A high-fat diet elicits differential responses in genes coordinating oxidative metabolism in skeletal muscle of lean and obese individuals

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 3, 2011, Pages 775-781

  Boyle, Kristen E ^a   Canham, J P ^a   Consitt, L A ^a   Zheng, D ^a   Koves, T R ^c   Gavin, T P ^a,b   Holbert, D ^a   Neufer, P D ^a,b   Ilkayeva, O ^c   Muoio, D M ^c   Houmard, J A ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b EAST CAROLINA UNIVERSITY   (United States)

^c DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACYLCARNITINE; CHOLESTEROL; FATTY ACID; GLUCOSE; INSULIN; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PYRUVATE DEHYDROGENASE KINASE 4; TRIACYLGLYCEROL; UNCOUPLING PROTEIN 3;

ADULT; AEROBIC METABOLISM; ARTICLE; BODY MASS; BODY SIZE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DIET; FEMALE; FOOD COMPOSITION; GENE CONTROL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; LEAN BODY WEIGHT; LIPID DIET; LIPID OXIDATION; MALE; MUSCLE BIOPSY; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE; TRIACYLGLYCEROL BLOOD LEVEL; VASTUS LATERALIS MUSCLE;

ADOLESCENT; ADULT; BLOOD GLUCOSE; BODY MASS INDEX; CARNITINE; DIET; DIETARY FATS; FATTY ACIDS, NONESTERIFIED; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INSULIN; ION CHANNELS; LIPID METABOLISM; MALE; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OBESITY; OXIDATION-REDUCTION; PPAR ALPHA; PYRUVATE DEHYDROGENASE (LIPOAMIDE); RNA, MESSENGER; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; YOUNG ADULT;

EID: 79952295016     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-2253     Document Type: Article

References (34)

