메뉴 건너뛰기




Volumn 21, Issue 11, 2007, Pages 885-900

Agmatine: Metabolic pathway and spectrum of activity in brain

Author keywords

Agmatine, general; Anxiety; Depression; Post traumatic stress disorder

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; AGMATINE; ALPHA 2 ADRENERGIC RECEPTOR; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; BRIMONIDINE; IDAZOXAN; IMIDAZOLINE I1 RECEPTOR; IMIPRAMINE; MORPHINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE SYNTHASE; YOHIMBINE;

EID: 35048891421     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200721110-00002     Document Type: Review
Times cited : (210)

References (99)
  • 1
    • 0028269271 scopus 로고
    • Agmatine: An endogenous clonidine-displacing substance in the brain
    • Li G, Regunathan S, Barrow CJ, et al. Agmatine: an endogenous clonidine-displacing substance in the brain. Science 1994; 263: 966-9
    • (1994) Science , vol.263 , pp. 966-969
    • Li, G.1    Regunathan, S.2    Barrow, C.J.3
  • 2
    • 4143151617 scopus 로고    scopus 로고
    • Arginine pathways and the inflammatory response: Interregulation of nitric oxide and polyamines: review article
    • Satriano J. Arginine pathways and the inflammatory response: interregulation of nitric oxide and polyamines: review article. Amino Acids 2004; 26: 321-9
    • (2004) Amino Acids , vol.26 , pp. 321-329
    • Satriano, J.1
  • 3
    • 1642450643 scopus 로고    scopus 로고
    • Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine
    • Zhu M, Iyo A, Piletz J, et al. Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. Biochim Biophys Acta 2004; 1670: 156-64
    • (2004) Biochim Biophys Acta , vol.1670 , pp. 156-164
    • Zhu, M.1    Iyo, A.2    Piletz, J.3
  • 4
    • 0034193104 scopus 로고    scopus 로고
    • Is agmatine a novel neurotransmitter in brain?
    • Reis DJ, Regunathan S. Is agmatine a novel neurotransmitter in brain? Trends Pharmacol Sci 2000; 21: 187-93
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 187-193
    • Reis, D.J.1    Regunathan, S.2
  • 5
    • 2542527672 scopus 로고    scopus 로고
    • Putrescine biosynthesis in mammalian tissues
    • Coleman CS, Hu G, Pegg AE. Putrescine biosynthesis in mammalian tissues. Biochem J 2004; 379: 849-55
    • (2004) Biochem J , vol.379 , pp. 849-855
    • Coleman, C.S.1    Hu, G.2    Pegg, A.E.3
  • 6
    • 33645098156 scopus 로고    scopus 로고
    • Expression of arginine decarboxylase in brain regions and neuronal cells
    • Iyo AH, Zhu MY, Ordway GA, et al. Expression of arginine decarboxylase in brain regions and neuronal cells. J Neurochem 2006; 96: 1042-50
    • (2006) J Neurochem , vol.96 , pp. 1042-1050
    • Iyo, A.H.1    Zhu, M.Y.2    Ordway, G.A.3
  • 7
    • 29344447039 scopus 로고    scopus 로고
    • Release of tritiated agmatine from spinal synaptosomes
    • Goracke-Postle CJ, Nguyen HO, Stone LS, et al. Release of tritiated agmatine from spinal synaptosomes. Neuroreport 2006; 17: 13-7
    • (2006) Neuroreport , vol.17 , pp. 13-17
    • Goracke-Postle, C.J.1    Nguyen, H.O.2    Stone, L.S.3
  • 8
    • 0032503938 scopus 로고    scopus 로고
    • Agmatine containing axon terminals in rat hippocampus form synapses on pyramidal cells
    • Reis DJ, Yang XC, Milner TA. Agmatine containing axon terminals in rat hippocampus form synapses on pyramidal cells. Neurosci Lett 1998; 250: 185-8
    • (1998) Neurosci Lett , vol.250 , pp. 185-188
    • Reis, D.J.1    Yang, X.C.2    Milner, T.A.3
  • 9
    • 1642534414 scopus 로고    scopus 로고
    • Anticonvulsive effect of agmatine in mice
    • Su R, Wei X, Zheng J, et al. Anticonvulsive effect of agmatine in mice. Pharmacol Biochem Behav 2004; 77: 345-9
    • (2004) Pharmacol Biochem Behav , vol.77 , pp. 345-349
    • Su, R.1    Wei, X.2    Zheng, J.3
  • 10
    • 22844448778 scopus 로고    scopus 로고
    • The synergistic anticonvulsant effect of agmatine and morphine: Possible role of alpha 2-adrenoceptors
    • Riazi K, Honar H, Homayoun H, et al. The synergistic anticonvulsant effect of agmatine and morphine: possible role of alpha 2-adrenoceptors. Epilepsy Res 2005; 65: 33-40
    • (2005) Epilepsy Res , vol.65 , pp. 33-40
    • Riazi, K.1    Honar, H.2    Homayoun, H.3
  • 11
    • 33747191382 scopus 로고    scopus 로고
    • Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons
    • Zhu MY, Wang WP, Bissette G. Neuroprotective effects of agmatine against cell damage caused by glucocorticoids in cultured rat hippocampal neurons. Neuroscience 2006; 141 (4): 2019-27
    • (2006) Neuroscience , vol.141 , Issue.4 , pp. 2019-2027
    • Zhu, M.Y.1    Wang, W.P.2    Bissette, G.3
  • 12
    • 26244454404 scopus 로고    scopus 로고
    • Gilad GM, Gilad VH, Finberg JP, et al. Neurochemical evidence for agmatine modulation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. Neurochem Res 2005; 30: 713-9
