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Volumn 217, Issue 3-4, 2012, Pages 397-411

Caenorhabditis elegans as a model organism to study APP function

Author keywords

Alzheimer's disease; Apl 1; Beta amyloid; C. elegans; Model system

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; HEPARIN; INSULIN; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PRESENILIN; PROTEIN; PROTEIN APL 1; PROTEIN FEH 1; PROTEIN IGF 1; PROTEIN SEL 12; UNCLASSIFIED DRUG;

EID: 84862834663     PISSN: 00144819     EISSN: 14321106     Source Type: Journal    
DOI: 10.1007/s00221-011-2905-7     Document Type: Review
Times cited : (27)

References (173)
  • 2
    • 79954571967 scopus 로고    scopus 로고
    • Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
    • doi: 10.1038/nature09873
    • Alavez S, Vantipalli MC, Zucker DJ, Klang IM, Lithgow GJ (2011) Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature 472(7342):226-229. doi: 10.1038/nature09873
    • (2011) Nature , vol.472 , Issue.7342 , pp. 226-229
    • Alavez, S.1    Vantipalli, M.C.2    Zucker, D.J.3    Klang, I.M.4    Lithgow, G.J.5
  • 4
    • 0042626242 scopus 로고    scopus 로고
    • SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
    • DOI 10.1101/gad.1107803
    • An JH, Blackwell TK (2003) SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev 17(15):1882-1893. doi:10.1101/gad.11078031107803 (Pubitemid 36944565)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1882-1893
    • An, J.H.1    Blackwell, T.K.2
  • 5
    • 79951528510 scopus 로고    scopus 로고
    • The caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein
    • doi:10.1523/JNEUROSCI.2653-10.2011
    • Arimoto M, Koushika SP, Choudhary BC, Li C, Matsumoto K, Hisamoto N (2011) The Caenorhabditis elegans JIP3 protein UNC-16 functions as an adaptor to link kinesin-1 with cytoplasmic dynein. J Neurosci 31(6):2216-2224. doi:10.1523/JNEUROSCI.2653-10.2011
    • (2011) J Neurosci , vol.31 , Issue.6 , pp. 2216-2224
    • Arimoto, M.1    Koushika, S.P.2    Choudhary, B.C.3    Li, C.4    Matsumoto, K.5    Hisamoto, N.6
  • 6
    • 33644869497 scopus 로고    scopus 로고
    • Inclusion-body myositis: A myodegenerative conformational disorder associated with Aβ, protein misfolding, and proteasome inhibition
    • PII 0000611420060124100007
    • Askanas V, Engel WK (2006) Inclusion-body myositis: a myodegen-erative conformational disorder associated with Abeta, protein misfolding, and proteasome inhibition. Neurology 66(2 Suppl 1):S39-S48. doi:10.1212/01.wnl. 0000192128.13875.1e (Pubitemid 43739983)
    • (2006) Neurology , vol.66 , Issue.2 SUPPL. 1
    • Askanas, V.1    King Engel, W.2
  • 7
    • 0034646141 scopus 로고    scopus 로고
    • αb-crystallin immunolocalization yields new insights into inclusion body myositis
    • Banwell BL, Engel AG (2000) AlphaB-crystallin immunolocalization yields new insights into inclusion body myositis. Neurology 54(5):1033-1041 (Pubitemid 30151842)
    • (2000) Neurology , vol.54 , Issue.5 , pp. 1033-1041
    • Banwell, B.L.1    Engel, A.G.2
  • 8
    • 0026002375 scopus 로고
    • Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans
    • Bargmann CI, Horvitz HR (1991) Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans. Neuron 7(5):729-742
    • (1991) Neuron , vol.7 , Issue.5 , pp. 729-742
    • Bargmann, C.I.1    Horvitz, H.R.2
  • 9
    • 0035082093 scopus 로고    scopus 로고
    • Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans
    • DOI 10.1096/fj.99-0966com
    • Barsyte D, Lovejoy DA, Lithgow GJ (2001) Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. Faseb J 15(3):627-634. doi:10.1096/fj.99-0966com15/3/627 (Pubitemid 32245981)
    • (2001) FASEB Journal , vol.15 , Issue.3 , pp. 627-634
    • Barsyte, D.1    Lovejoy, D.A.2    Lithgow, G.J.3
  • 10
    • 79952787104 scopus 로고    scopus 로고
    • Early-onset familial alzheimer disease
    • Pagon RA, Bird TD, Dolan CR, Stephens K (eds) University of Washington, Seattle
    • Bird TD (2010) Early-onset Familial Alzheimer Disease. In: Pagon RA, Bird TD, Dolan CR, Stephens K (eds) GeneReviews. University of Washington, Seattle. http://www.ncbi.nlm.nih.gov/pubmed/20301414
    • (2010) Gene Reviews
    • Bird, T.D.1
  • 11
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • DOI 10.1126/science.1078223
    • Bluher M, Kahn BB, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299(5606):572-574 (Pubitemid 36135156)
    • (2003) Science , vol.299 , Issue.5606 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3
  • 12
    • 0029805132 scopus 로고    scopus 로고
    • The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein
    • Borg JP, Ooi J, Levy E, Margolis B (1996) The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol Cell Biol 16(11):6229-6241 (Pubitemid 26360983)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.11 , pp. 6229-6241
    • Borg, J.-P.1    Ooi, J.2    Levy, E.3    Margolis, B.4
  • 13
    • 77951093230 scopus 로고    scopus 로고
    • Induction of terminal differentiation in melanoma cells on downregulation of beta-amyloid precursor protein
    • doi:10.1038/jid.2009.296
    • Botelho MG, Wang X, Arndt-Jovin DJ, Becker D, Jovin TM (2010) Induction of terminal differentiation in melanoma cells on downregulation of beta-amyloid precursor protein. J Invest Dermatol 130(5):1400-1410. doi:10.1038/jid.2009.296
    • (2010) J Invest Dermatol , vol.130 , Issue.5 , pp. 1400-1410
    • Botelho, M.G.1    Wang, X.2    Arndt-Jovin, D.J.3    Becker, D.4    Jovin, T.M.5
  • 14
    • 0016063911 scopus 로고
    • The genetics of caenorhabditis elegans
    • Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77(1):71-94
    • (1974) Genetics , vol.77 , Issue.1 , pp. 71-94
    • Brenner, S.1
  • 16
    • 2542519087 scopus 로고    scopus 로고
    • Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone
    • DOI 10.1242/dev.01103
    • Caille I, Allinquant B, Dupont E, Bouillot C, Langer A, Muller U, Prochiantz A (2004) Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development 131(9):2173-2181. doi:10.1242/dev.01103dev.01103 (Pubitemid 38702048)
    • (2004) Development , vol.131 , Issue.9 , pp. 2173-2181
    • Caille, I.1    Allinquant, B.2    Dupont, E.3    Bouillot, C.4    Langer, A.5    Muller, U.6    Prochiantz, A.7
  • 17
    • 58149503769 scopus 로고    scopus 로고
    • Neurotoxic effects induced by the drosophila amyloid-beta peptide suggest a conserved toxic function
    • doi:10.1016/j.nbd.2008. 10.014
    • Carmine-Simmen K, Proctor T, Tschape J, Poeck B, Triphan T, Strauss R, Kretzschmar D (2009) Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function. Neurobiol Dis 33(2):274-281. doi:10.1016/j.nbd.2008. 10.014
    • (2009) Neurobiol Dis , vol.33 , Issue.2 , pp. 274-281
    • Carmine-Simmen, K.1    Proctor, T.2    Tschape, J.3    Poeck, B.4    Triphan, T.5    Strauss, R.6    Kretzschmar, D.7
