Overfeeding reduces insulin sensitivity and increases oxidative stress, without altering markers of mitochondrial content and function in humans

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Samocha Bonet, Dorit ^a,b   Campbell, Lesley V ^a,b   Mori, Trevor A ^c   Croft, Kevin D ^c   Greenfield, Jerry R ^a,b   Turner, Nigel ^a,b   Heilbronn, Leonie K ^a,d  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CARNITINE PALMITOYLTRANSFERASE; ENOYL COENZYME A HYDRATASE; GLUCOSE; INSULIN; ISOPROSTANE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); UNCOUPLING PROTEIN 3; CITRATE SYNTHASE; SIGNAL PEPTIDE; SRC KINASE ASSOCIATED PHOSPHOPROTEIN 2;

ADULT; ANTHROPOMETRY; ARTICLE; BIOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FAMILY HISTORY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE INFUSION; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID METABOLISM; MALE; METABOLISM; MITOCHONDRION; MUSCLE BIOPSY; MUSCLE TISSUE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; OVERNUTRITION; OXIDATIVE STRESS; PROTEIN CARBONYLATION; RESPIRATORY CHAIN; RESPIRATORY QUOTIENT; SEDENTARY LIFESTYLE; SKELETAL MUSCLE; BIOPSY; BLOOD; BODY WEIGHT; COHORT ANALYSIS; ENZYMOLOGY; LIPID DIET; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; WEIGHT GAIN;

RODENTIA;

ADULT; BIOPSY; BLOOD GLUCOSE; BODY WEIGHT; CITRATE (SI)-SYNTHASE; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPID METABOLISM; MALE; MITOCHONDRIA; MUSCLE, SKELETAL; OBESITY; OXIDATIVE STRESS; WEIGHT GAIN;

EID: 84860641172     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036320     Document Type: Article

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