메뉴 건너뛰기




Volumn 19, Issue 9, 2008, Pages 324-330

Is mitochondrial dysfunction a cause of insulin resistance?

Author keywords

[No Author keywords available]

Indexed keywords

ACIPIMOX; ADENOSINE TRIPHOSPHATE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RESVERATROL; RNA DIRECTED DNA POLYMERASE INHIBITOR; ROSIGLITAZONE;

EID: 53649083550     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2008.08.001     Document Type: Review
Times cited : (142)

References (78)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    • Wild S., et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27 (2004) 1047-1053
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1
  • 2
    • 0036316341 scopus 로고    scopus 로고
    • Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats
    • Hegarty B.D., et al. Increased efficiency of fatty acid uptake contributes to lipid accumulation in skeletal muscle of high fat-fed insulin-resistant rats. Diabetes 51 (2002) 1477-1484
    • (2002) Diabetes , vol.51 , pp. 1477-1484
    • Hegarty, B.D.1
  • 3
    • 4544355465 scopus 로고    scopus 로고
    • Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36
    • Bonen A., et al. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J. 18 (2004) 1144-1146
    • (2004) FASEB J. , vol.18 , pp. 1144-1146
    • Bonen, A.1
  • 4
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • Lowell B.B., and Shulman G.I. Mitochondrial dysfunction and type 2 diabetes. Science 307 (2005) 384-387
    • (2005) Science , vol.307 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 5
    • 33644821858 scopus 로고    scopus 로고
    • Mitochondria are impaired in the adipocytes of type 2 diabetic mice
    • Choo H.J., et al. Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia 49 (2006) 784-791
    • (2006) Diabetologia , vol.49 , pp. 784-791
    • Choo, H.J.1
  • 6
    • 38949135755 scopus 로고    scopus 로고
    • Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome
    • Bugger H., and Abel E.D. Molecular mechanisms for myocardial mitochondrial dysfunction in the metabolic syndrome. Clin. Sci. (Lond.) 114 (2008) 195-210
    • (2008) Clin. Sci. (Lond.) , vol.114 , pp. 195-210
    • Bugger, H.1    Abel, E.D.2
  • 7
    • 0033668021 scopus 로고    scopus 로고
    • Lipid oxidation is reduced in obese human skeletal muscle
    • Kim J.Y., et al. Lipid oxidation is reduced in obese human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 279 (2000) E1039-E1044
    • (2000) Am. J. Physiol. Endocrinol. Metab. , vol.279
    • Kim, J.Y.1
  • 8
    • 0032752951 scopus 로고    scopus 로고
    • Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss
    • Simoneau J.A., et al. Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB J. 13 (1999) 2051-2060
    • (1999) FASEB J. , vol.13 , pp. 2051-2060
    • Simoneau, J.A.1
  • 9
    • 0033400310 scopus 로고    scopus 로고
    • Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
    • Kelley D.E., et al. Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss. Am. J. Physiol. 277 (1999) E1130-E1141
    • (1999) Am. J. Physiol. , vol.277
    • Kelley, D.E.1
  • 10
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley D.E., et al. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51 (2002) 2944-2950
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1
  • 11
    • 0037477855 scopus 로고    scopus 로고
    • Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1
    • Patti M.E., et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 8466-8471
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 8466-8471
    • Patti, M.E.1
  • 12
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha V.K., et al. PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 34 (2003) 267-273
    • (2003) Nat. Genet. , vol.34 , pp. 267-273
    • Mootha, V.K.1
  • 13
    • 31044433308 scopus 로고    scopus 로고
    • Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    • Morino K., et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. J. Clin. Invest. 115 (2005) 3587-3593
    • (2005) J. Clin. Invest. , vol.115 , pp. 3587-3593
    • Morino, K.1
  • 14
    • 34147175161 scopus 로고    scopus 로고
    • Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects
    • Heilbronn L.K., et al. Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects. J. Clin. Endocrinol. Metab. 92 (2007) 1467-1473
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 1467-1473
    • Heilbronn, L.K.1
  • 15
    • 34548429745 scopus 로고    scopus 로고
    • Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome
    • Skov V., et al. Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome. Diabetes 56 (2007) 2349-2355
    • (2007) Diabetes , vol.56 , pp. 2349-2355
    • Skov, V.1
  • 16
    • 33847611885 scopus 로고    scopus 로고
    • Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle
    • Boushel R., et al. Patients with type 2 diabetes have normal mitochondrial function in skeletal muscle. Diabetologia 50 (2007) 790-796
    • (2007) Diabetologia , vol.50 , pp. 790-796
    • Boushel, R.1
  • 17
    • 12144275294 scopus 로고    scopus 로고
    • Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
    • Ritov V.B., et al. Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes. Diabetes 54 (2005) 8-14
    • (2005) Diabetes , vol.54 , pp. 8-14
    • Ritov, V.B.1
  • 18
    • 0038025371 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in the elderly: possible role in insulin resistance
    • Petersen K.F., et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300 (2003) 1140-1142
    • (2003) Science , vol.300 , pp. 1140-1142
    • Petersen, K.F.1
  • 19
    • 33845947550 scopus 로고    scopus 로고
    • Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects
    • Schrauwen-Hinderling V.B., et al. Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects. Diabetologia 50 (2007) 113-120
    • (2007) Diabetologia , vol.50 , pp. 113-120
    • Schrauwen-Hinderling, V.B.1
  • 20
    • 34249681435 scopus 로고    scopus 로고
    • Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes
    • Szendroedi J., et al. Muscle mitochondrial ATP synthesis and glucose transport/phosphorylation in type 2 diabetes. PLoS Med. 4 (2007) e154
    • (2007) PLoS Med. , vol.4
    • Szendroedi, J.1
  • 21
    • 34248141686 scopus 로고    scopus 로고
    • Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
    • Befroy D.E., et al. Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes 56 (2007) 1376-1381
    • (2007) Diabetes , vol.56 , pp. 1376-1381
    • Befroy, D.E.1
  • 22
    • 1642377274 scopus 로고    scopus 로고
    • Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    • Petersen K.F., et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N. Engl. J. Med. 350 (2004) 664-671
    • (2004) N. Engl. J. Med. , vol.350 , pp. 664-671
    • Petersen, K.F.1
  • 23
    • 25644448096 scopus 로고    scopus 로고
    • Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents
    • Petersen K.F., et al. Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents. PLoS Med. 2 (2005) e233
    • (2005) PLoS Med. , vol.2
    • Petersen, K.F.1
  • 24
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • Bandyopadhyay G.K., et al. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 55 (2006) 2277-2285
    • (2006) Diabetes , vol.55 , pp. 2277-2285
    • Bandyopadhyay, G.K.1
  • 25
    • 34447576831 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women
    • Holloway G.P., et al. Skeletal muscle mitochondrial FAT/CD36 content and palmitate oxidation are not decreased in obese women. Am. J. Physiol. Endocrinol. Metab. 292 (2007) E1782-E1789
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292
    • Holloway, G.P.1
  • 26
    • 34249720640 scopus 로고    scopus 로고
    • Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes
    • Mogensen M., et al. Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes 56 (2007) 1592-1599
    • (2007) Diabetes , vol.56 , pp. 1592-1599
    • Mogensen, M.1
  • 27
    • 34250648975 scopus 로고    scopus 로고
    • Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults
    • Fleischman A., et al. Effects of a nucleoside reverse transcriptase inhibitor, stavudine, on glucose disposal and mitochondrial function in muscle of healthy adults. Am. J. Physiol. Endocrinol. Metab. 292 (2007) E1666-E1673
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.292
    • Fleischman, A.1
