-
1
-
-
34147175161
-
Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects
-
Heilbronn LK, Gan SK, Turner N, Campbell LV & Chisholm DJ. Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects. Journal of Clinical Endocrinology and Metabolism 2007 92 1467–1473. (doi:10.1210/ jc.2006-2210)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, pp. 1467-1473
-
-
Heilbronn, L.K.1
Gan, S.K.2
Turner, N.3
Campbell, L.V.4
Chisholm, D.J.5
-
2
-
-
0038054341
-
PGC-1a-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
-
Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstrale M, Laurila E et al. PGC-1a-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics 2003 34 267–273. (doi:10.1038/ng1180)
-
(2003)
Nature Genetics
, vol.34
, pp. 267-273
-
-
Mootha, V.K.1
Lindgren, C.M.2
Eriksson, K.F.3
Subramanian, A.4
Sihag, S.5
Lehar, J.6
Puigserver, P.7
Carlsson, E.8
Ridderstrale, M.9
Laurila, E.10
-
3
-
-
0037477855
-
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
-
Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. PNAS 2003 100 8466–8471. (doi:10.1073/pnas.1032913100)
-
(2003)
PNAS
, vol.100
, pp. 8466-8471
-
-
Patti, M.E.1
Butte, A.J.2
Crunkhorn, S.3
Cusi, K.4
Berria, R.5
Kashyap, S.6
Miyazaki, Y.7
Kohane, I.8
Costello, M.9
Saccone, R.10
-
4
-
-
34548429745
-
Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome
-
Skov V, Glintborg D, Knudsen S, Jensen T, Kruse TA, Tan Q, Brusgaard K, Beck-Nielsen H & Højlund K. Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome. Diabetes 2007 56 2349–2355. (doi:10.2337/db07-0275)
-
(2007)
Diabetes
, vol.56
, pp. 2349-2355
-
-
Skov, V.1
Glintborg, D.2
Knudsen, S.3
Jensen, T.4
Kruse, T.A.5
Tan, Q.6
Brusgaard, K.7
Beck-Nielsen, H.8
Højlund, K.9
-
5
-
-
12144275294
-
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
-
Ritov VB, Menshikova EV, He J, Ferrell RE, Goodpaster BH & Kelley DE. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 2005 54 8–14. (doi:10.2337/diabetes.54.1.8)
-
(2005)
Diabetes
, vol.54
, pp. 8-14
-
-
Ritov, V.B.1
Menshikova, E.V.2
He, J.3
Ferrell, R.E.4
Goodpaster, B.H.5
Kelley, D.E.6
-
6
-
-
0033400310
-
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
-
Kelley DE, Goodpaster B, Wing RR & Simoneau JA. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. American Journal of Physiology 1999 277 E1130–E1141
-
(1999)
American Journal of Physiology
, vol.277
-
-
Kelley, D.E.1
Goodpaster, B.2
Wing, R.R.3
Simoneau, J.A.4
-
7
-
-
0036788293
-
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
-
Kelley DE, He J, Menshikova EV & Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 2002 51 2944–2950. (doi:10.2337/diabetes.51.10.2944)
-
(2002)
Diabetes
, vol.51
, pp. 2944-2950
-
-
Kelley, D.E.1
He, J.2
Menshikova, E.V.3
Ritov, V.B.4
-
9
-
-
0032752951
-
Markers of capacity to utilize fatty acids in human skeletal muscle: Relation to insulin resistance and obesity and effects of weight loss
-
Simoneau J-A, Veerkamp JH, Turcotte LP & Kelley DE. Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB Journal 1999 13 2051–2060
-
(1999)
FASEB Journal
, vol.13
, pp. 2051-2060
-
-
Simoneau, J.-A.1
Veerkamp, J.H.2
Turcotte, L.P.3
Kelley, D.E.4
-
10
-
-
31044433308
-
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
-
Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. Journal of Clinical Investigation 2005 115 3587–3593. (doi:10.1172/JCI25151)
-
(2005)
Journal of Clinical Investigation
, vol.115
, pp. 3587-3593
-
-
Morino, K.1
Petersen, K.F.2
Dufour, S.3
Befroy, D.4
Frattini, J.5
Shatzkes, N.6
Neschen, S.7
White, M.F.8
Bilz, S.9
Sono, S.10
-
11
-
-
77953868236
-
Lipid-induced insulin resistance: Unravelling the mechanism
-
Samuel VT, Petersen KF & Shulman GI. Lipid-induced insulin resistance: unravelling the mechanism. Lancet 2010 375 2267–2277. (doi:10.1016/S0140-6736(10)60408-4)
-
(2010)
Lancet
, vol.375
, pp. 2267-2277
-
-
Samuel, V.T.1
Petersen, K.F.2
Shulman, G.I.3
-
12
-
-
84870341562
-
Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice
-
Bruce CR, Risis S, Babb JR, Yang C, Kowalski GM, Selathurai A, Lee-Young RS, Weir JM, Yoshioka K, Takuwa Y et al. Overexpression of sphingosine kinase 1 prevents ceramide accumulation and ameliorates muscle insulin resistance in high-fat diet-fed mice. Diabetes 2012 61 3148–3155. (doi:10.2337/db12-0029)
-
(2012)
Diabetes
, vol.61
, pp. 3148-3155
-
-
Bruce, C.R.1
Risis, S.2
Babb, J.R.3
Yang, C.4
Kowalski, G.M.5
Selathurai, A.6
Lee-Young, R.S.7
Weir, J.M.8
Yoshioka, K.9
Takuwa, Y.10
-
13
-
-
0033588253
-
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
-
Schmitz-Peiffer C, Craig DL & Biden TJ. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. Journal of Biological Chemistry 1999 274 24202–24210. (doi:10.1074/jbc.274.34.24202)
-
Journal of Biological Chemistry 1999 274
, pp. 24202-24210
-
-
Schmitz-Peiffer, C.1
Craig, D.L.2
Biden, T.J.3
-
14
-
-
58149379936
-
Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance
-
Holloszy JO. Skeletal muscle “mitochondrial deficiency” does not mediate insulin resistance. American Journal of Clinical Nutrition 2009 89 463S–466S. (doi:10.3945/ajcn.2008.26717C)
-
(2009)
American Journal of Clinical Nutrition
, vol.89
-
-
Holloszy, J.O.1
-
15
-
-
0016808251
-
Two distinct patterns of glucose intolerance in icteric rats and rabbits. Relationship to impaired liver mitochondria function
-
Yamada T, Ida T, Yamaoka Y, Ozawa K, Takasan H & Honjo I. Two distinct patterns of glucose intolerance in icteric rats and rabbits. Relationship to impaired liver mitochondria function. Journal of Laboratory and Clinical Medicine 1975 86 38–45
-
(1975)
Journal of Laboratory and Clinical Medicine
, vol.86
, pp. 38-45
-
-
Yamada, T.1
Ida, T.2
Yamaoka, Y.3
Ozawa, K.4
Takasan, H.5
Honjo, I.6
-
16
-
-
77449155964
-
Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes
-
Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Højlund K, Yi Z et al. Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes 2010 59 33–42. (doi:10.2337/db09-0214)
-
(2010)
Diabetes
, vol.59
, pp. 33-42
-
-
Hwang, H.1
Bowen, B.P.2
Lefort, N.3
Flynn, C.R.4
De Filippis, E.A.5
Roberts, C.6
Smoke, C.C.7
Meyer, C.8
Højlund, K.9
Yi, Z.10
-
17
-
-
53649083550
-
Is mitochondrial dysfunction a cause of insulin resistance?