    • Gilad GM, Gilad VH, Finberg JP, et al. Neurochemical evidence for agmatine modulation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. Neurochem Res 2005; 30: 713-9
  • 13
    • 33646395679 scopus 로고    scopus 로고
    • Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons
    • Wang WP, Iyo AH, Miguel-Hidalgo J, et al. Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res 2006; 1084: 210-6
    • (2006) Brain Res , vol.1084 , pp. 210-216
    • Wang, W.P.1    Iyo, A.H.2    Miguel-Hidalgo, J.3
  • 14
    • 1342305415 scopus 로고    scopus 로고
    • Relevance of imidazoline receptors and agmatine to psychiatry: A decade of progress
    • Halaris A, Piletz J. Relevance of imidazoline receptors and agmatine to psychiatry: a decade of progress. Ann N Y Acad Sci 2003; 1009: 1-20
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 1-20
    • Halaris, A.1    Piletz, J.2
  • 15
    • 20544435255 scopus 로고    scopus 로고
    • Agmatine attenuates stress- and lipopolysaccharide-induced fever in rats
    • Aricioglu F, Regunathan S. Agmatine attenuates stress- and lipopolysaccharide-induced fever in rats. Physiol Behav 2005; 85: 370-5
    • (2005) Physiol Behav , vol.85 , pp. 370-375
    • Aricioglu, F.1    Regunathan, S.2
  • 16
    • 0030695375 scopus 로고    scopus 로고
    • The imidazoline receptor in control of blood pressure by clonidine and allied drugs
    • Reis DJ, Piletz JE. The imidazoline receptor in control of blood pressure by clonidine and allied drugs. Am J Physiol 1997; 273: R1569-71
    • (1997) Am J Physiol , vol.273
    • Reis, D.J.1    Piletz, J.E.2
  • 17
    • 0031692835 scopus 로고    scopus 로고
    • Seeing through a glass darkly': Casting light on imidazoline 'I' sites
    • Eglen RM, Hudson AL, Kendall DA, et al. 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. Trends Pharmacol Sci 1998; 19: 381-90
    • (1998) Trends Pharmacol Sci , vol.19 , pp. 381-390
    • Eglen, R.M.1    Hudson, A.L.2    Kendall, D.A.3
  • 18
    • 0036177993 scopus 로고    scopus 로고
    • Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction
    • Raasch W, Schafer U, Qadri F, et al. Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction. Br J Pharmacol 2002; 135: 663-72
    • (2002) Br J Pharmacol , vol.135 , pp. 663-672
    • Raasch, W.1    Schafer, U.2    Qadri, F.3
  • 19
    • 0029145740 scopus 로고
    • Endogenous ligands of imidazoline receptors: Classic and immunoreactive clonidine-displacing substance and agmatine
    • Reis DJ, Li G, Regunathan S. Endogenous ligands of imidazoline receptors: classic and immunoreactive clonidine-displacing substance and agmatine. Ann N Y Acad Sci 1995; 763: 295-313
    • (1995) Ann N Y Acad Sci , vol.763 , pp. 295-313
    • Reis, D.J.1    Li, G.2    Regunathan, S.3
  • 20
    • 1342326710 scopus 로고    scopus 로고
    • Is agmatine an endogenous factor against stress?
    • Aricioglu F, Regunathan S, Piletz J. Is agmatine an endogenous factor against stress? Ann N Y Acad Sci 2003; 1009: 127-32
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 127-132
    • Aricioglu, F.1    Regunathan, S.2    Piletz, J.3
  • 21
    • 24344472244 scopus 로고    scopus 로고
    • IRAS, a candidate for I(1)-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence
    • Wu N, Su R, Xu B, et al. IRAS, a candidate for I(1)-imidazoline receptor, mediates inhibitory effect of agmatine on cellular morphine dependence. Biochem Pharmacol 2005; 70 (7): 1079-87
    • (2005) Biochem Pharmacol , vol.70 , Issue.7 , pp. 1079-1087
    • Wu, N.1    Su, R.2    Xu, B.3
  • 22
    • 33748713835 scopus 로고    scopus 로고
    • Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor
    • Wu N, Su RB, Liu Y, et al. Modulation of agmatine on calcium signal in morphine-dependent CHO cells by activation of IRAS, a candidate for imidazoline I1 receptor. Eur J Pharmacol 2006; 548 (1-3): 21-8
    • (2006) Eur J Pharmacol , vol.548 , Issue.1-3 , pp. 21-28
    • Wu, N.1    Su, R.B.2    Liu, Y.3
  • 23
    • 0032772901 scopus 로고    scopus 로고
    • Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor
    • Olmos G, DeGregorio-Rocasolano N, Paz Regalado M, et al. Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor. Br J Pharmacol 1999; 127: 1317-26
    • (1999) Br J Pharmacol , vol.127 , pp. 1317-1326
    • Olmos, G.1    DeGregorio-Rocasolano, N.2    Paz Regalado, M.3
  • 24
    • 0033020806 scopus 로고    scopus 로고
    • Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons
    • Yang XC, Reis DJ. Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons. J Pharmacol Exp Ther 1999; 288: 544-9
    • (1999) J Pharmacol Exp Ther , vol.288 , pp. 544-549
    • Yang, X.C.1    Reis, D.J.2
  • 25
    • 0029941131 scopus 로고    scopus 로고
    • Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine
    • Galea E, Regunathan S, Eliopoulos V, et al. Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J 1996; 316: 247-9
    • (1996) Biochem J , vol.316 , pp. 247-249
    • Galea, E.1    Regunathan, S.2    Eliopoulos, V.3
  • 26
    • 0035170477 scopus 로고    scopus 로고
    • Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme
    • Demady DR, Jianmongkol S, Vuletich JL, et al. Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme. Mol Pharmacol 2001; 59: 24-9
    • (2001) Mol Pharmacol , vol.59 , pp. 24-29
    • Demady, D.R.1    Jianmongkol, S.2    Vuletich, J.L.3
  • 27
    • 1342305418 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes
    • Dec;
    • Regunathan S, Piletz J. Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes. Ann N Y Acad Sci 2003 Dec; 1009: 20-9
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 20-29
    • Regunathan, S.1    Piletz, J.2
  • 28
    • 1342305412 scopus 로고    scopus 로고
    • Agmatine crosses the blood-brain barrier
    • Piletz J, May P, Wang G, et al. Agmatine crosses the blood-brain barrier. Ann N Y Acad Sci 2003; 1009: 64-74
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 64-74
    • Piletz, J.1    May, P.2    Wang, G.3
  • 29
    • 0037171030 scopus 로고    scopus 로고
    • Agmatine produces antidepressant-like effects in two models of depression in mice
    • Zomkowski AD, Hammes L, Lin J, et al. Agmatine produces antidepressant-like effects in two models of depression in mice. Neuroreport 2002; 13: 387-91
    • (2002) Neuroreport , vol.13 , pp. 387-391
    • Zomkowski, A.D.1    Hammes, L.2    Lin, J.3
  • 30
    • 1342305408 scopus 로고    scopus 로고
    • Is agmatine an endogenous anxiolytic/ antidepressant agent?
    • Aricioglu F, Altunbas H. Is agmatine an endogenous anxiolytic/ antidepressant agent? Ann N Y Acad Sci 2003; 1009: 136-40
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 136-140
    • Aricioglu, F.1    Altunbas, H.2
  • 31
    • 0038392436 scopus 로고    scopus 로고
    • Antidepressant-like effect of agmatine and its possible mechanism
    • Li Y, Gong Z, Cao J, et al. Antidepressant-like effect of agmatine and its possible mechanism. Eur J Pharmacol 2003; 469: 81-8
    • (2003) Eur J Pharmacol , vol.469 , pp. 81-88
    • Li, Y.1    Gong, Z.2    Cao, J.3
  • 32
    • 0037451828 scopus 로고    scopus 로고
    • Agmatine induces anxiolysis in the elevated plus maze task in adult rats
    • Lavinsky D, Arteni N, Netto C. Agmatine induces anxiolysis in the elevated plus maze task in adult rats. Behav Brain Res 2003; 141: 19-24
    • (2003) Behav Brain Res , vol.141 , pp. 19-24
    • Lavinsky, D.1    Arteni, N.2    Netto, C.3
  • 33
    • 0034004250 scopus 로고    scopus 로고
    • Acquisition deficit and time-dependent retrograde amnesia for contextual fear conditioning in agmatine-treated rats
    • Stewart LS, McKay BE. Acquisition deficit and time-dependent retrograde amnesia for contextual fear conditioning in agmatine-treated rats. Behav Pharmacol 2000; 11: 93-7
    • (2000) Behav Pharmacol , vol.11 , pp. 93-97
    • Stewart, L.S.1    McKay, B.E.2
  • 34
    • 0345149545 scopus 로고    scopus 로고
    • Effects of agmatine on ethanol withdrawal syndrome in rats
    • Uzbay IT, Yesilyurt O, Celik T, et al. Effects of agmatine on ethanol withdrawal syndrome in rats. Behav Brain Res 2000; 107: 153-9
    • (2000) Behav Brain Res , vol.107 , pp. 153-159
    • Uzbay, I.T.1    Yesilyurt, O.2    Celik, T.3
  • 35
    • 8544220416 scopus 로고    scopus 로고
    • Effect of agmatine on the development of morphine dependence in rats: Potential role of cAMP system
    • Aricioglu F, Means A, Regunathan S. Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system. Eur J Pharmacol 2004; 504: 191-7
    • (2004) Eur J Pharmacol , vol.504 , pp. 191-197
    • Aricioglu, F.1    Means, A.2    Regunathan, S.3
  • 36
    • 20344377628 scopus 로고    scopus 로고
    • Inhibition by agmatine on morphine-induced conditioned place preference in rats
    • Wei X, Su R, Lu X, et al. Inhibition by agmatine on morphine-induced conditioned place preference in rats. Eur J Pharmacol 2005; 515: 99-106
    • (2005) Eur J Pharmacol , vol.515 , pp. 99-106
    • Wei, X.1    Su, R.2    Lu, X.3
  • 37
    • 3343003565 scopus 로고    scopus 로고
    • Acute stress disorder, posttraumatic stress disorder, and depression in disaster or rescue workers
    • Fullerton CS, Ursano RJ, Wang L. Acute stress disorder, posttraumatic stress disorder, and depression in disaster or rescue workers. Am J Psychiatry 2004; 161: 1370-6
    • (2004) Am J Psychiatry , vol.161 , pp. 1370-1376
    • Fullerton, C.S.1    Ursano, R.J.2    Wang, L.3
  • 39
    • 10744229107 scopus 로고    scopus 로고
    • Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines
    • Molderings G, Bruss M, Bonisch H, et al. Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines. Ann N Y Acad Sci 2003; 1009: 75-81
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 75-81
    • Molderings, G.1    Bruss, M.2    Bonisch, H.3
  • 40
    • 0036087418 scopus 로고    scopus 로고
    • Cloning of human agmatinase: An alternate path for polyamine synthesis induced in liver by hepatitis B virus
    • Mistry SK, Burwell TJ, Chambers RM, et al. Cloning of human agmatinase: an alternate path for polyamine synthesis induced in liver by hepatitis B virus. Am J Physiol Gastrointest Liver Physiol 2002; 282: G375-81
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282
    • Mistry, S.K.1    Burwell, T.J.2    Chambers, R.M.3
  • 41
    • 0036351424 scopus 로고    scopus 로고
    • Cloning and characterization of human agmatinase
    • Iyer R, Kim H, Tsoa R, et al. Cloning and characterization of human agmatinase. Mol Genet Metab 2002; 75: 209-18
    • (2002) Mol Genet Metab , vol.75 , pp. 209-218
    • Iyer, R.1    Kim, H.2    Tsoa, R.3
  • 42
    • 2442605533 scopus 로고    scopus 로고
    • Recent advances in arginine metabolism
    • Morris S. Recent advances in arginine metabolism. Curr Opin Clin Nutr Metab Care 2004; 7: 45-51
    • (2004) Curr Opin Clin Nutr Metab Care , vol.7 , pp. 45-51
    • Morris, S.1
  • 43
    • 0034799312 scopus 로고    scopus 로고
    • Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei
    • Gorbatyuk OS, Milner TA, Wang G, et al. Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei. Exp Neurol 2001; 171: 235-45
    • (2001) Exp Neurol , vol.171 , pp. 235-245
    • Gorbatyuk, O.S.1    Milner, T.A.2    Wang, G.3
  • 44
    • 0028893547 scopus 로고
    • Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors
    • Piletz JE, Chikkala DN, Ernsberger P. Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. J Pharmacol Exp Ther 1995; 272: 581-7
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 581-587
    • Piletz, J.E.1    Chikkala, D.N.2    Ernsberger, P.3
  • 45
    • 1542314300 scopus 로고    scopus 로고
    • Mechanism underlying blockade of voltage-gated calcium channels by agmatine in cultured rat hippocampal neurons
    • Zheng J, Weng X, Gai X, et al. Mechanism underlying blockade of voltage-gated calcium channels by agmatine in cultured rat hippocampal neurons. Acta Pharmacol Sin 2004; 25: 281-5
    • (2004) Acta Pharmacol Sin , vol.25 , pp. 281-285
    • Zheng, J.1    Weng, X.2    Gai, X.3
  • 46
    • 21444451148 scopus 로고    scopus 로고
    • Effect of agmatine on heteromeric N-methyl-d-aspartate receptor channels
    • Askalany A, Yamakura T, Petrenko A, et al. Effect of agmatine on heteromeric N-methyl-d-aspartate receptor channels. Neurosci Res 2005; 52: 387-92
    • (2005) Neurosci Res , vol.52 , pp. 387-392
    • Askalany, A.1    Yamakura, T.2    Petrenko, A.3
  • 47
    • 0025096770 scopus 로고
    • Agmatine acts as an antagonist of neuronal nicotinic receptors
    • Loring RH. Agmatine acts as an antagonist of neuronal nicotinic receptors. Br J Pharmacol 1990; 99: 207-11
    • (1990) Br J Pharmacol , vol.99 , pp. 207-211
    • Loring, R.H.1
  • 48
    • 0029658644 scopus 로고    scopus 로고
    • Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: Potential involvement of sigma 2 binding sites
    • Molderings GJ, Schmidt K, Bonisch H, et al. Inhibition of 5-HT3 receptor function by imidazolines in mouse neuroblastoma cells: potential involvement of sigma 2 binding sites. Naunyn Schmiedebergs Arch Pharmacol 1996; 354: 245-52
    • (1996) Naunyn Schmiedebergs Arch Pharmacol , vol.354 , pp. 245-252
    • Molderings, G.J.1    Schmidt, K.2    Bonisch, H.3
  • 49
    • 0032536718 scopus 로고    scopus 로고
    • Regional localization of agmatine in the rat brain: An immunocytochemical study
    • Otake K, Ruggiero DA, Regunathan S, et al. Regional localization of agmatine in the rat brain: an immunocytochemical study. Brain Res 1998; 787: 1-14
    • (1998) Brain Res , vol.787 , pp. 1-14
    • Otake, K.1    Ruggiero, D.A.2    Regunathan, S.3
  • 50
    • 0030658984 scopus 로고    scopus 로고
    • Uptake of agmatine into rat brain synaptosomes: Possible role of cation channels
    • Sastre M, Regunathan S, Reis DJ. Uptake of agmatine into rat brain synaptosomes: possible role of cation channels. J Neurochem 1997; 69: 2421-6
    • (1997) J Neurochem , vol.69 , pp. 2421-2426
    • Sastre, M.1    Regunathan, S.2    Reis, D.J.3
  • 51
    • 1342326715 scopus 로고    scopus 로고
    • Gastrointestinal uptake of agmatine: Distribution in tissues and organs and pathophysiologic relevance
    • Molderings G, Heinen A, Menzel S, et al. Gastrointestinal uptake of agmatine: distribution in tissues and organs and pathophysiologic relevance. Ann N Y Acad Sci 2003; 1009: 44-51
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 44-51
