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Volumn 41, Issue 11, 2016, Pages 2836-2847

Effects of a Standardized Phenolic-Enriched Maple Syrup Extract on β-Amyloid Aggregation, Neuroinflammation in Microglial and Neuronal Cells, and β-Amyloid Induced Neurotoxicity in Caenorhabditis elegans

Author keywords

Alzheimer s disease; Amyloid 1 42; Caenorhabditis elegans; Maple syrup phenolics; Neuroinflammation; Neuroprotective

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; INTERLEUKIN 6; MAPLE SYRUP EXTRACT; NEUROPROTECTIVE AGENT; PLANT EXTRACT; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; LIPOPOLYSACCHARIDE; PHENOL DERIVATIVE; POLYPHENOL;

EID: 84978858036     PISSN: 03643190     EISSN: 15736903     Source Type: Journal    
DOI: 10.1007/s11064-016-1998-6     Document Type: Article
Times cited : (32)

References (42)
  • 1
    • 0034612148 scopus 로고    scopus 로고
    • Inflammatory hypotheses: novel mechanisms of Alzheimer’s neurodegeneration and new therapeutic targets?
    • PID: 10858591
    • Praticò D, Trojanowski JQ (2000) Inflammatory hypotheses: novel mechanisms of Alzheimer’s neurodegeneration and new therapeutic targets? Neurobiol Aging 21:441–445
    • (2000) Neurobiol Aging , vol.21 , pp. 441-445
    • Praticò, D.1    Trojanowski, J.Q.2
  • 2
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
    • COI: 1:CAS:528:DC%2BD28XhtlemtL7M, PID: 17180163
    • Block ML, Zecca L, Hong J-S (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57–69
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.-S.3
  • 3
    • 33847613885 scopus 로고    scopus 로고
    • Inflammatory processes in Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD2sXislejtLo%3D, PID: 17222916
    • Heneka MT, O’Banion MK (2007) Inflammatory processes in Alzheimer’s disease. J Neuroimmunol 184:69–91
    • (2007) J Neuroimmunol , vol.184 , pp. 69-91
    • Heneka, M.T.1    O’Banion, M.K.2
  • 4
    • 84875354777 scopus 로고    scopus 로고
    • 2013 Alzheimer’s disease facts and figures
    • Alzheimer’s Association (2013) 2013 Alzheimer’s disease facts and figures. Alzheimers Dement 9:208–245
    • (2013) Alzheimers Dement , vol.9 , pp. 208-245
  • 5
    • 0036250657 scopus 로고    scopus 로고
    • The public health impact of Alzheimer’s disease, 2000–2050: potential implication of treatment advances
    • PID: 11910061
    • Sloane PD, Zimmerman S, Suchindran C, Reed P, Wang L, Boustani M, Sudha S (2002) The public health impact of Alzheimer’s disease, 2000–2050: potential implication of treatment advances. Annu Rev Public Health 23:213–231
    • (2002) Annu Rev Public Health , vol.23 , pp. 213-231
    • Sloane, P.D.1    Zimmerman, S.2    Suchindran, C.3    Reed, P.4    Wang, L.5    Boustani, M.6    Sudha, S.7
  • 6
    • 0026597063 scopus 로고
    • Alzheimer’s disease: the amyloid cascade hypothesis
    • COI: 1:CAS:528:DyaK38Xitlarurg%3D, PID: 1566067
    • Hardy JA, Higgins GA (1992) Alzheimer’s disease: the amyloid cascade hypothesis. Science 256:184–185
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 7
    • 0027333557 scopus 로고
    • Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide
    • COI: 1:CAS:528:DyaK2cXnsVeksQ%3D%3D, PID: 8261505
    • Haass C, Selkoe DJ (1993) Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75:1039–1042
    • (1993) Cell , vol.75 , pp. 1039-1042
    • Haass, C.1    Selkoe, D.J.2
  • 8
    • 80053971718 scopus 로고    scopus 로고
    • Current and emerging drug treatment options for Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3MXhs1SlsbbI, PID: 21985169