  • 18
    • 0021923384 scopus 로고
    • The neural circuit for touch sensitivity in Caenorhabditis elegans
    • Chalfie M, Sulston JE, White JG, Southgate E, Thomson JN, Brenner S (1985) The neural circuit for touch sensitivity in Caenorhab-ditis elegans. J Neurosci 5(4):956-964 (Pubitemid 15123043)
    • (1985) Journal of Neuroscience , vol.5 , Issue.4 , pp. 956-964
    • Chalfie, M.1    Sulston, J.E.2    White, J.G.3
  • 19
    • 23444431611 scopus 로고
    • Green fluorescent protein as a marker for gene expression
    • Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC (1994) Green fluorescent protein as a marker for gene expression. Science 263(5148):802-805 (Pubitemid 24093206)
    • (1994) Science , vol.263 , Issue.5148 , pp. 802-805
    • Chalfie, M.1    Tu, Y.2    Euskirchen, G.3    Ward, W.W.4    Prasher, D.C.5
  • 21
    • 0037184062 scopus 로고    scopus 로고
    • Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch
    • doi: 10.1074/jbc.M205093200M205093200
    • Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P (2002) Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch. J Biol Chem 277(39):36521-36526. doi: 10.1074/jbc.M205093200M205093200
    • (2002) J Biol Chem , vol.277 , Issue.39 , pp. 36521-36526
    • Chen, F.1    Gu, Y.2    Hasegawa, H.3    Ruan, X.4    Arawaka, S.5    Fraser, P.6    Westaway, D.7    Mount, H.8    St. George-Hyslop, P.9
  • 23
    • 33748792821 scopus 로고    scopus 로고
    • Opposing activities protect against age-onset proteotoxicity
    • DOI 10.1126/science.1124646
    • Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A (2006) Opposing activities protect against age-onset proteotoxicity. Science 313(5793):1604-1610 (Pubitemid 44414028)
    • (2006) Science , vol.313 , Issue.5793 , pp. 1604-1610
    • Cohen, E.1    Bieschke, J.2    Perciavalle, R.M.3    Kelly, J.W.4    Dillin, A.5
  • 25
    • 77953247518 scopus 로고    scopus 로고
    • Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection
    • doi: 10.1111/j.1474-9726.2009.00541.x
    • Cohen E, Du D, Joyce D, Kapernick EA, Volovik Y, Kelly JW, Dillin A (2010) Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection. Aging Cell 9(2):126-134. doi: 10.1111/j.1474-9726.2009.00541.x
    • (2010) Aging Cell , vol.9 , Issue.2 , pp. 126-134
    • Cohen, E.1    Du, D.2    Joyce, D.3    Kapernick, E.A.4    Volovik, Y.5    Kelly, J.W.6    Dillin, A.7
  • 26
    • 0034639940 scopus 로고    scopus 로고
    • A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes
    • Culetto E, Sattelle DB (2000) A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes. Hum Mol Genet 9(6):869-877. doi:ddd102 (Pubitemid 30216097)
    • (2000) Human Molecular Genetics , vol.9 , Issue.6 , pp. 869-877
    • Culetto, E.1    Sattelle, D.B.2
  • 27
    • 0027333449 scopus 로고
    • Apl-1, a caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor
    • Daigle I, Li C (1993) apl-1, a Caenorhabditis elegans gene encoding a protein related to the human beta-amyloid protein precursor. Proc Natl Acad Sci USA 90(24):12045-12049
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.24 , pp. 12045-12049
    • Daigle, I.1    Li, C.2
  • 28
    • 77049097621 scopus 로고    scopus 로고
    • Behavioral phenotyping of a transgenic caenorhabditis elegans expressing neuronal amyloid-beta
    • doi: 10.3233/JAD-2010-1267
    • Dosanjh LE, Brown MK, Rao G, Link CD, Luo Y (2010) Behavioral phenotyping of a transgenic Caenorhabditis elegans expressing neuronal amyloid-beta. J Alzheimers Dis 19(2):681-690. doi: 10.3233/JAD-2010-1267
    • (2010) J Alzheimers Dis , vol.19 , Issue.2 , pp. 681-690
    • Dosanjh, L.E.1    Brown, M.K.2    Rao, G.3    Link, C.D.4    Luo, Y.5
  • 29
    • 78951482261 scopus 로고    scopus 로고
    • Genetic mechanisms of coffee extract protection in a caenorhabditis elegans model of beta-amyloid peptide toxicity
    • doi: 10.1534/genetics.110.120436
    • Dostal V, Roberts CM, Link CD (2010) Genetic mechanisms of coffee extract protection in a Caenorhabditis elegans model of beta-amyloid peptide toxicity. Genetics 186(3):857-866. doi: 10.1534/genetics.110.120436
    • (2010) Genetics , vol.186 , Issue.3 , pp. 857-866
    • Dostal, V.1    Roberts, C.M.2    Link, C.D.3
  • 30
    • 12244281810 scopus 로고    scopus 로고
    • Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid β-peptide (1-42) in a transgenic Caenorhabditis elegans model
    • DOI 10.1016/S0197-4580(02)00225-7
    • Drake J, Link CD, Butterfield DA (2003) Oxidative stress precedes fibrillar deposition of Alzheimer's disease amyloid beta-peptide (1-42) in a transgenic Caenorhabditis elegans model. Neurobiol Aging 24(3):415-420 (Pubitemid 36210870)
    • (2003) Neurobiology of Aging , vol.24 , Issue.3 , pp. 415-420
    • Drake, J.1    Link, C.D.2    Butterfield, D.A.3
  • 31
    • 38049075304 scopus 로고    scopus 로고
    • Identification of major classes of cholinergic neurons in the nematode caenorhabditis elegans
    • doi:10.1002/cne.21551
    • Duerr JS, Han HP, Fields SD, Rand JB (2008) Identification of major classes of cholinergic neurons in the nematode Caenorhabditis elegans. J Comp Neurol 506(3):398-408. doi:10.1002/cne.21551
    • (2008) J Comp Neurol , vol.506 , Issue.3 , pp. 398-408
    • Duerr, J.S.1    Han, H.P.2    Fields, S.D.3    Rand, J.B.4
  • 32
    • 77950460211 scopus 로고    scopus 로고
    • Understanding the molecular basis of alzheimer's disease using a caenorhabditis elegans model system
    • doi:10.1007/s00429-009-0235-3
    • Ewald CY, Li C (2010) Understanding the molecular basis of Alzheimer's disease using a Caenorhabditis elegans model system. Brain Struct Funct 214(2-3):263-283. doi:10.1007/s00429-009-0235-3
    • (2010) Brain Struct Funct , vol.214 , Issue.2-3 , pp. 263-283
    • Ewald, C.Y.1    Li, C.2
  • 34
    • 35848955910 scopus 로고    scopus 로고
    • Decreased insulin-receptor signaling promotes the autophagic degradation of β-amyloid peptide in C. elegans
    • Florez-McClure ML, Hohsfield LA, Fonte G, Bealor MT, Link CD (2007) Decreased insulin-receptor signaling promotes the auto-phagic degradation of beta-amyloid peptide in C. elegans. Autophagy 3(6):569-580 (Pubitemid 350060053)
    • (2007) Autophagy , vol.3 , Issue.6 , pp. 569-580
    • Florez-McClure, M.L.1    Hohsfield, L.A.2    Fonte, G.3    Bealor, M.T.4    Link, C.D.5
  • 36
    • 38149110518 scopus 로고    scopus 로고
    • Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein
    • Fonte V, Kipp DR, Yerg J III, Merin D, Forrestal M, Wagner E, Roberts CM, Link CD (2008) Suppression of in vivo beta-amyloid peptide toxicity by overexpression of the HSP-16.2 small chaperone protein. J Biol Chem 283(2):784-791
    • (2008) J Biol Chem , vol.283 , Issue.2 , pp. 784-791
    • Fonte, V.1    Kipp, D.R.2    Yerg III, J.3    Merin, D.4    Forrestal, M.5    Wagner, E.6    Roberts, C.M.7    Link, C.D.8
