, Manni A, Glikman P, Bartholomew M, Demers L (1988) Involvement of the polyamine pathway in antiestrogen-induced growth inhibition of human breast cancer. Cancer Res 48:6819–6825
-
(1988)
Cancer Res
, vol.48
, pp. 6819-6825
-
-
Cohen, F.J.1
Manni, A.2
Glikman, P.3
Bartholomew, M.4
Demers, L.5
-
61
-
-
0025780367
-
Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture
-
COI: 1:CAS:528:DyaK3MXlslGqtL8%3D, PID: 1912611
-
Kim I, Manni A, Lynch J, Demers L (1991) Polyamine involvement in the secretion and action of TGF-alpha in hormone sensitive human breast cancer cells in culture. Breast Cancer Res Treat 18:83–91
-
(1991)
Breast Cancer Res Treat
, vol.18
, pp. 83-91
-
-
Kim, I.1
Manni, A.2
Lynch, J.3
Demers, L.4
-
62
-
-
0029080675
-
Isolation and characterization of human breast cancer cells overexpressing S-adenosylmethionine decarboxylase
-
COI: 1:CAS:528:DyaK2MXnsFWhu7o%3D, PID: 7656236
-
Manni A, Badger B, Grove R, Kunselman S, Demers L (1995) Isolation and characterization of human breast cancer cells overexpressing S-adenosylmethionine decarboxylase. Cancer Lett 95:23–28
-
(1995)
Cancer Lett
, vol.95
, pp. 23-28
-
-
Manni, A.1
Badger, B.2
Grove, R.3
Kunselman, S.4
Demers, L.5
-
63
-
-
0029142821
-
Biochemical and growth-modulatory effects of the new S-adenosylmethionine decarboxylase inhibitor CGP 48664 in malignant and immortalized normal human breast epithelial cells in culture
-
COI: 1:CAS:528:DyaK2MXpsVWmsLw%3D, PID: 7635576
-
Manni A, Badger B, Wechter R, Kunselman S, Rossini A, Demers L (1995) Biochemical and growth-modulatory effects of the new S-adenosylmethionine decarboxylase inhibitor CGP 48664 in malignant and immortalized normal human breast epithelial cells in culture. Int J Cancer 62:485–491
-
(1995)
Int J Cancer
, vol.62
, pp. 485-491
-
-
Manni, A.1
Badger, B.2
Wechter, R.3
Kunselman, S.4
Rossini, A.5
Demers, L.6
-
64
-
-
0029781653
-
Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells
-
Thomas T, Faaland CA, Adhikarakunnathu S, Thomas TJ (1996) Structure-activity relations of S-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells. Breast Cancer Res Treat 139:293–306
-
(1996)
Breast Cancer Res Treat
, vol.139
, pp. 293-306
-
-
Thomas, T.1
Faaland, C.A.2
Adhikarakunnathu, S.3
Thomas, T.J.4
-
65
-
-
0028897596
-
Polyamine profiles and growth properties of ornithine decarboxylase overexpressing MCF-7 breast cancer cells in culture
-
COI: 1:CAS:528:DyaK2MXkvVGnsbY%3D, PID: 7749159
-
Manni A, Wechter R, Grove R, Wei L, Martel J, Demers L (1995) Polyamine profiles and growth properties of ornithine decarboxylase overexpressing MCF-7 breast cancer cells in culture. Breast Cancer Res Treat 34:45–53
-
(1995)
Breast Cancer Res Treat
, vol.34
, pp. 45-53
-
-
Manni, A.1
Wechter, R.2
Grove, R.3
Wei, L.4
Martel, J.5
Demers, L.6
-
66
-
-
0031019072
-
Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of human breast epithelial cells
-
COI: 1:CAS:528:DyaK2sXhtlOrsb8%3D, PID: 9009157
-
Manni A, Wechter R, Gilmour S, Verderame MF, Mauger D, Demers LM (1997) Ornithine decarboxylase over-expression stimulates mitogen-activated protein kinase and anchorage-independent growth of human breast epithelial cells. Int J Cancer 70:175–182
-
(1997)
Int J Cancer
, vol.70
, pp. 175-182
-
-
Manni, A.1
Wechter, R.2
Gilmour, S.3
Verderame, M.F.4
Mauger, D.5
Demers, L.M.6
-
67
-
-
7044285899
-
Role of polyamines in the function of nuclear transcription factor NF-κB in breast cancer cells
-
COI: 1:CAS:528:DC%2BD2cXhtVaitLzF, PID: 15494691
-
Zaletok S, Alexandrova N, Berdynskykh N, Ignatenko N, Gogol S, Orlovsky O, Tregubova N, Gerner E, Chekhun V (2004) Role of polyamines in the function of nuclear transcription factor NF-κB in breast cancer cells. Exp Oncol 26:221–225
-
(2004)
Exp Oncol
, vol.26
, pp. 221-225
-
-
Zaletok, S.1
Alexandrova, N.2
Berdynskykh, N.3
Ignatenko, N.4
Gogol, S.5
Orlovsky, O.6
Tregubova, N.7
Gerner, E.8
Chekhun, V.9
-
68
-
-
0037178588
-
Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells
-
COI: 1:CAS:528:DC%2BD38XkvFKjtro%3D, PID: 12095537
-
Pavlov V, Rodilla V, Kong Thoo Lin P (2002) Growth, morphological and biochemical changes in oxa-spermine derivative-treated MCF-7 human breast cancer cells. Life Sci 71:1161–1173
-
(2002)
Life Sci
, vol.71
, pp. 1161-1173
-
-
Pavlov, V.1
Rodilla, V.2
Kong Thoo Lin, P.3
-
69
-
-
0036240770
-
Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives
-
COI: 1:CAS:528:DC%2BD38XjtlWmur8%3D, PID: 12022477
-
Pavlov V, Lin PK, Rodilla V (2002) Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives. Cell Mol Life Sci 59:715–723
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 715-723
-
-
Pavlov, V.1
Lin, P.K.2
Rodilla, V.3
-
70
-
-
