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Volumn 4, Issue 1, 2015, Pages

Mitochondrial dysfunction and insulin resistance: An update

Author keywords

Insulin resistance; Lipid accumulation; Mitochondrial dynamics; Mitochondrial function; Mitophagy; Oxidative stress

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; CERAMIDE; CYTOCHROME C OXIDASE; DIACYLGLYCEROL; DYNAMIN; ESTROGEN RELATED RECEPTOR ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MALONYL COENZYME A; MESSENGER RNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOFUSIN 1; MITOFUSIN 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINATE DEHYDROGENASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF1; TRANSCRIPTION FACTOR YY1; VOLTAGE DEPENDENT ANION CHANNEL 1;

EID: 85043221259     PISSN: None     EISSN: 20493614     Source Type: Journal    
DOI: 10.1530/EC-14-0092     Document Type: Review
Times cited : (405)

References (139)
  • 3
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    • Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. PNAS 2003 100 8466–8471. (doi:10.1073/pnas.1032913100)
    • (2003) PNAS , vol.100 , pp. 8466-8471
    • Patti, M.E.1    Butte, A.J.2    Crunkhorn, S.3    Cusi, K.4    Berria, R.5    Kashyap, S.6    Miyazaki, Y.7    Kohane, I.8    Costello, M.9    Saccone, R.10
  • 4
    • 34548429745 scopus 로고    scopus 로고
    • Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome
    • Skov V, Glintborg D, Knudsen S, Jensen T, Kruse TA, Tan Q, Brusgaard K, Beck-Nielsen H & Højlund K. Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome. Diabetes 2007 56 2349–2355. (doi:10.2337/db07-0275)
    • (2007) Diabetes , vol.56 , pp. 2349-2355
    • Skov, V.1    Glintborg, D.2    Knudsen, S.3    Jensen, T.4    Kruse, T.A.5    Tan, Q.6    Brusgaard, K.7    Beck-Nielsen, H.8    Højlund, K.9
  • 6
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley DE, Goodpaster B, Wing RR & Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. American Journal of Physiology 1999 277 E1130–E1141
    • (1999) American Journal of Physiology , vol.277
    • Kelley, D.E.1    Goodpaster, B.2    Wing, R.R.3    Simoneau, J.A.4
  • 7
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV & Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002 51 2944–2950. (doi:10.2337/diabetes.51.10.2944)
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 9
    • 0032752951 scopus 로고    scopus 로고
    • Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss
    • Simoneau J-A, Veerkamp JH, Turcotte LP & Kelley DE. Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB Journal 1999 13 2051–2060
    • (1999) FASEB Journal , vol.13 , pp. 2051-2060
    • Simoneau, J.-A.1    Veerkamp, J.H.2    Turcotte, L.P.3    Kelley, D.E.4
  • 11
    • 77953868236 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance: Unravelling the mechanism
    • Samuel VT, Petersen KF & Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet 2010 375 2267–2277. (doi:10.1016/S0140-6736(10)60408-4)
    • (2010) Lancet , vol.375 , pp. 2267-2277
    • Samuel, V.T.1    Petersen, K.F.2    Shulman, G.I.3
  • 12
    • 84870341562 scopus 로고    scopus 로고
    • Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice
    • Bruce CR, Risis S, Babb JR, Yang C, Kowalski GM, Selathurai A, Lee-Young RS, Weir JM, Yoshioka K, Takuwa Y et al. Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice. Diabetes 2012 61 3148–3155. (doi:10.2337/db12-0029)
    • (2012) Diabetes , vol.61 , pp. 3148-3155
    • Bruce, C.R.1    Risis, S.2    Babb, J.R.3    Yang, C.4    Kowalski, G.M.5    Selathurai, A.6    Lee-Young, R.S.7    Weir, J.M.8    Yoshioka, K.9    Takuwa, Y.10
  • 13
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer C, Craig DL & Biden TJ. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. Journal of Biological Chemistry 1999 274 24202–24210. (doi:10.1074/jbc.274.34.24202)
    • Journal of Biological Chemistry 1999 274 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 14
    • 58149379936 scopus 로고    scopus 로고
    • Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance
    • Holloszy JO. Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance. American Journal of Clinical Nutrition 2009 89 463S–466S. (doi:10.3945/ajcn.2008.26717C)
    • (2009) American Journal of Clinical Nutrition , vol.89
    • Holloszy, J.O.1
  • 15
    • 0016808251 scopus 로고
    • Two distinct patterns of glucose intolerance in icteric rats and rabbits. Relationship to impaired liver mitochondria function
    • Yamada T, Ida T, Yamaoka Y, Ozawa K, Takasan H & Honjo I. Two distinct patterns of glucose intolerance in icteric rats and rabbits. Relationship to impaired liver mitochondria function. Journal of Laboratory and Clinical Medicine 1975 86 38–45
    • (1975) Journal of Laboratory and Clinical Medicine , vol.86 , pp. 38-45
    • Yamada, T.1    Ida, T.2    Yamaoka, Y.3    Ozawa, K.4    Takasan, H.5    Honjo, I.6
  • 17
    • 53649083550 scopus 로고    scopus 로고
    • Is mitochondrial dysfunction a cause of insulin resistance?
