Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction

Journal of Clinical Investigation

Volumn 121, Issue 11, 2011, Pages 4281-4288

  Schenk, Simon ^a,b   McCurdy, Carrie E ^c   Philp, Andrew ^d   Chen, Mark Z ^a   Holliday, Michael J ^c   Bandyopadhyay, Gautum K ^a   Osborn, Olivia ^a   Baar, Keith ^d   Olefsky, Jerrold M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Colorado Denver ^*  (United States)

^c Children's Hospital Colorado   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; SIRTUIN 1; STAT3 PROTEIN;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; DEACETYLATION; ENZYME ACTIVITY; EXON; GENE DELETION; GLUCOSE TRANSPORT; HYPERINSULINEMIA; IN VIVO STUDY; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE INSULIN SENSITIVITY;

ANIMALS; BASE SEQUENCE; CALORIC RESTRICTION; DIABETES MELLITUS, TYPE 2; DNA PRIMERS; GLUCOSE CLAMP TECHNIQUE; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SKELETAL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIRTUIN 1; STAT3 TRANSCRIPTION FACTOR;

EID: 80555142897     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI58554     Document Type: Article

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