Berberine and its more biologically available derivative, dihydroberberine, inhibit mitochondrial respiratory complex i: A mechanism for the action of berberine to activate amp-activated protein kinase and improve insulin action

Diabetes

Volumn 57, Issue 5, 2008, Pages 1414-1418

  Turner, Nigel ^a   Li, Jing Ya ^a,b   Gosby, Alison ^a   To, Sabrina W C ^a   Cheng, Zhe ^b   Miyoshi, Hiroyuki ^c   Taketo, Makoto M ^c   Cooney, Gregory J ^a   Kraegen, Edward W ^a   James, David E ^a   Hu, Li Hong ^b   Li, Jia ^b   Ye, Ji Ming ^a  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; BERBERINE; BERBERINE DERIVATIVE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; DIHYDROBERBERINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; METFORMIN; PROTEIN KINASE INHIBITOR; PROTEIN KINASE LKB1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROSIGLITAZONE; UNCLASSIFIED DRUG; CYCLIC NUCLEOTIDE DEPENDENT PROTEIN KINASE; DRUG DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; EMBRYO; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EPIDIDYMIS FAT; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; GLUCOSE TRANSPORT; IN VIVO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; MALE; MAXIMUM PLASMA CONCENTRATION; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE MITOCHONDRION; MYOTUBE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; WISTAR RAT;

ADENYLATE KINASE; ANIMALS; BERBERINE; CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES; ELECTRON TRANSPORT COMPLEX I; ENZYME ACTIVATION; INSULIN; MALE; MICE; MICE, INBRED C57BL; MITOCHONDRIA, MUSCLE; PHOSPHORYLATION; RATS; RATS, WISTAR;

EID: 48449084609     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-1552     Document Type: Article

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