    • Molderings, G.1    Heinen, A.2    Menzel, S.3
  • 52
    • 0029789277 scopus 로고    scopus 로고
    • Agmatinase activity in rat brain: A metabolic pathway for the degradation of agmatine
    • Sastre M, Regunathan S, Galea E, et al. Agmatinase activity in rat brain: a metabolic pathway for the degradation of agmatine. J Neurochem 1996; 67: 1761-5
    • (1996) J Neurochem , vol.67 , pp. 1761-1765
    • Sastre, M.1    Regunathan, S.2    Galea, E.3
  • 53
    • 0028863828 scopus 로고
    • Selective inhibition of inducible nitric oxide synthase by agmatine
    • Auguet M, Viossat I, Marin JG, et al. Selective inhibition of inducible nitric oxide synthase by agmatine. Jpn J Pharmacol 1995; 69: 285-7
    • (1995) Jpn J Pharmacol , vol.69 , pp. 285-287
    • Auguet, M.1    Viossat, I.2    Marin, J.G.3
  • 54
    • 26944494168 scopus 로고    scopus 로고
    • Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: A potential mechanism for the anticonvulsive effects
    • Feng Y, LeBlanc MH, Regunathan S. Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. Neurosci Lett 2005; 390: 129-33
    • (2005) Neurosci Lett , vol.390 , pp. 129-133
    • Feng, Y.1    LeBlanc, M.H.2    Regunathan, S.3
  • 55
    • 0034725920 scopus 로고    scopus 로고
    • Agmatine suppresses nitric oxide production in microglia
    • Abe K, Abe Y, Saito H. Agmatine suppresses nitric oxide production in microglia. Brain Res 2000; 872: 141-8
    • (2000) Brain Res , vol.872 , pp. 141-148
    • Abe, K.1    Abe, Y.2    Saito, H.3
  • 56
    • 0141918794 scopus 로고    scopus 로고
    • Agmatine induces glutamate release and cell death in cultured rat cerebellar granule neurons
    • Abe K, Abe Y, Saito H. Agmatine induces glutamate release and cell death in cultured rat cerebellar granule neurons. Brain Res 2003; 990: 165-71
    • (2003) Brain Res , vol.990 , pp. 165-171
    • Abe, K.1    Abe, Y.2    Saito, H.3
  • 57
    • 0034887609 scopus 로고    scopus 로고
    • Suppression of inducible nitric oxide generation by agmatine aldehyde: Beneficial effects in sepsis
    • Satriano J, Schwartz D, Ishizuka S, et al. Suppression of inducible nitric oxide generation by agmatine aldehyde: beneficial effects in sepsis. J Cell Physiol 2001; 188: 313-20
    • (2001) J Cell Physiol , vol.188 , pp. 313-320
    • Satriano, J.1    Schwartz, D.2    Ishizuka, S.3
  • 58
    • 33646154869 scopus 로고    scopus 로고
    • Involvement of nitric oxide system in enhancement of morphine-induced conditioned place preference by agmatine in male mice
    • Khoshnoodi MA, Motiei-Langroudi R, Tahsili-Fahadan P, et al. Involvement of nitric oxide system in enhancement of morphine-induced conditioned place preference by agmatine in male mice. Neurosci Lett 2006; 399 (3): 234-9
    • (2006) Neurosci Lett , vol.399 , Issue.3 , pp. 234-239
    • Khoshnoodi, M.A.1    Motiei-Langroudi, R.2    Tahsili-Fahadan, P.3
  • 59
    • 23944456673 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse
    • Roberts J, Grocholski B, Kitto K, et al. Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse. J Pharmacol Exp Ther 2005; 314: 1226-33
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1226-1233
    • Roberts, J.1    Grocholski, B.2    Kitto, K.3
  • 60
    • 35048827502 scopus 로고    scopus 로고
    • Feng Y, Halaris AE, Piletz JE. Determination of agmatine in brain and plasma using high-performance liquid chromatography with fluorescence detection [published erratum appears in J Chromatogr B Biomed Sci Appl 1997 Aug 15; 696 (1): 173]. J Chromatogr B Biomed Sci Appl 1997; 691 (2): 277-82
    • Feng Y, Halaris AE, Piletz JE. Determination of agmatine in brain and plasma using high-performance liquid chromatography with fluorescence detection [published erratum appears in J Chromatogr B Biomed Sci Appl 1997 Aug 15; 696 (1): 173]. J Chromatogr B Biomed Sci Appl 1997; 691 (2): 277-82
  • 61
    • 0842346114 scopus 로고    scopus 로고
    • Simultaneous determination of arginine and seven metabolites in plasma by reversed-phase liquid chromatography with a time-controlled orthophthaldialdehyde precolumn derivatization
    • Zhang W, Kaye D. Simultaneous determination of arginine and seven metabolites in plasma by reversed-phase liquid chromatography with a time-controlled orthophthaldialdehyde precolumn derivatization. Anal Biochem 2004; 326: 87-92
    • (2004) Anal Biochem , vol.326 , pp. 87-92
    • Zhang, W.1    Kaye, D.2
  • 62
    • 33745726204 scopus 로고    scopus 로고
    • Determination of agmatine in biological samples by capillary electrophoresis with optical fiber light-emitting-diode- induced fluorescence detector
    • Zhao S, Wang B, Yuan H, et al. Determination of agmatine in biological samples by capillary electrophoresis with optical fiber light-emitting-diode- induced fluorescence detector. J Chromatogr A 2006; 1123: 138-41
