Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans

ACS Chemical Neuroscience

Volumn 8, Issue 12, 2017, Pages 2596-2606

  Griffin, Edward F ^a   Caldwell, Kim A ^a   Caldwell, Guy A ^a,b  

^a UNIVERSITY OF ALABAMA   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

A ; genetics; Neurodegeneration; RNAi; screening; tau

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID PRECURSOR PROTEIN; BIOLOGICAL MARKER; TAU PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DAF 16; TRANSCRIPTION FACTOR DAF 2; UNCLASSIFIED DRUG;

AGING; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CAENORHABDITIS ELEGANS; CELL LINEAGE; CELL LYSATE; COMPARATIVE STUDY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; EXOSOME; HUMAN; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INSULIN SIGNALING; MOUSE; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; OLIGOMERIZATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEIN QUALITY; REVIEW; STRUCTURE ACTIVITY RELATION; TAUOPATHY; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; ANIMAL; DISEASE MODEL; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; METABOLISM; PHARMACOGENETIC TESTING; PROCEDURES;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CAENORHABDITIS ELEGANS; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; HUMANS; PHARMACOGENOMIC TESTING; TAU PROTEINS;

EID: 85038815715     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.7b00361     Document Type: Review

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