  • 28
    • 33644746318 scopus 로고    scopus 로고
    • Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle
    • Brehm A., et al. Increased lipid availability impairs insulin-stimulated ATP synthesis in human skeletal muscle. Diabetes 55 (2006) 136-140
    • (2006) Diabetes , vol.55 , pp. 136-140
    • Brehm, A.1
  • 29
    • 33748485573 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids
    • Hoeks J., et al. Peroxisome proliferator-activated receptor-γ coactivator-1 and insulin resistance: acute effect of fatty acids. Diabetologia 49 (2006) 2419-2426
    • (2006) Diabetologia , vol.49 , pp. 2419-2426
    • Hoeks, J.1
  • 30
    • 15444370639 scopus 로고    scopus 로고
    • Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle
    • Richardson D.K., et al. Lipid infusion decreases the expression of nuclear encoded mitochondrial genes and increases the expression of extracellular matrix genes in human skeletal muscle. J. Biol. Chem. 280 (2005) 10290-10297
    • (2005) J. Biol. Chem. , vol.280 , pp. 10290-10297
    • Richardson, D.K.1
  • 31
    • 21344444333 scopus 로고    scopus 로고
    • A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
    • Sparks L.M., et al. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 54 (2005) 1926-1933
    • (2005) Diabetes , vol.54 , pp. 1926-1933
    • Sparks, L.M.1
  • 32
    • 34748856784 scopus 로고    scopus 로고
    • Skeletal muscle subsarcolemmal mitochondrial dysfunction in high-fat fed rats exhibiting impaired glucose homeostasis
    • Lionetti L., et al. Skeletal muscle subsarcolemmal mitochondrial dysfunction in high-fat fed rats exhibiting impaired glucose homeostasis. Int. J. Obes. (Lond). 31 (2007) 1596-1604
    • (2007) Int. J. Obes. (Lond). , vol.31 , pp. 1596-1604
    • Lionetti, L.1
  • 33
    • 0842347859 scopus 로고    scopus 로고
    • Impaired expression of NADH dehydrogenase subunit 1 and PPARγ coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone
    • Jove M., et al. Impaired expression of NADH dehydrogenase subunit 1 and PPARγ coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. J. Lipid Res. 45 (2004) 113-123
    • (2004) J. Lipid Res. , vol.45 , pp. 113-123
    • Jove, M.1
  • 34
    • 38849199866 scopus 로고    scopus 로고
    • Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
    • Bonnard C., et al. Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice. J. Clin. Invest. 118 (2008) 789-800
    • (2008) J. Clin. Invest. , vol.118 , pp. 789-800
    • Bonnard, C.1
  • 35
    • 3042821172 scopus 로고    scopus 로고
    • Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity
    • Rimbert V., et al. Muscle fat oxidative capacity is not impaired by age but by physical inactivity: association with insulin sensitivity. FASEB J. 18 (2004) 737-739
    • (2004) FASEB J. , vol.18 , pp. 737-739
    • Rimbert, V.1
  • 36
    • 33646403717 scopus 로고    scopus 로고
    • Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients
    • Ostergard T., et al. Impact of exercise training on insulin sensitivity, physical fitness, and muscle oxidative capacity in first-degree relatives of type 2 diabetic patients. Am. J. Physiol. Endocrinol. Metab. 290 (2006) E998-E1005
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Ostergard, T.1
  • 37
    • 34547596186 scopus 로고    scopus 로고
    • Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes
    • Toledo F.G., et al. Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes. Diabetes 56 (2007) 2142-2147
    • (2007) Diabetes , vol.56 , pp. 2142-2147
    • Toledo, F.G.1
  • 38
    • 33746419647 scopus 로고    scopus 로고
    • Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects
    • Larson-Meyer D.E., et al. Effect of calorie restriction with or without exercise on insulin sensitivity, β-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 29 (2006) 1337-1344
    • (2006) Diabetes Care , vol.29 , pp. 1337-1344
    • Larson-Meyer, D.E.1
  • 39
    • 33750908045 scopus 로고    scopus 로고
    • Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial
    • Weiss E.P., et al. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am. J. Clin. Nutr. 84 (2006) 1033-1042
