메뉴 건너뛰기




Volumn 8, Issue 3, 2013, Pages

Oleuropein Aglycone Protects Transgenic C. elegans Strains Expressing Aβ42 by Reducing Plaque Load and Motor Deficit

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; AMYLIN; AMYLOID BETA PROTEIN; OLEUROPEIN; OLIGOMER; OLIVE OIL;

EID: 84874778760     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058893     Document Type: Article
Times cited : (130)

References (53)
  • 1
    • 0036250657 scopus 로고    scopus 로고
    • The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances
    • Sloane PD, Zimmerman S, Suchindran C, Reed P, Wang L, et al. (2002) The public health impact of Alzheimer's disease, 2000-2050: potential implication of treatment advances. Annu Rev Public Health 23: 213-231.
    • (2002) Annu Rev Public Health , vol.23 , pp. 213-231
    • Sloane, P.D.1    Zimmerman, S.2    Suchindran, C.3    Reed, P.4    Wang, L.5
  • 2
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: genes, proteins, and therapy
    • Selkoe DJ, (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81: 741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 3
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ, (2002) Alzheimer's disease is a synaptic failure. Science 298: 789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 4
    • 0038343343 scopus 로고    scopus 로고
    • Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease
    • Ling Y, Morgan K, Kalsheker N, (2003) Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer's disease. Int J Biochem Cell Biol 35: 1505-1535.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 1505-1535
    • Ling, Y.1    Morgan, K.2    Kalsheker, N.3
  • 5
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe DJ, (1991) The molecular pathology of Alzheimer's disease. Neuron 6: 487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 6
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416: 535-539.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5
  • 7
  • 8
    • 17944368176 scopus 로고    scopus 로고
    • The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation
    • Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, et al. (2001) The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci 4: 887-893.
    • (2001) Nat Neurosci , vol.4 , pp. 887-893
    • Nilsberth, C.1    Westlind-Danielsson, A.2    Eckman, C.B.3    Condron, M.M.4    Axelman, K.5
  • 9
    • 0042838303 scopus 로고    scopus 로고
    • Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss
    • Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, et al. (2003) Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc Natl Acad Sci U S A 100: 10417-10422.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10417-10422
    • Gong, Y.1    Chang, L.2    Viola, K.L.3    Lacor, P.N.4    Lambert, M.P.5
  • 10
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, et al. (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440: 352-357.
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesne, S.1    Koh, M.T.2    Kotilinek, L.3    Kayed, R.4    Glabe, C.G.5
  • 11
    • 34250819839 scopus 로고    scopus 로고
    • Intracellular amyloid-beta in Alzheimer's disease
    • LaFerla FM, Green KN, Oddo S, (2007) Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 8: 499-509.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 499-509
    • LaFerla, F.M.1    Green, K.N.2    Oddo, S.3
  • 12
    • 33644850570 scopus 로고    scopus 로고
    • Inclusion-body myositis: clinical, diagnostic, and pathologic aspects
    • Engel WK, Askanas V, (2006) Inclusion-body myositis: clinical, diagnostic, and pathologic aspects. Neurology 66: S20-29.
    • (2006) Neurology , vol.66
    • Engel, W.K.1    Askanas, V.2
  • 13
    • 56749104288 scopus 로고    scopus 로고
    • Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains
    • Askanas V, Engel WK, (2008) Inclusion-body myositis: muscle-fiber molecular pathology and possible pathogenic significance of its similarity to Alzheimer's and Parkinson's disease brains. Acta Neuropathol 116: 583-595.
    • (2008) Acta Neuropathol , vol.116 , pp. 583-595
    • Askanas, V.1    Engel, W.K.2
  • 14
    • 82355175806 scopus 로고    scopus 로고
    • Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis
    • D'Agostino C, Nogalska A, Cacciottolo M, Engel WK, Askanas V, (2011) Abnormalities of NBR1, a novel autophagy-associated protein, in muscle fibers of sporadic inclusion-body myositis. Acta Neuropathol 122: 627-636.
