The machinery of mitochondrial fusion, division, and distribution, and emerging connections to apoptosis

Mitochondrion

Volumn 4, Issue 4, 2004, Pages 285-308

  Hales, Karen G ^a  

^a DAVIDSON COLLEGE   (United States)

Author keywords

Apoptosis; Distribution; Fission; Fusion; Morphogenesis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL PROTEIN; DYNAMIN; F BOX PROTEIN; GENE PRODUCT; GUANOSINE TRIPHOSPHATASE; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; PROTEINASE; RAB PROTEIN;

ACTIN FILAMENT; APOPTOSIS; ASPERGILLUS NIDULANS; CELL DIVISION; CELL FUSION; CELL MOTION; CELL TYPE; CELLULAR DISTRIBUTION; CYTOSKELETON; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; DROSOPHILA; EUKARYOTE; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; MICROTUBULE; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MORPHOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REVIEW; SACCHAROMYCES CEREVISIAE; SPERMATOGENESIS;

EID: 11044230970     PISSN: 15677249     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mito.2004.05.007     Document Type: Review

References (157)

1. A.E. Aiken Hobbs M. Srinivasan J.M. McCaffery R.E. Jensen Mmm1p, a mitochondrial outer membrane protein, is connected to mitochondrial DNA (mtDNA) nucleoids and required for mtDNA stability J. Cell Biol. 152 2001 401-410
2. C. Alexander M. Votruba U.E. Pesch D.L. Thiselton S. Mayer A. Moore et al. OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28 Nat. Genet. 26 2000 211-215
3. N.M. Alto J. Soderling J.D. Scott Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics J. Cell Biol. 158 2002 659-668
4. J.R. Aprille Perinatal development of mitochondria in rat liver in: G. Fiskum (Ed.) Mitochondrial Physiology and Pathology 1986 Van Nostrand Reinhold New York, NY 66-99
5. S. Arimura N. Tsutsumi A dynamin-like protein (ADL2b), rather than FtsZ, is involved in Arabidopsis mitochondrial division Proc. Natl. Acad. Sci. USA 99 2002 5727-5731
6. D. Bach S. Pich F.X. Soriano N. Vega B. Baumgartner J. Oriola et al. Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity J. Biol. Chem. 278 2003 17190-17197
7. L.E. Bakeeva Y.S. Chentsov V.P. Skulachev Ontogenesis of mitochondrial reticulum in rat diaphragm muscle Eur. J. Cell Biol. 25 1981 175-181
8. P.L. Beech T. Nheu T. Schultz S. Herbert T. Lithgow P.R. Gilson G.I. McFadden Mitochondrial FtsZ in a chromophyte alga Science 287 2000 1276-1279
9. J. Bereiter-Hahn M. Voth Dynamics of mitochondria in living cells: Shape changes, dislocations, fusion, and fission of mitochondria Microsc. Res. Tech. 27 1994 198-219
10. K.H. Berger L.F. Sogo M.P. Yaffe Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast J. Cell Biol. 136 1997 545-553
11. W. Bleazard J.M. McCaffery E.J. King S. Bale A. Mozdy Q. Tieu et al. The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast Nat. Cell Biol. 1 1999 298-304
12. I. Boldogh N. Vojtov S. Karmon L.A. Pon Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p J. Cell Biol. 141 1998 1371-1381
13. I.R. Boldogh H.C. Yang W.D. Nowakowski S.L. Karmon L.G. Hays J.R. Yates 3rd L.A. Pon Arp2/3 complex and actin dynamics are required for actin-based mitochondrial motility in yeast Proc. Natl. Acad. Sci. USA 98 2001 3162-3167
14. I.R. Boldogh H.C. Yang L.A. Pon Mitochondrial inheritance in budding yeast Traffic 2 2001 368-374
15. I.R. Boldogh D.W. Nowakowski H.C. Yang H. Chung S. Karmon P. Royes L.A. Pon A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery Mol. Biol. Cell 14 2003 4618-4627
16. D.G. Breckenridge M. Stojanovic R.C. Marcellus G.C. Shore Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol J. Cell Biol. 160 2003 1115-1127
17. S.M. Burgess M. Delannoy R.E. Jensen MMM1 encodes a mitochondrial outer membrane protein essential for establishing and maintaining the structure of yeast mitochondria J. Cell Biol. 126 1994 1375-1391