84867867473
-
Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells
-
COI: 1:CAS:528:DC%2BC38XhsFamtLfM, PID: 22976807
-
Zhu Q, Jin L, Casero RA Jr, Davidson NE, Huang Y (2012) Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells. Breast Cancer Res Treat 136:57–66
-
(2012)
Breast Cancer Res Treat
, vol.136
, pp. 57-66
-
-
Zhu, Q.1
Jin, L.2
Casero, R.A.3
Davidson, N.E.4
Huang, Y.5
-
71
-
-
84858164318
-
Inhibition of ornithine decarboxylase alters the roscovitine-induced mitochondrial-mediated apoptosis in MCF-7 breast cancer cells
-
COI: 1:CAS:528:DC%2BC38XmslWltbY%3D, PID: 22344475
-
Arisan ED, Obakan P, Coker A, Palavan-Unsal N (2012) Inhibition of ornithine decarboxylase alters the roscovitine-induced mitochondrial-mediated apoptosis in MCF-7 breast cancer cells. Mol Med Rep 5:1323–1329
-
(2012)
Mol Med Rep
, vol.5
, pp. 1323-1329
-
-
Arisan, E.D.1
Obakan, P.2
Coker, A.3
Palavan-Unsal, N.4
-
72
-
-
84891928290
-
Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells
-
COI: 1:CAS:528:DC%2BC3sXhslWqurfI, PID: 24190492
-
Obakan P, Arısan ED, Özfiliz P, Çoker-Gürkan A, Palavan-Ünsal N (2014) Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells. Mol Biol Rep 41:145–154
-
(2014)
Mol Biol Rep
, vol.41
, pp. 145-154
-
-
Obakan, P.1
Arısan, E.D.2
Özfiliz, P.3
Çoker-Gürkan, A.4
Palavan-Ünsal, N.5
-
73
-
-
0021989550
-
N-2,3-butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase
-
COI: 1:CAS:528:DyaL2MXitVaisg%3D%3D, PID: 3965702
-
Bey P, Bolkenius FN, Seiler N, Casara P (1985) N-2,3-butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase. J Med Chem 28:1–2
-
(1985)
J Med Chem
, vol.28
, pp. 1-2
-
-
Bey, P.1
Bolkenius, F.N.2
Seiler, N.3
Casara, P.4
-
74
-
-
4143109032
-
1-bis(2,3-butadienyl)-1,4-butanediamine
-
COI: 1:CAS:528:DC%2BD2cXmslOhsbs%3D, PID: 15313165
-
1-bis(2,3-butadienyl)-1,4-butanediamine. Biochem Biophys Res Commun. 322:1–8
-
(2004)
Biochem Biophys Res Commun.
, vol.322
, pp. 1-8
-
-
Bellelli, A.1
Cavallo, S.2
Nicolini, L.3
Cervelli, M.4
Bianchi, M.5
Mariottini, P.6
Zelli, M.7
Federico, R.8
-
75
-
-
34249748927
-
Chronic sub-lethal oxidative stress by spermine oxidase overactivity induces continuous DNA repair and hypersensitivity to radiation exposure
-
COI: 1:CAS:528:DC%2BD2sXmtVansLw%3D, PID: 17363080
-
Bianchi M, Bellini A, Cervelli M, Degan P, Marcocci L, Martini F, Scatteia M, Mariottini P, Amendola R (2007) Chronic sub-lethal oxidative stress by spermine oxidase overactivity induces continuous DNA repair and hypersensitivity to radiation exposure. Biochim Biophys Acta 1773:774–783
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 774-783
-
-
Bianchi, M.1
Bellini, A.2
Cervelli, M.3
Degan, P.4
Marcocci, L.5
Martini, F.6
Scatteia, M.7
Mariottini, P.8
Amendola, R.9
-
76
-
-
39049171988
-
Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death
-
COI: 1:CAS:528:DC%2BD1cXitlKit7k%3D, PID: 17920946
-
Holst CM, Johansson VM, Alm K, Oredsson SM (2008) Novel anti-apoptotic effect of Bcl-2: prevention of polyamine depletion-induced cell death. Cell Biol Int 32:66–74
-
(2008)
Cell Biol Int
, vol.32
, pp. 66-74
-
-
Holst, C.M.1
Johansson, V.M.2
Alm, K.3
Oredsson, S.M.4
-
77
-
-
34047240000
-
Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine
-
COI: 1:CAS:528:DC%2BD2sXjvFGqur8%3D, PID: 17184909
-
Nair SK, Verma A, Thomas TJ, Chou TC, Gallo MA, Shirahata A, Thomas T (2007) Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. Cancer Lett 250:311–322
-
(2007)
Cancer Lett
, vol.250
, pp. 311-322
-
-
Nair, S.K.1
Verma, A.2
Thomas, T.J.3
Chou, T.C.4
Gallo, M.A.5
Shirahata, A.6
Thomas, T.7
-
78
-
-
77951927063
-
The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic eVects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines
-
Pledgie-Tracey A, Billam M, Hacker A, Sobolewski MD, Woster PM, Zhang Z, Casero RA Jr, Davidson NE (2010) The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic eVects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines. Cancer Chemother Pharmacol 65:1067–1081
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, pp. 1067-1081
-
-
Pledgie-Tracey, A.1
Billam, M.2
Hacker, A.3
Sobolewski, M.D.4
Woster, P.M.5
Zhang, Z.6
Casero, R.A.7
Davidson, N.E.8
-
79
-
-
0027424382
-
Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential anti-tumor agents
-
COI: 1:CAS:528:DyaK2cXjtVCntw%3D%3D, PID: 8411017
-
Saab MH, West EE, Bieszk NC, Preuss C, Mank AR, Casero RA Jr, Woster PM (1993) Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential anti-tumor agents. J Med Chem 36:2998–3004
-
(1993)
J Med Chem
, vol.36
, pp. 2998-3004
-
-
Saab, M.H.1
West, E.E.2
Bieszk, N.C.3
Preuss, C.4
Mank, A.R.5
Casero, R.A.6
Woster, P.M.7
-
80
-
-
0028967677
-
Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1
-
COI: 1:CAS:528:DyaK2MXlvFGmsbg%3D, PID: 7720179
-
Casero RA Jr, Mank AR, Saab NH, Wu R, Dyer WJ, Woster PM (1995) Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1. Cancer Chemother Pharmacol 36:69–74
-
(1995)
Cancer Chemother Pharmacol
, vol.36
, pp. 69-74
-
-
Casero, R.A.1
Mank, A.R.2
Saab, N.H.3
Wu, R.4
Dyer, W.J.5
Woster, P.M.6
-
81
-
-
0029081697
-
Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue
-
COI: 1:CAS:528:DyaK2MXnt1ans7s%3D, PID: 7614453
-
McCloskey DE, Casero RA Jr, Woster PM, Davidson NE (1995) Induction of programmed cell death in human breast cancer cells by an unsymmetrically alkylated polyamine analogue. Cancer Res 55:3233–3236
-
(1995)
Cancer Res
, vol.55
, pp. 3233-3236
-
-
McCloskey, D.E.1
Casero, R.A.2
Woster, P.M.3
Davidson, N.E.4
-
82
-
-
0032947019
-
Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment
-
COI: 1:CAS:528:DyaK1MXjtVKjur0%3D, PID: 10732790
-
Davidson NE, Hahm HA, McCloskey DE, Woster PM, Casero RA Jr (1999) Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment. Endocr Relat Cancer 6:69–73
-
(1999)
Endocr Relat Cancer
, vol.6
, pp. 69-73
-
-
Davidson, N.E.1
Hahm, H.A.2
McCloskey, D.E.3
Woster, P.M.4
Casero, R.A.5
-
83
-
-
26444441453
-
Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors
-
COI: 1:CAS:528:DC%2BD2MXpvFCnu74%3D, PID: 16190761
-
Varghese S, Gupta D, Baran T, Jiemjit A, Gore SD, Casero RA Jr, Woster PM (2005) Alkyl-substituted polyaminohydroxamic acids: a novel class of targeted histone deacetylase inhibitors. J Med Chem 48:6350–6365
-
(2005)
J Med Chem
, vol.48
, pp. 6350-6365
-
-
Varghese, S.1
Gupta, D.2
Baran, T.3
Jiemjit, A.4
Gore, S.D.5
Casero, R.A.6
Woster, P.M.7
-
84
-
-
43049129992
-
Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors
-
COI: 1:CAS:528:DC%2BD1cXjsVGnt7g%3D, PID: 18348516
-
Varghese S, Senanayake T, Murray-Stewart T, Doering K, Fraser A, Casero RA Jr, Woster PM (2008) Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors. J Med Chem 51:2447–2456
-
(2008)
J Med Chem
, vol.51
, pp. 2447-2456
-
-
Varghese, S.1
Senanayake, T.2
Murray-Stewart, T.3
Doering, K.4
Fraser, A.5
Casero, R.A.6
Woster, P.M.7
-
85
-
-
34249934238
-
Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes
-
COI: 1:CAS:528:DC%2BD2sXmtFCiurg%3D, PID: 17463086
-
Huang Y, Greene E, Murray Stewart T, Goodwin AC, Baylin SB, Woster PM, Casero RA Jr (2007) Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes. Proc Natl Acad Sci USA 104:8023–8028
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8023-8028
-
-
Huang, Y.1
Greene, E.2
Murray Stewart, T.3
Goodwin, A.C.4
Baylin, S.B.5
Woster, P.M.6
Casero, R.A.7
-
86
-
-
84863232569
-
Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes
-
COI: 1:CAS:528:DC%2BC38XivV2iu7s%3D, PID: 22132744
-
Wu Y, Steinbergs N, Murray-Stewart T, Marton LJ, Casero RA Jr (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem J 442:693–701
-
(2012)
Biochem J
, vol.442
, pp. 693-701
-
-
Wu, Y.1
Steinbergs, N.2
Murray-Stewart, T.3
Marton, L.J.4
Casero, R.A.5
-
87
-
-
0035120259
-
Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines
-
COI: 1:CAS:528:DC%2BD3MXhvFKnsbc%3D, PID: 11234895
-
Hahm HA, Dunn VR, Butash KA, Deveraux WL, Woster PM, Casero RA Jr, Davidson NE (2001) Combination of standard cytotoxic agents with polyamine analogues in the treatment of breast cancer cell lines. Clin Cancer Res 7:391–399
-
(2001)
Clin Cancer Res
, vol.7
, pp. 391-399
-
-
Hahm, H.A.1
Dunn, V.R.2
Butash, K.A.3
Deveraux, W.L.4
Woster, P.M.5
Casero, R.A.6
Davidson, N.E.7
-
88
-
-
49649129997
-
The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib
-
COI: 1:CAS:528:DC%2BD1cXnt1ejs7g%3D, PID: 18559525
-
Carew JS, Nawrocki ST, Reddy VK, Bush D, Rehg JE, Goodwin A, Houghton JA, Casero RA Jr, Marton LJ, Cleveland JL (2008) The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib. Cancer Res 68:4783–4790
-
(2008)
Cancer Res
, vol.68
, pp. 4783-4790
-
-
Carew, J.S.1
Nawrocki, S.T.2
Reddy, V.K.3
Bush, D.4
Rehg, J.E.5
Goodwin, A.6
Houghton, J.A.7
Casero, R.A.8
Marton, L.J.9
Cleveland, J.L.10
-
89
-
-
53149113412
-
In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells
-
COI: 1:CAS:528:DC%2BD1cXhtF2kur7P, PID: 18301893
-
Hacker A, Marton LJ, Sobolewski M, Casero RA Jr (2008) In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells. Cancer Chemother Pharmacol 63:45–53
-
(2008)
Cancer Chemother Pharmacol
, vol.63
, pp. 45-53
-
-
Hacker, A.1
Marton, L.J.2
Sobolewski, M.3
Casero, R.A.4
-
90
-
-
78650045248
-
Reduction of the putative CD44 + CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047
-
COI: 1:CAS:528:DC%2BC3cXht1Gkur%2FM, PID: 20838207
-
