Antiproliferative and apoptotic effects in rat and human hepatoma cell cultures of the orally active iron chelator ICL670 compared to CP20: A possible relationship with polyamine metabolism

Cell Proliferation

Volumn 40, Issue 5, 2007, Pages 755-767

  Lescoat, G ^a,b,c,e   Chantrel Groussard, K ^a,b,c   Pasdeloup, N ^a,b,c   Nick, H ^d   Brissot, P ^a,b,c   Gaboriau, F ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ DE RENNES 1   (France)

^c IFR 140   (France)

^d NOVARTIS PHARMA AG   (Switzerland)

^e PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DEFERASIROX; DEFERIPRONE; MESSENGER RNA; ORNITHINE DECARBOXYLASE; POLYAMINE; SPERMIDINE; SPERMINE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL VIABILITY; DNA REPLICATION; HEPATOMA CELL; IRON BINDING CAPACITY; IRON CHELATION; MASS SPECTROMETRY; NONHUMAN; RAT;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BENZOIC ACIDS; CARCINOMA, HEPATOCELLULAR; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHEMOTHERAPY, ADJUVANT; DNA PRIMERS; DNA REPLICATION; HUMANS; IRON CHELATING AGENTS; LIVER NEOPLASMS; LIVER NEOPLASMS, EXPERIMENTAL; POLYAMINES; PYRIDONES; RATS; TRIAZOLES;

RATTUS;

EID: 34548675357     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2007.00468.x     Document Type: Article

References (32)

