FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on Cbp and protect against proteotoxicity

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Lublin, Alex ^a   Isoda, Fumiko ^a   Patel, Harshil ^a   Yen, Kelvin ^b   Nguyen, Linda ^a   Hajje, Daher ^a   Schwartz, Marc ^a   Mobbs, Charles ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; AMINOBENZOIC ACID; AMINOGLUTETHIMIDE; AMINOSALICYLIC ACID; AMPROLIUM; BACITRACIN; BAICALEIN; BERBAMINE; BETAMETHASONE; BITHIONOL; BUSULFAN; CAFFEINE; CHLORZOXAZONE; CICLOPIROXOLAMINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESCULIN; ETODOLAC; FENBUFEN; HYDRALAZINE; METACYCLINE; PARACETAMOL; PHENAZONE; PINDOLOL; PIPERINE; PROTIONAMIDE; TANNIN; THIOURACIL; TOLAZAMIDE; TRANSCRIPTION FACTOR DAF 16; UNINDEXED DRUG; CAENORHABDITIS ELEGANS PROTEIN; CBP 1 PROTEIN, C ELEGANS; CBP-1 PROTEIN, C ELEGANS; DAF 16 PROTEIN, C ELEGANS; DAF-16 PROTEIN, C ELEGANS; DRUG; GLUCOSE; HISTONE ACETYLTRANSFERASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR;

AGING; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; HIGH THROUGHPUT SCREENING; LIFESPAN; NEUROPROTECTION; NONHUMAN; RNA INTERFERENCE; ALZHEIMER DISEASE; ANIMAL; CAENORHABDITIS ELEGANS; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; DRUG APPROVAL; DRUG EFFECT; FOOD AND DRUG ADMINISTRATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; NERVE CELL; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSGENIC ANIMAL; UNITED STATES;

CAENORHABDITIS ELEGANS; MAMMALIA;

AGING; ALZHEIMER DISEASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; DISEASE MODELS, ANIMAL; DRUG APPROVAL; GLUCOSE; HISTONE ACETYLTRANSFERASES; HUMANS; NEURONS; PHARMACEUTICAL PREPARATIONS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SURVIVAL RATE; TRANSCRIPTION FACTORS; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 81155134279     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027762     Document Type: Article

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