Cirenajwis H, Smiljanic S, Honeth G, Hegardt C, Marton LJ, Oredsson SM (2010) Reduction of the putative CD44 + CD24- breast cancer stem cell population by targeting the polyamine metabolic pathway with PG11047. Anticancer Drugs 21:897–906
-
(2010)
Anticancer Drugs
, vol.21
, pp. 897-906
-
-
Cirenajwis, H.1
Smiljanic, S.2
Honeth, G.3
Hegardt, C.4
Marton, L.J.5
Oredsson, S.M.6
-
91
-
-
84861715426
-
Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells
-
COI: 1:CAS:528:DC%2BC38Xhtlyqtbo%3D, PID: 21805138
-
Zhu Q, Huang Y, Marton LJ, Woster PM, Davidson NE, Casero RA Jr (2012) Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells. Amino Acids 42:887–898
-
(2012)
Amino Acids
, vol.42
, pp. 887-898
-
-
Zhu, Q.1
Huang, Y.2
Marton, L.J.3
Woster, P.M.4
Davidson, N.E.5
Casero, R.A.6
-
92
-
-
84895910981
-
Increased breast cancer cell toxicity by palladination of the polyamine analogue N1, N11-bis(ethyl)norspermine
-
COI: 1:CAS:528:DC%2BC3sXhvFOlsLrI, PID: 24363201
-
Silva TM, Fiuza SM, Marques MPM, Persson L, Oredsson S (2014) Increased breast cancer cell toxicity by palladination of the polyamine analogue N1, N11-bis(ethyl)norspermine. Amino Acids 46:339–352
-
(2014)
Amino Acids
, vol.46
, pp. 339-352
-
-
Silva, T.M.1
Fiuza, S.M.2
Marques, M.P.M.3
Persson, L.4
Oredsson, S.5
-
93
-
-
24644443129
-
Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs
-
COI: 1:CAS:528:DC%2BD2MXhtVSlsr7K, PID: 15894512
-
Brabec V, Kasparkova J (2005) Modifications of DNA by platinum complexes. Relation to resistance of tumors to platinum antitumor drugs. Drug Resist Updat 8:131–146
-
(2005)
Drug Resist Updat
, vol.8
, pp. 131-146
-
-
Brabec, V.1
Kasparkova, J.2
-
94
-
-
77951662950
-
Analytical methodologies for metallomics studies of antitumor Pt-containing drugs
-
PID: 21072372
-
Esteban-Fernández D, Moreno-Gordaliza E, Cañas B, Palacios MA, Gómez-Gómez MM (2010) Analytical methodologies for metallomics studies of antitumor Pt-containing drugs. Metallomics 2:19–38
-
(2010)
Metallomics
, vol.2
, pp. 19-38
-
-
Esteban-Fernández, D.1
Moreno-Gordaliza, E.2
Cañas, B.3
Palacios, M.A.4
Gómez-Gómez, M.M.5
-
95
-
-
84873905382
-
Norspermidine and novel Pd(II) and Pt(II) polynuclear complexes of norspermidine as potential antineoplastic agents against breast cancer
-
COI: 1:CAS:528:DC%2BC3sXjtlCmu7o%3D, PID: 23418450
-
Silva TM, Andersson S, Sukumaran SK, Marques MP, Persson L, Oredsson S (2013) Norspermidine and novel Pd(II) and Pt(II) polynuclear complexes of norspermidine as potential antineoplastic agents against breast cancer. PLoS ONE 8(2):e55651
-
(2013)
PLoS ONE
, vol.8
, Issue.2
, pp. e55651
-
-
Silva, T.M.1
Andersson, S.2
Sukumaran, S.K.3
Marques, M.P.4
Persson, L.5
Oredsson, S.6
-
96
-
-
84855870600
-
Novel Pt(II) and Pd(II) complexes with polyamine analogues: synthesis and vibrational analysis
-
COI: 1:CAS:528:DC%2BC38Xkt1ems7w%3D, PID: 22265832
-
Silva TM, Oredsson S, Persson L, Woster P, Marques MP (2012) Novel Pt(II) and Pd(II) complexes with polyamine analogues: synthesis and vibrational analysis. J Inorg Biochem 108:1–7
-
(2012)
J Inorg Biochem
, vol.108
, pp. 1-7
-
-
Silva, T.M.1
Oredsson, S.2
Persson, L.3
Woster, P.4
Marques, M.P.5
-
97
-
-
36549037548
-
Effects of polyamine depletion by α-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells
-
COI: 1:CAS:528:DC%2BD2sXhtlGrtb3I, PID: 17333337
-
Jun JY, Griffith JW, Bruggeman R, Washington S, Demers LM, Verderame MF, Manni A (2008) Effects of polyamine depletion by α-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells. Breast Cancer Res Treat 107:33–40
-
(2008)
Breast Cancer Res Treat
, vol.107
, pp. 33-40
-
-
Jun, J.Y.1
Griffith, J.W.2
Bruggeman, R.3
Washington, S.4
Demers, L.M.5
Verderame, M.F.6
Manni, A.7
-
98
-
-
0032875359
-
Antitumor effects of bis(ethyl)polyamine analogs on mammary tumor development in FVB/NTgN (MMTVneu) transgenic mice
-
COI: 1:CAS:528:DyaK1MXmsFaiurY%3D, PID: 10656605
-
Shah N, Antony T, Haddad S, Amenta P, Shirahata A, Thomas TJ, Thomas T (1999) Antitumor effects of bis(ethyl)polyamine analogs on mammary tumor development in FVB/NTgN (MMTVneu) transgenic mice. Cancer Lett 146:15–23
-
(1999)
Cancer Lett
, vol.146
, pp. 15-23
-
-
Shah, N.1
Antony, T.2
Haddad, S.3
Amenta, P.4
Shirahata, A.5
Thomas, T.J.6
Thomas, T.7
-
99
-
-
0026779817
-
Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice
-
COI: 1:CAS:528:DyaK3sXjvV0%3D, PID: 1451091
-
Manni A, Badger B, Martel J, Demers L (1992) Role of polyamines in the growth of hormone-responsive and -resistant human breast cancer cells in nude mice. Cancer Lett 66:1–9
-
(1992)
Cancer Lett
, vol.66
, pp. 1-9
-
-
Manni, A.1
Badger, B.2
Martel, J.3
Demers, L.4
-
100
-
-
0031027116
-