    • Herrmann N, Chau SA, Kircanski I, Lanctôt KL (2011) Current and emerging drug treatment options for Alzheimer’s disease. Drugs 71:2031–2065
    • (2011) Drugs , vol.71 , pp. 2031-2065
    • Herrmann, N.1    Chau, S.A.2    Kircanski, I.3    Lanctôt, K.L.4
  • 10
    • 77349084360 scopus 로고    scopus 로고
    • Naturally occurring phytochemicals for the prevention of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BC3cXjsFaku74%3D, PID: 20050972
    • Kim J, Lee HJ, Lee KW (2010) Naturally occurring phytochemicals for the prevention of Alzheimer’s disease. J Neurochem 112:1415–1430
    • (2010) J Neurochem , vol.112 , pp. 1415-1430
    • Kim, J.1    Lee, H.J.2    Lee, K.W.3
  • 11
    • 58149127262 scopus 로고    scopus 로고
    • Recent advances in berry supplementation and age-related cognitive decline
    • COI: 1:CAS:528:DC%2BD1cXhsVKntLnJ, PID: 19057194
    • Willis LM, Shukitt-Hale B, Joseph JA (2009) Recent advances in berry supplementation and age-related cognitive decline. Curr Opin Clin Nutr Metab Care 12:91–94
    • (2009) Curr Opin Clin Nutr Metab Care , vol.12 , pp. 91-94
    • Willis, L.M.1    Shukitt-Hale, B.2    Joseph, J.A.3
  • 13
    • 84877120241 scopus 로고    scopus 로고
    • Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies
    • COI: 1:CAS:528:DC%2BC3sXis1Slt7g%3D
    • Abuznait AH, Qosa H, Busnena BA, El Sayed KA, Kaddoumi A (2013) Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies. ACS Cheml Neurosci 4:973–982
    • (2013) ACS Cheml Neurosci , vol.4 , pp. 973-982
    • Abuznait, A.H.1    Qosa, H.2    Busnena, B.A.3    El Sayed, K.A.4    Kaddoumi, A.5
  • 14
    • 46749123053 scopus 로고    scopus 로고
    • Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer’s disease
    • COI: 1:CAS:528:DC%2BD1cXotVegt70%3D, PID: 18562609
    • Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB, Pasinetti GM (2008) Grape-derived polyphenolics prevent Aβ oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer’s disease. J Neurosci 28:6388–6392
    • (2008) J Neurosci , vol.28 , pp. 6388-6392
    • Wang, J.1    Ho, L.2    Zhao, W.3    Ono, K.4    Rosensweig, C.5    Chen, L.6    Humala, N.7    Teplow, D.B.8    Pasinetti, G.M.9
  • 15
    • 84883300370 scopus 로고    scopus 로고
    • Dietary bioactive compounds and their health implications
    • COI: 1:CAS:528:DC%2BC3sXhtFejtrjN, PID: 23789932
    • Liu RH (2013) Dietary bioactive compounds and their health implications. J Food Sci 78(Suppl 1):A18–A25
    • (2013) J Food Sci , vol.78 , Issue.1 , pp. A18-A25
    • Liu, R.H.1
  • 16
    • 35148844594 scopus 로고    scopus 로고
    • The chemical composition of maple syrup
    • COI: 1:CAS:528:DC%2BD2sXhtVCltLvP
    • Ball DW (2007) The chemical composition of maple syrup. J Chem Edu 84:1647–1650
    • (2007) J Chem Edu , vol.84 , pp. 1647-1650
    • Ball, D.W.1
  • 17
    • 38849155698 scopus 로고    scopus 로고
    • High-performance liquid chromatography characterization and identification of antioxidant polyphenols in maple syrup
    • COI: 1:CAS:528:DC%2BD1cXhtlOrt7w%3D
    • Abou-Zaid MM, Nozzolillo C, Tonon A, Coppens M, Lombardo DA (2008) High-performance liquid chromatography characterization and identification of antioxidant polyphenols in maple syrup. Pharm Biol 46:117–125
    • (2008) Pharm Biol , vol.46 , pp. 117-125
    • Abou-Zaid, M.M.1    Nozzolillo, C.2    Tonon, A.3    Coppens, M.4    Lombardo, D.A.5
  • 18
    • 79952277374 scopus 로고    scopus 로고
    • Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compounds
    • COI: 1:CAS:528:DC%2BC3cXhtlGktL7F, PID: 21033720
    • Li L, Seeram NP (2010) Maple syrup phytochemicals include lignans, coumarins, a stilbene, and other previously unreported antioxidant phenolic compounds. J Agric Food Chem 58:11673–11679
    • (2010) J Agric Food Chem , vol.58 , pp. 11673-11679
    • Li, L.1    Seeram, N.P.2
  • 19
    • 79960579948 scopus 로고    scopus 로고
    • Further investigation into maple syrup yields 3 new lignans, a new phenylpropanoid, and 26 other phytochemicals
    • COI: 1:CAS:528:DC%2BC3MXnslKisLs%3D, PID: 21675726
    • Li L, Seeram NP (2011) Further investigation into maple syrup yields 3 new lignans, a new phenylpropanoid, and 26 other phytochemicals. J Agric Food Chem 59:7708–7716
    • (2011) J Agric Food Chem , vol.59 , pp. 7708-7716
    • Li, L.1    Seeram, N.P.2
  • 20
    • 84955062761 scopus 로고    scopus 로고
    • A Maple Syrup extract prevents β-amyloid aggregation
    • PID: 26336085
    • Hawco CL, Wang Y, Taylor M, Weaver DF (2016) A Maple Syrup extract prevents β-amyloid aggregation. Can J Neurol Sci 43(1):198–201
    • (2016) Can J Neurol Sci , vol.43 , Issue.1 , pp. 198-201
    • Hawco, C.L.1    Wang, Y.2    Taylor, M.3    Weaver, D.F.4
  • 21
    • 84969253103 scopus 로고    scopus 로고
    • Maple syrup decreases TDP-43 proteotoxicity in a Caenorhabditis elegans model of amyotrophic lateral sclerosis (ALS)
    • COI: 1:CAS:528:DC%2BC28XlvVaitrg%3D, PID: 27071850
    • Aaron C, Beaudry G, Parker JA, Therrien M (2016) Maple syrup decreases TDP-43 proteotoxicity in a Caenorhabditis elegans model of amyotrophic lateral sclerosis (ALS). J Agric Food Chem 64:3338–3344
    • (2016) J Agric Food Chem , vol.64 , pp. 3338-3344
    • Aaron, C.1    Beaudry, G.2    Parker, J.A.3    Therrien, M.4
  • 22
    • 84904438995 scopus 로고    scopus 로고
    • Chemical compositional, biological, and safety studies of a novel maple syrup derived extract for nutraceutical applications
    • COI: 1:CAS:528:DC%2BC2cXhtVyit7rL, PID: 24983789
    • Zhang Y, Yuan T, Li L, Nahar P, Slitt A, Seeram NP (2014) Chemical compositional, biological, and safety studies of a novel maple syrup derived extract for nutraceutical applications. J Agric Food Chem 62:6687–6698
    • (2014) J Agric Food Chem , vol.62 , pp. 6687-6698
    • Zhang, Y.1    Yuan, T.2    Li, L.3    Nahar, P.4    Slitt, A.5    Seeram, N.P.6
  • 23
    • 84895070383 scopus 로고    scopus 로고
    • Phenolic mediated anti-inflammatory properties of a maple syrup extract in RAW 264.7 murine macrophages
    • COI: 1:CAS:528:DC%2BC3sXhslWltbzJ
    • Nahar PP, Driscoll MV, Li L, Slitt AL, Seeram NP (2014) Phenolic mediated anti-inflammatory properties of a maple syrup extract in RAW 264.7 murine macrophages. J Funct Foods 6:126–136
    • (2014) J Funct Foods , vol.6 , pp. 126-136
    • Nahar, P.P.1    Driscoll, M.V.2    Li, L.3    Slitt, A.L.4    Seeram, N.P.5
  • 24
    • 84955570396 scopus 로고    scopus 로고
    • Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, iIts ellagitannin-gut microbial derived metabolites
    • COI: 1:CAS:528:DC%2BC2MXhvVSlsLfJ, PID: 26559394
    • Yuan T, Ma H, Liu W, Niesen DB, Shah N, Crews R, Rose KN, Vattem DA, Seeram NP (2016) Pomegranate’s neuroprotective effects against Alzheimer’s disease are mediated by urolithins, iIts ellagitannin-gut microbial derived metabolites. ACS Chem Neurosci 7:26–33
    • (2016) ACS Chem Neurosci , vol.7 , pp. 26-33