1. Bhasin G, Kauser H, Athar M (2002) Low iron state is associated with reduced tumor promotion in a two-stage mouse skin carcinogenesis model. Food Chem. Toxicol. 40, 1105 1111.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248 254.
3. Brissot P, Loréal O (2002) Role of non-transferrin-bound iron in the pathogenesis of iron overload and toxicity. Adv. Exp. Med. Biol. 509, 45 53.
4. Chantrel-Groussard K, Gaboriau F, Pasdeloup N, Havouis R, Nick HP, Pierre JL, Brissot P, Lescoat G (2006) The new orally active iron chelator ICL670A exhibits a higher antiproliferative effect in human hepatocyte cultures than O-trensox. Eur. J. Pharmacol. 541, 129 137.
5. Chenoufi N, Drénou B, Loréal O, Pigeon C, Brissot P, Lescoat G (1998) Antiproliferative effect of deferiprone on the HepG2 cell line. Biochem. Pharmacol. 56, 431 437.
6. Chenoufi N, Hubert N, Loréal O, Morel I, Pasdeloup N, Cillard J, Brissot P, Lescoat G (1995) Inhibition of iron toxicity in rat and human hepatocyte cultures by the hydroxypyridin-4-ones CP20 and CP94. J. Hepatol. 23, 166 173.
7. Chenoufi N, Loréal O, Drénou B, Cariou S, Hubert N, Leroyer P, Brissot P, Lescoat G (1997) Iron may induce DNA synthesis and repair in rat hepatocytes stimulated by EGF/pyruvate. J. Hepatol. 26, 650 658.
8. Deschatrette J, Weiss MC (1974) Characterization of differentiated clones from a rat hepatoma. Biochimie 56, 1603 1611.
9. Gaboriau F, Chantrel-Groussard K, Rakba N, Loyer P, Pasdeloup N, Hider RC, Brissot P, Lescoat G (2004) Iron mobilization, cytoprotection, and inhibition of cell proliferation in normal and transformed rat hepatocyte cultures by the hydroxypyridinone CP411, compared to CP20: a biological and physicochemical study. Biochem. Pharmacol. 67, 1479 1487.
10. Gaboriau F, Havouis R, Moulinoux JP, Delcros JG (2003) Atmospheric pressure chemical ionization-mass spectrometry method to improve the determination of dansylated polyamines. Anal. Biochem. 318, 212 220.
11. Gaboriau F, Kreder A, Clavreul N, Moulinoux J, Delcros J, Lescoat G (2004) Polyamine modulation of iron uptake in CHO cells. Biochem. Pharmacol. 67, 1629 1637.
12. Hershko C, Konijn AM, Nick HP, Breuer W, Cabantchik ZI, Link G (2001) ICL670A: a new synthetic oral chelator: evaluation in hypertransfused rats with selective radioiron probes of hepatocellular and reticuloendothelial iron stores and in iron-loaded rat heart cells in culture. Blood 97, 1115 1122.
13. 1-acetyltransferase mRNA in HeLa cells accompanied by growth arrest. Biochem. Biophys. Res. Commun. 243, 518 521.
14. Kicic A, Chua AC, Baker E (2001) Effect of iron chelators on proliferation and iron uptake in hepatoma cells. Cancer 92, 3093 3110.
15. Kim K, Ryu JH, Park JW, Kim MS, Chun YS (2005) Induction of a SSAT isoform in response to hypoxia or iron deficiency and its protective effects on cell death. Biochem. Biophys. Res. Commun. 331, 78 85.
16. Li L, Li J, Rao J, Li M, Bass BL, Wang JY (1999) Inhibition of polyamine synthesis induces p53 gene expression but not apoptosis. Am. J. Physiol. Cell Physiol. 276, 946 954.
17. Li L, Rao J, Guo X, Liu L, Santora R, Bass BL, Wang JY (2001) Polyamine depletion stabilizes p53 resulting in inhibition of normal intestinal epithelial cell proliferation. Am. J. Physiol. Cell Physiol. 281, 941 953.
18. Liu YD, Liu ZD, Hider RC (2002) Oral iron chelators - development and application. Best Pract. Res. Clin. Haematol. 15, 369 384.
19. Marty C, Mori G, Sabini L, Rivarola V (2000) Effects of alpha-difluoromethylornithine on the cyclin A expression in Hep-2 cells. Biocell 24, 49 52.
20. Matsui I, Pegg AE (1980) Effect of thioacetamide, growth hormone or partial hepatectomy on spermidine acetylase activity of rat liver cytosol. Biochim. Biophys. Acta 633, 87 94.
21. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55 63.
22. Nick HP, Acklin P, Lattmann R, Buehlmayer P, Hauffe S, Schupp J, Alberti D (2003) Development of tridentate iron chelators: from desferrithiocin to ICL670. Curr. Med. Chem. 10, 1065 1076.
23. Oredsson SM (2003) Polyamine dependence of normal cell-cycle progression. Biochem. Soc. Trans. 31, 366 370.
24. Porter JB, Davis BA (2002) Monitoring chelation therapy to achieve optimal outcome in the treatment of thalassaemia. Best Pract. Res. Clin. Haematol. 15, 329 368.
25. Rakba N, Loyer P, Gilot D, Delcros JG, Glaise D, Baret P, Pierre JL, Brissot P, Lescoat G (2000) Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines. Carcinogenesis 21, 943 951.
26. Rouan MC, Marfil F, Mangoni P, Sechaud R, Humbert H, Maurer G (2001) Determination of a new oral iron chelator, ICL670, and its iron complex in plasma by high-performance liquid chromatography and ultraviolet detection. J. Chromatogr. B Biomed. Sci. Appl. 755, 203 213.
27. Schipper RG, Penning LC, Verhofstad AA (2000) Involvement of polyamines in apoptosis. Facts and controversies: effectors or protectors? Semin. Cancer Biol. 10, 55 68.
28. Stennicke HR, Salvesen GS (1997) Biochemical characteristics of caspases-3-6-7 and 8. J. Biol. Chem. 272, 25719 25723.
29. Thompson HJ, Kennedy K, Witt M, Juzefyk J (1991) Effect of dietary iron deficiency or excess on the induction of mammary carcinogenenis by 1-methyl-1-nitrosourea. Carcinogenesis 12, 111 114.
30. Wallace HM, Fraser AV, Hughes A (2003) A perspective of polyamine metabolism. Biochem. J. 376, 1 14.
31. Yano T, Obata Y, Yano Y, Otani S, Ichikawa T (1995) Stimulating effect of excess iron feeding on spontaneous lung tumor promotion in mice. Int. J. Vitam. Nutr. Res. 65, 127 131.
32. Yasumoto E, Nakano K, Nakayachi T, Morshed SR, Hashimoto K, Kikuchi H, Nishikawa H, Kawase M, Sakagami H (2004) Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines. Anticancer Res. 24, 755 762.