-
Turner N & Heilbronn LK. Is mitochondrial dysfunction a cause of insulin resistance? Trends in Endocrinology and Metabolism 2008 19 324–330. (doi:10.1016/j.tem.2008.08.001)
-
(2008)
Trends in Endocrinology and Metabolism
, vol.19
, pp. 324-330
-
-
Turner, N.1
Heilbronn, L.K.2
-
18
-
-
79952295016
-
A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals
-
Boyle KE, Canham JP, Consitt LA, Zheng D, Koves TR, Gavin TP, Holbert D, Neufer PD, Ilkayeva O, Muoio DM et al. A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals. Journal of Clinical Endocrinology and Metabolism 2011 96 775–781. (doi:10.1210/ jc.2010-2253)
-
(2011)
Journal of Clinical Endocrinology and Metabolism
, vol.96
, pp. 775-781
-
-
Boyle, K.E.1
Canham, J.P.2
Consitt, L.A.3
Zheng, D.4
Koves, T.R.5
Gavin, T.P.6
Holbert, D.7
Neufer, P.D.8
Ilkayeva, O.9
Muoio, D.M.10
-
19
-
-
33749370466
-
Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
-
Bandyopadhyay GK, Yu JG, Ofrecio J & Olefsky JM. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 2006 55 2277–2285. (doi:10.2337/db06-0062)
-
(2006)
Diabetes
, vol.55
, pp. 2277-2285
-
-
Bandyopadhyay, G.K.1
Yu, J.G.2
Ofrecio, J.3
Olefsky, J.M.4
-
20
-
-
33847611885
-
Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle
-
Boushel R, Gnaiger E, Schjerling P, Skovbro M, Kraunsøe R & Dela F. Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 2007 50 790–796. (doi:10.1007/ s00125-007-0594-3)
-
(2007)
Diabetologia
, vol.50
, pp. 790-796
-
-
Boushel, R.1
Gnaiger, E.2
Schjerling, P.3
Skovbro, M.4
Kraunsøe, R.5
Dela, F.6
-
21
-
-
34447576831
-
Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women
-
Holloway GP, Thrush AB, Heigenhauser GJ, Tandon NN, Dyck DJ, Bonen A & Spriet LL. Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women. American Journal of Physiology. Endocrinology and Metabolism 2007 292 E1782–E1789. (doi:10.1152/ajpendo.00639.2006)
-
(2007)
American Journal of Physiology. Endocrinology and Metabolism
, vol.292
-
-
Holloway, G.P.1
Thrush, A.B.2
Heigenhauser, G.J.3
Tandon, N.N.4
Dyck, D.J.5
Bonen, A.6
Spriet, L.L.7
-
22
-
-
58149346025
-
Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients
-
Phielix E, Schrauwen-Hinderling VB, Mensink M, Lenaers E, Meex R, Hoeks J, Kooi ME, Moonen-Kornips E, Sels JP, Hesselink MK et al. Lower intrinsic ADP-stimulated mitochondrial respiration underlies in vivo mitochondrial dysfunction in muscle of male type 2 diabetic patients. Diabetes 2008 57 2943–2949. (doi:10.2337/db08-0391)
-
(2008)
Diabetes
, vol.57
, pp. 2943-2949
-
-
Phielix, E.1
Schrauwen-Hinderling, V.B.2
Mensink, M.3
Lenaers, E.4
Meex, R.5
Hoeks, J.6
Kooi, M.E.7
Moonen-Kornips, E.8
Sels, J.P.9
Hesselink, M.K.10
-
23
-
-
79951706196
-
Skeletal muscle mitochondria in insulin resistance: Differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility
-
Chomentowski P, Coen PM, Radikova´ Z, Goodpaster BH & Toledo FG. Skeletal muscle mitochondria in insulin resistance: differences in intermyofibrillar versus subsarcolemmal subpopulations and relationship to metabolic flexibility. Journal of Clinical Endocrinology and Metabolism 2011 96 494–503. (doi:10.1210/jc.2010-0822)
-
(2011)
Journal of Clinical Endocrinology and Metabolism
, vol.96
, pp. 494-503
-
-
Chomentowski, P.1
Coen, P.M.2
Radikova´, Z.3
Goodpaster, B.H.4
Toledo, F.G.5
-
24
-
-
76149125131
-
Regional anatomic differences in skeletal muscle mitochondrial respiration in type 2 diabetes and obesity
-
Rabøl R, Larsen S, Højberg PM, Almdal T, Boushel R, Haugaard SB, Andersen JL, Madsbad S & Dela F. Regional anatomic differences in skeletal muscle mitochondrial respiration in type 2 diabetes and obesity. Journal of Clinical Endocrinology and Metabolism 2010 95 857–863. (doi:10.1210/jc.2009-1844)
-
(2010)
Journal of Clinical Endocrinology and Metabolism
, vol.95
, pp. 857-863
-
-
Rabøl, R.1
Larsen, S.2
Højberg, P.M.3
Almdal, T.4
Boushel, R.5
Haugaard, S.B.6
Ersen, J.L.7
Madsbad, S.8
Dela, F.9
-
25
-
-
0142167917
-
Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats
-
Iossa S, Lionetti L, Mollica MP, Crescenzo R, Botta M, Barletta A & Liverini G. Effect of high-fat feeding on metabolic efficiency and mitochondrial oxidative capacity in adult rats. British Journal of Nutrition 2003 90 953–960. (doi:10.1079/BJN2003000968)
-
(2003)
British Journal of Nutrition
, vol.90
, pp. 953-960
-
-
Iossa, S.1
Lionetti, L.2
Mollica, M.P.3
Crescenzo, R.4
Botta, M.5
Barletta, A.6
Liverini, G.7
-
26
-
-
49649115590
-
Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes
-
Trenell MI, Hollingsworth KG, Lim EL & Taylor R. Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes. Diabetes Care 2008 31 1644–1649. (doi:10.2337/dc08-0303)
-
(2008)
Diabetes Care
, vol.31
, pp. 1644-1649
-
-
Trenell, M.I.1
Hollingsworth, K.G.2
Lim, E.L.3
Taylor, R.4
-
27
-
-
84866181138
-
Physical activity is the key determinant of skeletal muscle mitochondrial function in type 2 diabetes
-
van Tienen FH, Praet SF, de Feyter HM, van den Broek NM, Lindsey PJ, Schoonderwoerd KG, de Coo IF, Nicolay K, Prompers JJ, Smeets HJ et al. Physical activity is the key determinant of skeletal muscle mitochondrial function in type 2 diabetes. Journal of Clinical Endocrinology and Metabolism 2012 97 3261–3269. (doi:10.1210/jc.2011-3454)
-
(2012)
Journal of Clinical Endocrinology and Metabolism
, vol.97
, pp. 3261-3269
-
-
Van Tienen, F.H.1
Praet, S.F.2
De Feyter, H.M.3
Van Den Broek, N.M.4
Lindsey, P.J.5
Schoonderwoerd, K.G.6
De Coo, I.F.7
Nicolay, K.8
Prompers, J.J.9
Smeets, H.J.10
-
28
-
-
84860641172
-
Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans
-
Samocha-Bonet D, Campbell LV, Mori TA, Croft KD, Greenfield JR, Turner N & Heilbronn LK. Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans. PLoS ONE 2012 7 e36320. (doi:10.1371/journal.pone.0036320)
-
(2012)
Plos ONE
, vol.7
-
-
Samocha-Bonet, D.1
Campbell, L.V.2
Mori, T.A.3
Croft, K.D.4
Greenfield, J.R.5
Turner, N.6
Heilbronn, L.K.7
-
29
-
-
0036081451
-
Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle
-
Sreekumar R, Unnikrishnan J, Fu A, Nygren J, Short KR, Schimke J, Barazzoni R & Nair KS. Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle. American Journal of Physiology. Endocrinology and Metabolism 2002 282 E1055–E1061. (doi:10.1152/ajpendo.00554.2001)
-
(2002)
American Journal of Physiology. Endocrinology and Metabolism
, vol.282
-
-
Sreekumar, R.1
Unnikrishnan, J.2
Fu, A.3
Nygren, J.4
Short, K.R.5
Schimke, J.6
Barazzoni, R.7
Nair, K.S.8
-
30
-
-
0033796676
-
Effect of long-term high-fat feeding on energy balance and liver oxidative activity in rats
-
Iossa S, Lionetti L, Mollica MP, Crescenzo R, Barletta A & Liverini G. Effect of long-term high-fat feeding on energy balance and liver oxidative activity in rats. British Journal of Nutrition 2000 84 377–385. (doi:10.1017/S0007114500001665)
-
(2000)
British Journal of Nutrition
, vol.84
, pp. 377-385
-
-
Iossa, S.1
Lionetti, L.2
Mollica, M.P.3
Crescenzo, R.4
Barletta, A.5
Liverini, G.6
-
31
-
-
34547588219
-
Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
-
Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS & Cooney GJ. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 2007 56 2085–2092. (doi:10.2337/db07-0093)
-
(2007)
Diabetes
, vol.56
, pp. 2085-2092
-
-
Turner, N.1
Bruce, C.R.2
Beale, S.M.3
Hoehn, K.L.4
So, T.5
Rolph, M.S.6
Cooney, G.J.7
-
32
-
-
70350539537
-
Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: Potent tissue-specific effects of medium-chain fatty acids
-
Turner N, Hariharan K, TidAng J, Frangioudakis G, Beale SM, Wright LE, Zeng XY, Leslie SJ, Li JY, Kraegen EWet al. Enhancement of muscle mitochondrial oxidative capacity and alterations in insulin action are lipid species dependent: potent tissue-specific effects of medium-chain fatty acids. Diabetes 2009 58 2547–2554. (doi:10.2337/db09-0784)
-
(2009)
Diabetes
, vol.58
, pp. 2547-2554
-
-
Turner, N.1
Hariharan, K.2
Tidang, J.3
Frangioudakis, G.4
Beale, S.M.5
Wright, L.E.6
Zeng, X.Y.7
Leslie, S.J.8
Li, J.Y.9
Ewet, K.10
-
33
-
-
40149096250
-
Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice
-
de Wilde J, Mohren R, van den Berg S, Boekschoten M, Dijk KW, de Groot P, Müller M, Mariman E & Smit E. Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice. Physiological Genomics 2008 32 360–369. (doi:10.1152/physiolgenomics.00219.2007)
-
(2008)
Physiological Genomics
, vol.32
, pp. 360-369
-
-
De Wilde, J.1
Mohren, R.2
Van Den Berg, S.3
Boekschoten, M.4
Dijk, K.W.5
De Groot, P.6
Müller, M.7
Mariman, E.8
Smit, E.9
-
34
-
-
34547505089
-
Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle
-
Garcia-Roves P, Huss JM, Han D-H, Hancock CR, Iglesias-Gutierrez E, Chen M & Holloszy JO. Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. PNAS 2007 104 10709–10713. (doi:10.1073/pnas.0704024104)
-
(2007)
PNAS
, vol.104
, pp. 10709-10713
-
-
Garcia-Roves, P.1
Huss, J.M.2
Han, D.-H.3
Hancock, C.R.4
Iglesias-Gutierrez, E.5
Chen, M.6
Holloszy, J.O.7
-
35
-
-
45549089279
-
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
-
Hancock CR, Han D-H, Chen M, Terada S, Yasuda T, Wright DC & Holloszy JO. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. PNAS 2008 105 7815–7820. (doi:10.1073/pnas.0802057105)
-
(2008)
PNAS
, vol.105
, pp. 7815-7820
-
-
Hancock, C.R.1
Han, D.-H.2
Chen, M.3
Terada, S.4
Yasuda, T.5
Wright, D.C.6
Holloszy, J.O.7
-
36
-
-
84878871217
-
Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
-
Turner N, Kowalski GM, Leslie SJ, Risis S, Yang C, Lee-Young RS, Babb JR, eikle PJ, Lancaster GI, Henstridge DC et al. Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia 2013 56 1638–1648. (doi:10.1007/s00125-013-2913-1)
-
(2013)
Diabetologia
, vol.56
, pp. 1638-1648
-
-
Turner, N.1
Kowalski, G.M.2
Leslie, S.J.3
Risis, S.4
Yang, C.5
Lee-Young, R.S.6
Babb, J.R.7
Eikle, P.J.8
Lancaster, G.I.9
Henstridge, D.C.10
-
37
-
-
84876465920
-
Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding
-
Montgomery MK, Hallahan NL, Brown SH, Liu M, Mitchell TW, Cooney GJ & Turner N. Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia 2013 56 1129–1139. (doi:10.1007/s00125-013-2846-8)
-
(2013)
Diabetologia
, vol.56
, pp. 1129-1139
-
-
Montgomery, M.K.1
Hallahan, N.L.2
Brown, S.H.3
Liu, M.4
Mitchell, T.W.5
Cooney, G.J.6
Turner, N.7
-
38
-
-
80052530278
-
Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1b involves reductions in long-chain acyl-CoA levels and oxidative stress
-
Wright LE, Brandon AE, Hoy AJ, Forsberg GB, Lelliott CJ, Reznick J, Lofgren L, Oscarsson J, Stromstedt M, Cooney GJ et al. Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1b involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia 2011 54 1417–1426. (doi:10.1007/ s00125-011-2068-x)
-
(2011)
Diabetologia
, vol.54
, pp. 1417-1426
-
-
Wright, L.E.1
Brandon, A.E.2
Hoy, A.J.3
Forsberg, G.B.4
Lelliott, C.J.5
Reznick, J.6
Lofgren, L.7
Oscarsson, J.8
Stromstedt, M.9
Cooney, G.J.10
-
39
-
-
84901376570
-
Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance
-
Henstridge DC, Bruce CR, Drew BG, Tory K, Kolonics A, Estevez E, Chung J, Watson N, Gardner T, Lee-Young RS et al. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes 2014 63 1881–1894. (doi:10.2337/db13-0967)
-
(2014)
Diabetes
, vol.63
, pp. 1881-1894
-
-
Henstridge, D.C.1
Bruce, C.R.2
Drew, B.G.3
Tory, K.4
Kolonics, A.5
Estevez, E.6
Chung, J.7
Watson, N.8
Gardner, T.9
Lee-Young, R.S.10
-
40
-
-
0028011017
-
Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: A potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis
-
Virbasius JV & Scarpulla RC. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. PNAS 1994 91 1309–1313. (doi:10.1073/pnas.914.1309)
-
(1994)
PNAS
, vol.91
, pp. 1309-1313
-
-
Virbasius, J.V.1
Scarpulla, R.C.2
-
41
-
-
0037069398
-
Increased mitochondrial mass in mitochondrial myopathy mice
-
Wredenberg A, Wibom R, Wilhelmsson H, Graff C, Wiener HH, Burden SJ, Oldfors A, Westerblad H & Larsson N-G. Increased mitochondrial mass in mitochondrial myopathy mice. PNAS 2002 99 15066–15071. (doi:10.1073/pnas.232591499)
-
(2002)
PNAS
, vol.99
, pp. 15066-15071
-
-
Wredenberg, A.1
Wibom, R.2
Wilhelmsson, H.3
Graff, C.4
Wiener, H.H.5
Burden, S.J.6
Oldfors, A.7
Westerblad, H.8
Larsson, N.-G.9
-
42
-
-
33749041269
-
Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance
-
Wredenberg A, Freyer C, Sandström ME, Katz A, Wibom R, Westerblad H & Larsson N-G. Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance. Biochemical and Biophysical Research Communications 2006 350 202–207. (doi:10.1016/j.bbrc.2006.09.029)
-
(2006)
Biochemical and Biophysical Research Communications
, vol.350
, pp. 202-207
-
-
Wredenberg, A.1
Freyer, C.2
Sandström, M.E.3
Katz, A.4
Wibom, R.5
Westerblad, H.6
Larsson, N.-G.7
-
43
-
-
84870549310
-
Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance
-
Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM et al. Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. Cell Metabolism 2012 16 765–776. (doi:10.1016/j.cmet.2012.10.016)
-
(2012)
Cell Metabolism
, vol.16
, pp. 765-776
-
-
Vernochet, C.1
Mourier, A.2
Bezy, O.3
Macotela, Y.4
Boucher, J.5
Rardin, M.J.6
An, D.7
Lee, K.Y.8
Ilkayeva, O.R.9
Zingaretti, C.M.10
-
44
-
-
79957960940
-
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network
-
Scarpulla RC. Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochimica et Biophysica Acta 2011 1813 1269–1278. (doi:10.1016/j.bbamcr.2010.09.019)
-
(2011)
Biochimica Et Biophysica Acta
, vol.1813
, pp. 1269-1278
-
-
Scarpulla, R.C.1
-
45
-
-
21144446106
-
PGC-1a deficiency causes multi-system energy metabolic derangements: Muscle dysfunction, abnormal weight control and hepatic steatosis
-
Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C et al. PGC-1a deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biology 2005 3 e101. (doi:10.1371/journal.pbio. 0030101)
-
(2005)
Plos Biology
, vol.3
-
-
Leone, T.C.1
Lehman, J.J.2
Finck, B.N.3
Schaeffer, P.J.4
Wende, A.R.5
Boudina, S.6
Courtois, M.7
Wozniak, D.F.8
Sambandam, N.9
Bernal-Mizrachi, C.10
-
46
-
-
84892570159
-
-
Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, Ruas JL, Haibe-Kains B & Estall JL. Loss of Pgc-1a expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation. American Journal of Physiology. Endocrinology and Metabolism 2014 306 E157–E167. (doi:10.1152/ajpendo.00578.2013)
-
(2014)
Loss of Pgc-1A Expression in Aging Mouse Muscle Potentiates Glucose Intolerance and Systemic Inflammation
, vol.306
-
-
Sczelecki, S.1
Besse-Patin, A.2
Abboud, A.3
Kleiner, S.4
Laznik-Bogoslavski, D.5
Wrann, C.D.6
Ruas, J.L.7
Haibe-Kains, B.8
Estall, J.L.9
-
47
-
-
58149401189
-
Paradoxical effects of increased expression of PGC-1a on muscle mitochondrial function and insulinstimulated muscle glucose metabolism
-
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang Y-J, Liu Z-X, Lee H-Y, Distefano A, Samuel VT et al. Paradoxical effects of increased expression of PGC-1a on muscle mitochondrial function and insulinstimulated muscle glucose metabolism. PNAS 2008 105 19926–19931. (doi:10.1073/pnas.0810339105)
-
(2008)
PNAS
, vol.105
, pp. 19926-19931
-
-
Choi, C.S.1
Befroy, D.E.2
Codella, R.3
Kim, S.4
Reznick, R.M.5
Hwang, Y.-J.6
Liu, Z.-X.7
Lee, H.-Y.8
Distefano, A.9
Samuel, V.T.10
-
48
-
-
0042232026
-
Overexpression of peroxisome proliferator-activated receptor g coactivator-1a down-regulates GLUT4 mRNA in skeletal muscles
-
Miura S, Kai Y, Ono M & Ezaki O. Overexpression of peroxisome proliferator-activated receptor g coactivator-1a down-regulates GLUT4 mRNA in skeletal muscles. Journal of Biological Chemistry 2003 278 31385–31390. (doi:10.1074/jbc.M304312200)
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 31385-31390
-
-
Miura, S.1
Kai, Y.2
Ono, M.3
Ezaki, O.4
-
49
-
-
77955560424
-
Increased levels of peroxisome proliferator-activated receptor g, coactivator 1 a (PGC-1a)improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats
-
Benton CR, Holloway GP, Han XX, Yoshida Y, Snook LA, Lally J, Glatz JF, Luiken JJ, Chabowski A & Bonen A. Increased levels of peroxisome proliferator-activated receptor g, coactivator 1 a (PGC-1a)improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker rats. Diabetologia 2010 53 2008–2019. (doi:10.1007/s00125-010-1773-1)