    • Yuan, T.1    Ma, H.2    Liu, W.3    Niesen, D.B.4    Shah, N.5    Crews, R.6    Rose, K.N.7    Vattem, D.A.8    Seeram, N.P.9
  • 25
    • 84959318492 scopus 로고    scopus 로고
    • Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity
    • COI: 1:CAS:528:DC%2BC28XhtF2msL0%3D, PID: 26815043
    • Das S, Stark L, Musgrave IF, Pukala T, Smid SD (2016) Bioactive polyphenol interactions with β amyloid: a comparison of binding modelling, effects on fibril and aggregate formation and neuroprotective capacity. Food Funct 7:1138–1146
    • (2016) Food Funct , vol.7 , pp. 1138-1146
    • Das, S.1    Stark, L.2    Musgrave, I.F.3    Pukala, T.4    Smid, S.D.5
  • 26
    • 54049103538 scopus 로고    scopus 로고
    • Polyphenol-induced dissociation of various amyloid fibrils results in a methionine-independent formation of ROS
    • COI: 1:CAS:528:DC%2BD1cXht12kur%2FJ, PID: 18778797
    • Shoval H, Weiner L, Gazit E, Levy M, Pinchuk I, Lichtenberg D (2008) Polyphenol-induced dissociation of various amyloid fibrils results in a methionine-independent formation of ROS. Biochim Biophys Acta 1784:1570–1577
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 1570-1577
    • Shoval, H.1    Weiner, L.2    Gazit, E.3    Levy, M.4    Pinchuk, I.5    Lichtenberg, D.6
  • 27
    • 33750686583 scopus 로고    scopus 로고
    • Amyloid fibrils formation and amorphous aggregation in concanavalin A
    • COI: 1:CAS:528:DC%2BD28Xht1SgsrjN, PID: 16934387
    • Vetri V, Canale C, Relini A, Librizzi F, Militello V, Gliozzi A, Leone M (2007) Amyloid fibrils formation and amorphous aggregation in concanavalin A. Biophys Chem 125:184–190
    • (2007) Biophys Chem , vol.125 , pp. 184-190
    • Vetri, V.1    Canale, C.2    Relini, A.3    Librizzi, F.4    Militello, V.5    Gliozzi, A.6    Leone, M.7
  • 28
    • 84930942494 scopus 로고    scopus 로고
    • Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK pathway in human breast cancer MCF-7 cells
    • COI: 1:CAS:528:DC%2BC2MXptFShtrc%3D, PID: 26006730
    • Song X, Wei Z, Shaikh ZA (2015) Requirement of ERα and basal activities of EGFR and Src kinase in Cd-induced activation of MAPK/ERK pathway in human breast cancer MCF-7 cells. Toxicol Appl Pharmacol 287:26–34
    • (2015) Toxicol Appl Pharmacol , vol.287 , pp. 26-34
    • Song, X.1    Wei, Z.2    Shaikh, Z.A.3
  • 29
    • 79551493048 scopus 로고    scopus 로고
    • Conditioned media from cell lines: a complementary model to clinical specimens for the discovery of disease-specific biomarkers
    • COI: 1:CAS:528:DC%2BC3MXhsVSnu7Y%3D, PID: 21229588
    • Dowling P, Clynes M (2011) Conditioned media from cell lines: a complementary model to clinical specimens for the discovery of disease-specific biomarkers. Proteomics 11:794–804
    • (2011) Proteomics , vol.11 , pp. 794-804
    • Dowling, P.1    Clynes, M.2
  • 30
    • 79956260639 scopus 로고    scopus 로고
    • Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation
    • COI: 1:CAS:528:DC%2BC3MXmsVWktL0%3D, PID: 21524691
    • Wang S, Wang H, Guo H, Kang L, Gao X, Hu L (2011) Neuroprotection of Scutellarin is mediated by inhibition of microglial inflammatory activation. Neuroscience 185:150–160
    • (2011) Neuroscience , vol.185 , pp. 150-160
    • Wang, S.1    Wang, H.2    Guo, H.3    Kang, L.4    Gao, X.5    Hu, L.6
  • 33
    • 84929353020 scopus 로고    scopus 로고
    • Chitosan oligosaccharides inhibit/disaggregate fibrils and attenuate amyloid β-mediated neurotoxicity
    • COI: 1:CAS:528:DC%2BC2MXht1eitLjM, PID: 26006224