    • (2011) Acta Neuropathol , vol.122 , pp. 627-636
    • D'Agostino, C.1    Nogalska, A.2    Cacciottolo, M.3    Engel, W.K.4    Askanas, V.5
  • 15
    • 33744739867 scopus 로고    scopus 로고
    • Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice
    • Kitazawa M, Green KN, Caccamo A, LaFerla FM, (2006) Genetically augmenting Abeta42 levels in skeletal muscle exacerbates inclusion body myositis-like pathology and motor deficits in transgenic mice. Am J Pathol 168: 1986-1997.
    • (2006) Am J Pathol , vol.168 , pp. 1986-1997
    • Kitazawa, M.1    Green, K.N.2    Caccamo, A.3    LaFerla, F.M.4
  • 16
    • 24344452961 scopus 로고    scopus 로고
    • Phytochemistry: ibuprofen-like activity in extra-virgin olive oil
    • Beauchamp GK, Keast RS, Morel D, Lin J, Pika J, et al. (2005) Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 437: 45-46.
    • (2005) Nature , vol.437 , pp. 45-46
    • Beauchamp, G.K.1    Keast, R.S.2    Morel, D.3    Lin, J.4    Pika, J.5
  • 17
    • 79954571967 scopus 로고    scopus 로고
    • Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    • Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ, (2011) Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature 472: 226-229.
    • (2011) Nature , vol.472 , pp. 226-229
    • Alavez, S.1    Vantipalli, M.C.2    Zucker, D.J.3    Klang, I.M.4    Lithgow, G.J.5
  • 18
    • 79952499466 scopus 로고    scopus 로고
    • Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease
    • Scarmeas N, Luchsinger JA, Stern Y, Gu Y, He J, et al. (2011) Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease. Ann Neurol 69: 257-268.
    • (2011) Ann Neurol , vol.69 , pp. 257-268
    • Scarmeas, N.1    Luchsinger, J.A.2    Stern, Y.3    Gu, Y.4    He, J.5
  • 19
    • 78149231737 scopus 로고    scopus 로고
    • Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis
    • Sofi F, Abbate R, Gensini GF, Casini A, (2010) Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr 92: 1189-1196.
    • (2010) Am J Clin Nutr , vol.92 , pp. 1189-1196
    • Sofi, F.1    Abbate, R.2    Gensini, G.F.3    Casini, A.4
  • 23
    • 59649099426 scopus 로고    scopus 로고
    • Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity
    • Papandreou MA, Dimakopoulou A, Linardaki ZI, Cordopatis P, Klimis-Zacas D, et al. (2009) Effect of a polyphenol-rich wild blueberry extract on cognitive performance of mice, brain antioxidant markers and acetylcholinesterase activity. Behav Brain Res 198: 352-358.
    • (2009) Behav Brain Res , vol.198 , pp. 352-358
    • Papandreou, M.A.1    Dimakopoulou, A.2    Linardaki, Z.I.3    Cordopatis, P.4    Klimis-Zacas, D.5
  • 24
    • 79952796718 scopus 로고    scopus 로고
    • Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways
    • Ladiwala AR, Dordick JS, Tessier PM, (2011) Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathways. J Biol Chem 286: 3209-3218.
    • (2011) J Biol Chem , vol.286 , pp. 3209-3218
    • Ladiwala, A.R.1    Dordick, J.S.2    Tessier, P.M.3
  • 25
    • 67649989131 scopus 로고    scopus 로고
    • Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons
    • Zhu JT, Choi RC, Xie HQ, Zheng KY, Guo AJ, et al. (2009) Hibifolin, a flavonol glycoside, prevents beta-amyloid-induced neurotoxicity in cultured cortical neurons. Neurosci Lett 461: 172-176.
