Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO

Experimental Cell Research

Volumn 261, Issue 1, 2000, Pages 293-302

  Weeks, Reitha S ^a   Vanderwerf, Scott M ^a   Carlson, C L ^a   Burns, Mark R ^a   O’Day, Christine L ^a   Cai, Feng ^a   Devens, Bruce H ^a   Webb, Heather K ^a  

^a Oridigm Corporation   (United States)

Author keywords

Cytostasis; DFMO; Growth inhibition; Polyamine transport inhibitor

Indexed keywords

EFLORNITHINE; LYSINE; N1 SPERMINE LEVO LYSINYL AMIDE; ORI 1202; POLYAMINE; POLYAMINE TRANSPORT INHIBITOR; PUTRESCINE; SPERMIDINE; SPERMINE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; GROWTH INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS; TUMOR CELL; TUMOR GROWTH; XENOGRAFT;

ANIMALIA; MAMMALIA; MUS MUSCULUS; TRITIUM;

EID: 0034715957     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5033     Document Type: Article

References (45)

1. Polyamine metabolism and its importance in neoplastic growth and as a target for chemotherapy
2. Molecular genetics of polyamine synthesis in eukaryotic cells
3. Polyamines: From molecular biology to clinical applications
4. Polyamine involvement in the cell cycle, apoptosis, and autoimmunity
5. Polyamines: Mysterious modulators of cellular functions
6. Role of polyamines in cell growth and differentiation
7. Polyamine transport in mammalian cells
8. Polyamine transport in mammalian cells. An update
9. Polyamines as targets for therapeutic intervention
10. The gastrointestinal tract as polyamine source for tumor growth
11. Ornithine decarboxylase as an enzyme target for therapy
12. S-Adenosylmethionine decarboxylase as an enzyme target for therapy
13. Ornithine decarboxylase as a target for chemoprevention
14. Antimetastatic activity of DL-α-difluoromethylornithine, an inhibitor of polyamine biosynthesis, in mice
15. Polyamines prevent DFMO-mediated inhibition of angiogenesis
16. Clinical aspects of inhibition of ornithine decarboxylase with emphasis on therapeutic trials of eflornithine (DFMO) in cancer and protozoan diseases
17. Evaluation of continuous-infusion α-difluoromethylornithine therapy for colorectal carcinoma
18. Increased survival of L1210 leukemic mice by prevention of the utilization of extracellular polyamines. Studies using a polyamine-uptake mutant, antibiotics and a polyamine-deficient diet
19. Polyamine deprivation, malnutrition and tumor growth
20. Polyamine membrane transport regulation
21. Dependence of mammalian putrescine and spermidine transport on plasma-membrane potential: Identification of an amiloride binding site on the putrescine carrier
22. Antizyme-dependent and-independent mechanisms are responsible for increased spermidine transport in amino acid-restricted human cancer cells
23. Proteoglycan involvement in polyamine uptake
24. Chemical highlights of polyamine transport
25. Antiproliferative properties of polyamine analogues: A structure-activity study
26. Endothelial polyamine uptake: Selective stimulation by L-arginine deprivation or polyamine depletion
27. Solid-phase extraction and determination of dansyl derivatives of unconjugated and acetylated polyamines by reversed-phase liquid chromatography: Improved separation systems for polyamines in cerebrospinal fluid, urine and tissue
28. Can anticancer therapy be improved by sequential use of cytotoxic and cytostatic (differentiating or immunomodulating) agents to suppress tumor cell phenotypic diversification?
29. Methylglyoxal-bis-(guanylhydrazone)-resistant Chinese hamster ovary cells: Genetic evidence that more than a single locus controls uptake
30. 12-bis(ethyl)spermine
31. Effects of novel spermine analogues on cell cycle progression and apoptosis in MALME-3M human melanoma cells
32. A novel polymeric spermine conjugate inhibits polyamine transport in pulmonary artery smooth muscle cells
33. 2, 2'-Dithiobis(N-ethyl-spermine-5-carboxamide) is a high affinity, membrane-impermeant antagonist of the mammalian polyamine transport system
34. Ornithine decarboxylase antizyme: A novel type of regulatory protein
35. Polyamines and cellular regulation: Perspectives
36. Loss of intracellular putrescine pool-size regulation induces apoptosis
37. Cytostasis induced in L1210 murine leukaemia cells by the S-adenosyl-L-methionine decarboxylase inhibitor 5'-([(Z)-4-amino-2-butenyl]methylamine)-5'-deoxyadenosine may be due to hypusine depletion
38. Antiproliferative effect of spermine depletion by N-cyclohexyl-1, 3-diaminopropane in human breast cancer cells
39. Effect of 1, 3, 6-triaminohexane and 1, 4, 7-triaminoheptane on growth and polyamine metabolism in SV-3T3 cells treated with 2-difluoromethylornithine
40. Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation
41. Polyamines in the male reproductive system
42. Regulation of ornithine decarboxylase gene expression in MCF-7 breast cancer cells by antiestrogens
43. Hormonal and feedback regulation of putrescine and spermidine transport in human breast cancer cells
44. Prostatic polyamines and polyamine targeting as a new approach to therapy of prostatic cancer
45. Comparative studies on the polyamine metabolism and DFMO treatment of MCF-7 and MDA-MB-231 breast cancer cell lines and xenografts