18. K.L. Cerveny R.E. Jensen The WD-repeats of Net2p interact with Dnm1p and Fis1p to regulate division of mitochondria Mol. Biol. Cell 14 2003 4126-4139
19. K.L. Cerveny J.M. McCaffery R.E. Jensen Division of mitochondria requires a novel DMN1-interacting protein, Net2p Mol. Biol. Cell 12 2001 309-321
20. S.R. Chada P.J. Hollenbeck Mitochondrial movement and positioning in axons: The role of growth factor signaling J. Exp. Biol. 206 2003 1985-1992
21. H. Chen S.A. Detmer A.J. Ewald E.E. Griffin S.E. Fraser D.C. Chan Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development J. Cell Biol. 160 2003 189-200
22. G.D. Clark-Walker G.L. Miklos Complementation in cytoplasmic petite mutants of yeast to form respiratory competent cells Proc. Natl. Acad. Sci. USA 72 1975 372-375
23. R.T. Cox A.C. Spradling A Balbiani body and the fusome mediate mitochondrial inheritance during Drosophila oogenesis Development 130 2003 1579-1590
24. D. Danino J.E. Hinshaw Dynamin family of mechanoenzymes Curr. Opin. Cell Biol. 13 2001 454-460
25. C. Delettre G. Lenaers J.M. Griffoin N. Gigarel C. Lorenzo P. Belenguer et al. Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy Nat. Genet. 26 2000 207-210
26. S. Desagher J.C. Martinou Mitochondria as the central control point of apoptosis Trends Cell Biol. 10 2000 369-377
27. K. De Vos J. Sable K.E. Miller M.P. Sheetz Expression of phosphatidylinositol (4,5) bisphosphate-specific pleckstrin homology domains alters direction but not the level of axonal transport of mitochondria Mol. Biol. Cell 14 2003 3636-3649
28. D.G. Drubin H.D. Jones K.F. Wertman Actin structure and function: Roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin-binding site Mol. Biol. Cell 4 1993 1277-1294
29. T. Ehara T. Osafune E. Hase Behavior of mitochondria in synchronized cells of Chlamydomonas reinhardtii (Chlorophyta) J. Cell Sci. 108 Pt 2 1995 499-507
30. J.A. Enriquez J. Cabezas-Herrera M.P. Bayona-Bafaluy G. Attardi Very rare complementation between mitochondria carrying different mitochondrial DNA mutations points to intrinsic genetic autonomy of the organelles in cultured human cells J. Biol. Chem. 275 2000 11207-11215
31. Y. Eura N. Ishihara S. Yokota K. Mihara Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion J. Biochem. (Tokyo) 134 2003 333-344
32. K. Fehrenbacher T. Huckaba H.C. Yang I. Boldogh L. Pon Actin comet tails, endosomes and endosymbionts J. Exp. Biol. 206 2003 1977-1984
33. P. Fekkes K.A. Shepard M.P. Yaffe Gag3p, an outer membrane protein required for fission of mitochondrial tubules J. Cell Biol. 151 2000 333-340
34. H.A. Fisk M.P. Yaffe Mutational analysis of Mdm1p function in nuclear and mitochondrial inheritance J. Cell Biol. 138 1997 485-494
35. H.A. Fisk M.P. Yaffe A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae J. Cell Biol. 145 1999 1199-1208
36. S. Frank B. Gaume E.S. Bergmann-Leitner W.W. Leitner E.G. Robert F. Catez et al. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis Dev. Cell 1 2001 515-525
37. M. Frieden D. James C. Castelbou A. Danckaert J.C. Martinou N. Demaurex Ca(2+) homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1 J. Biol. Chem. 279 2004 22704-22714
38. S. Fritz D. Rapaport E. Klanner W. Neupert B. Westermann Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion J. Cell Biol. 152 2001 683-692
39. S. Fritz N. Weinbach B. Westermann Mdm30 is an F-box protein required for maintenance of fusion-competent mitochondria in yeast Mol. Biol. Cell 14 2003 2303-2313
40. F. Fuchs H. Prokisch W. Neupert B. Westermann Interaction of mitochondria with microtubules in the filamentous fungus Neurospora crassa J. Cell Sci. 115 2002 1931-1937