-
(2010)
Diabetologia
, vol.53
, pp. 2008-2019
-
-
Benton, C.R.1
Holloway, G.P.2
Han, X.X.3
Yoshida, Y.4
Snook, L.A.5
Lally, J.6
Glatz, J.F.7
Luiken, J.J.8
Chabowski, A.9
Bonen, A.10
-
50
-
-
84875454999
-
Novel small-molecule PGC-1a transcriptional regulator with beneficial effects on diabetic db/db mice
-
Zhang L-N, Zhou H-Y, Fu Y-Y, Li Y-Y, Wu F, Gu M, Wu L-Y, Xia C-M, Dong T-C, Li J-Y et al. Novel small-molecule PGC-1a transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes 2013 62 1297–1307. (doi:10.2337/db12-0703)
-
(2013)
Diabetes
, vol.62
, pp. 1297-1307
-
-
Zhang, L.-N.1
Zhou, H.-Y.2
Fu, Y.-Y.3
Li, Y.-Y.4
Wu, F.5
Gu, M.6
Wu, L.-Y.7
Xia, C.-M.8
Dong, T.-C.9
Li, J.-Y.10
-
51
-
-
72649089588
-
Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity
-
Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y, Joshi H, Furler SM, Larance M, Hegarty BD et al. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism 2010 11 70–76. (doi:10.1016/j.cmet.2009.11.008)
-
(2010)
Cell Metabolism
, vol.11
, pp. 70-76
-
-
Hoehn, K.L.1
Turner, N.2
Swarbrick, M.M.3
Wilks, D.4
Preston, E.5
Phua, Y.6
Joshi, H.7
Furler, S.M.8
Larance, M.9
Hegarty, B.D.10
-
52
-
-
77952213776
-
Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake
-
Olson DP, Pulinilkunnil T, Cline GW, Shulman GI & Lowell BB. Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake. PNAS 2010 107 7598–7603. (doi:10.1073/pnas.0913492107)
-
(2010)
PNAS
, vol.107
, pp. 7598-7603
-
-
Olson, D.P.1
Pulinilkunnil, T.2
Cline, G.W.3
Shulman, G.I.4
Lowell, B.B.5
-
53
-
-
0035970805
-
Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl- CoA carboxylase 2
-
Abu-Elheiga L, Matzuk MM, Abo-Hashema KA & Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl- CoA carboxylase 2. Science 2001 291 2613–2616. (doi:10.1126/science.1056843)
-
(2001)
Science
, vol.291
, pp. 2613-2616
-
-
Abu-Elheiga, L.1
Matzuk, M.M.2
Abo-Hashema, K.A.3
Wakil, S.J.4
-
54
-
-
0042337449
-
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
-
Abu-Elheiga L, Oh W, Kordari P & Wakil SJ. Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets. PNAS 2003 100 10207–10212. (doi:10.1073/pnas.1733877100)
-
(2003)
PNAS
, vol.100
, pp. 10207-10212
-
-
Abu-Elheiga, L.1
Oh, W.2
Kordari, P.3
Wakil, S.J.4
-
55
-
-
84859480317
-
Acetyl-CoA carboxylase 2K/K mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions
-
Abu-Elheiga L, Wu H, Gu Z, Bressler R & Wakil SJ. Acetyl-CoA carboxylase 2K/K mutant mice are protected against fatty liver under high-fat, high-carbohydrate dietary and de novo lipogenic conditions. Journal of Biological Chemistry 2012 287 12578–12588. (doi:10.1074/ jbc.M111.309559)
-
(2012)
Journal of Biological Chemistry
, vol.287
, pp. 12578-12588
-
-
Abu-Elheiga, L.1
Wu, H.2
Gu, Z.3
Bressler, R.4
Wakil, S.J.5
-
56
-
-
36749052873
-
Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity
-
Choi CS, Savage DB, Abu-Elheiga L, Liu Z-X, Kim S, Kulkarni A, Distefano A, Hwang Y-J, Reznick RM, Codella R et al. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. PNAS 2007 104 16480–16485. (doi:10.1073/pnas.0706794104)
-
(2007)
PNAS
, vol.104
, pp. 16480-16485
-
-
Choi, C.S.1
Savage, D.B.2
Abu-Elheiga, L.3
Liu, Z.-X.4
Kim, S.5
Kulkarni, A.6
Distefano, A.7
Hwang, Y.-J.8
Reznick, R.M.9
Codella, R.10
-
57
-
-
0028904053
-
Insulin action and the insulin signaling network
-
Cheatham B & Kahn CR. Insulin action and the insulin signaling network. Endocrine Reviews 1995 16 117–142. (doi:10.1210/edrv- 16-2-117)
-
(1995)
Endocrine Reviews
, vol.16
, pp. 117-142
-
-
Cheatham, B.1
Kahn, C.R.2
-
59
-
-
84899824172
-
Insulin increases phosphorylation of mitochondrial proteins in human skeletal muscle in vivo
-
Zhao X, Bak S, Pedersen AJT, Jensen ON & Højlund K. Insulin increases phosphorylation of mitochondrial proteins in human skeletal muscle in vivo. Journal of Proteome Research 2014 13 2359–2369. (doi:10.1021/ pr401163t)
-
(2014)
Journal of Proteome Research
, vol.13
, pp. 2359-2369
-
-
Zhao, X.1
Bak, S.2
Pedersen, A.3
Jensen, O.N.4
Højlund, K.5
-
60
-
-
33845514376
-
Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia
-
Asmann YW, Stump CS, Short KR, Coenen-Schimke JM, Guo Z, Bigelow ML & Nair KS. Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia. Diabetes 2006 55 3309–3319. (doi:10.2337/ db05-1230)
-
(2006)
Diabetes
, vol.55
, pp. 3309-3319
-
-
Asmann, Y.W.1
Stump, C.S.2
Short, K.R.3
Coenen-Schimke, J.M.4
Guo, Z.5
Bigelow, M.L.6
Nair, K.S.7
-
61
-
-
0038271638
-
Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts
-
Stump CS, Short KR, Bigelow ML, Schimke JM & Nair KS. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. PNAS 2003 100 7996–8001. (doi:10.1073/pnas.1332551100)
-
(2003)
PNAS
, vol.100
, pp. 7996-8001
-
-
Stump, C.S.1
Short, K.R.2
Bigelow, M.L.3
Schimke, J.M.4
Nair, K.S.5
-
62
-
-
35748979445
-
Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects
-
Karakelides H, Asmann YW, Bigelow ML, Short KR, Dhatariya K, Coenen-Schimke J, Kahl J, Mukhopadhyay D & Nair KS. Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects. Diabetes 2007 56 2683–2689. (doi:10.2337/db07-0378)
-
(2007)
Diabetes
, vol.56
, pp. 2683-2689
-
-
Karakelides, H.1
Asmann, Y.W.2
Bigelow, M.L.3
Short, K.R.4
Dhatariya, K.5
Coenen-Schimke, J.6
Kahl, J.7
Mukhopadhyay, D.8
Nair, K.S.9
-
63
-
-
53649111489
-
Insulinstimulated mitochondrial adenosine triphosphate synthesis is blunted in skeletal muscles of high-fat-fed rats
-
Yerby B, Deacon R, Beaulieu V, Liang J, Gao J & Laurent D. Insulinstimulated mitochondrial adenosine triphosphate synthesis is blunted in skeletal muscles of high-fat-fed rats. Metabolism: Clinical and Experimental 2008 57 1584–1590. (doi:10.1016/j.metabol.2008.06.015)
-
(2008)
Metabolism: Clinical and Experimental
, vol.57
, pp. 1584-1590
-
-
Yerby, B.1
Deacon, R.2
Beaulieu, V.3
Liang, J.4
Gao, J.5
Laurent, D.6
-
64
-
-
78751485448
-
Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways
-
Long YC, Cheng Z, Copps KD & White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Molecular and Cellular Biology 2011 31 430–441. (doi:10.1128/MCB.00983-10)
-
(2011)
Molecular and Cellular Biology
, vol.31
, pp. 430-441
-
-
Long, Y.C.1
Cheng, Z.2
Copps, K.D.3
White, M.F.4
-
65
-
-
70449122132
-
Foxo1 integrates insulin signaling with mitochondrial function in the liver
-
Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P & White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nature Medicine 2009 15 1307–1311. (doi:10.1038/nm.2049)
-
(2009)
Nature Medicine
, vol.15
, pp. 1307-1311
-
-
Cheng, Z.1
Guo, S.2
Copps, K.3
Dong, X.4
Kollipara, R.5
Rodgers, J.T.6
Depinho, R.A.7
Puigserver, P.8
White, M.F.9
-
66
-
-
70249108137
-
The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis
-
Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV & White MF. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Molecular and Cellular Biology 2009 29 5070–5083. (doi:10.1128/MCB.00138-09)
-
(2009)
Molecular and Cellular Biology
, vol.29
, pp. 5070-5083
-
-
Guo, S.1
Copps, K.D.2
Dong, X.3
Park, S.4
Cheng, Z.5
Pocai, A.6
Rossetti, L.7
Sajan, M.8
Farese, R.V.9
White, M.F.10
-
67
-
-
77952541558
-
The sites and topology of mitochondrial superoxide production
-
Brand MD. The sites and topology of mitochondrial superoxide production. Experimental Gerontology 2010 45 466–472. (doi:10.1016/j.exger.2010.01.003)
-
(2010)
Experimental Gerontology
, vol.45
, pp. 466-472
-
-
Brand, M.D.1
-
68
-
-
70349769764
-
Reactive oxygen species production by mitochondria. In MitochondrialDNA:Methods and Protocols, volume554
-
Ed. JA Stuart. New York, NY, USA: Humana Press
-
Lambert A & Brand M. Reactive oxygen species production by mitochondria. In MitochondrialDNA:Methods and Protocols, volume554, pp 165–181. Ed. JA Stuart. New York, NY, USA: Humana Press, 2009
-
(2009)
Pp 165–181
-
-
Lambert, A.1
Brand, M.2
-
70
-
-
0029819955
-
Does free fatty acid infusion impair insulin action also through an increase in oxidative stress?