    • Turner N & Heilbronn LK. Is mitochondrial dysfunction a cause of insulin resistance? Trends in Endocrinology and Metabolism 2008 19 324–330. (doi:10.1016/j.tem.2008.08.001)
    • (2008) Trends in Endocrinology and Metabolism , vol.19 , pp. 324-330
    • Turner, N.1    Heilbronn, L.K.2
  • 19
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • Bandyopadhyay GK, Yu JG, Ofrecio J & Olefsky JM. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 2006 55 2277–2285. (doi:10.2337/db06-0062)
    • (2006) Diabetes , vol.55 , pp. 2277-2285
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 20
    • 33847611885 scopus 로고    scopus 로고
    • Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle
    • Boushel R, Gnaiger E, Schjerling P, Skovbro M, Kraunsøe R & Dela F. Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 2007 50 790–796. (doi:10.1007/ s00125-007-0594-3)
    • (2007) Diabetologia , vol.50 , pp. 790-796
    • Boushel, R.1    Gnaiger, E.2    Schjerling, P.3    Skovbro, M.4    Kraunsøe, R.5    Dela, F.6
  • 23
    • 79951706196 scopus 로고    scopus 로고
    • Skeletal muscle mitochondria in insulin resistance: Differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility
    • Chomentowski P, Coen PM, Radikova´ Z, Goodpaster BH & Toledo FG. Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility. Journal of Clinical Endocrinology and Metabolism 2011 96 494–503. (doi:10.1210/jc.2010-0822)
    • (2011) Journal of Clinical Endocrinology and Metabolism , vol.96 , pp. 494-503
    • Chomentowski, P.1    Coen, P.M.2    Radikova´, Z.3    Goodpaster, B.H.4    Toledo, F.G.5
  • 26
    • 49649115590 scopus 로고    scopus 로고
    • Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes
    • Trenell MI, Hollingsworth KG, Lim EL & Taylor R. Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes. Diabetes Care 2008 31 1644–1649. (doi:10.2337/dc08-0303)
    • (2008) Diabetes Care , vol.31 , pp. 1644-1649
    • Trenell, M.I.1    Hollingsworth, K.G.2    Lim, E.L.3    Taylor, R.4
  • 28
    • 84860641172 scopus 로고    scopus 로고
    • Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans
    • Samocha-Bonet D, Campbell LV, Mori TA, Croft KD, Greenfield JR, Turner N & Heilbronn LK. Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans. PLoS ONE 2012 7 e36320. (doi:10.1371/journal.pone.0036320)
    • (2012) Plos ONE , vol.7
    • Samocha-Bonet, D.1    Campbell, L.V.2    Mori, T.A.3    Croft, K.D.4    Greenfield, J.R.5    Turner, N.6    Heilbronn, L.K.7
  • 31
    • 34547588219 scopus 로고    scopus 로고
    • Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    • Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS & Cooney GJ. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 2007 56 2085–2092. (doi:10.2337/db07-0093)
    • (2007) Diabetes , vol.56 , pp. 2085-2092
    • Turner, N.1    Bruce, C.R.2    Beale, S.M.3    Hoehn, K.L.4    So, T.5    Rolph, M.S.6    Cooney, G.J.7
  • 32
    • 70350539537 scopus 로고    scopus 로고
    • Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: Potent tissue-specific effects of medium-chain fatty acids
    • Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li JY, Kraegen EWet al. Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids. Diabetes 2009 58 2547–2554. (doi:10.2337/db09-0784)
    • (2009) Diabetes , vol.58 , pp. 2547-2554
    • Turner, N.1    Hariharan, K.2    Tidang, J.3    Frangioudakis, G.4    Beale, S.M.5    Wright, L.E.6    Zeng, X.Y.7    Leslie, S.J.8    Li, J.Y.9    Ewet, K.10
  • 34
    • 34547505089 scopus 로고    scopus 로고
    • Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle
    • Garcia-Roves P, Huss JM, Han D-H, Hancock CR, Iglesias-Gutierrez E, Chen M & Holloszy JO. Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. PNAS 2007 104 10709–10713. (doi:10.1073/pnas.0704024104)
    • (2007) PNAS , vol.104 , pp. 10709-10713
    • Garcia-Roves, P.1    Huss, J.M.2    Han, D.-H.3    Hancock, C.R.4    Iglesias-Gutierrez, E.5    Chen, M.6    Holloszy, J.O.7
  • 35
    • 45549089279 scopus 로고    scopus 로고
    • High-fat diets cause insulin resistance despite an increase in muscle mitochondria
    • Hancock CR, Han D-H, Chen M, Terada S, Yasuda T, Wright DC & Holloszy JO. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. PNAS 2008 105 7815–7820. (doi:10.1073/pnas.0802057105)
    • (2008) PNAS , vol.105 , pp. 7815-7820
    • Hancock, C.R.1    Han, D.-H.2    Chen, M.3    Terada, S.4    Yasuda, T.5    Wright, D.C.6    Holloszy, J.O.7
  • 37
    • 84876465920 scopus 로고    scopus 로고
    • Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding
    • Montgomery MK, Hallahan NL, Brown SH, Liu M, Mitchell TW, Cooney GJ & Turner N. Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia 2013 56 1129–1139. (doi:10.1007/s00125-013-2846-8)
    • (2013) Diabetologia , vol.56 , pp. 1129-1139
    • Montgomery, M.K.1    Hallahan, N.L.2    Brown, S.H.3    Liu, M.4    Mitchell, T.W.5    Cooney, G.J.6    Turner, N.7
  • 38
    • 80052530278 scopus 로고    scopus 로고
    • Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1b involves reductions in long-chain acyl-CoA levels and oxidative stress
    • Wright LE, Brandon AE, Hoy AJ, Forsberg GB, Lelliott CJ, Reznick J, Lofgren L, Oscarsson J, Stromstedt M, Cooney GJ et al. Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1b involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia 2011 54 1417–1426. (doi:10.1007/ s00125-011-2068-x)