41. N.H. Fukushima E. Brisch B.R. Keegan W. Bleazard J.M. Shaw The GTPase effector domain sequence of the Dnm1p GTPase regulates self-assembly and controls a rate-limiting step in mitochondrial fission Mol. Biol. Cell 12 2001 2756-2766
42. M.T. Fuller Spermatogenesis in: M. Bate A. Martinez-Arias (Eds.) The Development of Drosophila melanogaster 1993 Cold Spring Harbor New York 71-147
43. J.G. Gindhart Jr C.J. Desai S. Beushausen K. Zinn L.S. Goldstein Kinesin light chains are essential for axonal transport in Drosophila J. Cell Biol. 141 1998 443-454
44. N.C. Grieder M. de Cuevas A.C. Spradling The fusome organizes the microtubule network during oocyte differentiation in Drosophila Development 127 2000 4253-4264
45. L. Griparic N.N. van der Wel I.J. Orozco P.J. Peters A.M. van der Bliek Loss of the intermembrane space protein Mgm1/OPA1 induces swelling and localized constrictions along the lengths of mitochondria J. Biol. Chem. 279 2004 18792-18798
46. K. Guan L. Farh T.K. Marshall R.J. Deschenes Normal mitochondrial structure and genome maintenance in yeast requires the dynamin-like product of the MGM1 gene Curr. Genet. 24 1993 141-148
47. K.G. Hales M.T. Fuller Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase Cell 90 1997 121-129
48. T. Hanekamp M.K. Thorsness I. Rebbapragada E.M. Fisher C. Seebart M.R. Darland et al. Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae Genetics 162 2002 1147-1156
49. Z. Harder R. Zunino H. McBride Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission Curr. Biol. 14 2004 340-345
50. M. Herlan F. Vogel C. Bornhovd W. Neupert A.S. Reichert Processing of Mgm1 by the Rhomboid-type protease Pcp1 is required for maintenance of mitochondrial morphology and of mitochondrial DNA J. Biol. Chem. 2003
51. M. Herlan C. Bornhovd K. Hell W. Neupert A.S. Reichert Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor J. Cell Biol. 165 2004 167-173
52. G.J. Hermann E.J. King J.M. Shaw The yeast gene, MDM20, is necessary for mitochondrial inheritance and organization of the actin cytoskeleton J. Cell Biol. 137 1997 141-153
53. G.J. Hermann J.W. Thatcher J.P. Mills K.G. Hales M.T. Fuller J. Nunnari J.M. Shaw Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p J. Cell Biol. 143 1998 359-373
54. A.N. Hodgson R.T.F. Bernard Ultrastructure of the sperm and spermatogenesis of three species of Mytilidae Mollusca bivalvia Gamete Res. 15 1986 123-136
55. H.P. Hoffmann C.J. Avers Mitochondrion of yeast: Ultrastructural evidence for one giant, branched organelle per cell Science 181 1973 749-751
56. P.J. Hollenbeck The pattern and mechanism of mitochondrial transport in axons Front Biosci. 1 1996 d91-d102
57. T.C. Huffaker J.H. Thomas D. Botstein Diverse effects of beta-tubulin mutations on microtubule formation and function J. Cell Biol. 106 1988 1997-2010
58. D.D. Hurd W.M. Saxton Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila Genetics 144 1996 1075-1085
59. J.J. Hwa M.A. Hiller M.T. Fuller A. Santel Differential expression of the Drosophila mitofusin genes fuzzy onions (fzo) and dmfn Mech. Dev. 116 2002 213-216
60. N. Ishihara A. Jofuku Y. Eura K. Mihara Regulation of mitochondrial morphology by membrane potential, and DRP1-dependent division and FZO1-dependent fusion reaction in mammalian cells Biochem. Biophys. Res. Commun. 301 2003 891-898
61. S. Jakobs N. Martini A.C. Schauss A. Egner B. Westermann S.W. Hell Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1p J. Cell Sci. 116 2003 2005-2014
62. D.I. James P.A. Parone Y. Mattenberger J.C. Martinou hFis1, a novel component of the mammalian mitochondrial fission machinery J. Biol. Chem. 2003
63. J.B. Jin H. Bae S.J. Kim Y.H. Jin C.H. Goh D.H. Kim et al. The Arabidopsis dynamin-like proteins ADL1C and ADL1E play a critical role in mitochondrial morphogenesis Plant Cell 15 2003 2357-2369