    • Dai X, Hou W, Sun Y, Gao Z, Zhu S, Jiang Z (2015) Chitosan oligosaccharides inhibit/disaggregate fibrils and attenuate amyloid β-mediated neurotoxicity. Int J Mol Sci 16:10526–10536
    • (2015) Int J Mol Sci , vol.16 , pp. 10526-10536
    • Dai, X.1    Hou, W.2    Sun, Y.3    Gao, Z.4    Zhu, S.5    Jiang, Z.6
  • 34
    • 84857395835 scopus 로고    scopus 로고
    • Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells
    • COI: 1:CAS:528:DC%2BC38XjsVartbo%3D, PID: 22363816
    • Zhong L-M, Zong Y, Sun L, Guo J-Z, Zhang W, He Y, Song R, Wang W-M, Xiao C-J, Lu D (2012) Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells. PloS One 7:e32195
    • (2012) PloS One , vol.7
    • Zhong, L.-M.1    Zong, Y.2    Sun, L.3    Guo, J.-Z.4    Zhang, W.5    He, Y.6    Song, R.7    Wang, W.-M.8    Xiao, C.-J.9    Lu, D.10
  • 35
    • 79952229315 scopus 로고    scopus 로고
    • San-Huang-Xie-Xin-Tang protects against activated microglia- and 6-OHDA-induced toxicity in neuronal SH-SY5Y cells
    • PID: 19339484
    • Shih Y-T, Chen I-J, Wu Y-C, Lo Y-C (2011) San-Huang-Xie-Xin-Tang protects against activated microglia- and 6-OHDA-induced toxicity in neuronal SH-SY5Y cells. Evid Based Complement Alternat Med 2011:429384
    • (2011) Evid Based Complement Alternat Med , vol.2011 , pp. 429384
    • Shih, Y.-T.1    Chen, I.-J.2    Wu, Y.-C.3    Lo, Y.-C.4
  • 36
    • 52449086907 scopus 로고    scopus 로고
    • The insulin paradox: aging, proteotoxicity and neurodegeneration
    • COI: 1:CAS:528:DC%2BD1cXhtFeit7fM, PID: 18769445
    • Cohen E, Dillin A (2008) The insulin paradox: aging, proteotoxicity and neurodegeneration. Nat Rev Neurosci 9:759–767
    • (2008) Nat Rev Neurosci , vol.9 , pp. 759-767
    • Cohen, E.1    Dillin, A.2
  • 37
    • 81855204959 scopus 로고    scopus 로고
    • Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA
    • COI: 1:CAS:528:DC%2BC3MXhsV2rsL3O, PID: 22020115
    • Radak Z, Zhao Z, Goto S, Koltai E (2011) Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA. Mol Aspects Med 32:305–315
    • (2011) Mol Aspects Med , vol.32 , pp. 305-315
    • Radak, Z.1    Zhao, Z.2    Goto, S.3    Koltai, E.4
  • 40
    • 84930182350 scopus 로고    scopus 로고
    • Neuroprotective effects of dried camu-camu (Myrciaria dubia HBK McVaugh) residue in C. elegans
    • Azevêdo JC, Borges KC, Genovese MI, Correia RT, Vattem DA (2015) Neuroprotective effects of dried camu-camu (Myrciaria dubia HBK McVaugh) residue in C. elegans. Food Res Int 73:135–141
    • (2015) Food Res Int , vol.73 , pp. 135-141
    • Azevêdo, J.C.1    Borges, K.C.2    Genovese, M.I.3    Correia, R.T.4    Vattem, D.A.5
  • 41
    • 33845613251 scopus 로고    scopus 로고
    • Amyloid-β-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BD2sXhs1Cnsw%3D%3D, PID: 17167099
    • Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y (2006) Amyloid-β-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 26:13102–13113
    • (2006) J Neurosci , vol.26 , pp. 13102-13113
    • Wu, Y.1    Wu, Z.2    Butko, P.3    Christen, Y.4    Lambert, M.P.5    Klein, W.L.6    Link, C.D.7    Luo, Y.8
  • 42
    • 78951482261 scopus 로고    scopus 로고
    • Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity
    • COI: 1:CAS:528:DC%2BC3cXhsFOnt7nP, PID: 20805557
    • Dostal V, Roberts CM, Link CD (2010) Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of β-amyloid peptide toxicity. Genetics 186:857–866
    • (2010) Genetics , vol.186 , pp. 857-866
    • Dostal, V.1    Roberts, C.M.2    Link, C.D.3


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