Effects of a bis(benzyl)spermine analog on MCF-7 breast cancer cells in culture and nude mice xenografts
-
PID: 21590003
-
Thomas T, Shah N, Faaland C, Gallo M, Yurkow E, Satyaswaroop P (1997) Effects of a bis(benzyl)spermine analog on MCF-7 breast cancer cells in culture and nude mice xenografts. Oncol Rep 4:5–13
-
(1997)
Oncol Rep
, vol.4
, pp. 5-13
-
-
Thomas, T.1
Shah, N.2
Faaland, C.3
Gallo, M.4
Yurkow, E.5
Satyaswaroop, P.6
-
101
-
-
0034113012
-
Benefits of complete polyamine deprivation in hormone responsive and hormone resistant MCF-7 human breast adenocarcinoma in vivo
-
COI: 1:CAS:528:DC%2BD3cXisl2ns7o%3D, PID: 10769640
-
Leveque J, Foucher F, Havouis R, Desury D, Grall JY, Moulinoux JP (2000) Benefits of complete polyamine deprivation in hormone responsive and hormone resistant MCF-7 human breast adenocarcinoma in vivo. Anticancer Res 20:97–101
-
(2000)
Anticancer Res
, vol.20
, pp. 97-101
-
-
Leveque, J.1
Foucher, F.2
Havouis, R.3
Desury, D.4
Grall, J.Y.5
Moulinoux, J.P.6
-
102
-
-
0036211154
-
Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells
-
COI: 1:CAS:528:DC%2BD38XjtlCitL4%3D, PID: 11964084
-
Manni A, Washington S, Griffith JW, Verderame MF, Mauger D, Demers LM, Samant RS, Welch DR (2002) Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells. Clin Exp Metastasis 19:95–105
-
(2002)
Clin Exp Metastasis
, vol.19
, pp. 95-105
-
-
Manni, A.1
Washington, S.2
Griffith, J.W.3
Verderame, M.F.4
Mauger, D.5
Demers, L.M.6
Samant, R.S.7
Welch, D.R.8
-
103
-
-
0018120634
-
Effect of alphadifluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice
-
COI: 1:CAS:528:DyaE1cXmtV2jtLw%3D, PID: 679213
-
Prakash NJ, Schechter PJ, Grove J, Koch-Weser J (1978) Effect of alphadifluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice. Cancer Res 38:3059–3062
-
(1978)
Cancer Res
, vol.38
, pp. 3059-3062
-
-
Prakash, N.J.1
Schechter, P.J.2
Grove, J.3
Koch-Weser, J.4
-
104
-
-
0000382583
-
Alphadifluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin
-
PID: 6821130
-
Herrmann AL, Nelson FR, Slaga TJ (1982) Alphadifluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin. Proc Natl Acad Sci USA 79:6028–6032
-
(1982)
Proc Natl Acad Sci USA
, vol.79
, pp. 6028-6032
-
-
Herrmann, A.L.1
Nelson, F.R.2
Slaga, T.J.3
-
105
-
-
0018097605
-
Anti-proliferative properties of DL-alpha-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase
-
COI: 1:CAS:528:DyaE1cXksVSjurY%3D, PID: 656104
-
Mamont PS, Duchesne MC, Grove J, Bey P (1978) Anti-proliferative properties of DL-alpha-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase. Biochem Biophys Res Comm 81:58–66
-
(1978)
Biochem Biophys Res Comm
, vol.81
, pp. 58-66
-
-
Mamont, P.S.1
Duchesne, M.C.2
Grove, J.3
Bey, P.4
-
106
-
-
0022965395
-
Phase I trial of α-difluoromethylornithine (DFMO) and methylglyoxal bis(guanylhydrazone) (MGBG) in patients with advanced prostatic cancer
-
COI: 1:STN:280:DyaL2s%2FntFertw%3D%3D, PID: 3097903
-
Herr HW, Warrel RP, Burchenal JH (1986) Phase I trial of α-difluoromethylornithine (DFMO) and methylglyoxal bis(guanylhydrazone) (MGBG) in patients with advanced prostatic cancer. Urology 28:508–511
-
(1986)
Urology
, vol.28
, pp. 508-511
-
-
Herr, H.W.1
Warrel, R.P.2
Burchenal, J.H.3
-
107
-
-
0022999939
-
A phase II study of α-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma
-
COI: 1:STN:280:DyaL2s7js1GjsQ%3D%3D, PID: 3102397
-
Meyskens FL Jr, Kingsley EM, Glattke T, Loescher L, Booth A (1986) A phase II study of α-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma. Invest New Drugs 4:257–262
-
(1986)
Invest New Drugs
, vol.4
, pp. 257-262
-
-
Meyskens, F.L.1
Kingsley, E.M.2
Glattke, T.3
Loescher, L.4
Booth, A.5
-
108
-
-
0023219533
-
Phase I-II clinical trial with α-difluoromethylornithine—an inhibitor of polyamine biosynthesis
-
COI: 1:STN:280:DyaL1c%2FgsVKlug%3D%3D, PID: 3115786
-
Horn Y, Schechter PJ, Marton LJ (1987) Phase I-II clinical trial with α-difluoromethylornithine—an inhibitor of polyamine biosynthesis. Eur J Cancer Clin Oncol 23:1103–1107
-
(1987)
Eur J Cancer Clin Oncol
, vol.23
, pp. 1103-1107
-
-
Horn, Y.1
Schechter, P.J.2
Marton, L.J.3
-
109
-
-
0028246617
-
Phase I study of combined α interferon, -difluoromethylornithine (DFMO), and doxorubicin in advanced malignancy
-
COI: 1:STN:280:DyaK2M%2FkvFarug%3D%3D, PID: 7960601
-
Ganju V, Edmonson JH, Buckner JC (1994) Phase I study of combined α interferon, -difluoromethylornithine (DFMO), and doxorubicin in advanced malignancy. Invest New Drugs 12:25–27
-
(1994)
Invest New Drugs
, vol.12
, pp. 25-27
-
-
Ganju, V.1
Edmonson, J.H.2
Buckner, J.C.3
-
110
-
-
0031889260
-
Phase I dose de-escalation trial of -difluoromethylornithine in patients with grade 3 cervical intraepithelial neoplasia