  • 39
    • 79959910328 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells
    • doi:10.1074/jbc.M111.227421
    • Freude KK, Penjwini M, Davis JL, LaFerla FM, Blurton-Jones M (2011) Soluble amyloid precursor protein induces rapid neural differentiation of human embryonic stem cells. J Biol Chem 286(27):24264-24274. doi:10.1074/jbc.M111. 227421
    • (2011) J Biol Chem , vol.286 , Issue.27 , pp. 24264-24274
    • Freude, K.K.1    Penjwini, M.2    Davis, J.L.3    LaFerla, F.M.4    Blurton-Jones, M.5
  • 40
    • 0021207461 scopus 로고
    • Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein
    • Glenner GG, Wong CW (1984) Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122(3):1131-1135 (Pubitemid 14027629)
    • (1984) Biochemical and Biophysical Research Communications , vol.122 , Issue.3 , pp. 1131-1135
    • Glenner, G.G.1    Wong, C.W.2
  • 42
    • 0032055561 scopus 로고    scopus 로고
    • Active currents regulate sensitivity and dynamic range in C. elegans Neurons
    • DOI 10.1016/S0896-6273(00)81014-4
    • Goodman MB, Hall DH, Avery L, Lockery SR (1998) Active currents regulate sensitivity and dynamic range in C. elegans neurons. Neuron 20(4):763-772. doi:S0896-6273(00)81014-4 (Pubitemid 28199054)
    • (1998) Neuron , vol.20 , Issue.4 , pp. 763-772
    • Goodman, M.B.1    Hall, D.H.2    Avery, L.3    Lockery, S.R.4
  • 44
    • 0034080403 scopus 로고    scopus 로고
    • Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
    • Goutte C, Hepler W, Mickey KM, Priess JR (2000) aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127(11):2481-2492 (Pubitemid 30386585)
    • (2000) Development , vol.127 , Issue.11 , pp. 2481-2492
    • Goutte, C.1    Hepler, W.2    Mickey, K.M.3    Priess, J.R.4
  • 45
    • 0027333557 scopus 로고
    • Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide
    • Haass C, Selkoe DJ (1993) Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 75(6):1039-1042
    • (1993) Cell , vol.75 , Issue.6 , pp. 1039-1042
    • Haass, C.1    Selkoe, D.J.2
  • 46
    • 0026735070 scopus 로고
    • Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments
    • doi:10.1038/357500a0
    • Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ (1992) Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature 357(6378):500-503. doi:10.1038/357500a0
    • (1992) Nature , vol.357 , Issue.6378 , pp. 500-503
    • Haass, C.1    Koo, E.H.2    Mellon, A.3    Hung, A.Y.4    Selkoe, D.J.5
  • 48
    • 77955270654 scopus 로고    scopus 로고
    • The nuclear receptor gene nhr-25 plays multiple roles in the caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition
    • doi:10.1016/j.ydbio.2010.05.508
    • Hada K, Asahina M, Hasegawa H, Kanaho Y, Slack FJ, Niwa R (2010) The nuclear receptor gene nhr-25 plays multiple roles in the Caenorhabditis elegans heterochronic gene network to control the larva-to-adult transition. Dev Biol 344(2):1100-1109. doi:10.1016/j.ydbio.2010.05.508
    • (2010) Dev Biol , vol.344 , Issue.2 , pp. 1100-1109
    • Hada, K.1    Asahina, M.2    Hasegawa, H.3    Kanaho, Y.4    Slack, F.J.5    Niwa, R.6
  • 49
    • 67650727585 scopus 로고    scopus 로고
    • AIP-1 ameliorates beta-amyloid peptide toxicity in a caenorhabditis elegans alzheimer's disease model
    • doi:10.1093/hmg/ddp209
    • Hassan WM, Merin DA, Fonte V, Link CD (2009) AIP-1 ameliorates beta-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model. Hum Mol Genet 18(15):2739-2747. doi:10.1093/hmg/ddp209
    • (2009) Hum Mol Genet , vol.18 , Issue.15 , pp. 2739-2747
    • Hassan, W.M.1    Merin, D.A.2    Fonte, V.3    Link, C.D.4
  • 50
    • 33846085944 scopus 로고    scopus 로고
    • The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25
    • DOI 10.1242/dev.02655
    • Hayes GD, Frand AR, Ruvkun G (2006) The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development 133(23):4631-4641. doi:10.1242/dev.02655 (Pubitemid 46063076)
    • (2006) Development , vol.133 , Issue.23 , pp. 4631-4641
    • Hayes, G.D.1    Frand, A.R.2    Ruvkun, G.3
  • 52
    • 8144230876 scopus 로고    scopus 로고
    • Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members
    • DOI 10.1038/sj.emboj.7600390
    • Herms J, Anliker B, Heber S, Ring S, Fuhrmann M, Kretzschmar H, Sisodia S, Muller U (2004) Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J 23(20):4106-4115 (Pubitemid 39472431)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 4106-4115
    • Herms, J.1    Anliker, B.2    Heber, S.3    Ring, S.4    Fuhrmann, M.5    Kretzschmar, H.6    Sisodia, S.7    Muller, U.8
  • 53
    • 0347664057 scopus 로고    scopus 로고
    • IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
    • DOI 10.1038/nature01298
    • Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421(6919): 182-187 (Pubitemid 36090987)
    • (2003) Nature , vol.421 , Issue.6919 , pp. 182-187
    • Holzenberger, M.1    Dupont, J.2    Ducos, B.3    Leneuve, P.4    Geloen, A.5    Even, P.C.6    Cervera, P.7    Le Bouc, Y.8
  • 54
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • Honda Y, Honda S (1999) The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismu-tase gene expression in Caenorhabditis elegans. FASEB J 13(11): 1385-1393 (Pubitemid 29382506)
    • (1999) FASEB Journal , vol.13 , Issue.11 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2
  • 55
    • 76249098107 scopus 로고    scopus 로고
    • Structural characterization of the E2 domain of APL-1, a caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site
    • doi:10.1074/jbc.M109.018432
    • Hoopes JT, Liu X, Xu X, Demeler B, Folta-Stogniew E, Li C, Ha Y (2010) Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site. J Biol Chem 285(3): 2165-2173. doi:10.1074/jbc.M109.018432
    • (2010) J Biol Chem , vol.285 , Issue.3 , pp. 2165-2173
    • Hoopes, J.T.1    Liu, X.2    Xu, X.3    Demeler, B.4    Folta-Stogniew, E.5    Li, C.6    Ha, Y.7
  • 58
    • 0019977293 scopus 로고
    • Serotonin and octopamine in the nematode Caenorhabditis elegans
    • Horvitz HR, Chalfie M, Trent C, Sulston JE, Evans PD (1982) Serotonin and octopamine in the nematode Caenorhabditis elegans. Science 216(4549):1012-1014 (Pubitemid 12025047)
    • (1982) Science , vol.216 , Issue.4549 , pp. 1012-1014
    • Horvitz, H.R.1    Chalfie, M.2    Trent, C.3
  • 59
    • 0023616451 scopus 로고
    • Mutations affecting acetylcholine levels in the nematode Caenorhabditis elegans
    • DOI 10.1111/j.1471-4159.1987.tb02442.x
    • Hosono R, Sassa T, Kuno S (1987) Mutations affecting acetylcholine levels in the nematode Caenorhabditis elegans. J Neurochem 49(6):1820-1823 (Pubitemid 17164641)
    • (1987) Journal of Neurochemistry , vol.49 , Issue.6 , pp. 1820-1823
    • Hosono, R.1    Sassa, T.2    Kuno, S.3
  • 61
    • 0029769923 scopus 로고    scopus 로고
