Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice

Journal of Neuroscience

Volumn 37, Issue 25, 2017, Pages 6132-6148

  Sompol, Pradoldej ^a   Furman, Jennifer L ^b   Pleiss, Melanie M ^b   Kraner, Susan D ^a   Artiushin, Irina A ^a   Batten, Seth R ^b   Quintero, Jorge E ^b   Simmerman, Linda A ^b   Beckett, Tina L ^a   Lovell, Mark A ^a,c   Murphy, M Paul ^a,c   Gerhardt, Greg A ^b   Norris, Christopher M ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer s disease; Astrocytes; Calcineurin; Dementia; Glutamate; Hyperexcitability

Indexed keywords

CALCINEURIN; EXCITATORY AMINO ACID TRANSPORTER 2; FLUORESCENT DYE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHOPROTEIN PHOSPHATASE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFAT3; AMYLOID BETA PROTEIN; NFATC3 PROTEIN, MOUSE; SLC1A2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL SURVIVAL; GENE EXPRESSION REGULATION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE CELL EXCITABILITY; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RADIAL ARM MAZE TEST; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; VOLTAGE CLAMP TECHNIQUE; ANIMAL; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE SILENCING; GENETICS; MAZE TEST; METABOLISM; PATCH CLAMP TECHNIQUE; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ASTROCYTES; CALCINEURIN; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY POSTSYNAPTIC POTENTIALS; GENE SILENCING; HIPPOCAMPUS; MAZE LEARNING; MICE; NERVE NET; NFATC TRANSCRIPTION FACTORS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 85021151160     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0877-17.2017     Document Type: Article

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