64. B.A. Jones W.L. Fangman Mitochondrial DNA maintenance in yeast requires a protein containing a region related to the GTP-binding domain of dynamin Genes Dev. 6 1992 380-389
65. M. Karbowski Y.J. Lee B. Gaume S.Y. Jeong S. Frank A. Nechushtan et al. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis J. Cell Biol. 159 2002 931-938
66. M. Karbowski D. Arnoult H. Chen D.C. Chan C.L. Smith R.J. Youle Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis J. Cell Biol. 164 2004 493-499
67. S. Kawano H. Takano J. Imai K. Mori T. Kurioiwa A genetic system controlling mitochondrial fusion in the slime mould, Physarum polycephalum Genetics 133 1993 213-224
68. S. Kawano H. Takano T. Kuroiwa Sexuality of mitochondria: Fusion, recombination, and plasmids Int. Rev. Cytol. 161 1995 49-110
69. S.P. Kirkwood E.A. Munn G.A. Brooks Mitochondrial reticulum in limb skeletal muscle Am. J. Physiol. 251 1986 C395-C402
70. K.V. Koch R. Suelmann R. Fischer Deletion of mdmB impairs mitochondrial distribution and morphology in Aspergillus nidulans Cell Motil. Cytoskeleton 55 2003 114-124
71. N. Kondo-Okamoto J.M. Shaw K. Okamoto Mmm1p spans both the outer and inner mitochondrial membranes and contains distinct domains for targeting and foci formation J. Biol. Chem. 278 2003 48997-49005
72. J.C.d. Kruger Ultrastructure of sperm development in the plant-parasitic nematode Xiphinema theresiae J. Morph. 210 1991 163-174
73. A.M. Labrousse M.D. Zappaterra D.A. Rube A.M. van der Bliek C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane Mol. Cell 4 1999 815-826
74. D.A. Lazzarino I. Boldogh M.G. Smith J. Rosand L.A. Pon Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity Mol. Biol. Cell 5 1994 807-818
75. A. Legesse-Miller R.H. Massol T. Kirchhausen Constriction and dnm1p recruitment are distinct processes in mitochondrial fission Mol. Biol. Cell 14 2003 1953-1963
76. F. Legros A. Lombes P. Frachon M. Rojo Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins Mol. Biol. Cell 13 2002 4343-4354
77. F. Legros F. Malka P. Frachon A. Lombes M. Rojo Organization and dynamics of human mitochondrial DNA J. Cell Sci. 117 2004 2653-2662
78. L.A. Ligon O. Steward Role of microtubules and actin filaments in the movement of mitochondria in the axons and dendrites of cultured hippocampal neurons J. Comp. Neurol. 427 2000 351-361
79. W. Margolin Spatial regulation of cytokinesis in bacteria Curr. Opin. Microbiol. 4 2001 647-652
80. M. Martin S.J. Iyadurai A. Gassman J.G. Gindhart Jr T.S. Hays W.M. Saxton Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport Mol. Biol. Cell 10 1999 3717-3728
81. Y. Mattenberger D.I. James J.C. Martinou Fusion of mitochondria in mammalian cells is dependent on the mitochondrial inner membrane potential and independent of microtubules or actin Fed. Eur. Biol. Soc. Lett. 538 2003 53-59
82. S.J. McConnell M.P. Yaffe Nuclear and mitochondrial inheritance in yeast depends on novel cytoplasmic structures defined by the MDM1 protein J. Cell Biol. 118 1992 385-395
83. S.J. McConnell M.P. Yaffe Intermediate filament formation by a yeast protein essential for organelle inheritance Science 260 1993 687-689
84. G.A. McQuibban S. Saurya M. Freeman Mitochondrial membrane remodelling regulated by a conserved rhomboid protease Nature 423 2003 537-541
85. S. Meeusen J. Nunnari Evidence for a two membrane-spanning autonomous mitochondrial DNA replisome J. Cell Biol. 163 2003 503-510
86. S. Meeusen Q. Tieu E. Wong E. Weiss D. Schieltz J.R. Yates J. Nunnari Mgm101p is a novel component of the mitochondrial nucleoid that binds DNA and is required for the repair of oxidatively damaged mitochondrial DNA J. Cell Biol. 145 1999 291-304