-
Paolisso G, Gambardella A, Tagliamonte MR, Saccomanno F, Salvatore T, Gualdiero P, D’Onofrio MV & Howard BV. Does free fatty acid infusion impair insulin action also through an increase in oxidative stress? Journal of Clinical Endocrinology and Metabolism 1996 81 4244–4248. (doi:10.1210/jcem.81.12.8954022)
-
(1996)
Journal of Clinical Endocrinology and Metabolism
, vol.81
, pp. 4244-4248
-
-
Paolisso, G.1
Gambardella, A.2
Tagliamonte, M.R.3
Saccomanno, F.4
Salvatore, T.5
Gualdiero, P.6
D’Onofrio, M.V.7
Howard, B.V.8
-
71
-
-
0031880858
-
Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin-dependent diabetes mellitus
-
De Mattia G, Bravi MC, Laurenti O, Cassone-Faldetta M, Armiento A, Ferri C & Balsano F. Influence of reduced glutathione infusion on glucose metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism: Clinical and Experimental 1998 47 993–997. (doi:10.1016/S0026-0495(98)90357-2)
-
(1998)
Metabolism: Clinical and Experimental
, vol.47
, pp. 993-997
-
-
De Mattia, G.1
Bravi, M.C.2
Laurenti, O.3
Cassone-Faldetta, M.4
Armiento, A.5
Ferri, C.6
Balsano, F.7
-
72
-
-
67650815430
-
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
-
Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin C-T, Price JW III, Kang L, Rabinovitch PS, Szeto HH et al. Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. Journal of Clinical Investigation 2009 119 573–581. (doi:10.1172/JCI37048)
-
(2009)
Journal of Clinical Investigation
, vol.119
, pp. 573-581
-
-
Erson, E.J.1
Lustig, M.E.2
Boyle, K.E.3
Woodlief, T.L.4
Kane, D.A.5
Lin, C.-T.6
Price, J.7
Kang, L.8
Rabinovitch, P.S.9
Szeto, H.H.10
-
73
-
-
70449552861
-
Insulin resistance is a cellular antioxidant defense mechanism
-
Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ et al. Insulin resistance is a cellular antioxidant defense mechanism. PNAS 2009 106 17787–17792. (doi:10.1073/pnas.0902380106)
-
(2009)
PNAS
, vol.106
, pp. 17787-17792
-
-
Hoehn, K.L.1
Salmon, A.B.2
Hohnen-Behrens, C.3
Turner, N.4
Hoy, A.J.5
Maghzal, G.J.6
Stocker, R.7
Van Remmen, H.8
Kraegen, E.W.9
Cooney, G.J.10
-
74
-
-
33645860825
-
Reactive oxygen species have a causal role in multiple forms of insulin resistance
-
Houstis N, Rosen ED & Lander ES. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006 440 944–948. (doi:10.1038/nature04634)
-
(2006)
Nature
, vol.440
, pp. 944-948
-
-
Houstis, N.1
Rosen, E.D.2
Lander, E.S.3
-
75
-
-
67649304876
-
Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria
-
Nakamura S, Takamura T, Matsuzawa-Nagata N, Takayama H, Misu H, Noda H, Nabemoto S, Kurita S, Ota T, Ando H et al. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. Journal of Biological Chemistry 2009 284 14809–14818. (doi:10.1074/jbc.M901488200)
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 14809-14818
-
-
Nakamura, S.1
Takamura, T.2
Matsuzawa-Nagata, N.3
Takayama, H.4
Misu, H.5
Noda, H.6
Nabemoto, S.7
Kurita, S.8
Ota, T.9
O, H.10
-
76
-
-
78649497300
-
Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance
-
Lee H-Y, Choi CS, Birkenfeld AL, Alves TC, Jornayvaz FR, Jurczak MJ, Zhang D, Woo DK, Shadel GS, Ladiges W et al. Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance. Cell Metabolism 2010 12 668–674. (doi:10.1016/j.cmet.2010.11.004)
-
(2010)
Cell Metabolism
, vol.12
, pp. 668-674
-
-
Lee, H.-Y.1
Choi, C.S.2
Birkenfeld, A.L.3
Alves, T.C.4
Jornayvaz, F.R.5
Jurczak, M.J.6
Zhang, D.7
Woo, D.K.8
Shadel, G.S.9
Ladiges, W.10
-
77
-
-
56849124393
-
Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice
-
Chen L, Na R, Gu M, Salmon AB, Liu Y, Liang H, Qi W, Van Remmen H, Richardson A & Ran Q. Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice. Aging Cell 2008 7 866–878. (doi:10.1111/j.1474-9726.200800432.x)
-
(2008)
Aging Cell
, vol.7
, pp. 866-878
-
-
Chen, L.1
Na, R.2
Gu, M.3
Salmon, A.B.4
Liu, Y.5
Liang, H.6
Qi, W.7
Van Remmen, H.8
Richardson, A.9
Ran, Q.10
-
78
-
-
84883280590
-
Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women
-
Asemi Z, Samimi M, Tabassi Z, Shakeri H & Esmaillzadeh A. Vitamin D supplementation affects serum high-sensitivity C-reactive protein, insulin resistance, and biomarkers of oxidative stress in pregnant women. Journal of Nutrition 2013 143 1432–1438.(doi:10.3945/ jn.113.177550)
-
(2013)
Journal of Nutrition
, vol.143
, pp. 1432-1438
-
-
Asemi, Z.1
Samimi, M.2
Tabassi, Z.3
Shakeri, H.4
Esmaillzadeh, A.5
-
79
-
-
77649303444
-
Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors
-
Fang F, Kang Z & Wong C. Vitamin E tocotrienols improve insulin sensitivity through activating peroxisome proliferator-activated receptors. Molecular Nutrition & Food Research 2010 54 345–352. (doi:10.1002/mnfr.200900119)
-
(2010)
Molecular Nutrition &Amp; Food Research
, vol.54
, pp. 345-352
-
-
Fang, F.1
Kang, Z.C.2
-
80
-
-
80054056526
-
Effects of short-term chromium supplementation on insulin sensitivity and body composition in overweight children: Randomized, double-blind, placebo-controlled study
-
Kim C-W, Kim B-T, Park K-H, Kim K-M, Lee D-J, Yang S-W & Joo N-S. Effects of short-term chromium supplementation on insulin sensitivity and body composition in overweight children: randomized, double-blind, placebo-controlled study. Journal of Nutritional Biochemistry 2011 22 1030–1034. (doi:10.1016/j.jnutbio.2010.10.001)
-
(2011)
Journal of Nutritional Biochemistry
, vol.22
, pp. 1030-1034
-
-
Kim, C.-W.1
Kim, B.-T.2
Park, K.-H.3
Kim, K.-M.4
Lee, D.-J.5
Yang, S.-W.6
Joo, N.-S.7
-
81
-
-
84892181498
-
Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients
-
Nguyen D, Hsu JW, Jahoor F & Sekhar RV. Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. Journal of Clinical Endocrinology and Metabolism 2014 99 169–177. (doi:10.1210/jc.2013-2376)
-
(2014)
Journal of Clinical Endocrinology and Metabolism
, vol.99
, pp. 169-177
-
-
Nguyen, D.1
Hsu, J.W.2
Jahoor, F.3
Sekhar, R.V.4
-
82
-
-
79955695959
-
Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: A randomized crossover design
-
Rhee Y & Brunt A. Flaxseed supplementation improved insulin resistance in obese glucose intolerant people: a randomized crossover design. Nutrition Journal 2011 10 44. (doi:10.1186/1475-2891-10-44)
-
(2011)
Nutrition Journal
, vol.10
, pp. 44
-
-
Rhee, Y.1
Brunt, A.2
-
83
-
-
67749142090
-
Inhibition of lipid infusion-induced skeletal muscle insulin resistance by cotreatment with tempol and glutathione in mice
-
Kim BS, Cha H-N, Kim Y-W, Kim J-Y, Dan J-M & Park S-Y. Inhibition of lipid infusion-induced skeletal muscle insulin resistance by cotreatment with tempol and glutathione in mice. Journal of Pharmacological Sciences 2009 110 370–380. (doi:10.1254/jphs.09046FP)
-
(2009)
Journal of Pharmacological Sciences
, vol.110
, pp. 370-380
-
-
Kim, B.S.1
Cha, H.-N.2
Kim, Y.-W.3
Kim, J.-Y.4
Dan, J.-M.5
Park, S.-Y.6
-
84
-
-
84891670272
-
Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice
-
Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Li H, Szeto IM, Shi Y et al. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radical Biology & Medicine 2014 67 396–407. (doi:10.1016/j.freeradbiomed. 2013.11.029)
-
Free Radical Biology &Amp; Medicine 2014 67 396–407. (Doi:10.1016/J.Freeradbiomed. 2013
, vol.11
, pp. 029
-
-
Cao, K.1
Xu, J.2
Zou, X.3
Li, Y.4
Chen, C.5
Zheng, A.6
Li, H.7
Li, H.8
Szeto, I.M.9
Shi, Y.10
-
85
-
-
84890411632
-
Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction
-
Jang H-J, Ridgeway SD & Kim J-A. Effects of the green tea polyphenol epigallocatechin-3-gallate on high-fat diet-induced insulin resistance and endothelial dysfunction. American Journal of Physiology. Endocrinology and Metabolism 2013 305 E1444–E1454. (doi:10.1152/ajpendo.00434.2013)
-
(2013)
American Journal of Physiology. Endocrinology and Metabolism
, vol.305
-
-
Jang, H.-J.1
Ridgeway, S.D.2
Kim, J.-A.3
-
86
-
-
84891876310
-
Effect of orally administered L. Fermentum NCIMB 5221 on markers of metabolic syndrome: An in vivo analysis using ZDF rats
-
Tomaro-Duchesneau C, Saha S, Malhotra M, Jones M, Labbe´ A, Rodes L, Kahouli I & Prakash S. Effect of orally administered L. fermentum NCIMB 5221 on markers of metabolic syndrome: an in vivo analysis using ZDF rats. Applied Microbiology and Biotechnology 2014 98 115–126. (doi:10.1007/s00253-013-5252-8)
-
(2014)
Applied Microbiology and Biotechnology
, vol.98
, pp. 115-126
-
-
Tomaro-Duchesneau, C.1
Saha, S.2
Malhotra, M.3
Jones, M.4
Labbe´, A.5
Rodes, L.6
Kahouli, I.7
Prakash, S.8
-
87
-
-
79955872580
-
The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled trial
-
de Oliveira AM, Rondo´ PH, Luzia LA, D’Abronzo FH & Illison VK. The effects of lipoic acid and a-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Diabetes Research and Clinical Practice 2011 92 253–260. (doi:10.1016/j.diabres.2011.02.010)
-
(2011)
Diabetes Research and Clinical Practice
, vol.92
, pp. 253-260
