Fusion of lysosomes with secretory organelles leads to uncontrolled exocytosis in the lysosomal storage disease mucolipidosis type IV

EMBO Reports

Volumn 17, Issue 2, 2016, Pages 266-278

  Park, Soonhong ^a,b   Ahuja, Malini ^a   Kim, Min Seuk ^c   Brailoiu, G Cristina ^d   Jha, Archana ^a   Zeng, Mei ^a   Baydyuk, Maryna ^e   Wu, Ling Gang ^e   Wassif, Christopher A ^f   Porter, Forbes D ^f   Zerfas, Patricia M ^a   Eckhaus, Michael A ^a   Brailoiu, Eugen ^g   Shin, Dong Min ^b   Muallem, Shmuel ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b Yonsei University College of Dentistry   (South Korea)

^c Wonkwang University   (South Korea)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^f EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^g TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

exocytosis; lysosomes; secretory organelles; TRPML1 channel

Indexed keywords

GLUTAMIC ACID; TRANSIENT RECEPTOR POTENTIAL CHANNEL M; TRANSIENT RECEPTOR POTENTIAL CHANNEL ML1; UNCLASSIFIED DRUG; MCOLN1 PROTEIN, MOUSE; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUSION; CELL ORGANELLE; CONTROLLED STUDY; EXOCYTOSIS; LYSOSOME; MOUSE; MUCOLIPIDOSIS TYPE 4; NERVE CELL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SECRETORY CELL; SECRETORY GRANULE; SYNAPSE VESICLE; ANIMAL; CELL CULTURE; EXCITATORY POSTSYNAPTIC POTENTIAL; GENETICS; METABOLISM; MINIATURE ENDPLATE POTENTIAL; MUCOLIPIDOSIS; NIEMANN PICK DISEASE; PHYSIOLOGY; SECRETORY VESICLE;

ANIMALS; CELLS, CULTURED; EXCITATORY POSTSYNAPTIC POTENTIALS; EXOCYTOSIS; GLUTAMIC ACID; LYSOSOMES; MICE; MINIATURE POSTSYNAPTIC POTENTIALS; MUCOLIPIDOSES; NEURONS; NIEMANN-PICK DISEASE, TYPE C; SECRETORY VESICLES; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84957434829     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201541542     Document Type: Article

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