    • Alzheimer amyloid protein precursor is localized in nerve terminal preparations to rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway
    • DOI 10.1074/jbc.271.50.31783
    • Ikin AF, Annaert WG, Takei K, De Camilli P, Jahn R, Greengard P, Buxbaum JD (1996) Alzheimer amyloid protein precursor is localized in nerve terminal preparations to Rab5-containing vesicular organelles distinct from those implicated in the synaptic vesicle pathway. J Biol Chem 271(50):31783-31786 (Pubitemid 26422193)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.50 , pp. 31783-31786
    • Ikin, A.F.1    Annaert, W.G.2    Takei, K.3    De Camilli, P.4    Jahn, R.5    Greengard, P.6    Buxbaum, J.D.7
  • 64
    • 0034075589 scopus 로고    scopus 로고
    • Axonal membrane proteins are transported in distinct carriers: A two- color video microscopy study in cultured hippocampal neurons
    • Kaether C, Skehel P, Dotti CG (2000) Axonal membrane proteins are transported in distinct carriers: a two-color video microscopy study in cultured hippocampal neurons. Mol Biol Cell 11(4): 1213-1224 (Pubitemid 30211025)
    • (2000) Molecular Biology of the Cell , vol.11 , Issue.4 , pp. 1213-1224
    • Kaether, C.1    Skehel, P.2    Dotti, C.G.3
  • 65
    • 0033636136 scopus 로고    scopus 로고
    • Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I
    • doi:S0896-6273(00)00124-0
    • Kamal A, Stokin GB, Yang Z, Xia CH, Goldstein LS (2000) Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I. Neuron 28(2):449-459. doi:S0896-6273(00)00124-0
    • (2000) Neuron , vol.28 , Issue.2 , pp. 449-459
    • Kamal, A.1    Stokin, G.B.2    Yang, Z.3    Xia, C.H.4    Goldstein, L.S.5
  • 66
    • 0023105114 scopus 로고
    • The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
    • DOI 10.1038/325733a0
    • Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B (1987) The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 325(6106):733-736 (Pubitemid 17054046)
    • (1987) Nature , vol.325 , Issue.6106 , pp. 733-736
    • Kang, J.1    Lemaire, H.-G.2    Unterbeck, A.3
  • 67
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • DOI 10.1038/366461a0
    • Kenyon C, Chang J, Gensch E, Rudner A, Tabtiang R (1993) A C. elegans mutant that lives twice as long as wild type. Nature 366(6454):461-464 (Pubitemid 24013878)
    • (1993) Nature , vol.366 , Issue.6454 , pp. 461-464
    • Kenyon, C.1    Chang, J.2    Gensch, E.3    Rudner, A.4    Tabtiang, R.5
  • 68
    • 0033680858 scopus 로고    scopus 로고
    • Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans
    • doi: S0896-6273(00)81196-4
    • Kerr R, Lev-Ram V, Baird G, Vincent P, Tsien RY, Schafer WR (2000) Optical imaging of calcium transients in neurons and pharyngeal muscle of C. elegans. Neuron 26(3):583-594. doi: S0896-6273(00)81196-4
    • (2000) Neuron , vol.26 , Issue.3 , pp. 583-594
    • Kerr, R.1    Lev-Ram, V.2    Baird, G.3    Vincent, P.4    Tsien, R.Y.5    Schafer, W.R.6
  • 69
    • 77952851112 scopus 로고    scopus 로고
    • Chaperone-assisted degradation: Multiple paths to destruction
    • doi:10.1515/BC.2010.058
    • Kettern N, Dreiseidler M, Tawo R, Hohfeld J (2010) Chaperone-assisted degradation: multiple paths to destruction. Biol Chem 391(5):481-489. doi:10.1515/BC.2010.058
    • (2010) Biol Chem , vol.391 , Issue.5 , pp. 481-489
    • Kettern, N.1    Dreiseidler, M.2    Tawo, R.3    Hohfeld, J.4
  • 70
    • 0001120692 scopus 로고
    • Alzheimer's disease - An electron microscopical study
    • Kidd M (1964) Alzheimer's disease - an electron microscopical study. Brain 87:307-320
    • (1964) Brain , vol.87 , pp. 307-320
    • Kidd, M.1
  • 73
    • 0029950149 scopus 로고    scopus 로고
    • Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody
    • Koo EH, Squazzo SL, Selkoe DJ, Koo CH (1996) Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. J Cell Sci 109(5):991-998
    • (1996) J Cell Sci , vol.109 , Issue.5 , pp. 991-998
    • Koo, E.H.1    Squazzo, S.L.2    Selkoe, D.J.3    Koo, C.H.4
  • 75
    • 0029128232 scopus 로고
    • LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation
    • doi:0092-8674(95)90320-8
    • Kounnas MZ, Moir RD, Rebeck GW, Bush AI, Argraves WS, Tanzi RE, Hyman BT, Strickland DK (1995) LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 82(2):331-340. doi:0092-8674(95)90320-8
    • (1995) Cell , vol.82 , Issue.2 , pp. 331-340
    • Kounnas, M.Z.1    Moir, R.D.2    Rebeck, G.W.3    Bush, A.I.4    Argraves, W.S.5    Tanzi, R.E.6    Hyman, B.T.7    Strickland, D.K.8
  • 76
    • 38549182459 scopus 로고    scopus 로고
    • Basement membranes
    • doi: 10.1895/wormbook.1.16.1
    • Kramer JM (2005) Basement membranes. WormBook 1-15. doi: 10.1895/wormbook.1.16.1
    • (2005) WormBook 1-15
    • Kramer, J.M.1
  • 77
    • 8544239449 scopus 로고
    • Alzheimer's presenile dementia. A histochemical and electron microscopic study
    • Krigman MR, Feldman RG, Bensch K (1965) Alzheimer's presenile dementia. A histochemical and electron microscopic study. Lab Invest 14:381-396
    • (1965) Lab Invest , vol.14 , pp. 381-396
    • Krigman, M.R.1    Feldman, R.G.2    Bensch, K.3
  • 78
    • 79955915609 scopus 로고    scopus 로고
    • The crystal structure of death receptor 6 (DR6): A potential receptor of the amyloid precursor protein (APP)
    • doi:10.1016/j.jmb.2011.03.048
    • Kuester M, Kemmerzehl S, Dahms SO, Roeser D, Than ME (2011) The crystal structure of death receptor 6 (DR6): a potential receptor of the amyloid precursor protein (APP). J Mol Biol 409(2):189-201. doi:10.1016/j.jmb.2011.03. 048
    • (2011) J Mol Biol , vol.409 , Issue.2 , pp. 189-201
    • Kuester, M.1    Kemmerzehl, S.2    Dahms, S.O.3    Roeser, D.4    Than, M.E.5
  • 80
    • 0028981717 scopus 로고
    • The alzheimer's abeta peptide induces neurodegeneration and apoptotic cell death in transgenic mice
    • LaFerla FM, Tinkle BT, Bieberich CJ, Haudenschild CC, Jay G (1995) The Alzheimer's Abeta peptide induces neurodegeneration and apoptotic cell death in transgenic mice. Nat Genet 9(1):21-30
    • (1995) Nat Genet , vol.9 , Issue.1 , pp. 21-30
    • LaFerla, F.M.1    Tinkle, B.T.2    Bieberich, C.J.3    Haudenschild, C.C.4    Jay, G.5
  • 81
    • 0030793522 scopus 로고    scopus 로고
    • Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Aβ stabilization
    • LaFerla FM, Troncoso JC, Strickland DK, Kawas CH, Jay G (1997) Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. J Clin Invest 100(2):310-320. doi:10.1172/JCI119536 (Pubitemid 27349077)
    • (1997) Journal of Clinical Investigation , vol.100 , Issue.2 , pp. 310-320
    • LaFerla, F.M.1    Troncoso, J.C.2    Strickland, D.K.3    Kawas, C.H.4    Jay, G.5
  • 82
    • 0032959163 scopus 로고    scopus 로고
    • EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotransmission in Caenorhabditis elegans