    • (2006) Am. J. Clin. Nutr. , vol.84 , pp. 1033-1042
    • Weiss, E.P.1
  • 40
    • 33947710793 scopus 로고    scopus 로고
    • Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    • Civitarese A.E., et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med. 4 (2007) e76
    • (2007) PLoS Med. , vol.4
    • Civitarese, A.E.1
  • 41
    • 26844558334 scopus 로고    scopus 로고
    • Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    • Nisoli E., et al. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science 310 (2005) 314-317
    • (2005) Science , vol.310 , pp. 314-317
    • Nisoli, E.1
  • 42
    • 33845399894 scopus 로고    scopus 로고
    • Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
    • Lagouge M., et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell 127 (2006) 1109-1122
    • (2006) Cell , vol.127 , pp. 1109-1122
    • Lagouge, M.1
  • 43
    • 36049002392 scopus 로고    scopus 로고
    • Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle
    • Ling C., et al. Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle. J. Clin. Invest. 117 (2007) 3427-3435
    • (2007) J. Clin. Invest. , vol.117 , pp. 3427-3435
    • Ling, C.1
  • 44
    • 0031004167 scopus 로고    scopus 로고
    • Increased prevalence of mitochondrial DNA deletions in skeletal muscle of older individuals with impaired glucose tolerance: possible marker of glycemic stress
    • Liang P., et al. Increased prevalence of mitochondrial DNA deletions in skeletal muscle of older individuals with impaired glucose tolerance: possible marker of glycemic stress. Diabetes 46 (1997) 920-923
    • (1997) Diabetes , vol.46 , pp. 920-923
    • Liang, P.1
  • 45
    • 33244465167 scopus 로고    scopus 로고
    • Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes
    • Barroso I., et al. Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes. Diabetologia 49 (2006) 501-505
    • (2006) Diabetologia , vol.49 , pp. 501-505
    • Barroso, I.1
  • 46
    • 22144472218 scopus 로고    scopus 로고
    • Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor
    • Ukropcova B., et al. Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor. J. Clin. Invest. 115 (2005) 1934-1941
    • (2005) J. Clin. Invest. , vol.115 , pp. 1934-1941
    • Ukropcova, B.1
  • 47
    • 33644821916 scopus 로고    scopus 로고
    • Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans
    • Hulver M.W., et al. Elevated stearoyl-CoA desaturase-1 expression in skeletal muscle contributes to abnormal fatty acid partitioning in obese humans. Cell Metab. 2 (2005) 251-261
    • (2005) Cell Metab. , vol.2 , pp. 251-261
    • Hulver, M.W.1
  • 48
    • 0037230261 scopus 로고    scopus 로고
    • Plasticity of skeletal muscle mitochondria: structure and function
    • Hoppeler H., and Fluck M. Plasticity of skeletal muscle mitochondria: structure and function. Med. Sci. Sports Exerc. 35 (2003) 95-104
    • (2003) Med. Sci. Sports Exerc. , vol.35 , pp. 95-104
    • Hoppeler, H.1    Fluck, M.2
  • 49
    • 12844251803 scopus 로고    scopus 로고
    • Interindividual variation in posture allocation: possible role in human obesity
    • Levine J.A., et al. Interindividual variation in posture allocation: possible role in human obesity. Science 307 (2005) 584-586
    • (2005) Science , vol.307 , pp. 584-586
    • Levine, J.A.1
  • 50
    • 35748941921 scopus 로고    scopus 로고
    • Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease
    • Hamilton M.T., et al. Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular disease. Diabetes 56 (2007) 2655-2667
    • (2007) Diabetes , vol.56 , pp. 2655-2667
    • Hamilton, M.T.1
  • 51
    • 40949159363 scopus 로고    scopus 로고
    • The role of free-living daily walking in human weight gain and obesity
    • Levine J.A., et al. The role of free-living daily walking in human weight gain and obesity. Diabetes 57 (2008) 548-554
    • (2008) Diabetes , vol.57 , pp. 548-554
    • Levine, J.A.1
  • 52
    • 17144422877 scopus 로고    scopus 로고
    • Mitochondrial metabolism of reactive oxygen species
    • Andreyev A.Y., et al. Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc.) 70 (2005) 200-214
    • (2005) Biochemistry (Mosc.) , vol.70 , pp. 200-214
    • Andreyev, A.Y.1