    • (2006) J Chromatogr A , vol.1123 , pp. 138-141
    • Zhao, S.1    Wang, B.2    Yuan, H.3
  • 63
    • 4544249477 scopus 로고    scopus 로고
    • Dias Elpo Zomkowski A, Oscar Rosa A, Lin J, et al. Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test. Brain Res 2004; 1023: 253-63
    • Dias Elpo Zomkowski A, Oscar Rosa A, Lin J, et al. Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test. Brain Res 2004; 1023: 253-63
  • 64
    • 19344375685 scopus 로고    scopus 로고
    • Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test
    • Zomkowski A, Santos A, Rodrigues A. Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test. Neurosci Lett 2005; 381: 279-83
    • (2005) Neurosci Lett , vol.381 , pp. 279-283
    • Zomkowski, A.1    Santos, A.2    Rodrigues, A.3
  • 65
    • 0029972165 scopus 로고    scopus 로고
    • Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail artery
    • Gonzalez C, Regunathan S, Reis DJ, et al. Agmatine, an endogenous modulator of noradrenergic neurotransmission in the rat tail artery. Br J Pharmacol 1996; 119: 677-84
    • (1996) Br J Pharmacol , vol.119 , pp. 677-684
    • Gonzalez, C.1    Regunathan, S.2    Reis, D.J.3
  • 66
    • 14744300498 scopus 로고    scopus 로고
    • Non-adrenergic inhibition at prejunctional sites by agmatine of purinergic vasoconstriction in rabbit saphenous artery
    • Zhao D, Ren L. Non-adrenergic inhibition at prejunctional sites by agmatine of purinergic vasoconstriction in rabbit saphenous artery. Neuropharmacology 2005; 48: 597-606
    • (2005) Neuropharmacology , vol.48 , pp. 597-606
    • Zhao, D.1    Ren, L.2
  • 67
    • 0028814678 scopus 로고
    • An antibody to agmatine localizes the amine in bovine adrenal chromaffin cells
    • Wang H, Regunathan S, Youngson C, et al. An antibody to agmatine localizes the amine in bovine adrenal chromaffin cells. Neurosci Lett 1995; 183: 17-21
    • (1995) Neurosci Lett , vol.183 , pp. 17-21
    • Wang, H.1    Regunathan, S.2    Youngson, C.3
  • 68
    • 0030098067 scopus 로고    scopus 로고
    • Imidazoline receptors and agmatine in blood vessels: A novel system inhibiting vascular smooth muscle proliferation
    • Regunathan S, Youngson C, Raasch W, et al. Imidazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferation. J Pharmacol Exp Ther 1996; 276: 1272-82
    • (1996) J Pharmacol Exp Ther , vol.276 , pp. 1272-1282
    • Regunathan, S.1    Youngson, C.2    Raasch, W.3
  • 69
    • 28444464800 scopus 로고    scopus 로고
    • Central actions of agmatine in conscious spontaneously hypertensive rats
    • Briaud S, Zhang BL, Sannajust F. Central actions of agmatine in conscious spontaneously hypertensive rats. Clin Exp Hypertens 2005; 27: 619-27
    • (2005) Clin Exp Hypertens , vol.27 , pp. 619-627
    • Briaud, S.1    Zhang, B.L.2    Sannajust, F.3
  • 70
    • 33746288934 scopus 로고    scopus 로고
    • Agmatine potentiates morphine-induced conditioned place preference in mice: Modulation by alpha(2)-adrenoceptors
    • Tahsili-Fahadan P, Yahyavi-Firouz-Abadi N, Khoshnoodi MA, et al. Agmatine potentiates morphine-induced conditioned place preference in mice: modulation by alpha(2)-adrenoceptors. Neuropsychopharmacology 2006; 31 (8): 1722-32
    • (2006) Neuropsychopharmacology , vol.31 , Issue.8 , pp. 1722-1732
    • Tahsili-Fahadan, P.1    Yahyavi-Firouz-Abadi, N.2    Khoshnoodi, M.A.3
  • 71
    • 0024555785 scopus 로고
    • Stimulus-secretion coupling of arginine-induced insulin release: Insulinotropic action of agmatine
    • Sener A, Lebrun P, Blachier F, et al. Stimulus-secretion coupling of arginine-induced insulin release: insulinotropic action of agmatine. Biochem Pharmacol 1989; 38: 327-30
    • (1989) Biochem Pharmacol , vol.38 , pp. 327-330
    • Sener, A.1    Lebrun, P.2    Blachier, F.3
  • 72
    • 0029077131 scopus 로고
    • Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro
    • Kalra SP, Pearson E, Sahu A, et al. Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro. Neurosci Lett 1995; 194: 165-8
    • (1995) Neurosci Lett , vol.194 , pp. 165-168
    • Kalra, S.P.1    Pearson, E.2    Sahu, A.3
  • 73
    • 0029077781 scopus 로고
    • Inhibitory presynaptic imidazoline receptors on sympathetic nerves in the rabbit aorta differ from I1- and I2-imidazoline binding sites
    • Molderings GJ, Gothert M. Inhibitory presynaptic imidazoline receptors on sympathetic nerves in the rabbit aorta differ from I1- and I2-imidazoline binding sites. Naunyn Schmiedebergs Arch Pharmacol 1995; 351: 507-16
    • (1995) Naunyn Schmiedebergs Arch Pharmacol , vol.351 , pp. 507-516
    • Molderings, G.J.1    Gothert, M.2
  • 74
    • 0032796565 scopus 로고    scopus 로고
    • Anti-proliferative and anti-inflammatory actions of imidazoline agents: Are imidazoline receptors involved?