    • (2011) Diabetologia , vol.54 , pp. 1417-1426
    • Wright, L.E.1    Brandon, A.E.2    Hoy, A.J.3    Forsberg, G.B.4    Lelliott, C.J.5    Reznick, J.6    Lofgren, L.7    Oscarsson, J.8    Stromstedt, M.9    Cooney, G.J.10
  • 39
  • 40
    • 0028011017 scopus 로고
    • Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis
    • Virbasius JV & Scarpulla RC. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. PNAS 1994 91 1309–1313. (doi:10.1073/pnas.914.1309)
    • (1994) PNAS , vol.91 , pp. 1309-1313
    • Virbasius, J.V.1    Scarpulla, R.C.2
  • 44
    • 79957960940 scopus 로고    scopus 로고
    • Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
    • Scarpulla RC. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochimica et Biophysica Acta 2011 1813 1269–1278. (doi:10.1016/j.bbamcr.2010.09.019)
    • (2011) Biochimica Et Biophysica Acta , vol.1813 , pp. 1269-1278
    • Scarpulla, R.C.1
  • 47
    • 58149401189 scopus 로고    scopus 로고
    • Paradoxical effects of increased expression of PGC-1a on muscle mitochondrial function and insulinstimulated muscle glucose metabolism
    • Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang Y-J, Liu Z-X, Lee H-Y, Distefano A, Samuel VT et al. Paradoxical effects of increased expression of PGC-1a on muscle mitochondrial function and insulinstimulated muscle glucose metabolism. PNAS 2008 105 19926–19931. (doi:10.1073/pnas.0810339105)
    • (2008) PNAS , vol.105 , pp. 19926-19931
    • Choi, C.S.1    Befroy, D.E.2    Codella, R.3    Kim, S.4    Reznick, R.M.5    Hwang, Y.-J.6    Liu, Z.-X.7    Lee, H.-Y.8    Distefano, A.9    Samuel, V.T.10
  • 48
    • 0042232026 scopus 로고    scopus 로고
    • Overexpression of peroxisome proliferator-activated receptor g coactivator-1a down-regulates GLUT4 mRNA in skeletal muscles
    • Miura S, Kai Y, Ono M & Ezaki O. Overexpression of peroxisome proliferator-activated receptor g coactivator-1a down-regulates GLUT4 mRNA in skeletal muscles. Journal of Biological Chemistry 2003 278 31385–31390. (doi:10.1074/jbc.M304312200)
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 31385-31390
    • Miura, S.1    Kai, Y.2    Ono, M.3    Ezaki, O.4
  • 49
    • 77955560424 scopus 로고    scopus 로고
    • Increased levels of peroxisome proliferator-activated receptor g, coactivator 1 a (PGC-1a)improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats
    • Benton CR, Holloway GP, Han XX, Yoshida Y, Snook LA, Lally J, Glatz JF, Luiken JJ, Chabowski A & Bonen A. Increased levels of peroxisome proliferator-activated receptor g, coactivator 1 a (PGC-1a)improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats. Diabetologia 2010 53 2008–2019. (doi:10.1007/s00125-010-1773-1)
    • (2010) Diabetologia , vol.53 , pp. 2008-2019
    • Benton, C.R.1    Holloway, G.P.2    Han, X.X.3    Yoshida, Y.4    Snook, L.A.5    Lally, J.6    Glatz, J.F.7    Luiken, J.J.8    Chabowski, A.9    Bonen, A.10
  • 50
    • 84875454999 scopus 로고    scopus 로고
    • Novel small-molecule PGC-1a transcriptional regulator with beneficial effects on diabetic db/db mice
    • Zhang L-N, Zhou H-Y, Fu Y-Y, Li Y-Y, Wu F, Gu M, Wu L-Y, Xia C-M, Dong T-C, Li J-Y et al. Novel small-molecule PGC-1a transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes 2013 62 1297–1307. (doi:10.2337/db12-0703)
    • (2013) Diabetes , vol.62 , pp. 1297-1307
    • Zhang, L.-N.1    Zhou, H.-Y.2    Fu, Y.-Y.3    Li, Y.-Y.4    Wu, F.5    Gu, M.6    Wu, L.-Y.7    Xia, C.-M.8    Dong, T.-C.9    Li, J.-Y.10
  • 52
    • 77952213776 scopus 로고    scopus 로고
    • Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake
    • Olson DP, Pulinilkunnil T, Cline GW, Shulman GI & Lowell BB. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. PNAS 2010 107 7598–7603. (doi:10.1073/pnas.0913492107)
    • (2010) PNAS , vol.107 , pp. 7598-7603
    • Olson, D.P.1    Pulinilkunnil, T.2    Cline, G.W.3    Shulman, G.I.4    Lowell, B.B.5
  • 53
    • 0035970805 scopus 로고    scopus 로고
    • Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl- CoA carboxylase 2
    • Abu-Elheiga L, Matzuk MM, Abo-Hashema KA & Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl- CoA carboxylase 2. Science 2001 291 2613–2616. (doi:10.1126/science.1056843)
    • (2001) Science , vol.291 , pp. 2613-2616
    • Abu-Elheiga, L.1    Matzuk, M.M.2    Abo-Hashema, K.A.3    Wakil, S.J.4
  • 54
    • 0042337449 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
    • Abu-Elheiga L, Oh W, Kordari P & Wakil SJ. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. PNAS 2003 100 10207–10212. (doi:10.1073/pnas.1733877100)
    • (2003) PNAS , vol.100 , pp. 10207-10212
    • Abu-Elheiga, L.1    Oh, W.2    Kordari, P.3    Wakil, S.J.4
  • 55
    • 84859480317 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase 2K/K mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions
    • Abu-Elheiga L, Wu H, Gu Z, Bressler R & Wakil SJ. Acetyl-CoA carboxylase 2K/K mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. Journal of Biological Chemistry 2012 287 12578–12588. (doi:10.1074/ jbc.M111.309559)
    • (2012) Journal of Biological Chemistry , vol.287 , pp. 12578-12588
    • Abu-Elheiga, L.1    Wu, H.2    Gu, Z.3    Bressler, R.4    Wakil, S.J.5
  • 56
    • 36749052873 scopus 로고    scopus 로고
    • Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
    • Choi CS, Savage DB, Abu-Elheiga L, Liu Z-X, Kim S, Kulkarni A, Distefano A, Hwang Y-J, Reznick RM, Codella R et al. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. PNAS 2007 104 16480–16485. (doi:10.1073/pnas.0706794104)