    • (2009) Neurosci Lett , vol.461 , pp. 172-176
    • Zhu, J.T.1    Choi, R.C.2    Xie, H.Q.3    Zheng, K.Y.4    Guo, A.J.5
  • 26
    • 70549096064 scopus 로고    scopus 로고
    • Ellagic acid promotes Abeta42 fibrillization and inhibits Abeta42-induced neurotoxicity
    • Feng Y, Yang SG, Du XT, Zhang X, Sun XX, et al. (2009) Ellagic acid promotes Abeta42 fibrillization and inhibits Abeta42-induced neurotoxicity. Biochem Biophys Res Commun 390: 1250-1254.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 1250-1254
    • Feng, Y.1    Yang, S.G.2    Du, X.T.3    Zhang, X.4    Sun, X.X.5
  • 27
    • 71249124418 scopus 로고    scopus 로고
    • Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation
    • Feng Y, Wang XP, Yang SG, Wang YJ, Zhang X, et al. (2009) Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation. Neurotoxicology 30: 986-995.
    • (2009) Neurotoxicology , vol.30 , pp. 986-995
    • Feng, Y.1    Wang, X.P.2    Yang, S.G.3    Wang, Y.J.4    Zhang, X.5
  • 28
  • 29
    • 82055197196 scopus 로고    scopus 로고
    • Abeta(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon
    • Rigacci S, Guidotti V, Bucciantini M, Nichino D, Relini A, et al. (2011) Abeta(1-42) aggregates into non-toxic amyloid assemblies in the presence of the natural polyphenol oleuropein aglycon. Curr Alzheimer Res 8: 841-852.
    • (2011) Curr Alzheimer Res , vol.8 , pp. 841-852
    • Rigacci, S.1    Guidotti, V.2    Bucciantini, M.3    Nichino, D.4    Relini, A.5
  • 30
    • 79953707326 scopus 로고    scopus 로고
    • Oleuropein and derivatives from olives as Tau aggregation inhibitors
    • Daccache A, Lion C, Sibille N, Gerard M, Slomianny C, et al. (2011) Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem Int 58: 700-707.
    • (2011) Neurochem Int , vol.58 , pp. 700-707
    • Daccache, A.1    Lion, C.2    Sibille, N.3    Gerard, M.4    Slomianny, C.5
  • 31
    • 84857497814 scopus 로고    scopus 로고
    • Tannic acid is a natural beta-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice
    • Mori T, Rezai-Zadeh K, Koyama N, Arendash GW, Yamaguchi H, et al. (2012) Tannic acid is a natural beta-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J Biol Chem 287: 6912-6927.
    • (2012) J Biol Chem , vol.287 , pp. 6912-6927
    • Mori, T.1    Rezai-Zadeh, K.2    Koyama, N.3    Arendash, G.W.4    Yamaguchi, H.5
  • 32
    • 60249098801 scopus 로고    scopus 로고
    • Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
    • Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, et al. (2009) Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int 54: 111-118.
    • (2009) Neurochem Int , vol.54 , pp. 111-118
    • Karuppagounder, S.S.1    Pinto, J.T.2    Xu, H.3    Chen, H.L.4    Beal, M.F.5
  • 33
    • 44249116000 scopus 로고    scopus 로고
    • Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice
    • Rezai-Zadeh K, Arendash GW, Hou H, Fernandez F, Jensen M, et al. (2008) Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice. Brain Res 1214: 177-187.
    • (2008) Brain Res , vol.1214 , pp. 177-187
    • Rezai-Zadeh, K.1    Arendash, G.W.2    Hou, H.3    Fernandez, F.4    Jensen, M.5
  • 35
    • 48349093043 scopus 로고    scopus 로고
    • Localization of the noncovalent binding site between amyloid-beta-peptide and oleuropein using electrospray ionization FT-ICR mass spectrometry
    • Bazoti FN, Bergquist J, Markides K, Tsarbopoulos A, (2008) Localization of the noncovalent binding site between amyloid-beta-peptide and oleuropein using electrospray ionization FT-ICR mass spectrometry. J Am Soc Mass Spectrom 19: 1078-1085.