87. M. Messerschmitt S. Jakobs F. Vogel S. Fritz K.S. Dimmer W. Neupert B. Westermann The inner membrane protein Mdm33 controls mitochondrial morphology in yeast J. Cell Biol. 160 2003 553-564
88. K.E. Miller M.P. Sheetz Axonal mitochondrial transport and potential are correlated J. Cell Sci. 117 2004 2791-2804
89. T. Misaka T. Miyashita Y. Kubo Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology J. Biol. Chem. 277 2002 15834-15842
90. I. Miyakawa K. Higo F. Osake N. Sando Double staining of mitochondria and mitochondrial nucleoids in the living yeast during the life cycle J. Gen. Appl. Microbiol. 40 1994 1-14
91. R.L. Morris P.J. Hollenbeck Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons J. Cell Biol. 131 1995 1315-1326
92. P. Mose-Larsen R. Bravo S.J. Fey J.V. Small J.E. Celis Putative association of mitochondria with a subpopulation of intermediate-sized filaments in cultured human skin fibroblasts Cell 31 1982 681-692
93. A.D. Mozdy J.M. McCaffery J.M. Shaw Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p J. Cell Biol. 151 2000 367-380
94. K. Nakada K. Inoue T. Ono K. Isobe A. Ogura Y.I. Goto et al. Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA Nat. Med. 7 2001 934-940
95. M. Nangaku R. Sato-Yoshitake Y. Okada Y. Noda R. Takemura H. Yamazaki N. Hirokawa KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria Cell 79 1994 1209-1220
96. K. Nishida M. Takahara S.Y. Miyagishima H. Kuroiwa M. Matsuzaki T. Kuroiwa Dynamic recruitment of dynamin for final mitochondrial severance in a primitive red alga Proc. Natl. Acad. Sci. USA 100 2003 2146-2151
97. J. Nunnari W.F. Marshall A. Straight A. Murray J.W. Sedat P. Walter Mitochondrial transmission during mating in Saccharomyces cerevisiae is determined by mitochondrial fusion and fission and the intramitochondrial segregation of mitochondrial DNA Mol. Biol. Cell 8 1997 1233-1242
98. A. Olichon L.J. Emorine E. Descoins L. Pelloquin L. Brichese N. Gas et al. The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space Fed. Eur. Biol. Soc. Lett. 523 2002 171-176
99. A. Olichon L. Baricault N. Gas E. Guillou A. Valette P. Belenguer G. Lenaers Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis J. Biol. Chem. 278 2003 7743-7746
100. G.E. Olson V.P. Winfrey Structural organization of surface domains of sperm mitochondria Mol. Reprod. Dev. 33 1992 89-98
101. T. Ono K. Isobe K. Nakada J.I. Hayashi Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria Nat. Genet. 28 2001 272-275
102. D. Otsuga B.R. Keegan E. Brisch J.W. Thatcher G.J. Hermann W. Bleazard J.M. Shaw The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeast J. Cell Biol. 143 1998 333-349
103. L. Pelloquin P. Belenguer Y. Menon N. Gas B. Ducommun Fission yeast Msp1 is a mitochondrial dynamin-related protein J. Cell Sci. 112 Pt 22 1999 4151-4161
104. A.J. Pereira B. Dalby R.J. Stewart S.J. Doxsey L.S. Goldstein Mitochondrial association of a plus end-directed microtubule motor expressed during mitosis in Drosophila J. Cell Biol. 136 1997 1081-1090
105. H. Prokisch W. Neupert B. Westermann Role of MMM1 in maintaining mitochondrial morphology in Neurospora crassa Mol. Biol. Cell 11 2000 2961-2971
106. D. Rapaport M. Brunner W. Neupert B. Westermann Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiae J. Biol. Chem. 273 1998 20150-20155
107. K.S. Renzaglia J.G. Duckett Ultrastructural studies of spermatogenesis in Antherocerophyta V. Nuclear metamorphosis and the posterior mitochondrion of Notothylas orbicularis and Phaeoceros laevis Protoplasma 151 1989 137-150
108. M. Rojo F. Legros D. Chateau A. Lombes Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo J. Cell Sci. 115 2002 1663-1674
109. A. Santel M.T. Fuller Control of mitochondrial morphology by a human mitofusin J. Cell Sci. 114 2001 867-874