-
-
De Oliveira, A.M.1
Rondo´, P.H.2
Luzia, L.A.3
D’Abronzo, F.H.4
Illison, V.K.5
-
88
-
-
80052145967
-
Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebocontrolled clinical trial
-
Hsu C-H, Liao Y-L, Lin S-C, Tsai T-H, Huang C-J & Chou P. Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebocontrolled clinical trial. Alternative Medicine Review 2011 16 157–164
-
(2011)
Alternative Medicine Review
, vol.16
, pp. 157-164
-
-
Hsu, C.-H.1
Liao, Y.-L.2
Lin, S.-C.3
Tsai, T.-H.4
Huang, C.-J.5
Chou, P.6
-
89
-
-
84900495551
-
Effects of dietary supplementation with epigallocatechin- 3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: Randomised, double-blind, placebo-controlled clinical trial
-
Mielgo-Ayuso J, Barrenechea L, Alcorta P, Larrarte E, Margareto J & Labayen I. Effects of dietary supplementation with epigallocatechin- 3-gallate on weight loss, energy homeostasis, cardiometabolic risk factors and liver function in obese women: randomised, double-blind, placebo-controlled clinical trial. British Journal of Nutrition 2014 111 1263–1271. (doi:10.1017/S0007114513003784)
-
(2014)
British Journal of Nutrition
, vol.111
, pp. 1263-1271
-
-
Mielgo-Ayuso, J.1
Barrenechea, L.2
Alcorta, P.3
Larrarte, E.4
Margareto, J.5
Labayen, I.6
-
90
-
-
67949094377
-
Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults
-
Czernichow S, Vergnaud A-C, Galan P, Arnaud J, Favier A, Faure H, Huxley R, Hercberg S & Ahluwalia N. Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults. American Journal of Clinical Nutrition 2009 90 329–335. (doi:10.3945/ajcn.2009.27635)
-
(2009)
American Journal of Clinical Nutrition
, vol.90
, pp. 329-335
-
-
Czernichow, S.1
Vergnaud, A.-C.2
Galan, P.3
Arnaud, J.4
Favier, A.5
Faure, H.6
Huxley, R.7
Hercberg, S.8
Ahluwalia, N.9
-
91
-
-
84866107987
-
Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice
-
Paglialunga S, van Bree B, Bosma M, Valdecantos MP, Amengual- Cladera E, Jo¨rgensen JA, van Beurden D, den Hartog GJ, Ouwens DM, Briedé JJ et al. Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice. Diabetologia 2012 55 2759–2768. (doi:10.1007/ s00125-012-2626-x)
-
(2012)
Diabetologia
, vol.55
, pp. 2759-2768
-
-
Paglialunga, S.1
Van Bree, B.2
Bosma, M.3
Valdecantos, M.P.4
Amengual- Cladera, E.5
Ja, J.6
Van Beurden, D.7
Den Hartog, G.J.8
Ouwens, D.M.9
Briedé, J.J.10
-
92
-
-
84867724832
-
Mitochondria and mitophagy: The yin and yang of cell death control
-
Kubli DA & GustafssonA° B. Mitochondria and mitophagy: the yin and yang of cell death control. Circulation Research 2012 111 1208–1221. (doi:10.1161/CIRCRESAHA.112.265819)
-
(2012)
Circulation Research
, vol.111
, pp. 1208-1221
-
-
Kubli, D.A.1
Gustafssona°, B.2
-
93
-
-
84867773087
-
Mitophagy: Mechanisms, pathophysiological roles, and analysis
-
Ding WX & Yin XM. Mitophagy: mechanisms, pathophysiological roles, and analysis. Biological Chemistry 2012 393 547–564. (doi:10.1515/hsz-2012-0119)
-
(2012)
Biological Chemistry
, vol.393
, pp. 547-564
-
-
Ding, W.X.1
Yin, X.M.2
-
94
-
-
84863430453
-
Mitophagy: A complex mechanism of mitochondrial removal
-
Novak I. Mitophagy: a complex mechanism of mitochondrial removal. Antioxidants & Redox Signaling 2012 17 794–802. (doi:10.1089/ars.2011.4407)
-
(2012)
Antioxidants &Amp; Redox Signaling
, vol.17
, pp. 794-802
-
-
Novak, I.1
-
95
-
-
84899113035
-
HSP72 is a mitochondrial stress sensor critical for parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle
-
Drew BG, Ribas V, Le JA, Henstridge DC, Phun J, Zhou Z, Soleymani T, Daraei P, Sitz D, Vergnes L et al. HSP72 is a mitochondrial stress sensor critical for parkin action, oxidative metabolism, and insulin sensitivity in skeletal muscle. Diabetes 2014 63 1488–1505. (doi:10.2337/db13- 0665)
-
(2014)
Diabetes
, vol.63
, pp. 1488-1505
-
-
Drew, B.G.1
Ribas, V.2
Le, J.A.3
Henstridge, D.C.4
Phun, J.5
Zhou, Z.6
Soleymani, T.7
Daraei, P.8
Sitz, D.9
Vergnes, L.10
-
96
-
-
78649413837
-
Mitochondrial fusion and fission in cell life and death. Nature Reviews
-
Westermann B. Mitochondrial fusion and fission in cell life and death. Nature Reviews. Molecular Cell Biology 2010 11 872–884. (doi:10.1038/ nrm3013)
-
(2010)
Molecular Cell Biology
, vol.11
, pp. 872-884
-
-
Westermann, B.1
-
97
-
-
49349102894
-
Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
-
Twig G, Hyde B & Shirihai OS. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochimica et Biophysica Acta 2008 1777 1092–1097. (doi:10.1016/j.bbabio.200805.001)
-
(2008)
Biochimica Et Biophysica Acta
, vol.1777
, pp. 1092-1097
-
-
Twig, G.1
Hyde, B.2
Shirihai, O.S.3
-
98
-
-
8644270474
-
OPA1 requires mitofusin 1 to promote mitochondrial fusion
-
Cipolat S, de Brito OM, Dal Zilio B & Scorrano L. OPA1 requires mitofusin 1 to promote mitochondrial fusion. PNAS 2004 101 15927–15932. (doi:10.1073/pnas.0407043101)
-
(2004)
PNAS
, vol.101
, pp. 15927-15932
-
-
Cipolat, S.1
De Brito, O.M.2
Dal Zilio, B.3
Scorrano, L.4
-
99
-
-
0031440879
-
Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase
-
Hales KG & Fuller MT. Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase. Cell 1997 90 121–129. (doi:10.1016/S0092-8674(00)80319-0)
-
(1997)
Cell
, vol.90
, pp. 121-129
-
-
Hales, K.G.1
Fuller, M.T.2
-
100
-
-
11044230970
-
The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis
-
Hales KG. The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis. Mitochondrion 2004 4 285–308. (doi:10.1016/j.mito.2004.05.007)
-
(2004)
Mitochondrion
, vol.4
, pp. 285-308
-
-
Hales, K.G.1
-
101
-
-
80054921669
-
All the little pieces – regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitinlike modifier and their potential relevance in the heart
-
Zungu M, Schisler J & Willis MS. All the little pieces – regulation of mitochondrial fusion and fission by ubiquitin and small ubiquitinlike modifier and their potential relevance in the heart. Circulation Journal 2011 75 2513–2521. (doi:10.1253/circj.CJ-11-0967)
-
(2011)
Circulation Journal
, vol.75
, pp. 2513-2521
-
-
Zungu, M.1
Schisler, J.2
Willis, M.S.3
-
102
-
-
68949116271
-
Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes
-
Zorzano A, Liesa M & Palacı´n M. Role of mitochondrial dynamics proteins in the pathophysiology of obesity and type 2 diabetes. International Journal of Biochemistry & Cell Biology 2009 41 1846–1854. (doi:10.1016/j.biocel.2009.02.004)
-
(2009)
International Journal of Biochemistry &Amp; Cell Biology
, vol.41
, pp. 1846-1854
-
-
Zorzano, A.1
Liesa, M.2
-
103
-
-
0037593949
-
Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism: A novel regulatory mechanism altered in obesity
-
Bach D, Pich S, Soriano FX, Vega N, Baumgartner B, Oriola J, Daugaard JR, Lloberas J, Camps M, Zierath JR et al. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism: a novel regulatory mechanism altered in obesity. Journal of Biological Chemistry 2003 278 17190–17197. (doi:10.1074/jbc.M212754200)
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 17190-17197
-
-
Bach, D.1
Pich, S.2
Soriano, F.X.3
Vega, N.4
Baumgartner, B.5
Oriola, J.6
Daugaard, J.R.7
Lloberas, J.8
Camps, M.9
Zierath, J.R.10
-
104
-
-
20444461625
-
The Charcot–Marie–Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system
-
Pich S, Bach D, Briones P, Liesa M, Camps M, Testar X, Palacìn M & Zorzano A. The Charcot–Marie–Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Human Molecular Genetics 2005 14 1405–1415.(doi:10.1093/hmg/ ddi149)
-
(2005)
Human Molecular Genetics
, vol.14
, pp. 1405-1415
-
-
Pich, S.1
Bach, D.2
Briones, P.3
Liesa, M.4
Camps, M.5
Testar, X.6
Palacìn, M.7
Zorzano, A.8
-
105
-
-
77951737783
-
Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations
-
Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM & Chan DC. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell 2010 141 280–289. (doi:10.1016/j.cell.2010.02.026)
-
(2010)
Cell
, vol.141
, pp. 280-289
-
-
Chen, H.1
Vermulst, M.2
Wang, Y.E.3
Chomyn, A.4
Prolla, T.A.5
McCaffery, J.M.6
Chan, D.C.7
-
106
-
-
24144462451
-
Expression of Mfn2, the Charcot–Marie–Tooth neuropathy type 2A gene, in human skeletal muscle: Effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor a and interleukin-6
-
Bach D, Naon D, Pich S, Soriano FX, Vega N, Rieusset J, Laville M, Guillet C, Boirie Y, Wallberg-Henriksson H et al. Expression of Mfn2, the Charcot–Marie–Tooth neuropathy type 2A gene, in human skeletal muscle: effects of type 2 diabetes, obesity, weight loss, and the regulatory role of tumor necrosis factor a and interleukin-6. Diabetes 2005 54 2685–2693. (doi:10.2337/diabetes.54.9.2685)
-
(2005)
Diabetes
, vol.54
, pp. 2685-2693
-
-
Bach, D.1
Naon, D.2
Pich, S.3
Soriano, F.X.4
Vega, N.5
Rieusset, J.6
Laville, M.7
Guillet, C.8
Boirie, Y.9
Wallberg-Henriksson, H.10
-
107
-
-
26244456362
-
Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity?