-
COI: 1:CAS:528:DyaK1cXhtlSmsL0%3D, PID: 9516915
-
Mitchell MF, Tortolero-Luna G, Lee JJ, Hittelman WN, Lotan R, Wharton JT, Hong WK, Nishioka K (1998) Phase I dose de-escalation trial of -difluoromethylornithine in patients with grade 3 cervical intraepithelial neoplasia. Clin Cancer Res 4:303–310
-
(1998)
Clin Cancer Res
, vol.4
, pp. 303-310
-
-
Mitchell, M.F.1
Tortolero-Luna, G.2
Lee, J.J.3
Hittelman, W.N.4
Lotan, R.5
Wharton, J.T.6
Hong, W.K.7
Nishioka, K.8
-
111
-
-
0032713928
-
α-Difluoromethylornithine as treatment for metastatic breast cancer patients
-
PID: 10589756
-
O’Shaughnessy JA, Demers LM, Jones SE, Arsenau J, Khandelwal P, George T, Gersh R, Mauger D, Manni A (1999) α-Difluoromethylornithine as treatment for metastatic breast cancer patients. Clin Cancer Res 5:3438–3444
-
(1999)
Clin Cancer Res
, vol.5
, pp. 3438-3444
-
-
O’Shaughnessy, J.A.1
Demers, L.M.2
Jones, S.E.3
Arsenau, J.4
Khandelwal, P.5
George, T.6
Gersh, R.7
Mauger, D.8
Manni, A.9
-
112
-
-
0035160247
-
Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme
-
COI: 1:CAS:528:DC%2BD3MXisVWmsA%3D%3D, PID: 11163499
-
Prados MD, Wara WM, Sneed PK, McDermott M, Chang SM, Rabbitt J, Page M, Malec M, Davis RL, Gutin PH, Lamborn K, Wilson CB, Phillips TL, Larson DA (2001) Phase III trial of accelerated hyperfractionation with or without difluromethylornithine (DFMO) versus standard fractionated radiotherapy with or without DFMO for newly diagnosed patients with glioblastoma multiforme. Int J Radiat Oncol Biol Phys 49:71–77
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.49
, pp. 71-77
-
-
Prados, M.D.1
Wara, W.M.2
Sneed, P.K.3
McDermott, M.4
Chang, S.M.5
Rabbitt, J.6
Page, M.7
Malec, M.8
Davis, R.L.9
Gutin, P.H.10
Lamborn, K.11
Wilson, C.B.12
Phillips, T.L.13
Larson, D.A.14
-
113
-
-
0036794934
-
A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers
-
COI: 1:CAS:528:DC%2BD38XosFKhs7s%3D, PID: 12374678
-
Fabian CJ, Kimler BF, Brady DA, Mayo MS, Chang CH, Ferraro JA, Zalles CM, Stanton AL, Masood S, Grizzle WE, Boyd NF, Arneson DW, Johnson KA (2002) A phase II breast cancer chemoprevention trial of oral alpha-difluoromethylornithine: breast tissue, imaging, and serum and urine biomarkers. Clin Cancer Res 8:3105–3117
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3105-3117
-
-
Fabian, C.J.1
Kimler, B.F.2
Brady, D.A.3
Mayo, M.S.4
Chang, C.H.5
Ferraro, J.A.6
Zalles, C.M.7
Stanton, A.L.8
Masood, S.9
Grizzle, W.E.10
Boyd, N.F.11
Arneson, D.W.12
Johnson, K.A.13
-
114
-
-
0037342691
-
Phase III randomized study of postradiotherapy chemotherapy with combination -difluoromethylornithine-PCV versus PCV for anaplastic gliomas
-
COI: 1:CAS:528:DC%2BD3sXhvFKiu78%3D, PID: 12631596
-
Levin VA, Hess KR, Choucair A, Flynn P, Jaeckle KA, Kyritsis AP, Yung WK, Prados MD, Bruner JM, Ictech S, Gleason MJ, Kim HW (2003) Phase III randomized study of postradiotherapy chemotherapy with combination -difluoromethylornithine-PCV versus PCV for anaplastic gliomas. Clin Cancer Res 9:981–990
-
(2003)
Clin Cancer Res
, vol.9
, pp. 981-990
-
-
Levin, V.A.1
Hess, K.R.2
Choucair, A.3
Flynn, P.4
Jaeckle, K.A.5
Kyritsis, A.P.6
Yung, W.K.7
Prados, M.D.8
Bruner, J.M.9
Ictech, S.10
Gleason, M.J.11
Kim, H.W.12
-
115
-
-
33645682384
-
Combination therapy with 2-difluoromethylornithine and a polyamone transport inhibitor against murine squamous cell carcinoma
-
COI: 1:CAS:528:DC%2BD28XjsVCgtLY%3D, PID: 16331620
-
Chen Y, Weeks RS, Burns MR, Boorman DW, Klein-Szanto A, O’Brien TG (2006) Combination therapy with 2-difluoromethylornithine and a polyamone transport inhibitor against murine squamous cell carcinoma. Int J Cancer 118:2344–2349
-
(2006)
Int J Cancer
, vol.118
, pp. 2344-2349
-
-
Chen, Y.1
Weeks, R.S.2
Burns, M.R.3
Boorman, D.W.4
Klein-Szanto, A.5
O’Brien, T.G.6
-
116
-
-
0042098091
-
Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention
-
COI: 1:CAS:528:DyaK1cXlslylt70%3D, PID: 9719082
-
Meyskens FL Jr, Gerner EW, Emerson S, Pelot D, Durbin T, Doyle K, Lagerberg W (1998) Effect of alpha-difluoromethylornithine on rectal mucosal levels of polyamines in a randomized, double-blinded trial for colon cancer prevention. J Natl Cancer Inst 90:1212–1218
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 1212-1218
-
-
Meyskens, F.L.1
Gerner, E.W.2
Emerson, S.3
Pelot, D.4
Durbin, T.5
Doyle, K.6
Lagerberg, W.7
-
117
-
-
55549132996
-
Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial
-
COI: 1:CAS:528:DC%2BD1MXltFCisL0%3D
-
Meyskens FL Jr, McLaren CE, Pelot D, Fujikawa-Brooks S, Carpenter PM, Hawk E, Kelloff G, Lawson MJ, Kidao J, McCracken J, Albers CG, Ahnen DJ, Turgeon DK, Goldschmid S, Lance P, Hagedorn CH, Gillen DL, Gerner EW (2008) Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial. Cancer Prev Res (Phila) 1:32–38