    • Lee RY, Sawin ER, Chalfie M, Horvitz HR, Avery L (1999) EAT-4, a homolog of a mammalian sodium-dependent inorganic phosphate cotransporter, is necessary for glutamatergic neurotrans-mission in Caenorhabditis elegans. J Neurosci 19(1):159-167 (Pubitemid 29028958)
    • (1999) Journal of Neuroscience , vol.19 , Issue.1 , pp. 159-167
    • Lee, R.Y.N.1    Sawin, E.R.2    Chalfie, M.3    Horvitz, H.R.4    Avery, L.5
  • 84
    • 0029116848 scopus 로고
    • Facilitation of lin-12-mediated signalling by sel-12, a caenorhabditis elegans S182 alzheimer's disease gene
    • Levitan D, Greenwald I (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377(6547):351-354
    • (1995) Nature , vol.377 , Issue.6547 , pp. 351-354
    • Levitan, D.1    Greenwald, I.2
  • 87
    • 0030671560 scopus 로고    scopus 로고
    • HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling
    • DOI 10.1073/pnas.94.22.12204
    • Li X, Greenwald I (1997) HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc Natl Acad Sci USA 94(22):12204-12209 (Pubitemid 27467867)
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.22 , pp. 12204-12209
    • Li, X.1    Greenwald, I.2
  • 88
    • 55249084960 scopus 로고    scopus 로고
    • Neuropeptides in C. elegans
    • WormBook. doi:10.1895/wormbook. 1.142.1
    • Li C, Kim K (2008) Neuropeptides in C. elegans. In: The C. elegans Research Community, WormBook. doi:10.1895/wormbook. 1.142.1. http://www.wormbook.org
    • (2008) The C. Elegans Research Community
    • Li, C.1    Kim, K.2
  • 90
    • 78049267204 scopus 로고    scopus 로고
    • Soluble amyloid precursor protein (APP) regulates transthyretin and klotho gene expression without rescuing the essential function of APP
    • doi:10.1073/pnas.1012568107
    • Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Sudhof TC, Zheng H (2010a) Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci USA 107(40):17362-17367. doi:10.1073/pnas.1012568107
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.40 , pp. 17362-17367
    • Li, H.1    Wang, B.2    Wang, Z.3    Guo, Q.4    Tabuchi, K.5    Hammer, R.E.6    Sudhof, T.C.7    Zheng, H.8
  • 91
    • 77957254613 scopus 로고    scopus 로고
    • Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis
    • doi: 10.1074/jbc.M110.137729
    • Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Sudhof TC, Wang R, Zheng H (2010b) Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem 285(40):30598-30605. doi: 10.1074/jbc.M110.137729
    • (2010) J Biol Chem , vol.285 , Issue.40 , pp. 30598-30605
    • Li, H.1    Wang, Z.2    Wang, B.3    Guo, Q.4    Dolios, G.5    Tabuchi, K.6    Hammer, R.E.7    Sudhof, T.C.8    Wang, R.9    Zheng, H.10
  • 92
    • 0030657540 scopus 로고    scopus 로고
    • Daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
    • DOI 10.1126/science.278.5341.1319
    • Lin K, Dorman JB, Rodan A, Kenyon C (1997) daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278(5341):1319-1322 (Pubitemid 27495748)
    • (1997) Science , vol.278 , Issue.5341 , pp. 1319-1322
    • Lin, K.1    Dorman, J.B.2    Rodan, A.3    Kenyon, C.4
  • 93
    • 0028981288 scopus 로고
    • Expression of human beta-amyloid peptide in transgenic caenorhabditis elegans
    • Link CD (1995) Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci USA 92(20):9368-9372
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.20 , pp. 9368-9372
    • Link, C.D.1
  • 94
    • 0035975702 scopus 로고    scopus 로고
    • Transgenic invertebrate models of age-associated neurodegenerative diseases
    • DOI 10.1016/S0047-6374(01)00291-3, PII S0047637401002913
    • Link CD (2001) Transgenic invertebrate models of age-associated neurodegenerative diseases. Mech Ageing Dev 122(14):1639-1649 (Pubitemid 32757137)
    • (2001) Mechanisms of Ageing and Development , vol.122 , Issue.14 , pp. 1639-1649
    • Link, C.D.1
  • 95
    • 17644382712 scopus 로고    scopus 로고
    • Invertebrate models of Alzheimer's disease
    • DOI 10.1111/j.1601-183X.2004.00105.x
    • Link CD (2005) Invertebrate models of Alzheimer's disease. Genes Brain Behav 4(3):147-156. doi:10.1111/j.1601-183X.2004. 00105.x (Pubitemid 40559141)
    • (2005) Genes, Brain and Behavior , vol.4 , Issue.3 , pp. 147-156
    • Link, C.D.1
  • 96
    • 33751397131 scopus 로고    scopus 로고
    • C. elegans models of age-associated neurodegenerative diseases: Lessons from transgenic worm models of Alzheimer's disease
    • DOI 10.1016/j.exger.2006.06.059, PII S0531556506002385
    • Link CD (2006) C. elegans models of age-associated neurodegenerative diseases: lessons from transgenic worm models of Alzheimer's disease. Exp Gerontol 41(10):1007-1013 (Pubitemid 44821699)
    • (2006) Experimental Gerontology , vol.41 , Issue.10 , pp. 1007-1013
    • Link, C.D.1
  • 97
    • 0035109444 scopus 로고    scopus 로고
    • Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34
    • DOI 10.1016/S0197-4580(00)00237-2, PII S0197458000002372
    • Link CD, Johnson CJ, Fonte V, Paupard M, Hall DH, Styren S, Mathis CA, Klunk WE (2001) Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34. Neurobiol Aging 22(2): 217-226 (Pubitemid 32162970)
    • (2001) Neurobiology of Aging , vol.22 , Issue.2 , pp. 217-226
    • Link, C.D.1    Johnson, C.J.2    Fonte, V.3    Paupard, M.-C.4    Hall, D.H.5    Styren, S.6    Mathis, C.A.7    Klunk, W.E.8
  • 98
    • 0037405291 scopus 로고    scopus 로고
    • Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model
    • DOI 10.1016/S0197-4580(02)00224-5
    • Link CD, Taft A, Kapulkin V, Duke K, Kim S, Fei Q, Wood DE, Sahagan BG (2003) Gene expression analysis in a transgenic Caenorhabditis elegans Alzheimer's disease model. Neurobiol Aging 24(3):397-413 (Pubitemid 36205048)
    • (2003) Neurobiology of Aging , vol.24 , Issue.3 , pp. 397-413
    • Link, C.D.1    Taft, A.2    Kapulkin, V.3    Duke, K.4    Kim, S.5    Fei, Q.6    Wood, D.E.7    Sahagan, B.G.8
  • 99
    • 63649141230 scopus 로고    scopus 로고
    • The quest for action potentials in C. elegans neurons hits a plateau
    • doi:10.1038/nn0409-377
    • Lockery SR, Goodman MB (2009) The quest for action potentials in C. elegans neurons hits a plateau. Nat Neurosci 12(4):377-378. doi:10.1038/nn0409- 377
    • (2009) Nat Neurosci , vol.12 , Issue.4 , pp. 377-378
    • Lockery, S.R.1    Goodman, M.B.2
  • 100
    • 0026783241 scopus 로고
    • Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene
    • Luo L, Tully T, White K (1992) Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene. Neuron 9(4):595-605
    • (1992) Neuron , vol.9 , Issue.4 , pp. 595-605
    • Luo, L.1    Tully, T.2    White, K.3
  • 101
    • 0013769584 scopus 로고
    • The ultrastructure of senile plaques
    • Luse SA, Smith KR Jr (1964) The ultrastructure of senile plaques. Am J Pathol 44(4):553-563
    • (1964) Am J Pathol , vol.44 , Issue.4 , pp. 553-563