    • (2008) J Am Soc Mass Spectrom , vol.19 , pp. 1078-1085
    • Bazoti, F.N.1    Bergquist, J.2    Markides, K.3    Tsarbopoulos, A.4
  • 36
    • 70349241517 scopus 로고    scopus 로고
    • Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal
    • Pitt J, Roth W, Lacor P, Smith AB 3rd, Blankenship M, et al (2009) Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol 240: 189-197.
    • (2009) Toxicol Appl Pharmacol , vol.240 , pp. 189-197
    • Pitt, J.1    Roth, W.2    Lacor, P.3    Smith 3rd, A.B.4    Blankenship, M.5
  • 38
    • 33645125772 scopus 로고    scopus 로고
    • Noncovalent interaction between amyloid-beta-peptide (1-40) and oleuropein studied by electrospray ionization mass spectrometry
    • Bazoti FN, Bergquist J, Markides KE, Tsarbopoulos A, (2006) Noncovalent interaction between amyloid-beta-peptide (1-40) and oleuropein studied by electrospray ionization mass spectrometry. J Am Soc Mass Spectrom 17: 568-575.
    • (2006) J Am Soc Mass Spectrom , vol.17 , pp. 568-575
    • Bazoti, F.N.1    Bergquist, J.2    Markides, K.E.3    Tsarbopoulos, A.4
  • 39
    • 77954661025 scopus 로고    scopus 로고
    • Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin
    • Rigacci S, Guidotti V, Bucciantini M, Parri M, Nediani C, et al. (2010) Oleuropein aglycon prevents cytotoxic amyloid aggregation of human amylin. J Nutr Biochem 21: 726-735.
    • (2010) J Nutr Biochem , vol.21 , pp. 726-735
    • Rigacci, S.1    Guidotti, V.2    Bucciantini, M.3    Parri, M.4    Nediani, C.5
  • 40
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans
    • Link CD, (1995) Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci U S A 92: 9368-9372.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9368-9372
    • Link, C.D.1
  • 41
    • 17644382712 scopus 로고    scopus 로고
    • Invertebrate models of Alzheimer's disease
    • Link CD, (2005) Invertebrate models of Alzheimer's disease. Genes Brain Behav 4: 147-156.
    • (2005) Genes Brain Behav , vol.4 , pp. 147-156
    • Link, C.D.1
  • 42
    • 33845613251 scopus 로고    scopus 로고
    • Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    • Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, et al. (2006) Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 26: 13102-13113.
    • (2006) J Neurosci , vol.26 , pp. 13102-13113
    • Wu, Y.1    Wu, Z.2    Butko, P.3    Christen, Y.4    Lambert, M.P.5
  • 43
    • 69249153430 scopus 로고    scopus 로고
    • The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42
    • McColl G, Roberts BR, Gunn AP, Perez KA, Tew DJ, et al. (2009) The Caenorhabditis elegans A beta 1-42 model of Alzheimer disease predominantly expresses A beta 3-42. J Biol Chem 284: 22697-22702.
    • (2009) J Biol Chem , vol.284 , pp. 22697-22702
    • McColl, G.1    Roberts, B.R.2    Gunn, A.P.3    Perez, K.A.4    Tew, D.J.5
  • 44
    • 33644887168 scopus 로고    scopus 로고
    • Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract
    • Luo Y, (2006) Alzheimer's disease, the nematode Caenorhabditis elegans, and ginkgo biloba leaf extract. Life Sci 78: 2066-2072.
    • (2006) Life Sci , vol.78 , pp. 2066-2072
    • Luo, Y.1
  • 45
    • 26444582959 scopus 로고    scopus 로고
    • Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans
    • Gutierrez-Zepeda A, Santell R, Wu Z, Brown M, Wu Y, et al. (2005) Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans. BMC Neurosci 6: 54.