-
Mingrone G, Manco M, Calvani M, Castagneto M, Naon D & Zorzano A. Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity? Diabetologia 2005 48 2108–2114. (doi:10.1007/s00125-005-1918-9)
-
(2005)
Diabetologia
, vol.48
, pp. 2108-2114
-
-
Mingrone, G.1
Manco, M.2
Calvani, M.3
Castagneto, M.4
Naon, D.5
Zorzano, A.6
-
108
-
-
77955508579
-
Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals
-
Phielix E, Meex R, Moonen-Kornips E, Hesselink MK & Schrauwen P. Exercise training increases mitochondrial content and ex vivo mitochondrial function similarly in patients with type 2 diabetes and in control individuals. Diabetologia 2010 53 1714–1721. (doi:10.1007/s00125-010-1764-2)
-
(2010)
Diabetologia
, vol.53
, pp. 1714-1721
-
-
Phielix, E.1
Meex, R.2
Moonen-Kornips, E.3
Hesselink, M.K.4
Schrauwen, P.5
-
109
-
-
3042821172
-
Muscle fat oxidative capacity is not impaired by age but by physical inactivity: Association with insulin sensitivity
-
Rimbert V, Boirie Y, Bedu M, Hocquette JF, Ritz P & Morio B. Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity. FASEB Journal 2004 18 737–739. (doi:10.1096/fj.03-1104fje)
-
(2004)
FASEB Journal
, vol.18
, pp. 737-739
-
-
Rimbert, V.1
Boirie, Y.2
Bedu, M.3
Hocquette, J.F.4
Ritz, P.5
Morio, B.6
-
110
-
-
34547596186
-
Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
-
Toledo FG, Menshikova EV, Ritov VB, Azuma K, Radikova Z, DeLany J & Kelley DE. Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes 2007 56 2142–2147. (doi:10.2337/db07-0141)
-
(2007)
Diabetes
, vol.56
, pp. 2142-2147
-
-
Toledo, F.G.1
Menshikova, E.V.2
Ritov, V.B.3
Azuma, K.4
Radikova, Z.5
Delany, J.6
Kelley, D.E.7
-
111
-
-
77349125802
-
Increased subsarcolemmal lipids in type 2 diabetes: Effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle. American Journal of Physiology
-
Nielsen J, Mogensen M, Vind BF, Sahlin K, Hojlund K, Schroder HD & Ortenblad N. Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism 2010 298 E706–E713. (doi:10.1152/ ajpendo.00692.2009)
-
Endocrinology and Metabolism 2010 298 E706–E713. (Doi:10.1152/ Ajpendo
, vol.692
, pp. 2009
-
-
Nielsen, J.1
Mogensen, M.2
Vind, B.F.3
Sahlin, K.4
Hojlund, K.5
Schroder, H.D.6
Ortenblad, N.7
-
112
-
-
77950349827
-
Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity
-
Meex RC, Schrauwen-Hinderling VB, Moonen-Kornips E, Schaart G, Mensink M, Phielix E, van de Weijer T, Sels JP, Schrauwen P & Hesselink MK. Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity. Diabetes 2010 59 572–579. (doi:10.2337/db09-1322)
-
(2010)
Diabetes
, vol.59
, pp. 572-579
-
-
Meex, R.C.1
Schrauwen-Hinderling, V.B.2
Moonen-Kornips, E.3
Schaart, G.4
Mensink, M.5
Phielix, E.6
Van De Weijer, T.7
Sels, J.P.8
Schrauwen, P.9
Hesselink, M.K.10
-
113
-
-
0030017181
-
Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men
-
Dengel DR, Pratley RE, Hagberg JM, Rogus EM & Goldberg AP. Distinct effects of aerobic exercise training and weight loss on glucose homeostasis in obese sedentary men. Journal of Applied Physiology 1996 81 318–325. (doi:10.1097/00005768)
-
(1996)
Journal of Applied Physiology
, vol.81
, pp. 318-325
-
-
Dengel, D.R.1
Pratley, R.E.2
Hagberg, J.M.3
Rogus, E.M.4
Goldberg, A.P.5
-
114
-
-
0030052636
-
Palja¨rvi L & LaaksoM. The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects
-
Niskanen L, Uusitupa M, Sarlund H, Siitonen O, Palja¨rvi L & LaaksoM. The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects. International Journal of Obesity and Related Metabolic Disorders 1996 20 154–160
-
(1996)
International Journal of Obesity and Related Metabolic Disorders
, vol.20
, pp. 154-160
-
-
Niskanen, L.1
Uusitupa, M.2
Sarlund, H.3
Siitonen, O.4
-
115
-
-
33750908045
-
Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: A randomized controlled trial
-
Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S & Holloszy JO. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. American Journal of Clinical Nutrition 2006 84 1033–1042
-
(2006)
American Journal of Clinical Nutrition
, vol.84
, pp. 1033-1042
-
-
Weiss, E.P.1
Racette, S.B.2
Villareal, D.T.3
Fontana, L.4
Steger-May, K.5
Schechtman, K.B.6
Klein, S.7
Holloszy, J.O.8
-
116
-
-
33746419647
-
Effect of calorie restriction with or without exercise on insulin sensitivity, b-cell function, fat cell size, and ectopic lipid in overweight subjects
-
Larson-Meyer DE, Heilbronn LK, Redman LM, Newcomer BR, Frisard MI, Anton S, Smith SR, Alfonso A & Ravussin E. Effect of calorie restriction with or without exercise on insulin sensitivity, b-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 2006 29 1337–1344. (doi:10.2337/dc05-2565)
-
(2006)
Diabetes Care
, vol.29
, pp. 1337-1344
-
-
Larson-Meyer, D.E.1
Heilbronn, L.K.2
Redman, L.M.3
Newcomer, B.R.4
Frisard, M.I.5
Anton, S.6
Smith, S.R.7
Alfonso, A.8
Ravussin, E.9
-
117
-
-
33947710793
-
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
-
Civitarese AE, Carling S, Heilbronn LK, Hulver MH, Ukropcova B, Deutsch WA, Smith SR & Ravussin E. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Medicine 2007 4 e76. (doi:10.1371/journal.pmed.0040076)
-
(2007)
Plos Medicine
, vol.4
-
-
Civitarese, A.E.1
Carling, S.2
Heilbronn, L.K.3
Hulver, M.H.4
Ukropcova, B.5
Deutsch, W.A.6
Smith, S.R.7
Ravussin, E.8
-
118
-
-
84881116641
-
Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation
-
KitadaM, Kume S, Takeda-Watanabe A, Tsuda S, Kanasaki K & Koya D
-
KitadaM, Kume S, Takeda-Watanabe A, Tsuda S, Kanasaki K & Koya D. Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation. Biochimica et Biophysica Acta 2013 1830 4820–4827. (doi:10.1016/j.bbagen.201306.014)
-
(2013)
Biochimica Et Biophysica Acta
, vol.1830
, pp. 4820-4827
-
-
-
119
-
-
80555142897
-
Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction
-
Schenk S, McCurdy CE, Philp A, Chen MZ, Holliday MJ, Bandyopadhyay GK, Osborn O, Baar K & Olefsky JM. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction. Journal of Clinical Investigation 2011 121 4281–4288. (doi:10.1172/ JCI58554)
-
(2011)
Journal of Clinical Investigation
, vol.121
, pp. 4281-4288
-
-
Schenk, S.1
McCurdy, C.E.2
Philp, A.3
Chen, M.Z.4
Holliday, M.J.5
Bandyopadhyay, G.K.6
Osborn, O.7
Baar, K.8
Olefsky, J.M.9
-
120
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1a
-
Lagouge M, Argmann C, Gerhart-Hines Z, Meziane H, Lerin C, Daussin F, Messadeq N, Milne J, Lambert P, Elliott P et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1a. Cell 2006 127 1109–1122. (doi:10.1016/j.cell.2006.11.013)
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
Meziane, H.4
Lerin, C.5
Daussin, F.6
Messadeq, N.7
Milne, J.8
Lambert, P.9
Elliott, P.10
-
121
-
-
33751072349
-
Resveratrol improves health and survival of mice on a high-calorie diet
-
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006 444 337–342. (doi:10.1038/nature05354)
-
(2006)
Nature
, vol.444
, pp. 337-342
-
-
Baur, J.A.1
Pearson, K.J.2
Price, N.L.3
Jamieson, H.A.4
Lerin, C.5
Kalra, A.6
Prabhu, V.V.7
Allard, J.S.8
Lopez-Lluch, G.9
Lewis, K.10
-
122
-
-
36749087548
-
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
-
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature 2007 450 712–716. (doi:10.1038/nature06261)
-
(2007)
Nature
, vol.450
, pp. 712-716
-
-
Milne, J.C.1
Lambert, P.D.2
Schenk, S.3
Carney, D.P.4
Smith, J.J.5
Gagne, D.J.6
Jin, L.7
Boss, O.8
Perni, R.B.9
Vu, C.B.10
-
123
-
-
84892500218
-
SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass
-
Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y et al. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell 2014 13 787–796. (doi:10.1111/acel.12151)
