Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler

Cell Metabolism

Volumn 18, Issue 5, 2013, Pages 740-748

  Perry, Rachel J ^a   Kim, Taehan ^a   Zhang, Xian Man ^a   Lee, Hui Young ^a   Pesta, Dominik ^a   Popov, Violeta B ^a   Zhang, Dongyan ^a   Rahimi, Yasmeen ^a   Jurczak, Michael J ^a   Cline, Gary W ^a   Spiegel, David A ^a,b   Shulman, Gerald I ^a,c  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

^c Capital Region   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; 2,4 DINITROPHENOL METHYL ETHER; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; DIACYLGLYCEROL; INSULIN; PHENOL DERIVATIVE; PROTEIN KINASE C DELTA; PROTEIN KINASE C EPSILON; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL METABOLIC RATE; BODY WEIGHT; CITRIC ACID CYCLE; CONTROLLED STUDY; CREATININE CLEARANCE; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAT INTAKE; FATTY LIVER; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; GLYCOGEN LIVER LEVEL; HISTOPATHOLOGY; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER CELL; MALE; METABOLIC SYNDROME X; MITOCHONDRIAL RESPIRATION; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN TARGETING; RAT; TRIACYLGLYCEROL BLOOD LEVEL; WHITE ADIPOSE TISSUE;

2,4-DINITROPHENOL; ANIMALS; DIET, HIGH-FAT; ETHERS; FATTY LIVER; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

EID: 84887432240     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.10.004     Document Type: Article

References (19)

1. T.C. Alves, D.E. Befroy, R.G. Kibbey, M. Kahn, R. Codella, R.A. Carvalho, K. Falk Petersen, and G.I. Shulman Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance Hepatology 53 2011 1175 1181
2. Z.B. Andrews, Z.-W. Liu, N. Walllingford, D.M. Erion, E. Borok, J.M. Friedman, M.H. Tschöp, M. Shanabrough, G. Cline, and G.I. Shulman UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals Nature 454 2008 846 851
3. E.G. Bligh, and W.J. Dyer A rapid method of total lipid extraction and purification Can. J. Biochem. Physiol. 37 1959 911 917
4. C.S. Choi, D.B. Savage, L. Abu-Elheiga, Z.-X. Liu, S. Kim, A. Kulkarni, A. Distefano, Y.-J. Hwang, R.M. Reznick, and R. Codella Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity Proc. Natl. Acad. Sci. USA 104 2007 16480 16485
5. D.M. Erion, V. Popov, J.J. Hsiao, D. Vatner, K. Mitchell, S. Yonemitsu, Y. Nagai, M. Kahn, M.P. Gillum, and J. Dong The role of the carbohydrate response element-binding protein in male fructose-fed rats Endocrinology 154 2013 36 44
6. M.E. Griffin, M.J. Marcucci, G.W. Cline, K. Bell, N. Barucci, D. Lee, L.J. Goodyear, E.W. Kraegen, M.F. White, and G.I. Shulman Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade Diabetes 48 1999 1270 1274
7. S.I. Itani, N.B. Ruderman, F. Schmieder, and G. Boden Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha Diabetes 51 2002 2005 2011
8. D.E. Kleiner, E.M. Brunt, M. Van Natta, C. Behling, M.J. Contos, O.W. Cummings, L.D. Ferrell, Y.C. Liu, M.S. Torbenson, A. Unalp-Arida Nonalcoholic Steatohepatitis Clinical Research Network Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
9. H.-Y. Lee, A.L. Birkenfeld, F.R. Jornayvaz, M.J. Jurczak, S. Kanda, V. Popov, D.W. Frederick, D. Zhang, B. Guigni, and K.G. Bharadwaj Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance Hepatology 54 2011 1650 1660
10. P. Masiello, C. Broca, R. Gross, M. Roye, M. Manteghetti, D. Hillaire-Buys, M. Novelli, and G. Ribes Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide Diabetes 47 1998 224 229
11. D.S. Neufeld Isolation of rat liver hepatocytes Methods Mol. Biol. 75 1997 145 151
12. J.V. Passonneau, and V.R. Lauderdale A comparison of three methods of glycogen measurement in tissues Anal. Biochem. 60 1974 405 412
13. K.F. Petersen, S. Dufour, D. Befroy, M. Lehrke, R.E. Hendler, and G.I. Shulman Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes Diabetes 54 2005 603 608
14. M.J. Reed, K. Meszaros, L.J. Entes, M.D. Claypool, J.G. Pinkett, T.M. Gadbois, and G.M. Reaven A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat Metabolism 49 2000 1390 1394
15. V.T. Samuel, and G.I. Shulman Mechanisms for insulin resistance: common threads and missing links Cell 148 2012 852 871
16. V.T. Samuel, Z.-X. Liu, X. Qu, B.D. Elder, S. Bilz, D. Befroy, A.J. Romanelli, and G.I. Shulman Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease J. Biol. Chem. 279 2004 32345 32353
17. V.T. Samuel, Z.X. Liu, A. Wang, S.A. Beddow, J.G. Geisler, M. Kahn, X.M. Zhang, B.P. Monia, S. Bhanot, and G.I. Shulman Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease J. Clin. Invest. 117 2007 739 745
18. D.L. White, F. Kanwal, and H.B. El-Serag Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review Clin. Gastroenterol. Hepatol. 10 2012 1342.e2
19. C. Yu, Y. Chen, G.W. Cline, D. Zhang, H. Zong, Y. Wang, R. Bergeron, J.K. Kim, S.W. Cushman, and G.J. Cooney Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle J. Biol. Chem. 277 2002 50230 50236