    • Luse, S.A.1    Smith Jr., K.R.2
  • 102
    • 0024503377 scopus 로고
    • The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Downs' syndrome
    • DOI 10.1016/0022-510X(89)90019-1
    • Mann DM, Esiri MM (1989) The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome. J Neurol Sci 89(2-3):169-179 (Pubitemid 19052948)
    • (1989) Journal of the Neurological Sciences , vol.89 , Issue.2-3 , pp. 169-179
    • Mann, D.M.A.1    Esiri, M.M.2
  • 105
    • 0042631524 scopus 로고    scopus 로고
    • Transcriptional outputs of the caenorhabditis elegans forkhead protein DAF-16
    • McElwee J, Bubb K, Thomas JH (2003) Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2(2):111-121
    • (2003) Aging Cell , vol.2 , Issue.2 , pp. 111-121
    • McElwee, J.1    Bubb, K.2    Thomas, J.H.3
  • 106
    • 0027200882 scopus 로고
    • The GABAergic nervous system of Caenorhabditis elegans
    • DOI 10.1038/364337a0
    • McIntire SL, Jorgensen E, Kaplan J, Horvitz HR (1993) The GABAergic nervous system of Caenorhabditis elegans. Nature 364(6435):337-341. doi:10.1038/364337a0 (Pubitemid 23265274)
    • (1993) Nature , vol.364 , Issue.6435 , pp. 337-341
    • McIntire, S.L.1    Jorgensen, E.2    Kaplan, J.3    Horvitz, H.R.4
  • 107
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • DOI 10.1126/science.1087782
    • Meléndez A, Tallóczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301(5638): 1387-1391 (Pubitemid 37075816)
    • (2003) Science , vol.301 , Issue.5638 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.-L.4    Hall, D.H.5    Levine, B.6
  • 109
    • 0025942107 scopus 로고
    • Efficient gene transfer in C.elegans: Extrachromosomal maintenance and integration of transforming sequences
    • Mello CC, Kramer JM, Stinchcomb D, Ambros V (1991) Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J 10(12):3959-3970 (Pubitemid 21905425)
    • (1991) EMBO Journal , vol.10 , Issue.12 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 111
    • 0028018919 scopus 로고
    • Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene
    • doi: 0092-8674(94)90066-3
    • Muller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rulicke T, Brandner S, Aguzzi A, Weissmann C (1994) Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene. Cell 79(5):755-765. doi: 0092-8674(94)90066-3
    • (1994) Cell , vol.79 , Issue.5 , pp. 755-765
    • Muller, U.1    Cristina, N.2    Li, Z.W.3    Wolfer, D.P.4    Lipp, H.P.5    Rulicke, T.6    Brandner, S.7    Aguzzi, A.8    Weissmann, C.9
  • 113
    • 0025950987 scopus 로고
    • A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease
    • Murrell J, Farlow M, Ghetti B, Benson MD (1991) A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science 254(5028):97-99 (Pubitemid 21917324)
    • (1991) Science , vol.254 , Issue.5028 , pp. 97-99
    • Murrell, J.1    Farlow, M.2    Ghetti, B.3    Benson, M.D.4
  • 114
    • 29044433616 scopus 로고    scopus 로고
    • Light activation of Channelrhodopsin-2 in excitable cells of caenorhabditis elegans triggers rapid behavioral responses
    • DOI 10.1016/j.cub.2005.11.032, PII S0960982205014077
    • Nagel G, Brauner M, Liewald JF, Adeishvili N, Bamberg E, Gottschalk A (2005) Light activation of channelrhodopsin-2 in excitable cells of Caenorhabditis elegans triggers rapid behavioral responses. Curr Biol 15(24):2279-2284. doi:10.1016/j.cub. 2005.11.032 (Pubitemid 41790623)
    • (2005) Current Biology , vol.15 , Issue.24 , pp. 2279-2284
    • Nagel, G.1    Brauner, M.2    Liewald, J.F.3    Adeishvili, N.4    Bamberg, E.5    Gottschalk, A.6
  • 115
    • 0029053849 scopus 로고
    • Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase
    • Nguyen M, Alfonso A, Johnson CD, Rand JB (1995) Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase. Genetics 140(2):527-535
    • (1995) Genetics , vol.140 , Issue.2 , pp. 527-535
    • Nguyen, M.1    Alfonso, A.2    Johnson, C.D.3    Rand, J.B.4
  • 116
    • 60549089207 scopus 로고    scopus 로고
    • APP binds DR6 to trigger axon pruning and neuron death via distinct caspases
    • Nikolaev A, Mclaughlin T, O'Leary DD, Tessier-Lavigne M (2009) APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 457(7232):981-989
    • (2009) Nature , vol.457 , Issue.7232 , pp. 981-989
    • Nikolaev, A.1    Mclaughlin, T.2    O'Leary, D.D.3    Tessier-Lavigne, M.4
  • 117
    • 78650639882 scopus 로고    scopus 로고
    • Identification of a spatio-temporal enhancer element for the alzheimer's amyloid precursor protein-like-1 gene in the nematode caenorhabditis elegans
    • doi:JST.JSTAGE/bbb/100450
    • Niwa R, Hada K (2010) Identification of a spatio-temporal enhancer element for the Alzheimer's amyloid precursor protein-like-1 gene in the nematode Caenorhabditis elegans. Biosci Biotechnol Biochem 74(12):2497-2500. doi:JST.JSTAGE/bbb/100450
    • (2010) Biosci Biotechnol Biochem , vol.74 , Issue.12 , pp. 2497-2500
    • Niwa, R.1    Hada, K.2
  • 118
    • 40149088267 scopus 로고    scopus 로고
    • The expression of the alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in caeno-rhabditis elegans
    • Niwa R, Zhou F, Li C, Slack FJ (2008) The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caeno-rhabditis elegans. Dev Biol 315(2):418-425
    • (2008) Dev Biol , vol.315 , Issue.2 , pp. 418-425
    • Niwa, R.1    Zhou, F.2    Li, C.3    Slack, F.J.4
  • 119
    • 0027389118 scopus 로고
    • Identification of the Alzheimer β/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells
    • Nordstedt C, Caporaso GL, Thyberg J, Gandy SE, Greengard P (1993) Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. J Biol Chem 268(1):608-612 (Pubitemid 23021365)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.1 , pp. 608-612
    • Nordstedt, C.1    Caporaso, G.L.2    Thyberg, J.3    Gandy, S.E.4    Greengard, P.5
  • 120
    • 0034644836 scopus 로고    scopus 로고
    • Regulation of APP cleavage by alpha-, beta- and gamma-secretases
    • doi: S0014-5793(00)02076-7
    • Nunan J, Small DH (2000) Regulation of APP cleavage by alpha-, beta- and gamma-secretases. FEBS Lett 483(1):6-10. doi: S0014-5793(00)02076-7
    • (2000) FEBS Lett , vol.483 , Issue.1 , pp. 6-10
    • Nunan, J.1    Small, D.H.2
  • 121
    • 0030659557 scopus 로고    scopus 로고
    • The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
    • DOI 10.1038/40194
    • Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389(6654):994-999 (Pubitemid 27485694)
    • (1997) Nature , vol.389 , Issue.6654 , pp. 994-999
    • Ogg, S.1    Paradis, S.2    Gottlieb, S.3    Patterson, G.I.4    Lee, L.5    Tissenbaum, H.A.6    Ruvkun, G.7
  • 122
    • 70350625466 scopus 로고    scopus 로고
    • Condition-adapted stress and longevity gene regulation by caenorhabditis elegans SKN-1/Nrf
    • doi:10.1111/j.1474-9726.2009.00501.x