-
(2014)
Aging Cell
, vol.13
, pp. 787-796
-
-
Mercken, E.M.1
Mitchell, S.J.2
Martin-Montalvo, A.3
Minor, R.K.4
Almeida, M.5
Gomes, A.P.6
Scheibye-Knudsen, M.7
Palacios, H.H.8
Licata, J.J.9
Zhang, Y.10
-
124
-
-
84859909860
-
SRT1720 improves survival and healthspan of obese mice
-
Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin Y-K, Canto C, Scheibye-Knudsen M et al. SRT1720 improves survival and healthspan of obese mice. Scientific Reports 2011 1 70. (doi:10.1038/srep00070)
-
(2011)
Scientific Reports
, vol.1
-
-
Minor, R.K.1
Baur, J.A.2
Gomes, A.P.3
Ward, T.M.4
Csiszar, A.5
Mercken, E.M.6
Abdelmohsen, K.7
Shin, Y.-K.8
Canto, C.9
Scheibye-Knudsen, M.10
-
125
-
-
77956182566
-
JastrochM& Brand MD. Mitochondrial uncoupling and lifespan
-
Mookerjee SA, Divakaruni AS, JastrochM& Brand MD. Mitochondrial uncoupling and lifespan. Mechanisms of Ageing and Development 2010 131 463–472. (doi:10.1016/j.mad.2010.03.010)
-
(2010)
Mechanisms of Ageing and Development
, vol.131
, pp. 463-472
-
-
Mookerjee, S.A.1
Divakaruni, A.S.2
-
126
-
-
84922080375
-
Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice
-
Tao H, Zhang Y, Zeng X, Shulman GI & Jin S. Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice. Nature Medicine 2014 20 1263–1269. (doi:10.1038/nm.3699)
-
(2014)
Nature Medicine
, vol.20
, pp. 1263-1269
-
-
Tao, H.1
Zhang, Y.2
Zeng, X.3
Shulman, G.I.4
Jin, S.5
-
127
-
-
84880986388
-
. Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production
-
Adjeitey CN, Mailloux RJ, deKemp RA & Harper ME. Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production. American Journal of Physiology. Endocrinology and Metabolism 2013 305 E405–E415. (doi:10.1152/ajpendo.00057.2013)
-
(2013)
American Journal of Physiology. Endocrinology and Metabolism
, vol.305
-
-
Adjeitey, C.N.1
Mailloux, R.J.2
Dekemp, R.A.3
Harper, M.E.4
-
128
-
-
84887432240
-
Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler
-
Perry RJ, Kim T, Zhang X-M, Lee H-Y, Pesta D, Popov VB, Zhang D, Rahimi Y, Jurczak MJ, Cline GW et al. Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler. Cell Metabolism 2013 18 740–748. (doi:10.1016/j.cmet.2013.10.004)
-
(2013)
Cell Metabolism
, vol.18
, pp. 740-748
-
-
Perry, R.J.1
Kim, T.2
Zhang, X.-M.3
Lee, H.-Y.4
Pesta, D.5
Popov, V.B.6
Zhang, D.7
Rahimi, Y.8
Jurczak, M.J.9
Cline, G.W.10
-
130
-
-
79955961858
-
Derivatives of rhodamine 19 as mild mitochondria-targeted cationic uncouplers
-
Antonenko YN, Avetisyan AV, Cherepanov DA, Knorre DA, Korshunova GA, Markova OV, Ojovan SM, Perevoshchikova IV, Pustovidko AV, Rokitskaya TI et al. Derivatives of rhodamine 19 as mild mitochondria-targeted cationic uncouplers. Journal of Biological Chemistry 2011 286 17831–17840. (doi:10.1074/jbc.M110.212837)
-
(2011)
Journal of Biological Chemistry
, vol.286
, pp. 17831-17840
-
-
Antonenko, Y.N.1
Avetisyan, A.V.2
Cherepanov, D.A.3
Knorre, D.A.4
Korshunova, G.A.5
Markova, O.V.6
Ojovan, S.M.7
Perevoshchikova, I.V.8
Pustovidko, A.V.9
Rokitskaya, T.I.10
-
131
-
-
35148890391
-
Mitochondrial uncouplers with an extraordinary dynamic range
-
Lou PH, Hansen BS, Olsen PH, Tullin S, Murphy MP & Brand MD. Mitochondrial uncouplers with an extraordinary dynamic range. Biochemical Journal 2007 407 129–140. (doi:10.1042/BJ20070606)
-
(2007)
Biochemical Journal
, vol.407
, pp. 129-140
-
-
Lou, P.H.1
Hansen, B.S.2
Olsen, P.H.3
Tullin, S.4
Murphy, M.P.5
Brand, M.D.6
-
132
-
-
76249108242
-
Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore
-
Severin FF, Severina II, Antonenko YN, Rokitskaya TI, Cherepanov DA, Mokhova EN, Vyssokikh MY, Pustovidko AV, Markova OV, Yaguzhinsky LS et al. Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore. PNAS 2010 107 663–668. (doi:10.1073/pnas.0910216107)
-
(2010)
PNAS
, vol.107
, pp. 663-668
-
-
Severin, F.F.1
Severina, I.I.2
Antonenko, Y.N.3
Rokitskaya, T.I.4
Cherepanov, D.A.5
Mokhova, E.N.6
Vyssokikh, M.Y.7
Pustovidko, A.V.8
Markova, O.V.9
Yaguzhinsky, L.S.10
-
133
-
-
84868692016
-
Berberine in the treatment of type 2 diabetes mellitus: A systemic review and meta-analysis
-
Dong H, Wang N, Zhao L & Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evidence-Based Complementary and Alternative Medicine 2012 2012 591654. (doi:10.1155/2012/591654)
-
(2012)
Evidence-Based Complementary and Alternative Medicine
, vol.2012
-
-
Dong, H.1
Wang, N.2
Zhao, L.3
Lu, F.4
-
134
-
-
33749336146
-
Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states
-
Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT et al. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 2006 55 2256–2264. (doi:10.2337/db06-0006)
-
(2006)
Diabetes
, vol.55
, pp. 2256-2264
-
-
Lee, Y.S.1
Kim, W.S.2
Kim, K.H.3
Yoon, M.J.4
Cho, H.J.5
Shen, Y.6
Ye, J.M.7
Lee, C.H.8
Oh, W.K.9
Kim, C.T.10
-
135
-
-
48449084609
-
Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: A mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action
-
Turner N, Li JY, Gosby A, To SW, Cheng Z, Miyoshi H, Taketo MM, Cooney GJ, Kraegen EW, James DE et al. Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex I: a mechanism for the action of berberine to activate AMP-activated protein kinase and improve insulin action. Diabetes 2008 57 1414–1418. (doi:10.2337/db07-1552)
-
(2008)
Diabetes
, vol.57
, pp. 1414-1418
-
-
Turner, N.1
Li, J.Y.2
Gosby, A.3
To, S.W.4
Cheng, Z.5
Miyoshi, H.6
Taketo, M.M.7
Cooney, G.J.8
Kraegen, E.W.9
James, D.E.10
-
136
-
-
77954652820
-
Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea
-
Eid HM, Martineau LC, Saleem A, Muhammad A, Vallerand D, Benhaddou-Andaloussi A, Nistor L, Afshar A, Arnason JT & Haddad PS. Stimulation of AMP-activated protein kinase and enhancement of basal glucose uptake in muscle cells by quercetin and quercetin glycosides, active principles of the antidiabetic medicinal plant Vaccinium vitis-idaea. Molecular Nutrition & Food Research 2010 54 991–1003. (doi:10.1002/mnfr.200900218)
-
(2010)
Molecular Nutrition &Amp; Food Research
, vol.54
, pp. 991-1003
-
-
Eid, H.M.1
Martineau, L.C.2
Saleem, A.3
Muhammad, A.4
Vallerand, D.5
Benhaddou-Andaloussi, A.6
Nistor, L.7
Afshar, A.8
Arnason, J.T.9
Haddad, P.S.10
-
137
-
-
12144291275
-
Thiazolidinediones, like metformin, inhibit respiratory complex I: A common mechanism contributing to their antidiabetic actions?
-
Brunmair B, Staniek K, Gras F, Scharf N, Althaym A, Clara R, Roden M, Gnaiger E, Nohl H, Waldhausl W et al. Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 2004 53 1052–1059. (doi:10.2337/diabetes.53.4.1052)
-
(2004)
Diabetes
, vol.53
, pp. 1052-1059
-
-
Brunmair, B.1
Staniek, K.2
Gras, F.3
Scharf, N.4
Althaym, A.5
Clara, R.6
Roden, M.7
Gnaiger, E.8
Nohl, H.9
Waldhausl, W.10
-
138
-
-
0034659785
-
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
-
Owen MR, Doran E & Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochemical Journal 2000 348 607–614.(doi:10.1042/0264-6021:3480607)
-
(2000)
Biochemical Journal
, vol.348
, pp. 607-614
-
-
Owen, M.R.1
Doran, E.2
Halestrap, A.P.3
-
139
-
-
84862558716
-
Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice
-
Huang SL, Yu RT, Gong J, Feng Y, Dai YL, Hu F, Hu YH, Tao YD & Leng Y. Arctigenin, a natural compound, activates AMP-activated protein kinase via inhibition of mitochondria complex I and ameliorates metabolic disorders in ob/ob mice. Diabetologia 2012 55 1469–1481. (doi:10.1007/s00125-011-2366-3)
-
(2012)
Diabetologia
, vol.55
, pp. 1469-1481
-
-
Huang, S.L.1
Yu, R.T.2
Gong, J.3
Feng, Y.4
Dai, Y.L.5
Hu, F.6
Hu, Y.H.7
Tao, Y.D.8
Leng, Y.9
|