    • (2007) PNAS , vol.104 , pp. 16480-16485
    • Choi, C.S.1    Savage, D.B.2    Abu-Elheiga, L.3    Liu, Z.-X.4    Kim, S.5    Kulkarni, A.6    Distefano, A.7    Hwang, Y.-J.8    Reznick, R.M.9    Codella, R.10
  • 57
    • 0028904053 scopus 로고
    • Insulin action and the insulin signaling network
    • Cheatham B & Kahn CR. Insulin action and the insulin signaling network. Endocrine Reviews 1995 16 117–142. (doi:10.1210/edrv- 16-2-117)
    • (1995) Endocrine Reviews , vol.16 , pp. 117-142
    • Cheatham, B.1    Kahn, C.R.2
  • 59
    • 84899824172 scopus 로고    scopus 로고
    • Insulin increases phosphorylation of mitochondrial proteins in human skeletal muscle in vivo
    • Zhao X, Bak S, Pedersen AJT, Jensen ON & Højlund K. Insulin increases phosphorylation of mitochondrial proteins in human skeletal muscle in vivo. Journal of Proteome Research 2014 13 2359–2369. (doi:10.1021/ pr401163t)
    • (2014) Journal of Proteome Research , vol.13 , pp. 2359-2369
    • Zhao, X.1    Bak, S.2    Pedersen, A.3    Jensen, O.N.4    Højlund, K.5
  • 60
    • 33845514376 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia
    • Asmann YW, Stump CS, Short KR, Coenen-Schimke JM, Guo Z, Bigelow ML & Nair KS. Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia. Diabetes 2006 55 3309–3319. (doi:10.2337/ db05-1230)
    • (2006) Diabetes , vol.55 , pp. 3309-3319
    • Asmann, Y.W.1    Stump, C.S.2    Short, K.R.3    Coenen-Schimke, J.M.4    Guo, Z.5    Bigelow, M.L.6    Nair, K.S.7
  • 61
    • 0038271638 scopus 로고    scopus 로고
    • Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts
    • Stump CS, Short KR, Bigelow ML, Schimke JM & Nair KS. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. PNAS 2003 100 7996–8001. (doi:10.1073/pnas.1332551100)
    • (2003) PNAS , vol.100 , pp. 7996-8001
    • Stump, C.S.1    Short, K.R.2    Bigelow, M.L.3    Schimke, J.M.4    Nair, K.S.5
  • 63
    • 53649111489 scopus 로고    scopus 로고
    • Insulinstimulated mitochondrial adenosine triphosphate synthesis is blunted in skeletal muscles of high-fat-fed rats
    • Yerby B, Deacon R, Beaulieu V, Liang J, Gao J & Laurent D. Insulinstimulated mitochondrial adenosine triphosphate synthesis is blunted in skeletal muscles of high-fat-fed rats. Metabolism: Clinical and Experimental 2008 57 1584–1590. (doi:10.1016/j.metabol.2008.06.015)
    • (2008) Metabolism: Clinical and Experimental , vol.57 , pp. 1584-1590
    • Yerby, B.1    Deacon, R.2    Beaulieu, V.3    Liang, J.4    Gao, J.5    Laurent, D.6
  • 64
    • 78751485448 scopus 로고    scopus 로고
    • Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways
    • Long YC, Cheng Z, Copps KD & White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Molecular and Cellular Biology 2011 31 430–441. (doi:10.1128/MCB.00983-10)
    • (2011) Molecular and Cellular Biology , vol.31 , pp. 430-441
    • Long, Y.C.1    Cheng, Z.2    Copps, K.D.3    White, M.F.4
  • 67
    • 77952541558 scopus 로고    scopus 로고
    • The sites and topology of mitochondrial superoxide production
    • Brand MD. The sites and topology of mitochondrial superoxide production. Experimental Gerontology 2010 45 466–472. (doi:10.1016/j.exger.2010.01.003)
    • (2010) Experimental Gerontology , vol.45 , pp. 466-472
    • Brand, M.D.1
  • 68
    • 70349769764 scopus 로고    scopus 로고
    • Reactive oxygen species production by mitochondria. In MitochondrialDNA:Methods and Protocols, volume554
    • Ed. JA Stuart. New York, NY, USA: Humana Press
    • Lambert A & Brand M. Reactive oxygen species production by mitochondria. In MitochondrialDNA:Methods and Protocols, volume554, pp 165–181. Ed. JA Stuart. New York, NY, USA: Humana Press, 2009
    • (2009) Pp 165–181
    • Lambert, A.1    Brand, M.2
  • 69
    • 0015363173 scopus 로고
    • The cellular production of hydrogen peroxide
    • Boveris A, Oshino N & Chance B. The cellular production of hydrogen peroxide. Biochemical Journal 1972 128 617–630
    • (1972) Biochemical Journal , vol.128 , pp. 617-630
    • Boveris, A.1    Oshino, N.2    Chance, B.3
  • 74
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED & Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006 440 944–948. (doi:10.1038/nature04634)
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 77
    • 56849124393 scopus 로고    scopus 로고
    • Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice
    • Chen L, Na R, Gu M, Salmon AB, Liu Y, Liang H, Qi W, Van Remmen H, Richardson A & Ran Q. Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice. Aging Cell 2008 7 866–878. (doi:10.1111/j.1474-9726.200800432.x)
    • (2008) Aging Cell , vol.7 , pp. 866-878
    • Chen, L.1    Na, R.2    Gu, M.3    Salmon, A.B.4    Liu, Y.5    Liang, H.6    Qi, W.7    Van Remmen, H.8    Richardson, A.9    Ran, Q.10
  • 78
    • 84883280590 scopus 로고    scopus 로고
    • Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women
    • Asemi Z, Samimi M, Tabassi Z, Shakeri H & Esmaillzadeh A. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. Journal of Nutrition 2013 143 1432–1438.(doi:10.3945/ jn.113.177550)
    • (2013) Journal of Nutrition , vol.143 , pp. 1432-1438
    • Asemi, Z.1    Samimi, M.2    Tabassi, Z.3    Shakeri, H.4    Esmaillzadeh, A.5
  • 79
    • 77649303444 scopus 로고    scopus 로고
    • Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors
    • Fang F, Kang Z & Wong C. Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors. Molecular Nutrition & Food Research 2010 54 345–352. (doi:10.1002/mnfr.200900119)
    • (2010) Molecular Nutrition &Amp; Food Research , vol.54 , pp. 345-352
    • Fang, F.1    Kang, Z.C.2
  • 80
    • 80054056526 scopus 로고    scopus 로고
    • Effects of short-term chromium supplementation on insulin sensitivity and body composition in overweight children: Randomized, double-blind, placebo-controlled study
    • Kim C-W, Kim B-T, Park K-H, Kim K-M, Lee D-J, Yang S-W & Joo N-S. Effects of short-term chromium supplementation on insulin sensitivity and body composition in overweight children: randomized, double-blind, placebo-controlled study. Journal of Nutritional Biochemistry 2011 22 1030–1034. (doi:10.1016/j.jnutbio.2010.10.001)
    • (2011) Journal of Nutritional Biochemistry , vol.22 , pp. 1030-1034
    • Kim, C.-W.1    Kim, B.-T.2    Park, K.-H.3    Kim, K.-M.4    Lee, D.-J.5    Yang, S.-W.6    Joo, N.-S.7
  • 81
    • 84892181498 scopus 로고    scopus 로고
    • Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients
    • Nguyen D, Hsu JW, Jahoor F & Sekhar RV. Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. Journal of Clinical Endocrinology and Metabolism 2014 99 169–177. (doi:10.1210/jc.2013-2376)
    • (2014) Journal of Clinical Endocrinology and Metabolism , vol.99 , pp. 169-177
    • Nguyen, D.1    Hsu, J.W.2    Jahoor, F.3    Sekhar, R.V.4
  • 82
    • 79955695959 scopus 로고    scopus 로고
    • Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: A randomized crossover design
    • Rhee Y & Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutrition Journal 2011 10 44. (doi:10.1186/1475-2891-10-44)
    • (2011) Nutrition Journal , vol.10 , pp. 44
    • Rhee, Y.1    Brunt, A.2
  • 83
    • 67749142090 scopus 로고    scopus 로고
    • Inhibition of lipid infusion-induced skeletal muscle insulin resistance by cotreatment with tempol and glutathione in mice
    • Kim BS, Cha H-N, Kim Y-W, Kim J-Y, Dan J-M & Park S-Y. Inhibition of lipid infusion-induced skeletal muscle insulin resistance by cotreatment with tempol and glutathione in mice. Journal of Pharmacological Sciences 2009 110 370–380. (doi:10.1254/jphs.09046FP)
    • (2009) Journal of Pharmacological Sciences , vol.110 , pp. 370-380
    • Kim, B.S.1    Cha, H.-N.2    Kim, Y.-W.3    Kim, J.-Y.4    Dan, J.-M.5    Park, S.-Y.6
  • 85
    • 84890411632 scopus 로고    scopus 로고
    • Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction
    • Jang H-J, Ridgeway SD & Kim J-A. Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction. American Journal of Physiology. Endocrinology and Metabolism 2013 305 E1444–E1454. (doi:10.1152/ajpendo.00434.2013)
    • (2013) American Journal of Physiology. Endocrinology and Metabolism , vol.305
    • Jang, H.-J.1    Ridgeway, S.D.2    Kim, J.-A.3
  • 87
    • 79955872580 scopus 로고    scopus 로고
    • The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial
    • de Oliveira AM, Rondo´ PH, Luzia LA, D’Abronzo FH & Illison VK. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Diabetes Research and Clinical Practice 2011 92 253–260. (doi:10.1016/j.diabres.2011.02.010)
    • (2011) Diabetes Research and Clinical Practice , vol.92 , pp. 253-260
    • De Oliveira, A.M.1    Rondo´, P.H.2    Luzia, L.A.3    D’Abronzo, F.H.4    Illison, V.K.5
  • 88
    • 80052145967 scopus 로고    scopus 로고
    • Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebocontrolled clinical trial
    • Hsu C-H, Liao Y-L, Lin S-C, Tsai T-H, Huang C-J & Chou P. Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebocontrolled clinical trial. Alternative Medicine Review 2011 16 157–164
    • (2011) Alternative Medicine Review , vol.16 , pp. 157-164
    • Hsu, C.-H.1    Liao, Y.-L.2    Lin, S.-C.3    Tsai, T.-H.4    Huang, C.-J.5    Chou, P.6
  • 89
    • 84900495551 scopus 로고    scopus 로고
    • Effects of dietary supplementation with epigallocatechin- 3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: Randomised, double-blind, placebo-controlled clinical trial
    • Mielgo-Ayuso J, Barrenechea L, Alcorta P, Larrarte E, Margareto J & Labayen I. Effects of dietary supplementation with epigallocatechin- 3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial. British Journal of Nutrition 2014 111 1263–1271. (doi:10.1017/S0007114513003784)
    • (2014) British Journal of Nutrition , vol.111 , pp. 1263-1271
    • Mielgo-Ayuso, J.1    Barrenechea, L.2    Alcorta, P.3    Larrarte, E.4    Margareto, J.5    Labayen, I.6
  • 92
    • 84867724832 scopus 로고    scopus 로고
    • Mitochondria and mitophagy: The yin and yang of cell death control
    • Kubli DA & GustafssonA° B. Mitochondria and mitophagy: the yin and yang of cell death control. Circulation Research 2012 111 1208–1221. (doi:10.1161/CIRCRESAHA.112.265819)
    • (2012) Circulation Research , vol.111 , pp. 1208-1221
    • Kubli, D.A.1    Gustafssona°, B.2
  • 93
    • 84867773087 scopus 로고    scopus 로고
    • Mitophagy: Mechanisms, pathophysiological roles, and analysis
    • Ding WX & Yin XM. Mitophagy: mechanisms, pathophysiological roles, and analysis. Biological Chemistry 2012 393 547–564. (doi:10.1515/hsz-2012-0119)
    • (2012) Biological Chemistry , vol.393 , pp. 547-564
    • Ding, W.X.1    Yin, X.M.2
  • 94
    • 84863430453 scopus 로고    scopus 로고
    • Mitophagy: A complex mechanism of mitochondrial removal