    • Regunathan S, Feinstein DL, Reis DJ. Anti-proliferative and anti-inflammatory actions of imidazoline agents: are imidazoline receptors involved? Ann N Y Acad Sci 1999; 881: 410-9
    • (1999) Ann N Y Acad Sci , vol.881 , pp. 410-419
    • Regunathan, S.1    Feinstein, D.L.2    Reis, D.J.3
  • 75
    • 0035863255 scopus 로고    scopus 로고
    • The polyamine stress response: Tissue-, endocrine-, and developmental-dependent regulation
    • Gilad VH, Rabey JM, Kimiagar Y, et al. The polyamine stress response: tissue-, endocrine-, and developmental-dependent regulation. Biochem Pharmacol 2001; 61: 207-13
    • (2001) Biochem Pharmacol , vol.61 , pp. 207-213
    • Gilad, V.H.1    Rabey, J.M.2    Kimiagar, Y.3
  • 76
    • 0041315749 scopus 로고    scopus 로고
    • Overview of the brain polyamine-stress-response: Regulation, development, and modulation by lithium and role in cell survival
    • Gilad GM, Gilad VH. Overview of the brain polyamine-stress-response: regulation, development, and modulation by lithium and role in cell survival. Cell Mol Neurobiol 2003; 23: 637-49
    • (2003) Cell Mol Neurobiol , vol.23 , pp. 637-649
    • Gilad, G.M.1    Gilad, V.H.2
  • 77
    • 0029819080 scopus 로고    scopus 로고
    • Brain polyamine stress response: Recurrence after repetitive stressor and inhibition by lithium
    • Gilad GM, Gilad VH. Brain polyamine stress response: recurrence after repetitive stressor and inhibition by lithium. J Neurochem 1996; 67: 1992-6
    • (1996) J Neurochem , vol.67 , pp. 1992-1996
    • Gilad, G.M.1    Gilad, V.H.2
  • 79
    • 0032806929 scopus 로고    scopus 로고
    • Plasma agmatine and platelet imidazoline receptors in depression
    • Halaris A, Zhu H, Feng Y, et al. Plasma agmatine and platelet imidazoline receptors in depression. Ann N Y Acad Sci 1999; 881: 445-51
    • (1999) Ann N Y Acad Sci , vol.881 , pp. 445-451
    • Halaris, A.1    Zhu, H.2    Feng, Y.3
  • 80
    • 0032521641 scopus 로고    scopus 로고
    • Metabolism of agmatine in macrophages: Modulation by lipopolysaccharide and inhibitory cytokines
    • Sastre M, Galea E, Feinstein D, et al. Metabolism of agmatine in macrophages: modulation by lipopolysaccharide and inhibitory cytokines. Biochem J 1998; 330: 1405-9
    • (1998) Biochem J , vol.330 , pp. 1405-1409
    • Sastre, M.1    Galea, E.2    Feinstein, D.3
  • 81
    • 0030595281 scopus 로고    scopus 로고
    • Arginine and ornithine decarboxylation in rodent brain: Coincidental changes during development and after ischemia
    • Gilad GM, Gilad VH, Rabey JM. Arginine and ornithine decarboxylation in rodent brain: coincidental changes during development and after ischemia. Neurosci Lett 1996; 216: 33-6
    • (1996) Neurosci Lett , vol.216 , pp. 33-36
    • Gilad, G.M.1    Gilad, V.H.2    Rabey, J.M.3
  • 82
    • 0036787990 scopus 로고    scopus 로고
    • Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats
    • Feng Y, Piletz JE, Leblanc MH. Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res 2002; 52: 606-11
    • (2002) Pediatr Res , vol.52 , pp. 606-611
    • Feng, Y.1    Piletz, J.E.2    Leblanc, M.H.3
  • 83
    • 35048886631 scopus 로고    scopus 로고
    • Pre-treatment with antisera raised against agmatine sensitizes mice to plasticity-mediated events [abstract]
    • Fairbanks C, Kaminski L, Nguyen H, et al. Pre-treatment with antisera raised against agmatine sensitizes mice to plasticity-mediated events [abstract]. Soc Neurosci Abstr 2001; 27: 465
    • (2001) Soc Neurosci Abstr , vol.27 , pp. 465
    • Fairbanks, C.1    Kaminski, L.2    Nguyen, H.3
  • 84
    • 35048862430 scopus 로고    scopus 로고
    • Agmatine and morphine tolerance/dependance: Molecular mechanisms of interactions [abstract]
    • Aricioglu-Kartel F, Reis D, Regunathan S. Agmatine and morphine tolerance/dependance: molecular mechanisms of interactions [abstract]. Soc Neurosci Abstr 2001; 27: 685
    • (2001) Soc Neurosci Abstr , vol.27 , pp. 685
    • Aricioglu-Kartel, F.1    Reis, D.2    Regunathan, S.3
  • 85
    • 0030040402 scopus 로고    scopus 로고
    • Agmatine treatment is neuroprotective in rodent brain injury models
    • Gilad GM, Salame K, Rabey JM, et al. Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci 1996; 58: 41-6
    • (1996) Life Sci , vol.58 , pp. 41-46
    • Gilad, G.M.1    Salame, K.2    Rabey, J.M.3
  • 86
    • 0034704417 scopus 로고    scopus 로고
    • Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats
    • Gilad GM, Gilad VH. Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats. Neurosci Lett 2000; 296: 97-100
    • (2000) Neurosci Lett , vol.296 , pp. 97-100
    • Gilad, G.M.1    Gilad, V.H.2
  • 87
    • 4243378111 scopus 로고    scopus 로고
    • Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
    • Fairbanks CA, Schreiber KL, Brewer KL, et al. Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury. Proc Natl Acad Sci U S A 2000; 97: 10584-9
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 10584-10589
    • Fairbanks, C.A.1    Schreiber, K.L.2    Brewer, K.L.3
  • 88
    • 0037959800 scopus 로고    scopus 로고
    • Agmatine attenuates neuropathic pain in rats: Possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum
    • Onal A, Delen Y, Ulker S, et al. Agmatine attenuates neuropathic pain in rats: possible mediation of nitric oxide and noradrenergic activity in the brainstem and cerebellum. Life Sci 2003; 73: 413-28
    • (2003) Life Sci , vol.73 , pp. 413-428
    • Onal, A.1    Delen, Y.2    Ulker, S.3
  • 89
    • 1342284216 scopus 로고    scopus 로고
    • Effect of agmatine on acute and mononeuropathic pain
    • Aricioglu F, Korcegez E, Bozkurt A, et al. Effect of agmatine on acute and mononeuropathic pain. Ann N Y Acad Sci 2003; 1009: 106-15
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 106-115
    • Aricioglu, F.1    Korcegez, E.2    Bozkurt, A.3
  • 91
    • 8544260280 scopus 로고    scopus 로고
    • Effects of agmatine on tolerance to and substance dependence on morphine in mice
    • Li J, Li X, Pei G, et al. Effects of agmatine on tolerance to and substance dependence on morphine in mice. Chung Kuo Yao Li Hsueh Pao 1999; 20: 232-8
    • (1999) Chung Kuo Yao Li Hsueh Pao , vol.20 , pp. 232-238
    • Li, J.1    Li, X.2    Pei, G.3
  • 92
    • 0030869684 scopus 로고    scopus 로고
    • Inhibitory effect of agmatine on naloxone-precipitated abstinence syndrome in morphine dependent rats
    • Aricioglu-Kartal F, Uzbay IT. Inhibitory effect of agmatine on naloxone-precipitated abstinence syndrome in morphine dependent rats. Life Sci 1997; 61: 1775-81
    • (1997) Life Sci , vol.61 , pp. 1775-1781
    • Aricioglu-Kartal, F.1    Uzbay, I.T.2
  • 93
    • 0036011290 scopus 로고    scopus 로고
    • Learning and memory in agmatine-treated rats
    • McKay B, Lado W, Martin L, et al. Learning and memory in agmatine-treated rats. Pharmacol Biochem Behav 2002; 72: 551-7
    • (2002) Pharmacol Biochem Behav , vol.72 , pp. 551-557
    • McKay, B.1    Lado, W.2    Martin, L.3
  • 94
    • 0037453206 scopus 로고    scopus 로고
    • Combined effects of complex magnetic fields and agmatine for contextual fear learning deficits in rats
    • McKay B, Persinger M. Combined effects of complex magnetic fields and agmatine for contextual fear learning deficits in rats. Life Sci 2003; 72: 2489-98
    • (2003) Life Sci , vol.72 , pp. 2489-2498
    • McKay, B.1    Persinger, M.2
  • 95
    • 0018268297 scopus 로고
    • Behavioural despair in rats: A new model sensitive to antidepressant treatments
    • Porsolt RD, Anton G, Blavet N, et al. Behavioural despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978; 47: 379-91
    • (1978) Eur J Pharmacol , vol.47 , pp. 379-391
    • Porsolt, R.D.1    Anton, G.2    Blavet, N.3
  • 96
    • 0018413242 scopus 로고
    • Forced swimming in rats: Hypothermia, immobility and the effects of imipramine
    • Porsolt RD, Deniel M, Jalfre M. Forced swimming in rats: hypothermia, immobility and the effects of imipramine. Eur J Pharmacol 1979; 57: 431-6
    • (1979) Eur J Pharmacol , vol.57 , pp. 431-436
    • Porsolt, R.D.1    Deniel, M.2    Jalfre, M.3
  • 97
    • 0032098346 scopus 로고    scopus 로고
    • Developmental regulation of the brain polyamine-stress-response
    • Gilad GM, Gilad VH, Eliyayev Y, et al. Developmental regulation of the brain polyamine-stress-response. Int J Dev Neurosci 1998; 16: 271-8
    • (1998) Int J Dev Neurosci , vol.16 , pp. 271-278
    • Gilad, G.M.1    Gilad, V.H.2    Eliyayev, Y.3
  • 98
    • 10744228217 scopus 로고    scopus 로고
    • Structure-activity analysis of guanidine group in agmatine for brain agmatinase
    • Huang M, Regunathan S, Botta M, et al. Structure-activity analysis of guanidine group in agmatine for brain agmatinase. Ann N Y Acad Sci 2003; 1009: 52-63
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 52-63
    • Huang, M.1    Regunathan, S.2    Botta, M.3
  • 99
    • 35048834839 scopus 로고    scopus 로고
    • Jackson State University, assignee. Mammalian agmatinase inhibitory substance
    • US patent application 20050220707; Apr 5
    • Piletz J, Huang M, Lee K, inventors. Jackson State University, assignee. Mammalian agmatinase inhibitory substance. US patent application 20050220707; 2004 Apr 5
    • (2004)
    • Piletz, J.1    Huang, M.2    Lee, K.3    inventors4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.