    • Oliveira RP, Porter Abate J, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK (2009) Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf. Aging Cell 8(5):524-541. doi:10.1111/j.1474- 9726.2009.00501.x
    • (2009) Aging Cell , vol.8 , Issue.5 , pp. 524-541
    • Oliveira, R.P.1    Porter Abate, J.2    Dilks, K.3    Landis, J.4    Ashraf, J.5    Murphy, C.T.6    Blackwell, T.K.7
  • 124
    • 66149175591 scopus 로고    scopus 로고
    • Oxidative stress and longevity in caenorhabditis elegans as mediated by SKN-1
    • doi:10.1111/j.1474-9726.2009. 00473.x
    • Park SK, Tedesco PM, Johnson TE (2009) Oxidative stress and longevity in Caenorhabditis elegans as mediated by SKN-1. Aging Cell 8(3):258-269. doi:10.1111/j.1474-9726.2009. 00473.x
    • (2009) Aging Cell , vol.8 , Issue.3 , pp. 258-269
    • Park, S.K.1    Tedesco, P.M.2    Johnson, T.E.3
  • 125
    • 0022371626 scopus 로고
    • Molecular basis of drug-resistance mutations in C. elegans
    • Rand JB, Russell RL (1985) Molecular basis of drug-resistance mutations in C. elegans. Psychopharmacol Bull 21(3):623-630 (Pubitemid 16240082)
    • (1985) Psychopharmacology Bulletin , vol.21 , Issue.3 , pp. 623-630
    • Rand, J.B.1    Russell, R.L.2
  • 128
  • 129
    • 0029101491 scopus 로고
    • Familial alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the alzheimer's disease type 3 gene
    • Rogaev EI, Sherrington R, Rogaeva EA, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T et al (1995) Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene. Nature 376(6543):775-778
    • (1995) Nature , vol.376 , Issue.6543 , pp. 775-778
    • Rogaev, E.I.1    Sherrington, R.2    Rogaeva, E.A.3    Levesque, G.4    Ikeda, M.5    Liang, Y.6    Chi, H.7    Lin, C.8    Holman, K.9    Tsuda, T.10
  • 132
    • 0035954426 scopus 로고    scopus 로고
    • The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement
    • DOI 10.1083/jcb.153.7.1403
    • Sabo SL, Ikin AF, Buxbaum JD, Greengard P (2001) The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. J Cell Biol 153(7):1403-1414 (Pubitemid 34286125)
    • (2001) Journal of Cell Biology , vol.153 , Issue.7 , pp. 1403-1414
    • Sabo, S.L.1    Ikin, A.F.2    Buxbaum, J.D.3    Greengard, P.4
  • 133
    • 0028445312 scopus 로고
    • Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons
    • Salbaum JM, Ruddle FH (1994) Embryonic expression pattern of amyloid protein precursor suggests a role in differentiation of specific subsets of neurons. J Exp Zool 269(2):116-127. doi: 10.1002/jez.1402690205 (Pubitemid 2090018)
    • (1994) Journal of Experimental Zoology , vol.269 , Issue.2 , pp. 116-127
    • Salbaum, J.M.1    Ruddle, F.H.2
  • 134
  • 135
    • 79957467830 scopus 로고    scopus 로고
    • OrthoList: A compendium of C. elegans genes with human orthologs
    • doi:10.1371/journal.pone.0020085PONE-D-11-05121
    • Shaye DD, Greenwald I (2011) OrthoList: a compendium of C. elegans genes with human orthologs. PLoS One 6(5):e20085. doi:10.1371/journal.pone. 0020085PONE-D-11-05121
    • (2011) PLoS One , vol.6 , Issue.5
    • Shaye, D.D.1    Greenwald, I.2
  • 137
    • 0002635897 scopus 로고
    • Some observations on molting in C. elegans
    • Singh R, Sulston J (1978) Some observations on molting in C. elegans. Nematologica 24(1):63-71
    • (1978) Nematologica , vol.24 , Issue.1 , pp. 63-71
    • Singh, R.1    Sulston, J.2
  • 139
    • 0028059841 scopus 로고
    • Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP)
    • Slunt HH, Thinakaran G, Von Koch C, Lo AC, Tanzi RE, Sisodia SS (1994) Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP). J Biol Chem 269(4):2637-2644
    • (1994) J Biol Chem , vol.269 , Issue.4 , pp. 2637-2644
    • Slunt, H.H.1    Thinakaran, G.2    Von Koch, C.3    Lo, A.C.4    Tanzi, R.E.5    Sisodia, S.S.6
  • 140
    • 0027198831 scopus 로고
    • Molecular cloning of the cDNA for a human amyloid precursor protein homolog: Evidence for a multigene family
    • Sprecher CA, Grant FJ, Grimm G, O'Hara PJ, Norris F, Norris K, Foster DC (1993) Molecular cloning of the cDNA for a human amyloid precursor protein homolog: evidence for a multigene family. Biochemistry 32(17):4481-4486 (Pubitemid 23143234)
    • (1993) Biochemistry , vol.32 , Issue.17 , pp. 4481-4486
    • Sprecher, C.A.1    Grant, F.J.2    Grimm, G.3    O'Hara, P.J.4    Norris, F.5    Norris, K.6    Foster, D.C.7
  • 143
    • 0017618537 scopus 로고
    • Post embryonic cell lineages of the nematode. Caenorhabditis elegans
    • Sulston JE, Horvitz HR (1977) Post-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev Biol 56(1):110-156 (Pubitemid 8049332)
    • (1977) Developmental Biology , vol.56 , Issue.1 , pp. 110-156
    • Sulston, J.E.1    Horvitz, H.R.2
  • 144
    • 0019311310 scopus 로고
    • Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans
    • DOI 10.1016/0012-1606(80)90353-X
    • Sulston JE, White JG (1980) Regulation and cell autonomy during postembryonic development of Caenorhabditis elegans. Dev Biol 78(2):577-597 (Pubitemid 10012074)
    • (1980) Developmental Biology , vol.78 , Issue.2 , pp. 577-597
    • Sulston, J.E.1    White, J.G.2
  • 145
    • 0016766336 scopus 로고
    • Dopaminergic neurons in the nematode caenorhabditis elegans
    • doi:10.1002/cne.901630207
    • Sulston J, Dew M, Brenner S (1975) Dopaminergic neurons in the nematode Caenorhabditis elegans. J Comp Neurol 163(2):215-226. doi:10.1002/cne.901630207
    • (1975) J Comp Neurol , vol.163 , Issue.2 , pp. 215-226
    • Sulston, J.1    Dew, M.2    Brenner, S.3
  • 146
    • 0020858899 scopus 로고
    • The embryonic cell lineage of the nematode caenorhabditis elegans
    • doi:0012-1606(83)90201-4
    • Sulston JE, Schierenberg E, White JG, Thomson JN (1983) The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 100(1):64-119. doi:0012-1606(83)90201-4
    • (1983) Dev Biol , vol.100 , Issue.1 , pp. 64-119
    • Sulston, J.E.1    Schierenberg, E.2    White, J.G.3    Thomson, J.N.4
  • 147
    • 70349916647 scopus 로고    scopus 로고
    • UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in caenorhabditis elegans
    • doi:10.1083/jcb.200902096
    • Sumakovic M, Hegermann J, Luo L, Husson SJ, Schwarze K, Olendrowitz C, Schoofs L, Richmond J, Eimer S (2009) UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans. J Cell Biol 186(6):897-914. doi:10.1083/jcb.200902096
    • (2009) J Cell Biol , vol.186 , Issue.6 , pp. 897-914
    • Sumakovic, M.1    Hegermann, J.2    Luo, L.3    Husson, S.J.4    Schwarze, K.5    Olendrowitz, C.6    Schoofs, L.7    Richmond, J.8    Eimer, S.9
  • 149
    • 0035815445 scopus 로고    scopus 로고
    • A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
    • DOI 10.1126/science.1057987
    • Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292(5514):107-110 (Pubitemid 32289137)
    • (2001) Science , vol.292 , Issue.5514 , pp. 107-110