110. A. Santel S. Frank B. Gaume M. Herrler R.J. Youle M.T. Fuller Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells J. Cell Sci. 116 2003 2763-2774
111. J.S. Seeler A. Dejean Nuclear and unclear functions of SUMO Nat. Rev. Mol. Cell Biol. 4 2003 690-699
112. H. Sesaki R.E. Jensen Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape J. Cell Biol. 147 1999 699-706
113. H. Sesaki R.E. Jensen UGO1 encodes an outer membrane protein required for mitochondrial fusion J. Cell Biol. 152 2001 1123-1134
114. H. Sesaki R.E. Jensen Ugo1p links the Fzo1p and Mgm1p GTPases for mitochondrial fusion J. Biol. Chem. 2004
115. H. Sesaki S.M. Southard A.E. Hobbs R.E. Jensen Cells lacking Pcp1p/Ugo2p, a rhomboid-like protease required for Mgm1p processing, lose mtDNA and mitochondrial structure in a Dnm1p-dependent manner, but remain competent for mitochondrial fusion Biochem. Biophys. Res. Commun. 308 2003 276-283
116. H. Sesaki S.M. Southard M.P. Yaffe R.E. Jensen Mgm1p, a dynamin-related GTPase, is essential for fusion of the mitochondrial outer membrane Mol. Biol. Cell 14 2003 2342-2356
117. J.M. Shaw J. Nunnari Mitochondrial dynamics and division in budding yeast Trends Cell Biol. 12 2002 178-184
118. K.A. Shepard M.P. Yaffe The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance J. Cell Biol. 144 1999 711-720
119. H. Shin H. Takatsu H. Mukai E. Munekata K. Murakami K. Nakayama Intermolecular and interdomain interactions of a dynamin-related GTP-binding protein, Dnm1p/Vpsp-like protein J. Biol. Chem. 274 1999 2780-2785
120. V.R. Simon T.C. Swayne L.A. Pon Actin-dependent mitochondrial motility in mitotic yeast and cell-free systems: Identification of a motor activity on the mitochondrial surface J. Cell Biol. 130 1995 345-354
121. J.M. Singer J.M. Shaw Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast Proc. Natl. Acad. Sci. USA 100 2003 7644-7649
122. V.P. Skulachev Power transmission along biological membranes J. Membr. Biol. 114 1990 97-112
123. V.P. Skulachev Mitochondrial filaments and clusters as intracellular power-transmitting cables Trends Biochem. Sci. 26 2001 23-29
124. E. Smirnova D.L. Shurland S.N. Ryazantsev A.M. van der Bliek A human dynamin-related protein controls the distribution of mitochondria J. Cell Biol. 143 1998 351-358
125. E. Smirnova L. Griparic D.L. Shurland A.M. van der Bliek Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells Mol. Biol. Cell 12 2001 2245-2256
126. D.M. Smith The ontogenic history of the mitochondria of the hepatic cell of the white rat J. Morph. Physiol. 52 1931 485-512
127. M.G. Smith V.R. Simon H. O'Sullivan L.A. Pon Organelle-cytoskeletal interactions: Actin mutations inhibit meiosis-dependent mitochondrial rearrangement in the budding yeast Saccharomyces cerevisiae Mol. Biol. Cell 6 1995 1381-1396
128. L.F. Sogo M.P. Yaffe Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane J. Cell Biol. 126 1994 1361-1373
129. G. Steinberg M. Schliwa Organelle movements in the wild type and wall-less fz;sg;os-1 mutants of Neurospora crassa are mediated by cytoplasmic microtubules J. Cell Sci. 106 Pt 2 1993 555-564
130. B. Stevens Mitochondrial structure in: J.M. Strathern E.W. Jones J.R. Broach (Eds.) The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance 1981 Cold Spring Harbor Cold Spring Harbor, NY 471-504
131. L.C. Stewart M.P. Yaffe A role for unsaturated fatty acids in mitochondrial movement and inheritance J. Cell Biol. 115 1991 1249-1257
132. D. Stojanovski O.S. Koutsopoulos K. Okamoto M.T. Ryan Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology J. Cell Sci. 117 2004 1201-1210
133. R.S. Stowers L.J. Megeath J. Gorska-Andrzejak I.A. Meinertzhagen T.L. Schwarz Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein Neuron 36 2002 1063-1077