  • 53
    • 1342264360 scopus 로고    scopus 로고
    • Oxidatively damaged proteins of heart mitochondrial electron transport complexes
    • Choksi K.B., et al. Oxidatively damaged proteins of heart mitochondrial electron transport complexes. Biochim. Biophys. Acta 1688 (2004) 95-101
    • (2004) Biochim. Biophys. Acta , vol.1688 , pp. 95-101
    • Choksi, K.B.1
  • 54
    • 50949108782 scopus 로고    scopus 로고
    • Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat
    • Lesnefsky E.J., et al. Cardiolipin as an oxidative target in cardiac mitochondria in the aged rat. Biochim. Biophys. Acta 1777 (2008) 1020-1027
    • (2008) Biochim. Biophys. Acta , vol.1777 , pp. 1020-1027
    • Lesnefsky, E.J.1
  • 55
    • 2542593338 scopus 로고    scopus 로고
    • Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes
    • Schrauwen P., and Hesselink M.K. Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes. Diabetes 53 (2004) 1412-1417
    • (2004) Diabetes , vol.53 , pp. 1412-1417
    • Schrauwen, P.1    Hesselink, M.K.2
  • 56
    • 0036796875 scopus 로고    scopus 로고
    • Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes
    • Evans J.L., et al. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 23 (2002) 599-622
    • (2002) Endocr. Rev. , vol.23 , pp. 599-622
    • Evans, J.L.1
  • 57
    • 0038271638 scopus 로고    scopus 로고
    • Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts
    • Stump C.S., et al. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7996-8001
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 7996-8001
    • Stump, C.S.1
  • 58
    • 33845514376 scopus 로고    scopus 로고
    • Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia
    • Asmann Y.W., et al. Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia. Diabetes 55 (2006) 3309-3319
    • (2006) Diabetes , vol.55 , pp. 3309-3319
    • Asmann, Y.W.1
  • 59
    • 35748979445 scopus 로고    scopus 로고
    • Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects
    • Karakelides H., et al. Effect of insulin deprivation on muscle mitochondrial ATP production and gene transcript levels in type 1 diabetic subjects. Diabetes 56 (2007) 2683-2689
    • (2007) Diabetes , vol.56 , pp. 2683-2689
    • Karakelides, H.1
  • 60
    • 43449097093 scopus 로고    scopus 로고
    • Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance
    • Nair K.S., et al. Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance. Diabetes 57 (2008) 1166-1175
    • (2008) Diabetes , vol.57 , pp. 1166-1175
    • Nair, K.S.1
  • 61
    • 43149125385 scopus 로고    scopus 로고
    • Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction
    • De Feyter H.M., et al. Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction. Eur. J. Endocrinol. 158 (2008) 643-653
    • (2008) Eur. J. Endocrinol. , vol.158 , pp. 643-653
    • De Feyter, H.M.1
  • 62
    • 33847347318 scopus 로고    scopus 로고
    • Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration
    • Bajaj M., et al. Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration. Diabetes 56 (2007) 743-752
    • (2007) Diabetes , vol.56 , pp. 743-752
    • Bajaj, M.1
  • 63
    • 42449094965 scopus 로고    scopus 로고
    • Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content
    • Toledo F.G., et al. Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid content. Diabetes 57 (2008) 987-994
    • (2008) Diabetes , vol.57 , pp. 987-994
    • Toledo, F.G.1
  • 64
    • 47549092186 scopus 로고    scopus 로고
    • The insulin sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function
    • Schrauwen-Hinderling V.B., et al. The insulin sensitizing effect of rosiglitazone in type 2 diabetes mellitus patients does not require improved in vivo muscle mitochondrial function. J. Clin. Endocrinol. Metab. 93 (2008) 2917-2921
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 2917-2921
    • Schrauwen-Hinderling, V.B.1
  • 65
    • 33749041269 scopus 로고    scopus 로고
    • Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance
    • Wredenberg A., et al. Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance. Biochem. Biophys. Res. Commun. 350 (2006) 202-207