    • Novak I. Mitophagy: a complex mechanism of mitochondrial removal. Antioxidants & Redox Signaling 2012 17 794–802. (doi:10.1089/ars.2011.4407)
    • (2012) Antioxidants &Amp; Redox Signaling , vol.17 , pp. 794-802
    • Novak, I.1
  • 95
    • 84899113035 scopus 로고    scopus 로고
    • HSP72 is a mitochondrial stress sensor critical for parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle
    • Drew BG, Ribas V, Le JA, Henstridge DC, Phun J, Zhou Z, Soleymani T, Daraei P, Sitz D, Vergnes L et al. HSP72 is a mitochondrial stress sensor critical for parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes 2014 63 1488–1505. (doi:10.2337/db13- 0665)
    • (2014) Diabetes , vol.63 , pp. 1488-1505
    • Drew, B.G.1    Ribas, V.2    Le, J.A.3    Henstridge, D.C.4    Phun, J.5    Zhou, Z.6    Soleymani, T.7    Daraei, P.8    Sitz, D.9    Vergnes, L.10
  • 96
    • 78649413837 scopus 로고    scopus 로고
    • Mitochondrial fusion and fission in cell life and death. Nature Reviews
    • Westermann B. Mitochondrial fusion and fission in cell life and death. Nature Reviews. Molecular Cell Biology 2010 11 872–884. (doi:10.1038/ nrm3013)
    • (2010) Molecular Cell Biology , vol.11 , pp. 872-884
    • Westermann, B.1
  • 97
    • 49349102894 scopus 로고    scopus 로고
    • Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
    • Twig G, Hyde B & Shirihai OS. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochimica et Biophysica Acta 2008 1777 1092–1097. (doi:10.1016/j.bbabio.200805.001)
    • (2008) Biochimica Et Biophysica Acta , vol.1777 , pp. 1092-1097
    • Twig, G.1    Hyde, B.2    Shirihai, O.S.3
  • 98
    • 8644270474 scopus 로고    scopus 로고
    • OPA1 requires mitofusin 1 to promote mitochondrial fusion
    • Cipolat S, de Brito OM, Dal Zilio B & Scorrano L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. PNAS 2004 101 15927–15932. (doi:10.1073/pnas.0407043101)
    • (2004) PNAS , vol.101 , pp. 15927-15932
    • Cipolat, S.1    De Brito, O.M.2    Dal Zilio, B.3    Scorrano, L.4
  • 99
    • 0031440879 scopus 로고    scopus 로고
    • Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase
    • Hales KG & Fuller MT. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell 1997 90 121–129. (doi:10.1016/S0092-8674(00)80319-0)
    • (1997) Cell , vol.90 , pp. 121-129
    • Hales, K.G.1    Fuller, M.T.2
  • 100
    • 11044230970 scopus 로고    scopus 로고
    • The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis
    • Hales KG. The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis. Mitochondrion 2004 4 285–308. (doi:10.1016/j.mito.2004.05.007)
    • (2004) Mitochondrion , vol.4 , pp. 285-308
    • Hales, K.G.1
  • 101
    • 80054921669 scopus 로고    scopus 로고
    • All the little pieces – regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitinlike modifier and their potential relevance in the heart
    • Zungu M, Schisler J & Willis MS. All the little pieces – regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitinlike modifier and their potential relevance in the heart. Circulation Journal 2011 75 2513–2521. (doi:10.1253/circj.CJ-11-0967)
    • (2011) Circulation Journal , vol.75 , pp. 2513-2521
    • Zungu, M.1    Schisler, J.2    Willis, M.S.3
  • 102
    • 68949116271 scopus 로고    scopus 로고
    • Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes
    • Zorzano A, Liesa M & Palacı´n M. Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes. International Journal of Biochemistry & Cell Biology 2009 41 1846–1854. (doi:10.1016/j.biocel.2009.02.004)
    • (2009) International Journal of Biochemistry &Amp; Cell Biology , vol.41 , pp. 1846-1854
    • Zorzano, A.1    Liesa, M.2
  • 104
    • 20444461625 scopus 로고    scopus 로고
    • The Charcot–Marie–Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system
    • Pich S, Bach D, Briones P, Liesa M, Camps M, Testar X, Palacìn M & Zorzano A. The Charcot–Marie–Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Human Molecular Genetics 2005 14 1405–1415.(doi:10.1093/hmg/ ddi149)
    • (2005) Human Molecular Genetics , vol.14 , pp. 1405-1415
    • Pich, S.1    Bach, D.2    Briones, P.3    Liesa, M.4    Camps, M.5    Testar, X.6    Palacìn, M.7    Zorzano, A.8
  • 105
    • 77951737783 scopus 로고    scopus 로고
    • Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations
    • Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM & Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 2010 141 280–289. (doi:10.1016/j.cell.2010.02.026)
    • (2010) Cell , vol.141 , pp. 280-289
    • Chen, H.1    Vermulst, M.2    Wang, Y.E.3    Chomyn, A.4    Prolla, T.A.5    McCaffery, J.M.6    Chan, D.C.7
  • 106
    • 24144462451 scopus 로고    scopus 로고
    • Expression of Mfn2, the Charcot–Marie–Tooth neuropathy type 2A gene, in human skeletal muscle: Effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor a and interleukin-6
    • Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H et al. Expression of Mfn2, the Charcot–Marie–Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor a and interleukin-6. Diabetes 2005 54 2685–2693. (doi:10.2337/diabetes.54.9.2685)
    • (2005) Diabetes , vol.54 , pp. 2685-2693
    • Bach, D.1    Naon, D.2    Pich, S.3    Soriano, F.X.4    Vega, N.5    Rieusset, J.6    Laville, M.7    Guillet, C.8    Boirie, Y.9    Wallberg-Henriksson, H.10
  • 107
    • 26244456362 scopus 로고    scopus 로고
    • Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity?