-
(2008)
Cancer Prev Res (Phila)
, vol.1
, pp. 32-38
-
-
Meyskens, F.L.1
McLaren, C.E.2
Pelot, D.3
Fujikawa-Brooks, S.4
Carpenter, P.M.5
Hawk, E.6
Kelloff, G.7
Lawson, M.J.8
Kidao, J.9
McCracken, J.10
Albers, C.G.11
Ahnen, D.J.12
Turgeon, D.K.13
Goldschmid, S.14
Lance, P.15
Hagedorn, C.H.16
Gillen, D.L.17
Gerner, E.W.18
-
118
-
-
39449086676
-
The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial
-
COI: 1:CAS:528:DC%2BD1cXhslarur0%3D, PID: 18268112
-
Simoneau AR, Gerner EW, Nagle R, Ziogas A, Fujikawa-Brooks S, Yerushalmi H, Ahlering TE, Lieberman R, McLaren CE, Anton-Culver H, Meyskens FL Jr (2008) The effect of difluoromethylornithine on decreasing prostate size and polyamines in men: results of a year-long phase IIb randomized placebo-controlled chemoprevention trial. Cancer Epidemiol Biomarkers Prev 17:292–299
-
(2008)
Cancer Epidemiol Biomarkers Prev
, vol.17
, pp. 292-299
-
-
Simoneau, A.R.1
Gerner, E.W.2
Nagle, R.3
Ziogas, A.4
Fujikawa-Brooks, S.5
Yerushalmi, H.6
Ahlering, T.E.7
Lieberman, R.8
McLaren, C.E.9
Anton-Culver, H.10
Meyskens, F.L.11
-
119
-
-
0026667443
-
Treatment of recurrent gliomas with eflornithine
-
COI: 1:STN:280:DyaK38zotFOntw%3D%3D, PID: 1380989
-
Levin VA, Prados MD, Yung WK, Gleason MJ, Ictech S, Malec M (1992) Treatment of recurrent gliomas with eflornithine. J Natl Cancer Inst 84:1432–1437
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1432-1437
-
-
Levin, V.A.1
Prados, M.D.2
Yung, W.K.3
Gleason, M.J.4
Ictech, S.5
Malec, M.6
-
120
-
-
0024151667
-
Regulation of polyamine biosynthetic activity by spermidine and spermine analogs, a novel antiproliferative strategy
-
COI: 1:CAS:528:DyaK3cXhvFWhsr0%3D, PID: 3076344
-
Porter CW, Bergeron RJ (1988) Regulation of polyamine biosynthetic activity by spermidine and spermine analogs, a novel antiproliferative strategy. Adv Exp Med Biol 250:677–690
-
(1988)
Adv Exp Med Biol
, vol.250
, pp. 677-690
-
-
Porter, C.W.1
Bergeron, R.J.2
-
121
-
-
0035804314
-
Terminally alkylated polyamine analogues as chemotherapeutic agents
-
COI: 1:CAS:528:DC%2BD3cXptVOmu78%3D, PID: 11141084
-
Casero RA Jr, Woster PM (2001) Terminally alkylated polyamine analogues as chemotherapeutic agents. J Med Chem 44:1–26
-
(2001)
J Med Chem
, vol.44
, pp. 1-26
-
-
Casero, R.A.1
Woster, P.M.2
-
122
-
-
68549101792
-
Recent advances in the development of polyamine analogues as antitumor agents
-
COI: 1:CAS:528:DC%2BD1MXnsVWhsLo%3D, PID: 19534534
-
Casero RA Jr, Woster PM (2009) Recent advances in the development of polyamine analogues as antitumor agents. J Med Chem 52:4551–4573
-
(2009)
J Med Chem
, vol.52
, pp. 4551-4573
-
-
Casero, R.A.1
Woster, P.M.2
-
123
-
-
0028101980
-
Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues
-
COI: 1:CAS:528:DyaK2cXlsVyhsLw%3D, PID: 8033120
-
Casero RA Jr, Gabrielson EW, Pegg AE (1994) Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues. Cancer Res 54:3955–3958
-
(1994)
Cancer Res
, vol.54
, pp. 3955-3958
-
-
Casero, R.A.1
Gabrielson, E.W.2
Pegg, A.E.3
-
124
-
-
0032790812
-
The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1, N11-bis(ethyl)norspermine
-
COI: 1:CAS:528:DyaK1MXltVCqsb0%3D, PID: 10430062
-
Gabrielson EW, Pegg AE, Casero RA Jr (1999) The induction of spermidine/spermine N1-acetyltransferase (SSAT) is a common event in the response of human primary non-small cell lung carcinomas to exposure to the new antitumor polyamine analogue N1, N11-bis(ethyl)norspermine. Clin Cancer Res 5:1638–1641
-
(1999)
Clin Cancer Res
, vol.5
, pp. 1638-1641
-
-
Gabrielson, E.W.1
Pegg, A.E.2
Casero, R.A.3
-
125
-
-
0029085526
-
Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion
-
COI: 1:CAS:528:DyaK2MXnsVeqsL4%3D, PID: 9816054
-
Bernacki RJ, Oberman EJ, Seweryniak KE, Atwood A, Bergeron RJ, Porter CW (1995) Preclinical antitumor efficacy of the polyamine analogue N1, N11-diethylnorspermine administered by multiple injection or continuous infusion. Clin Cancer Res 1:847–857
-
(1995)
Clin Cancer Res
, vol.1
, pp. 847-857
-
-
Bernacki, R.J.1
Oberman, E.J.2
Seweryniak, K.E.3
Atwood, A.4
Bergeron, R.J.5
Porter, C.W.6
-
126
-
-
0035094510
-
Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies
-
COI: 1:CAS:528:DC%2BD3MXisFyqs7Y%3D, PID: 11291831
-
Streiff RR, Bender JF (2001) Phase 1 study of N1-N11-diethylnorspermine (DENSPM) administered TID for 6 days in patients with advanced malignancies. Invest New Drugs 19:29–39
-
(2001)
Invest New Drugs
, vol.19
, pp. 29-39
-
-
Streiff, R.R.1
Bender, J.F.2
-
127
-
-
0346734280
-
A phase II study of the polyamine analog N1, N11-diethylnorspermine (DENSPM) daily for five days every 21 days in patients with previously treated metastatic breast cancer
