A small-molecule screen in C. elegans yields a new calcium channel antagonist

Nature

Volumn 441, Issue 1, 2006, Pages 91-95

  Kwok, Trevor C Y ^a   Ricker, Nicole ^a   Fraser, Regina ^b   Chan, Allen W ^a   Burns, Andrew ^a   Stanley, Elise F ^a   McCourt, Peter ^b   Cutler, Sean R ^b   Roy, Peter J ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME IMMOBILIZATION; GENETIC ENGINEERING; MORPHOLOGY; NITROGEN COMPOUNDS; BIOASSAY; CALCIUM; GENES; MOLECULES;

PHENOTYPES; TARGET IDENTIFICATION; ANTI-HYPERTENSION DRUGS; BIOACTIVITY; CALCIUM CHANNEL ANTAGONIST;

PROTEINS;

1,4 DIHYDROPYRIDINE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL L TYPE ALPHA1; FELODIPINE; NEMADIPINE A; NEMADIPINE B; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; AMLODIPINE; ANTIHYPERTENSIVE AGENT; BEPRIDIL; DILTIAZEM; IMIPRAMINE; NICARDIPINE; NIFEDIPINE; NIMODIPINE; NITRENDIPINE; VERAPAMIL; NEMADIPINE-A; PYRIDINE DERIVATIVE;

DRUG DEVELOPMENT; NEMATODE; ORGANIC NITROGEN COMPOUND; PHENOTYPE; PROTEIN; VERTEBRATE; ANTAGONISM; BIOACTIVITY; BIOLOGICAL ANALYSIS; DRUG; EGG PRODUCTION; INHIBITOR; MORPHOLOGY;

ARTICLE; CAENORHABDITIS ELEGANS; DRUG IDENTIFICATION; DRUG SCREENING; DRUG STRUCTURE; EGG LAYING; EGL 19 GENE; GENE; GENE FUNCTION; GENE REPRESSION; GENETIC SCREENING; NONHUMAN; ORTHOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; STRUCTURE ANALYSIS; ANIMAL EXPERIMENT; CONTROLLED STUDY; DRUG ACTIVITY; GENE INTERACTION; GENOME; MOLECULE; MORPHOLOGY; PROTEIN TARGETING; REPRODUCTIVE TOXICITY; SCREENING; TERATOGENESIS; VERTEBRATE; WILD TYPE; WORM; ANIMAL; CHEMISTRY; DRUG EFFECT; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; PHYSIOLOGY; PRENATAL DEVELOPMENT;

CAENORHABDITIS ELEGANS; VERTEBRATA;

ANIMALS; CAENORHABDITIS ELEGANS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DRUG EVALUATION, PRECLINICAL; FELODIPINE; OVIPOSITION; PHENOTYPE; PYRIDINES;

EID: 33646933785     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature04657     Document Type: Article

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