Could the low level of expression of the gene encoding skeletal muscle mitofusin-2 account for the metabolic inflexibility of obesity?

Diabetologia

Volumn 48, Issue 10, 2005, Pages 2108-2114

  Mingrone, G ^a   Manco, M ^a   Calvani, M ^a   Castagneto, M ^b   Naon, D ^c,d   Zorzano, A ^c,d  

^a CATHOLIC UNIVERSITY   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Glucose oxidation; Insulin sensitivity; Metabolic inflexibility; Mitofusin 2 mRNA expression; Morbid obesity

Indexed keywords

CITRATE SYNTHASE; CYCLOOXYGENASE 3; GLUCOSE; GLUCOSE TRANSPORTER 4; MEMBRANE PROTEIN; MESSENGER RNA; MITOFUSIN 2; UNCLASSIFIED DRUG;

ARTICLE; BARIATRIC SURGERY; BILIOPANCREATIC BYPASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE EXPRESSION; GLUCOSE OXIDATION; GLUCOSE TRANSPORT; HUMAN; HUMAN TISSUE; INSULIN SENSITIVITY; METABOLIC DISORDER; METABOLIC INFLEXIBILITY; MITOCHONDRIAL MEMBRANE; MORBIDITY; OBESITY; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; STATISTICAL SIGNIFICANCE;

ADULT; BILIOPANCREATIC DIVERSION; BODY COMPOSITION; CALORIMETRY, INDIRECT; CITRATE (SI)-SYNTHASE; CITRIC ACID CYCLE; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX IV; ENERGY METABOLISM; FEMALE; GENE EXPRESSION; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TRANSPORTER TYPE 4; HUMANS; KINETICS; MEMBRANE PROTEINS; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; NITROGEN; OBESITY, MORBID; OXIDATION-REDUCTION; RNA, MESSENGER;

EID: 26244456362     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1918-9     Document Type: Article

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