The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox

European Journal of Pharmacology

Volumn 541, Issue 3, 2006, Pages 129-137

  Chantrel Groussard, Karine ^a   Gaboriau, François ^a   Pasdeloup, Nicole ^a   Havouis, René ^a   Nick, Hanspeter ^b   Pierre, Jean Louis ^c   Brissot, Pierre ^a   Lescoat, Gérard ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIV GRENOBLE ALPES   (France)

Author keywords

Cell proliferation; Human hepatocyte; Iron chelation; Polyamine metabolism

Indexed keywords

ACYLTRANSFERASE; DEFERASIROX; DNA FRAGMENT; IRON CHELATING AGENT; O TRENSOX; ORNITHINE DECARBOXYLASE; POLYAMINE; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOSYNTHESIS; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DNA REPLICATION; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL CULTURE; PRIORITY JOURNAL;

ACETYLTRANSFERASES; APOPTOSIS; BENZOIC ACIDS; BIOGENIC POLYAMINES; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL PROLIFERATION; DNA REPLICATION; ETHYLAMINES; HEPATOCYTES; HUMANS; HYDROXYQUINOLINES; IRON CHELATING AGENTS; ORNITHINE DECARBOXYLASE; RNA, MESSENGER; TRIAZOLES;

EID: 33745261785     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.05.001     Document Type: Article

References (25)

1. Bhasin G., Kauser H., and Athar M. Low iron state is associated with reduced tumor promotion in a two-stage mouse skin carcinogenesis model. Food Chem. Toxicol. 40 (2002) 1105-1111
2. Brissot P., and Loreal O. Role of non-transferrin-bound iron in the pathogenesis of iron overload and toxicity. Adv. Exp. Med. Biol. 509 (2002) 45-53
3. Caris C., Baret P., Beguin C., Serratrice G., Pierre J.L., and Laulhere J.P. Metabolization of iron by plant cells using O-Trensox, a high-affinity abiotic iron-chelating agent. Biochem. J. 312 Pt 3 (1995) 879-885
4. Chenoufi N., Hubert N., Loréal O., Morel I., Pasdeloup N., Cillard J., Brissot P., and Lescoat G. Inhibition of iron toxicity in rat and human hepatocyte cultures by the hydroxypyridin-4-ones CP20 and CP94. J. Hepatol. 23 (1995) 166-173
5. Chenoufi N., Loréal O., Drénou B., Cariou S., Hubert N., Leroyer P., Brissot P., and Lescoat G. Iron may induce DNA synthesis and repair in rat hepatocytes stimulated by EGF/pyruvate. J. Hepatol. 26 (1997) 650-658
6. Chenoufi N., Drénou B., Loréal O., Pigeon C., Brissot P., and Lescoat G. Antiproliferative effect of deferiprone on the HepG2 cell line. Biochem. Pharmacol. 56 (1998) 431-437
7. Deugnier Y., and Turlin B. Iron and hepatocellular carcinoma. J. Gastroenterol. Hepatol. 16 (2001) 491-494
8. Gaboriau F., Havouis R., Moulinoux J.P., and Delcros J.G. Atmospheric pressure chemical ionization-mass spectrometry method to improve the determination of dansylated polyamines. Anal. Biochem. 318 (2003) 212-220
9. Gaboriau F., Kreder A., Clavreul N., Moulinoux J., Delcros J.G., and Lescoat G. Polyamine modulation of iron uptake in CHO cells. Biochem. Pharmacol. 67 (2004) 1629-1637
10. Hershko C., Konijn A.M., Nick H.P., Breuer W., Cabantchik Z.I., and Link G. ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 97 (2001) 1115-1122
11. Ichimura S., Hamana K., and Nenoi M. Significant increases in the steady states of putrescine and spermidine/spermine N1-acetyltransferase mRNA in HeLa cells accompanied by growth arrest. Biochem. Biophys. Res. Commun. 243 (1998) 518-521
12. Kicic A., Chua A.C., and Baker E. Effect of iron chelators on proliferation and iron uptake in hepatoma cells. Cancer 92 (2001) 3093-3110
13. Kim K., Ryu J.H., Park J.W., Kim M.S., and Chun Y.S. Induction of a SSAT isoform in response to hypoxia or iron deficiency and its protective effects on cell death. Biochem. Biophys. Res. Commun. 331 (2005) 78-85
14. Marty C., Mori G., Sabini L., and Rivarola V. Effects of alpha-difluoromethylornithine on the cyclin A expression in Hep-2 cells. Biocell 24 (2000) 49-52
15. Matsui I., and Pegg A.E. Effect of thioacetamide, growth hormone or partial hepatectomy on spermidine acetylase activity of rat liver cytosol. Biochim. Biophys. Acta 633 (1980) 87-94
16. Oredsson S.M. Polyamine dependence of normal cell-cycle progression. Biochem. Soc. Trans. 31 (2003) 366-370
17. Porter J.B., and Davis B.A. Monitoring chelation therapy to achieve optimal outcome in the treatment of thalassaemia. Best Pract. Res. Clin. Haematol. 15 (2002) 329-368
18. Rakba N., Aouad F., Henry C., Caris C., Morel I., Baret P., Pierre J.L., Brissot P., Ward R.J., Lescoat G., and Crichton R.R. Iron mobilisation and cellular protection by a new synthetic chelator O-Trensox. Biochem. Pharmacol. 55 (1998) 1797-1806
19. Rakba N., Loyer P., Gilot D., Delcros J.G., Glaise D., Baret P., Pierre J.L., Brissot P., and Lescoat G. Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines. Carcinogenesis 21 (2000) 943-951
20. Rouan M.C., Marfil F., Mangoni P., Sechaud R., Humbert H., and Maurer G. Determination of a new oral iron chelator, ICL670, and its iron complex in plasma by high-performance liquid chromatography and ultraviolet detection. J. Chromatogr., B, Biomed. Sci. Appl. 755 (2001) 203-213
21. Schipper R.G., Penning L.C., and Verhofstad A.A. Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors?. Semin. Cancer Biol. 10 (2000) 55-68
22. Thompson H.J., Kennedy K., Witt M., and Juzefyk J. Effect of dietary iron deficiency or excess on the induction of mammary carcinogenenis by 1-methyl-1-nitrosourea. Carcinogenesis 12 (1991) 111-114
23. Wallace H.M., Fraser A.V., and Hughes A. A perspective of polyamine metabolism. Biochem. J. 376 (2003) 1-14
24. Yano T., Obata Y., Yano Y., Otani S., and Ichikawa T. Stimulating effect of excess iron feeding on spontaneous lung tumor promotion in mice. Int. J. Vitam. Nutr. Res. 65 (1995) 127-131
25. Yasumoto E., Nakano K., Nakayachi T., Morshed S.R., Hashimoto K., Kikuchi H., Nishikawa H., Kawase M., and Sakagami H. Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines. Anticancer Res. 24 (2004) 755-762