    • Mingrone G, Manco M, Calvani M, Castagneto M, Naon D & Zorzano A. Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity? Diabetologia 2005 48 2108–2114. (doi:10.1007/s00125-005-1918-9)
    • (2005) Diabetologia , vol.48 , pp. 2108-2114
    • Mingrone, G.1    Manco, M.2    Calvani, M.3    Castagneto, M.4    Naon, D.5    Zorzano, A.6
  • 108
    • 77955508579 scopus 로고    scopus 로고
    • Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
    • Phielix E, Meex R, Moonen-Kornips E, Hesselink MK & Schrauwen P. Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals. Diabetologia 2010 53 1714–1721. (doi:10.1007/s00125-010-1764-2)
    • (2010) Diabetologia , vol.53 , pp. 1714-1721
    • Phielix, E.1    Meex, R.2    Moonen-Kornips, E.3    Hesselink, M.K.4    Schrauwen, P.5
  • 109
    • 3042821172 scopus 로고    scopus 로고
    • Muscle fat oxidative capacity is not impaired by age but by physical inactivity: Association with insulin sensitivity
    • Rimbert V, Boirie Y, Bedu M, Hocquette JF, Ritz P & Morio B. Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity. FASEB Journal 2004 18 737–739. (doi:10.1096/fj.03-1104fje)
    • (2004) FASEB Journal , vol.18 , pp. 737-739
    • Rimbert, V.1    Boirie, Y.2    Bedu, M.3    Hocquette, J.F.4    Ritz, P.5    Morio, B.6
  • 110
    • 34547596186 scopus 로고    scopus 로고
    • Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
    • Toledo FG, Menshikova EV, Ritov VB, Azuma K, Radikova Z, DeLany J & Kelley DE. Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes 2007 56 2142–2147. (doi:10.2337/db07-0141)
    • (2007) Diabetes , vol.56 , pp. 2142-2147
    • Toledo, F.G.1    Menshikova, E.V.2    Ritov, V.B.3    Azuma, K.4    Radikova, Z.5    Delany, J.6    Kelley, D.E.7
  • 112
    • 77950349827 scopus 로고    scopus 로고
    • Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity
    • Meex RC, Schrauwen-Hinderling VB, Moonen-Kornips E, Schaart G, Mensink M, Phielix E, van de Weijer T, Sels JP, Schrauwen P & Hesselink MK. Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes 2010 59 572–579. (doi:10.2337/db09-1322)
    • (2010) Diabetes , vol.59 , pp. 572-579
    • Meex, R.C.1    Schrauwen-Hinderling, V.B.2    Moonen-Kornips, E.3    Schaart, G.4    Mensink, M.5    Phielix, E.6    Van De Weijer, T.7    Sels, J.P.8    Schrauwen, P.9    Hesselink, M.K.10
  • 113
    • 0030017181 scopus 로고    scopus 로고
    • Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men
    • Dengel DR, Pratley RE, Hagberg JM, Rogus EM & Goldberg AP. Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men. Journal of Applied Physiology 1996 81 318–325. (doi:10.1097/00005768)
    • (1996) Journal of Applied Physiology , vol.81 , pp. 318-325
    • Dengel, D.R.1    Pratley, R.E.2    Hagberg, J.M.3    Rogus, E.M.4    Goldberg, A.P.5
  • 114
    • 0030052636 scopus 로고    scopus 로고
    • Palja¨rvi L & LaaksoM. The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects
    • Niskanen L, Uusitupa M, Sarlund H, Siitonen O, Palja¨rvi L & LaaksoM. The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects. International Journal of Obesity and Related Metabolic Disorders 1996 20 154–160
    • (1996) International Journal of Obesity and Related Metabolic Disorders , vol.20 , pp. 154-160
    • Niskanen, L.1    Uusitupa, M.2    Sarlund, H.3    Siitonen, O.4
  • 116
    • 33746419647 scopus 로고    scopus 로고
    • Effect of calorie restriction with or without exercise on insulin sensitivity, b-cell function, fat cell size, and ectopic lipid in overweight subjects
    • Larson-Meyer DE, Heilbronn LK, Redman LM, Newcomer BR, Frisard MI, Anton S, Smith SR, Alfonso A & Ravussin E. Effect of calorie restriction with or without exercise on insulin sensitivity, b-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 2006 29 1337–1344. (doi:10.2337/dc05-2565)
    • (2006) Diabetes Care , vol.29 , pp. 1337-1344
    • Larson-Meyer, D.E.1    Heilbronn, L.K.2    Redman, L.M.3    Newcomer, B.R.4    Frisard, M.I.5    Anton, S.6    Smith, S.R.7    Alfonso, A.8    Ravussin, E.9
  • 118
    • 84881116641 scopus 로고    scopus 로고
    • Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation
    • KitadaM, Kume S, Takeda-Watanabe A, Tsuda S, Kanasaki K & Koya D
    • KitadaM, Kume S, Takeda-Watanabe A, Tsuda S, Kanasaki K & Koya D. Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation. Biochimica et Biophysica Acta 2013 1830 4820–4827. (doi:10.1016/j.bbagen.201306.014)
    • (2013) Biochimica Et Biophysica Acta , vol.1830 , pp. 4820-4827
  • 125
    • 77956182566 scopus 로고    scopus 로고