    • (2005) BMC Neurosci , vol.6 , pp. 54
    • Gutierrez-Zepeda, A.1    Santell, R.2    Wu, Z.3    Brown, M.4    Wu, Y.5
  • 46
    • 70349253896 scopus 로고    scopus 로고
    • Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans
    • Morita M, Osoda K, Yamazaki M, Shirai F, Matsuoka N, et al. (2009) Effects of non-steroidal anti-inflammatory drugs on Abeta deposition in Abeta(1-42) transgenic C. elegans. Brain Res 1295: 186-191.
    • (2009) Brain Res , vol.1295 , pp. 186-191
    • Morita, M.1    Osoda, K.2    Yamazaki, M.3    Shirai, F.4    Matsuoka, N.5
  • 47
    • 78650104379 scopus 로고    scopus 로고
    • Tetracycline and its analogues protect Caenorhabditis elegans from beta amyloid-induced toxicity by targeting oligomers
    • Diomede L, Cassata G, Fiordaliso F, Salio M, Ami D, et al. (2010) Tetracycline and its analogues protect Caenorhabditis elegans from beta amyloid-induced toxicity by targeting oligomers. Neurobiol Dis 40: 424-431.
    • (2010) Neurobiol Dis , vol.40 , pp. 424-431
    • Diomede, L.1    Cassata, G.2    Fiordaliso, F.3    Salio, M.4    Ami, D.5
  • 48
    • 0036725918 scopus 로고    scopus 로고
    • Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans
    • Wu Z, Smith JV, Paramasivam V, Butko P, Khan I, et al. (2002) Ginkgo biloba extract EGb 761 increases stress resistance and extends life span of Caenorhabditis elegans. Cell Mol Biol (Noisy-le-grand) 48: 725-731.
    • (2002) Cell Mol Biol (Noisy-Le-Grand) , vol.48 , pp. 725-731
    • Wu, Z.1    Smith, J.V.2    Paramasivam, V.3    Butko, P.4    Khan, I.5
  • 49
    • 0035109444 scopus 로고    scopus 로고
    • Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
    • Link CD, Johnson CJ, Fonte V, Paupard M, Hall DH, et al. (2001) Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging 22: 217-226.
    • (2001) Neurobiol Aging , vol.22 , pp. 217-226
    • Link, C.D.1    Johnson, C.J.2    Fonte, V.3    Paupard, M.4    Hall, D.H.5
  • 50
    • 77954643863 scopus 로고    scopus 로고
    • Oleuropein in olive and its pharmacological effects
    • Omar SH, (2010) Oleuropein in olive and its pharmacological effects. Sci Pharm 78: 133-154.
    • (2010) Sci Pharm , vol.78 , pp. 133-154
    • Omar, S.H.1
  • 51
    • 78049290389 scopus 로고    scopus 로고
    • Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity
    • Stefani M, (2010) Biochemical and biophysical features of both oligomer/fibril and cell membrane in amyloid cytotoxicity. FEBS J 277: 4602-4613.
    • (2010) FEBS J , vol.277 , pp. 4602-4613
    • Stefani, M.1
  • 52
    • 79954437554 scopus 로고    scopus 로고
    • Inhibition and disaggregation of alpha-synuclein oligomers by natural polyphenolic compounds
    • Caruana M, Hogen T, Levin J, Hillmer A, Giese A, et al. (2011) Inhibition and disaggregation of alpha-synuclein oligomers by natural polyphenolic compounds. FEBS Lett 585: 1113-1120.
    • (2011) FEBS Lett , vol.585 , pp. 1113-1120
    • Caruana, M.1    Hogen, T.2    Levin, J.3    Hillmer, A.4    Giese, A.5
  • 53
    • 45549095784 scopus 로고    scopus 로고
    • Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease
    • Bastianetto S, Krantic S, Quirion R, (2008) Polyphenols as potential inhibitors of amyloid aggregation and toxicity: possible significance to Alzheimer's disease. Mini Rev Med Chem 8: 429-435.
    • (2008) Mini Rev Med Chem , vol.8 , pp. 429-435
    • Bastianetto, S.1    Krantic, S.2    Quirion, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.