-
COI: 1:CAS:528:DC%2BD3sXpsl2ls70%3D, PID: 14676116
-
Wolff AC, Armstrong DK, Fetting JH, Carducci MK, Riley CD, Bender JF, Casero RA Jr, Davidson NE (2003) A phase II study of the polyamine analog N1, N11-diethylnorspermine (DENSPM) daily for five days every 21 days in patients with previously treated metastatic breast cancer. Clin Cancer Res 9:5922–5928
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5922-5928
-
-
Wolff, A.C.1
Armstrong, D.K.2
Fetting, J.H.3
Carducci, M.K.4
Riley, C.D.5
Bender, J.F.6
Casero, R.A.7
Davidson, N.E.8
-
128
-
-
0030659113
-
Unusual central nervous system toxicity in a Phase I study of N1, N11 diethylnorspermine in patients with advanced malignancy
-
COI: 1:CAS:528:DyaK2sXnslylsLk%3D, PID: 9387045
-
Creaven PJ, Perez R, Pendyala L, Meropol NJ, Loewen G, Levine E, Berghorn E, Raghavan D (1997) Unusual central nervous system toxicity in a Phase I study of N1, N11 diethylnorspermine in patients with advanced malignancy. Invest New Drugs 15:227–234
-
(1997)
Invest New Drugs
, vol.15
, pp. 227-234
-
-
Creaven, P.J.1
Perez, R.2
Pendyala, L.3
Meropol, N.J.4
Loewen, G.5
Levine, E.6
Berghorn, E.7
Raghavan, D.8
-
129
-
-
4444295545
-
Polyamine catabolism in platinum drug action: interactions between oxaliplatin and the polyamine analogue N1, N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase
-
COI: 1:CAS:528:DC%2BD2cXls1amsrw%3D, PID: 15252142
-
Hector S, Porter CW, Kramer DL, Clark K, Prey J, Kisiel N, Diegelman P, Chen Y, Pendyala L (2004) Polyamine catabolism in platinum drug action: interactions between oxaliplatin and the polyamine analogue N1, N11-diethylnorspermine at the level of spermidine/spermine N1-acetyltransferase. Mol Cancer Ther 3:813–822
-
(2004)
Mol Cancer Ther
, vol.3
, pp. 813-822
-
-
Hector, S.1
Porter, C.W.2
Kramer, D.L.3
Clark, K.4
Prey, J.5
Kisiel, N.6
Diegelman, P.7
Chen, Y.8
Pendyala, L.9
-
130
-
-
20244382266
-
N1, N12-diacetylspermine as a sensitive and specific novel marker for early- and late-stage colorectal and breast cancers
-
COI: 1:CAS:528:DC%2BD2MXjtlejtL0%3D, PID: 15837752
-
Hiramatsu K, Takahashi K, Yamaguchi T, Matsumoto H, Miyamoto H, Tanaka S, Tanaka C, Tamamori Y, Imajo M, Kawaguchi M, Toi M, Mori T, Kawakita M (2005) N1, N12-diacetylspermine as a sensitive and specific novel marker for early- and late-stage colorectal and breast cancers. Clin Cancer Res 11:2986–2990
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2986-2990
-
-
Hiramatsu, K.1
Takahashi, K.2
Yamaguchi, T.3
Matsumoto, H.4
Miyamoto, H.5
Tanaka, S.6
Tanaka, C.7
Tamamori, Y.8
Imajo, M.9
Kawaguchi, M.10
Toi, M.11
Mori, T.12
Kawakita, M.13
-
131
-
-
84890544974
-
High-throughput LC-MS/MS based simultaneous determination of polyamines including N-acetylated forms in human saliva and the diagnostic approach to breast cancer patients
-
COI: 1:CAS:528:DC%2BC3sXhslynu7fI, PID: 24274257
-
Tsutsui H, Mochizuki T, Inoue K, Toyama T, Yoshimoto N, Endo Y, Todoroki K, Zhe Min J, Toyo’oka T (2013) High-throughput LC-MS/MS based simultaneous determination of polyamines including N-acetylated forms in human saliva and the diagnostic approach to breast cancer patients. Anal Chem 85:11835–11842
-
(2013)
Anal Chem
, vol.85
, pp. 11835-11842
-
-
Tsutsui, H.1
Mochizuki, T.2
Inoue, K.3
Toyama, T.4
Yoshimoto, N.5
Endo, Y.6
Todoroki, K.7
Zhe Min, J.8
Toyo’oka, T.9
-
132
-
-
0034623954
-
Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs
-
COI: 1:CAS:528:DC%2BD3cXoslymsLg%3D, PID: 10978316
-
Vujcic S, Halmekyto M, Diegelman P, Gan G, Kramer DL, Janne J, Porter CW (2000) Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. J Biol Chem 275:38319–38328
-
(2000)
J Biol Chem
, vol.275
, pp. 38319-38328
-
-
Vujcic, S.1
Halmekyto, M.2
Diegelman, P.3
Gan, G.4
Kramer, D.L.5
Janne, J.6
Porter, C.W.7
-
133
-
-
67849085497
-
Breast cancer stem cells and intrinsic subtypes: controversies rage on
-
COI: 1:CAS:528:DC%2BD1MXkvVSgtLo%3D, PID: 19149630
-
Nakshatri H, Srour EF, Badve S (2009) Breast cancer stem cells and intrinsic subtypes: controversies rage on. Curr Stem Cell Res Ther 4:50–60
-
(2009)
Curr Stem Cell Res Ther
, vol.4
, pp. 50-60
-
-
Nakshatri, H.1
Srour, E.F.2
Badve, S.3
-
134
-
-
84862013828
-
Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer
-
Dong Y, Zhu Y, Jing L, Zhou Q, Wu C, Oupický D (2012) Synthesis of bisethylnorspermine lipid prodrug as gene delivery vector targeting polyamine metabolism in breast cancer. Mol Pharm 4:1654–1664
-
(2012)
Mol Pharm
, vol.4
, pp. 1654-1664
-
-
Dong, Y.1
Zhu, Y.2
Jing, L.3
Zhou, Q.4
Wu, C.5
Oupický, D.6
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