    • (2006) Biochem. Biophys. Res. Commun. , vol.350 , pp. 202-207
    • Wredenberg, A.1
  • 66
    • 35548999739 scopus 로고    scopus 로고
    • Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes
    • Pospisilik J.A., et al. Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 131 (2007) 476-491
    • (2007) Cell , vol.131 , pp. 476-491
    • Pospisilik, J.A.1
  • 67
    • 36048931015 scopus 로고    scopus 로고
    • Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic β cell crosstalk
    • Handschin C., et al. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1α knockout mice reveals skeletal muscle-pancreatic β cell crosstalk. J. Clin. Invest. 117 (2007) 3463-3474
    • (2007) J. Clin. Invest. , vol.117 , pp. 3463-3474
    • Handschin, C.1
  • 68
    • 33751400561 scopus 로고    scopus 로고
    • Hypomorphic mutation of PGC-1β causes mitochondrial dysfunction and liver insulin resistance
    • Vianna C.R., et al. Hypomorphic mutation of PGC-1β causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 4 (2006) 453-464
    • (2006) Cell Metab. , vol.4 , pp. 453-464
    • Vianna, C.R.1
  • 69
    • 45149108625 scopus 로고    scopus 로고
    • Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake
    • Calvo J.A., et al. Muscle-specific expression of PPARγ coactivator-1α improves exercise performance and increases peak oxygen uptake. J. Appl. Physiol. 104 (2008) 1304-1312
    • (2008) J. Appl. Physiol. , vol.104 , pp. 1304-1312
    • Calvo, J.A.1
  • 70
    • 40149096250 scopus 로고    scopus 로고
    • Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice
    • de Wilde J., et al. Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice. Physiol. Genomics 32 (2008) 360-369
    • (2008) Physiol. Genomics , vol.32 , pp. 360-369
    • de Wilde, J.1
  • 71
    • 34547588219 scopus 로고    scopus 로고
    • Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents
    • Turner N., et al. Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle: evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents. Diabetes 56 (2007) 2085-2092
    • (2007) Diabetes , vol.56 , pp. 2085-2092
    • Turner, N.1
  • 72
    • 45549089279 scopus 로고    scopus 로고
    • High-fat diets cause insulin resistance despite an increase in muscle mitochondria
    • Hancock C.R., et al. High-fat diets cause insulin resistance despite an increase in muscle mitochondria. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 7815-7820
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 7815-7820
    • Hancock, C.R.1
  • 73
    • 37449020075 scopus 로고    scopus 로고
    • Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance
    • Koves T.R., et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab. 7 (2008) 45-56
    • (2008) Cell Metab. , vol.7 , pp. 45-56
    • Koves, T.R.1
  • 74
    • 0034035262 scopus 로고    scopus 로고
    • Muscle oxygen uptake in humans at onset of and during intense exercise
    • Bangsbo J. Muscle oxygen uptake in humans at onset of and during intense exercise. Acta Physiol. Scand. 168 (2000) 457-464
    • (2000) Acta Physiol. Scand. , vol.168 , pp. 457-464
    • Bangsbo, J.1
  • 75
    • 34248581989 scopus 로고    scopus 로고
    • Disordered lipid metabolism and the pathogenesis of insulin resistance
    • Savage D.B., et al. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol. Rev. 87 (2007) 507-520
    • (2007) Physiol. Rev. , vol.87 , pp. 507-520
    • Savage, D.B.1
  • 76
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • Holland W.L., et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5 (2007) 167-179
    • (2007) Cell Metab. , vol.5 , pp. 167-179
    • Holland, W.L.1
  • 77
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C., et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277 (2002) 50230-50236
    • (2002) J. Biol. Chem. , vol.277 , pp. 50230-50236
    • Yu, C.1
  • 78
    • 0042160182 scopus 로고    scopus 로고
    • The role of intramuscular lipid in insulin resistance
    • Hegarty B.D., et al. The role of intramuscular lipid in insulin resistance. Acta Physiol. Scand. 178 (2003) 373-383
    • (2003) Acta Physiol. Scand. , vol.178 , pp. 373-383
    • Hegarty, B.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.