134. K. Sturmer O. Baumann B. Walz Actin-dependent light-induced translocation of mitochondria and ER cisternae in the photoreceptor cells of the locust Schistocerca gregaria J Cell Sci 108 Pt 6 1995 2273-2283
135. R. Suelmann R. Fischer Mitochondrial movement and morphology depend on an intact actin cytoskeleton in Aspergillus nidulans Cell Motil. Cytoskeleton 45 2000 42-50
136. H. Takano S. Kawano N. Sasaki H. Kuroiwa T. Kuroiwa Characterization of a putative fusogen encoded in a mitochondrial plasmid of Physarum polycephalum J. Plant Res. 115 2002 255-261
137. Y. Tanaka Y. Kanai Y. Okada S. Nonaka S. Takeda A. Harada N. Hirokawa Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria Cell 93 1998 1147-1158
138. A.D. Tates Cytodifferentiation during spermatogenesis in Drosophila melanogaster: An electron microscope study 1971 Rijksuniversiteit Leiden
139. P.E. Thorsness T.D. Fox Nuclear mutations in Saccharomyces cerevisiae that affect the escape of DNA from mitochondria to the nucleus Genetics 134 1993 21-28
140. Q. Tieu J. Nunnari Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division J. Cell Biol. 151 2000 353-366
141. Q. Tieu V. Okreglak K. Naylor J. Nunnari The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fission J. Cell Biol. 158 2002 445-452
142. B.H. Toh S.J. Lolait J.P. Mathy R. Baum Association of mitochondria with intermediate filaments and of polyribosomes with cytoplasmic actin Cell Tissue Res. 211 1980 163-169
143. D. Tyler The Mitochondrion in Health and Disease 1992 VCH New York, NY
144. A.M. van der Bliek Functional diversity in the dynamin family Trends Cell Biol. 9 1999 96-102
145. W. Visser E.A. van Spronsen N. Nanninga J.T. Pronk J. Gijs Kuenen J.P. van Dijken Effects of growth conditions on mitochondrial morphology in Saccharomyces cerevisiae Antonie Van Leeuwenhoek 67 1995 243-253
146. B.A. Weir M.P. Yaffe Mmd1p, a novel, conserved protein essential for normal mitochondrial morphology and distribution in the fission yeast, Schizosaccharomyces pombe Mol. Biol. Cell 2004
147. J.L. Werth S.A. Thayer Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons J. Neurosci. 14 1994 348-356
148. E.D. Wong J.A. Wagner S.W. Gorsich J.M. McCaffery J.M. Shaw J. Nunnari The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria J. Cell Biol. 151 2000 341-352
149. E.D. Wong J.A. Wagner S.V. Scott V. Okreglak T.J. Holewinske A. Cassidy-Stone J. Nunnari The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion J. Cell Biol. 160 2003 303-311
150. M.P. Yaffe D. Harata F. Verde M. Eddison T. Toda P. Nurse Microtubules mediate mitochondrial distribution in fission yeast Proc. Natl. Acad. Sci. USA 93 1996 11664-11668
151. M.P. Yaffe N. Stuurman R.D. Vale Mitochondrial positioning in fission yeast is driven by association with dynamic microtubules and mitotic spindle poles Proc. Natl. Acad. Sci. USA 100 2003 11424-11428
152. H.C. Yang A. Palazzo T.C. Swayne L.A. Pon A retention mechanism for distribution of mitochondria during cell division in budding yeast Curr. Biol. 9 1999 1111-1114
153. Y. Yoon K. Pitts M.A. McNiven Mammalian dynamin-like protein DLP1 tubulates membranes Mol. Biol. Cell 12 2001 2894-2905
154. Y. Yoon E.W. Krueger B.J. Oswald M.A. McNiven The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1 Mol. Cell Biol. 23 2003 5409-5420
155. M.J. Youngman A.E. Aiken Hobbs S.M. Burgess M. Srinivasan R.E. Jensen Mmm2p, a mitochondrial outer membrane protein required for mitochondrial shape and maintenance of mtDNA nucleoids J. Cell Biol. 164 2004 677-688
156. C. Zhao J. Takita Y. Tanaka M. Setou T. Nakagawa S. Takeda et al. Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1Bbeta Cell 105 2001 587-597
157. D.B. Zorov V.P. Skulachev V. Khalangk Membranous electric cable: 4. Mitochondrial helix of rat spermatozoan Biologicheskie Membrany 7 1990 243-249