1. Andres R, Cader G, Zierler KL 1956 The quantitatively minor role of carbohydrate in oxidative metabolism by skeletal muscle in intact man in the basal state; measurements of oxygen and glucose uptake and carbon dioxide and lactate production in the forearm. J Clin Invest 35:671-682
2. Kelley DE, Reilly JP, Veneman T, Mandarino LJ 1990 Effects of insulin on skeletal muscle glucose storage, oxidation, and glycolysis in humans. Am J Physiol 258:E923-929
3. Kelley DE, Mandarino LJ 2000 Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49:677-683 (Pubitemid 30339979)
4. Kelley DE, Goodpaster B, Wing RR, Simoneau JA 1999 Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am J Physiol 277:E1130-E1141 (Pubitemid 30046009)
5. Astrup A, Buemann B, Christensen NJ, Toubro S 1994 Failure to increase lipid oxidation in response to increasing dietary fat content in formerly obese women. Am J Physiol 266:E592-E599
6. Schrauwen P, van Marken Lichtenbelt WD, Saris WH, Westerterp KR1997 Changes in fat oxidation in response to a high-fat diet. Am J Clin Nutr 66:276-282
7. Schrauwen P, Wagenmakers AJ, van Marken Lichtenbelt WD, Saris WH, Westerterp KR 2000 Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation. Diabetes 49:640-646 (Pubitemid 30183754)
8. Smith SR, de Jonge L, Zachwieja JJ, Roy H, Nguyen T, Rood JC, Windhauser MM, Bray GA 2000 Fat and carbohydrate balances during adaptation to a high-fat. Am J Clin Nutr 71:450-457 (Pubitemid 30061222)
9. Ukropcova B, McNeil M, Sereda O, de Jonge L, Xie H, Bray GA, Smith SR 2005 Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J Clin Invest 115:1934-1941 (Pubitemid 40979733)
10. Cameron-Smith D, Burke LM, Angus DJ, Tunstall RJ, Cox GR, Bonen A, Hawley JA, Hargreaves M 2003 A short-term, high-fat diet up-regulates lipid metabolism and gene expression in human skeletal muscle. Am J Clin Nutr 77:313-318 (Pubitemid 36133371)
11. Arkinstall MJ, Tunstall RJ, Cameron-Smith D, Hawley JA 2004 Regulation of metabolic genes in human skeletal muscle by short-term exercise and diet manipulation. Am J Physiol Endocrinol Metab 287:E25-E31 (Pubitemid 38856278)
12. Pehleman TL, Peters SJ, Heigenhauser GJ, Spriet LL 2005 Enzymatic regulation of glucose disposal in human skeletal muscle after a high-fat, low-carbohydrate diet. J Appl Physiol 98:100-107 (Pubitemid 40041235)
13. Peters SJ, Harris RA, Wu P, Pehleman TL, Heigenhauser GJ, Spriet LL 2001 Human skeletal muscle PDH kinase activity and isoform expression during a 3-day high-fat/low-carbohydrate diet. Am J Physiol Endocrinol Metab 281:E1151-E1158
14. Muoio DM, Koves TR 2007 Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease. Appl Physiol Nutr Metab 32:874-883
15. Thomas CD, Peters JC, Reed GW, Abumrad NN, Sun M, Hill JO 1992 Nutrient balance and energy expenditure during ad libitum feeding of high-fat and high-carbohydrate diets in humans. Am J Clin Nutr 55:934-942
16. Bonora E, Kiechl S, Willeit J, Oberhollenzer F, Egger G, Targher G, Alberiche M, Bonadonna RC, Muggeo M 1998 Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 47:1643-1649 (Pubitemid 28445355)
17. Harris JA, Benedict FG 1918 A Biometric Study of Human Basal Metabolism. Proc Natl Acad Sci USA 4:370-373
18. Koves TR, Li P, An J, Akimoto T, Slentz D, Ilkayeva O, Dohm GL, Yan Z, Newgard CB, Muoio DM 2005 Peroxisome proliferatoractivated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem 280:33588-33598
19. Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, Bain J, Stevens R, Dyck JR, Newgard CB, Lopaschuk GD, Muoio DM 2008 Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 7:45-56
20. Schrauwen P, vanMarken Lichtenbelt WD, Westerterp KR 2000 Fat and carbohydrate balances during adaptation to a high-fat diet. Am J Clin Nutr 72:1239-1241
21. Schrauwen P, van Marken Lichtenbelt WD, Westerterp KR 1997 Energy balance in a respiration chamber: individual adjustment of energy intake to energy expenditure. Int J Obes Relat Metab Disord 21:769-774
22. Feige JN, Lagouge M, Canto C, Strehle A, Houten SM, Milne JC, Lambert PD, Mataki C, Elliott PJ, Auwerx J 2008 Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab 8:347-358
23. Muoio DM, Way JM, Tanner CJ, Winegar DA, Kliewer SA, Houmard JA, Kraus WE, Dohm GL 2002 Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes 51:901-909 (Pubitemid 34438329)
24. Spiegelman BM, Heinrich R 2004 Biological control through regulated transcriptional coactivators. Cell 119:157-167 (Pubitemid 39360899)
25. Garcia-Roves P, Huss JM, Han DH, Hancock CR, Iglesias-Gutierrez E, Chen M, Holloszy JO 2007 Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. Proc Natl Acad Sci USA 104:10709-10713 (Pubitemid 47185729)
26. Turner N, Bruce CR, Beale SM, Hoehn KL, So T, Rolph MS, Cooney GJ 2007 Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 56:2085-2092 (Pubitemid 47195821)
27. Chokkalingam K, Jewell K, Norton L, Littlewood J, van Loon LJ, Mansell P, Macdonald IA, Tsintzas K 2007 High-fat/low-carbohydrate diet reduces insulin-stimulated carbohydrate oxidation but stimulates nonoxidative glucose disposal in humans: An important role for skeletal muscle pyruvate dehydrogenase kinase 4. J Clin Endocrinol Metab 92:284-292
28. Helge JW, Bentley D, Schjerling P, Willer M, Gibala MJ, Franch J, Tapia-Laliena MA, Daugaard JR, Andersen JL 2007 Four weeks one-leg training and high fat diet does not alter PPARalpha protein or mRNA expression in human skeletal muscle. Eur J Appl Physiol 101:105-114 (Pubitemid 47323291)
29. Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, Smith SR 2005 A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 54:1926-1933 (Pubitemid 40911253)
30. Sugden MC, Holness MJ 2006 Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases. Arch Physiol Biochem 112:139-149 (Pubitemid 44871041)
31. Schrauwen P 2007 High-fat diet, muscular lipotoxicity and insulin resistance. Proc Nutr Soc 66:33-41 (Pubitemid 46748242)
32. Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, Price 3rd JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD 2009 Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest 119:573-581
33. Anderson EJ, Yamazaki H, Neufer PD 2007 Induction of endogenous uncoupling protein 3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration. J Biol Chem 282:31257-31266 (Pubitemid 350044867)
34. Rinaldo P, Cowan TM, Matern D 2008 Acylcarnitine profile analysis. Genet Med 10:151-156 (Pubitemid 351271727)