    • Tatar, M.1    Kopelman, A.2    Epstein, D.3    Tu, M.-P.4    Yin, C.-M.5    Garofalo, R.S.6
  • 150
    • 78651158156 scopus 로고
    • Ultrastructural studies in alzheimer's presenile dementia
    • Terry RD, Gonatas NK, Weiss M (1964) Ultrastructural studies in Alzheimer's presenile dementia. Am J Pathol 44:269-297
    • (1964) Am J Pathol , vol.44 , pp. 269-297
    • Terry, R.D.1    Gonatas, N.K.2    Weiss, M.3
  • 151
    • 40849118472 scopus 로고    scopus 로고
    • Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans
    • DOI 10.1016/j.cell.2008.01.030, PII S009286740800130X
    • Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132(6):1025-1038. doi:10.1016/j.cell.2008.01.030 (Pubitemid 351391953)
    • (2008) Cell , vol.132 , Issue.6 , pp. 1025-1038
    • Tullet, J.M.A.1    Hertweck, M.2    An, J.H.3    Baker, J.4    Hwang, J.Y.5    Liu, S.6    Oliveira, R.P.7    Baumeister, R.8    Blackwell, T.K.9
  • 156
    • 4143105782 scopus 로고    scopus 로고
    • The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain
    • DOI 10.1016/j.molcel.2004.06.037, PII S109727650400379X
    • Wang Y, Ha Y (2004) The X-ray structure of an antiparallel dimer of the human amyloid precursor protein E2 domain. Mol Cell 15(3):343-353 (Pubitemid 39092751)
    • (2004) Molecular Cell , vol.15 , Issue.3 , pp. 343-353
    • Wang, Y.1    Ha, Y.2
  • 157
    • 0026442891 scopus 로고
    • Identification of a mouse brain cDNA that encodes a protein related to the alzheimer disease-associated amyloid beta protein precursor
    • Wasco W, Bupp K, Magendantz M, Gusella JF, Tanzi RE, Solomon F (1992) Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor. Proc Natl Acad Sci USA 89(22):10758-10762
    • (1992) Proc Natl Acad Sci USA , vol.89 , Issue.22 , pp. 10758-10762
    • Wasco, W.1    Bupp, K.2    Magendantz, M.3    Gusella, J.F.4    Tanzi, R.E.5    Solomon, F.6
  • 158
    • 0027240503 scopus 로고
    • Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor
    • DOI 10.1038/ng0993-95
    • Wasco W, Gurubhagavatula S, Paradis MD, Romano DM, Sisodia SS, Hyman BT, Neve RL, Tanzi RE (1993a) Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet 5(1):95-100. doi:10.1038/ng0993-95 (Pubitemid 23261528)
    • (1993) Nature Genetics , vol.5 , Issue.1 , pp. 95-100
    • Wasco, W.1    Gurubhagavatula, S.2    Paradis, M.D.3    Romano, D.M.4    Sisodia, S.S.5    Hyman, B.T.6    Neve, R.L.7    Tanzi, R.E.8
  • 161
    • 0032835248 scopus 로고    scopus 로고
    • Human and nematode orthologs - Lessons from the analysis of 1800 human genes and the proteome of Caenorhabditis elegans
    • DOI 10.1016/S0378-1119(99)00298-X, PII S037811199900298X
    • Wheelan SJ, Boguski MS, Duret L, Makalowski W (1999) Human and nematode orthologs-lessons from the analysis of 1800 human genes and the proteome of Caenorhabditis elegans. Gene 238(1):163-170. doi:S0378-1119(99)00298-X (Pubitemid 29436106)
    • (1999) Gene , vol.238 , Issue.1 , pp. 163-170
    • Wheelan, S.J.1    Boguski, M.S.2    Duret, L.3    Makalowski, W.4
  • 163
    • 77958478701 scopus 로고    scopus 로고
    • Intracellular trafficking and synaptic function of APL-1 in caenorhabditis elegans
    • doi:10.1371/journal.pone.0012790
    • Wiese M, Antebi A, Zheng H (2010) Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans. PLoS One 5(9). doi:10.1371/journal. pone.0012790
    • (2010) PLoS One , vol.5 , Issue.9
    • Wiese, M.1    Antebi, A.2    Zheng, H.3
  • 165
    • 0035933279 scopus 로고    scopus 로고
    • Intraneuronal Aβ accumulation precedes plaque formation in β-amyloid precursor protein and presenilin-1 double-transgenic mice
    • DOI 10.1016/S0304-3940(01)01876-6, PII S0304394001018766
    • Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S, Tremp G, Pradier L, Beyreuther K, Bayer TA (2001) Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett 306(1-2):116-120. doi:S0304-3940(01)01876- 6 (Pubitemid 32524311)
    • (2001) Neuroscience Letters , vol.306 , Issue.1-2 , pp. 116-120
    • Wirths, O.1    Multhaup, G.2    Czech, C.3    Blanchard, V.4    Moussaoui, S.5    Tremp, G.6    Pradier, L.7    Beyreuther, K.8    Bayer, T.A.9
  • 166
    • 33845613251 scopus 로고    scopus 로고
    • Amyloid-β-induced pathological behaviors are suppressed by Ginkgo biloba extract EGB 761 and ginkgolides in transgenic Caenorhabditis elegans
    • DOI 10.1523/JNEUROSCI.3448-06.2006
    • Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y (2006) Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. J Neurosci 26(50):13102-13113 (Pubitemid 44954628)
    • (2006) Journal of Neuroscience , vol.26 , Issue.50 , pp. 13102-13113
    • Wu, Y.1    Wu, Z.2    Butko, P.3    Christen, Y.4    Lambert, M.P.5    Klein, W.L.6    Link, C.D.7    Luo, Y.8
  • 167
    • 0035960074 scopus 로고    scopus 로고
    • 2+ release from the endoplasmic reticulum
    • DOI 10.1016/S0896-6273(01)00432-9
    • Xu K, Tavernarakis N, Driscoll M (2001) Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca(2+) release from the endoplasmic reticulum. Neuron 31(6):957-971. doi:S0896-6273(01)00432-9 (Pubitemid 32925282)
    • (2001) Neuron , vol.31 , Issue.6 , pp. 957-971
    • Xu, K.1    Tavernarakis, N.2    Driscoll, M.3
  • 169
    • 0033000965 scopus 로고    scopus 로고
    • A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting
    • Yochem J, Tuck S, Greenwald I, Han M (1999) A gp330/megalin-related protein is required in the major epidermis of Caeno-rhabditis elegans for completion of molting. Development 126(3):597-606 (Pubitemid 29082046)
    • (1999) Development , vol.126 , Issue.3 , pp. 597-606
    • Yochem, J.1    Tuck, S.2    Greenwald, I.3    Min, H.4
  • 171
    • 0027525104 scopus 로고
    • The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
    • DOI 10.1016/0092-8674(93)90485-9
    • Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR (1993) The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 75(4):641-652. doi:0092-8674(93)90485-9 (Pubitemid 23346363)
    • (1993) Cell , vol.75 , Issue.4 , pp. 641-652
    • Yuan, J.1    Shaham, S.2    Ledoux, S.3    Ellis, H.M.4    Horvitz, H.R.5
  • 172
    • 0036537553 scopus 로고    scopus 로고
    • Feh-1 and apl-1, the Caenorhabditis elegans orthologues of mammalian Fe65 and β-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping
    • Zambrano N, Bimonte M, Arbucci S, Gianni D, Russo T, Bazzicalupo P (2002) feh-1 and apl-1, the Caenorhabditis elegans ortho-logues of mammalian Fe65 and beta-amyloid precursor protein genes, are involved in the same pathway that controls nematode pharyngeal pumping. J Cell Sci 115(Pt 7):1411-1422 (Pubitemid 34428699)
    • (2002) Journal of Cell Science , vol.115 , Issue.7 , pp. 1411-1422
    • Zambrano, N.1    Bimonte, M.2    Arbucci, S.3    Gianni, D.4    Russo, T.5    Bazzicalupo, P.6


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