    • JastrochM& Brand MD. Mitochondrial uncoupling and lifespan
    • Mookerjee SA, Divakaruni AS, JastrochM& Brand MD. Mitochondrial uncoupling and lifespan. Mechanisms of Ageing and Development 2010 131 463–472. (doi:10.1016/j.mad.2010.03.010)
    • (2010) Mechanisms of Ageing and Development , vol.131 , pp. 463-472
    • Mookerjee, S.A.1    Divakaruni, A.S.2
  • 126
    • 84922080375 scopus 로고    scopus 로고
    • Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice
    • Tao H, Zhang Y, Zeng X, Shulman GI & Jin S. Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nature Medicine 2014 20 1263–1269. (doi:10.1038/nm.3699)
    • (2014) Nature Medicine , vol.20 , pp. 1263-1269
    • Tao, H.1    Zhang, Y.2    Zeng, X.3    Shulman, G.I.4    Jin, S.5
  • 127
    • 84880986388 scopus 로고    scopus 로고
    • . Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production
    • Adjeitey CN, Mailloux RJ, deKemp RA & Harper ME. Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production. American Journal of Physiology. Endocrinology and Metabolism 2013 305 E405–E415. (doi:10.1152/ajpendo.00057.2013)
    • (2013) American Journal of Physiology. Endocrinology and Metabolism , vol.305
    • Adjeitey, C.N.1    Mailloux, R.J.2    Dekemp, R.A.3    Harper, M.E.4
  • 133
    • 84868692016 scopus 로고    scopus 로고
    • Berberine in the treatment of type 2 diabetes mellitus: A systemic review and meta-analysis
    • Dong H, Wang N, Zhao L & Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine 2012 2012 591654. (doi:10.1155/2012/591654)
    • (2012) Evidence-Based Complementary and Alternative Medicine , vol.2012
    • Dong, H.1    Wang, N.2    Zhao, L.3    Lu, F.4
  • 134
    • 33749336146 scopus 로고    scopus 로고
    • Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
    • Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006 55 2256–2264. (doi:10.2337/db06-0006)
    • (2006) Diabetes , vol.55 , pp. 2256-2264
    • Lee, Y.S.1    Kim, W.S.2    Kim, K.H.3    Yoon, M.J.4    Cho, H.J.5    Shen, Y.6    Ye, J.M.7    Lee, C.H.8    Oh, W.K.9    Kim, C.T.10
  • 135
    • 48449084609 scopus 로고    scopus 로고
    • Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
    • Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 2008 57 1414–1418. (doi:10.2337/db07-1552)
    • (2008) Diabetes , vol.57 , pp. 1414-1418
    • Turner, N.1    Li, J.Y.2    Gosby, A.3    To, S.W.4    Cheng, Z.5    Miyoshi, H.6    Taketo, M.M.7    Cooney, G.J.8    Kraegen, E.W.9    James, D.E.10
  • 136
    • 77954652820 scopus 로고    scopus 로고
    • Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea
    • Eid HM, Martineau LC, Saleem A, Muhammad A, Vallerand D, Benhaddou-Andaloussi A, Nistor L, Afshar A, Arnason JT & Haddad PS. Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea. Molecular Nutrition & Food Research 2010 54 991–1003. (doi:10.1002/mnfr.200900218)
    • (2010) Molecular Nutrition &Amp; Food Research , vol.54 , pp. 991-1003
    • Eid, H.M.1    Martineau, L.C.2    Saleem, A.3    Muhammad, A.4    Vallerand, D.5    Benhaddou-Andaloussi, A.6    Nistor, L.7    Afshar, A.8    Arnason, J.T.9    Haddad, P.S.10
  • 137
    • 12144291275 scopus 로고    scopus 로고
    • Thiazolidinediones, like metformin, inhibit respiratory complex I: A common mechanism contributing to their antidiabetic actions?
    • Brunmair B, Staniek K, Gras F, Scharf N, Althaym A, Clara R, Roden M, Gnaiger E, Nohl H, Waldhausl W et al. Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 2004 53 1052–1059. (doi:10.2337/diabetes.53.4.1052)
    • (2004) Diabetes , vol.53 , pp. 1052-1059
    • Brunmair, B.1    Staniek, K.2    Gras, F.3    Scharf, N.4    Althaym, A.5    Clara, R.6    Roden, M.7    Gnaiger, E.8    Nohl, H.9    Waldhausl, W.10
  • 138
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen MR, Doran E & Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochemical Journal 2000 348 607–614.(doi:10.1042/0264-6021:3480607)
    • (2000) Biochemical Journal , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 139
    • 84862558716 scopus 로고    scopus 로고
    • Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice
    • Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD & Leng Y. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia 2012 55 1469–1481. (doi:10.1007/s00125-011-2366-3)
    • (2012) Diabetologia , vol.55 , pp. 1469-1481
    • Huang, S.L.1    Yu, R.T.2    Gong, J.3    Feng, Y.4    Dai, Y.L.5    Hu, F.6    Hu, Y.H.7    Tao, Y.D.8    Leng, Y.9


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