Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes

Diabetes Care

Volumn 31, Issue 8, 2008, Pages 1644-1649

  Trenell, Michael I ^a,b   Lim, Ee Lin ^a,b   Hollingsworth, Kieren G ^a,b   Taylor, Roy ^a,b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; GLUCOSE; HEMOGLOBIN A1C; INSULIN; METFORMIN; SULFONYLUREA; GLYCOSYLATED HEMOGLOBIN; LIPID;

ADULT; ANTHROPOMETRY; ARTICLE; BODY WEIGHT; CALORIMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; DAILY LIFE ACTIVITY; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; LIPID OXIDATION; METABOLITE; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SKELETAL MUSCLE; WALKING; ENZYME LINKED IMMUNOSORBENT ASSAY; EXERCISE; FEMALE; MALE; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY; PHYSIOLOGY; REFERENCE VALUE;

ADENOSINE TRIPHOSPHATE; CALORIMETRY, INDIRECT; DIABETES MELLITUS, TYPE 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXERCISE; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; LIPIDS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MITOCHONDRIA; OXIDATION-REDUCTION; REFERENCE VALUES; WALKING;

EID: 49649115590     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc08-0303     Document Type: Article

References (29)

1. Kelley DE, He J, Menshikova EV, Ritov VB: Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51:2944-2950, 2002
2. Petersen KF, Dufour S, Befroy D, Garcia BA, Shulman GI: Impaired mitochondrial activity in the insulin resistant offspring of patients with type 2 diabetes. N Engl J Med 350:664-671, 2004
3. Schrauwen-Hinderling VB, Kooi ME, Hesselink MK, Jeneson JA, Backes WH, van Echteld CJ, van Engelshoven JM, Mensink M, Schrauwen P: Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects. Diabetologia 50: 113-120, 2007
4. Vondra K, Rath R, Bass A, SlabochovaZ, Teisinger J, Vitek V: Enzyme activities in quadriceps femoris muscle of obese diabetic male patients. Diabetologia 13:527-529, 1977
5. Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI: Reduced mitochondrial density and increased IRS-1 serine phos- phorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J Clin Invest 115:3587-3593, 2005
6. Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL, Shulman GI: Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes 56:1376-1381, 2007
7. Kelley DE, Simoneau JA: Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitu. J Clin lnvest 94:2349-2345, 1994
8. 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606, 1999
9. Szendroedi J, Schmid AI, Chmelik M, Toth C, Brehm A, Krssak M, Nowotny P, Wolzt M, Waldhausl W, Roden M: Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes. PLos Med 4:e154, 2007
10. Boushel R, Gnaiger E, Schjerling P, Sk-ovbro M, Kraunsøe R, Dela F: Patients with type 2 diabetes have normal mito-chondrial function in skeletal muscle. Diabetologia 50:790-796, 2007
11. Morrato EH, Hill JO, Wyatt HR, Ghush- chyan V, Sullivan PW: Physical activity in U.S. adults with diabetes and at risk for developing diabetes. Diabetes Care 30: 203-209, 2007
12. Thomas DE, Elliott EJ, Naughton GA: Exercise for type 2 diabetes mellitus. Coch Data System Rev CD002968, 2006
13. Holloszy JO: Biochemical adaptations in muscle: effects of exercise on mitochon- drial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem 242:2278-2282, 1967
14. Toledo FG, Menshikova EV, Ritov VB, Azuma K, Radikova Z, DeLany J, Kelley DE: Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes 56:2142-2147, 2007
15. Di Loreto C, Fanelli C, Lucidi P, Murdolo G, De Cicco A, Parlanti N, Ranchelli A, Fatone C, Taglioni C, Santeusanio F, De Feo P: Make your diabetic patients walk: long-term impact of different amounts of physical activity on type 2 diabetes. Diabetes Care 28:1295-1302, 2005
16. Taylor R: Causation of type 2 diabetes: the Gordian Knot unravels. N Engl J Med 350: 639-641, 2004
17. Lebon V, Dufour S, Petersen KF, Ren J, Jucker BM, Slezak LA, Cline GW, Roth-man DL, Shulman GI: Effect of triiodothy- ronine on mitochondrial energy coupling in human skeletal muscle. J Clin Invest 108:733-737, 2001
18. Forsen S, Hoffman R: Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance. J ChemPhys 39:2892-2901, 1963
19. 1H magnetic resonance spectroscopic studies of skeletal muscle: an analytical review. Mag Res Quart 10:43-63, 1994
20. Naressi A, Couturier C, Castang I, de Beer R, Graveron-Demilly D: Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectros- copy signals. Comput Biol Med 31:269-286, 2001
21. Vanhamme L, Van Huffel S, Van Hecke P, van Ormondt D: Time-domain quantification of series of biomedical magnetic resonance spectroscopy signals. J Mag Res 140:120-130, 1999
22. St-Onge M, Mignault D, Allison DB, Ra-basa-Lhoret R: Evaluation of a portable device to measure daily energy expenditure in free-living adults. Am J Clin Nutr 85:742-749, 2007
23. Frayn K: Calculation of substrate oxida- tion rates in vivo from gaseous exchange. J App Physiol 55:628 -634, 1983
24. Hawley J, Lessard S: Mitochondrial function: use it or lose it. Diabetologia 50:699 - 702, 2007
25. Fritz T, Kramer DK, Karlsson HK, Ga- luska D, Engfeldt P, Zierath JR, Krook A: Low-intensity exercise increases skeletal muscle protein expression of PPARdelta and UCP3 in type 2 diabetic patients. Diabetes Metab Res Rev 22:492-498, 2006
26. Menshikova EV, Ritov VB, Toledo FGS, Ferrell RE, Goodpaster BH, Kelley DE: Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity. Am J Physiol Endocrinol Metab 288:E818-E825, 2005
27. Toledo FG, Menshikova EV, Azuma K, Radikova Z, Kelley CA, Ritov VB, Kelley DE: Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content. Diabetes 57:987-994, 2008
28. Krssak M, Falk Petersen K, Dresner A, DiPietro L, Vogel SM, Rothman DL, Ro- den M, Shulman GI: Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia 42:113-116, 1999
29. Healy GN, Wijndaele K, Dunstan DW, Shaw JE, Salmon J, Zimmet PZ, Owen N: Objectively measured sedentary time, physical activity, and metabolic risk: the Australian Diabetes, Obesity and Lifestyle Study (AusDiab). Diabetes Care 31:369 -371, 2008