-
1
-
-
84956610009
-
Artemisinin-based combination therapy (ACT) versus atovaquone-proguanil: do not choose between but, rather, combine them
-
Schwartz, E. and T. Lachish, Artemisinin-based combination therapy (ACT) versus atovaquone-proguanil: do not choose between but, rather, combine them. Evidence Based Medicine, 2016. 21(2): p. 64-64.
-
(2016)
Evidence Based Medicine
, vol.21
, Issue.2
, pp. 64-64
-
-
Schwartz, E.1
Lachish, T.2
-
2
-
-
1942504778
-
Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: a review
-
Olliaro PL, Taylor WR. Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: a review. J Postgrad Med. 2004;50(1):40.
-
(2004)
J Postgrad Med
, vol.50
, Issue.1
, pp. 40
-
-
Olliaro, P.L.1
Taylor, W.R.2
-
3
-
-
70449732094
-
Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
-
Eastman RT, Fidock DA. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat Rev Microbiol. 2009;7(12):864-74.
-
(2009)
Nat Rev Microbiol
, vol.7
, Issue.12
, pp. 864-874
-
-
Eastman, R.T.1
Fidock, D.A.2
-
4
-
-
85002050109
-
Emerging drug resistance in plasmodium falciparum: a review of well-characterized drug targets for novel antimalarial chemotherapy
-
Chakraborty A. Emerging drug resistance in plasmodium falciparum: a review of well-characterized drug targets for novel antimalarial chemotherapy. Asian Pac J of Tro Dis. 2016;6(7):581-8.
-
(2016)
Asian Pac J of Tro Dis
, vol.6
, Issue.7
, pp. 581-588
-
-
Chakraborty, A.1
-
5
-
-
84994000411
-
Malaria: biology and disease
-
Cowman AF, et al. Malaria: biology and disease. Cell. 2016;167(3):610-24.
-
(2016)
Cell
, vol.167
, Issue.3
, pp. 610-624
-
-
Cowman, A.F.1
-
6
-
-
85025084538
-
World antimalarial resistance network (WARN) III: molecular markers for drug resistant malaria
-
Plowe CV, et al. World antimalarial resistance network (WARN) III: molecular markers for drug resistant malaria. Malar J. 2007;6(1):1-10.
-
(2007)
Malar J
, vol.6
, Issue.1
, pp. 1-10
-
-
Plowe, C.V.1
-
7
-
-
0037020024
-
Chloroquine resistance in plasmodium falciparum malaria parasites conferred by pfcrt mutations
-
Sidhu AB, Verdier-Pinard D, Fidock DA. Chloroquine resistance in plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science. 2002;298
-
(2002)
Science.
, pp. 298
-
-
Sidhu, A.B.1
Verdier-Pinard, D.2
Fidock, D.A.3
-
8
-
-
84920163293
-
Atovaquone tolerance in plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor
-
Guler JL, et al. Atovaquone tolerance in plasmodium falciparum parasites selected for high-level resistance to a dihydroorotate dehydrogenase inhibitor. Antimicrob Agents Chemother. 2015;59(1):686-9.
-
(2015)
Antimicrob Agents Chemother
, vol.59
, Issue.1
, pp. 686-689
-
-
Guler, J.L.1
-
9
-
-
84927911800
-
A genomic and evolutionary approach reveals non-genetic drug resistance in malaria
-
Herman JD, et al. A genomic and evolutionary approach reveals non-genetic drug resistance in malaria. Genome Biol. 2014;15(11):511.
-
(2014)
Genome Biol.
, vol.15
, Issue.11
, pp. 511
-
-
Herman, J.D.1
-
10
-
-
85001950339
-
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology
-
Gabryszewski, S.J., et al., Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology. PLOS Pathog, 2016. 12(11): p. e1005976.
-
(2016)
PLOS Pathog
, vol.12
, Issue.11
-
-
Gabryszewski, S.J.1
-
11
-
-
85009737092
-
Carbon sources tune antibiotic susceptibility in Pseudomonas Aeruginosa via tricarboxylic acid cycle control
-
Meylan S, et al. Carbon sources tune antibiotic susceptibility in Pseudomonas Aeruginosa via tricarboxylic acid cycle control. Cell Chem Biol. 2017; 24:195-206.
-
(2017)
Cell Chem Biol.
, vol.24
, pp. 195-206
-
-
Meylan, S.1
-
12
-
-
84866883403
-
Non-genetic mechanisms communicating antibiotic resistance: rethinking strategies for antimicrobial drug design
-
El-Halfawy OM, Valvano MA. Non-genetic mechanisms communicating antibiotic resistance: rethinking strategies for antimicrobial drug design. Expert Opin Drug Discov. 2012;7(10):923-33.
-
(2012)
Expert Opin Drug Discov
, vol.7
, Issue.10
, pp. 923-933
-
-
El-Halfawy, O.M.1
Valvano, M.A.2
-
13
-
-
84904892931
-
Spread of artemisinin resistance in plasmodium falciparum malaria
-
Ashley EA, et al. Spread of artemisinin resistance in plasmodium falciparum malaria. N Engl J Med. 2014;371(5):411-23.
-
(2014)
N Engl J Med
, vol.371
, Issue.5
, pp. 411-423
-
-
Ashley, E.A.1
-
14
-
-
84924080547
-
Genetic architecture of artemisinin-resistant plasmodium falciparum
-
Miotto O, et al. Genetic architecture of artemisinin-resistant plasmodium falciparum. Nat Genet. 2015;47(3):226-34.
-
(2015)
Nat Genet
, vol.47
, Issue.3
, pp. 226-234
-
-
Miotto, O.1
-
15
-
-
84921719133
-
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
-
Straimer J, et al. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science. 2015;347(6220):428-31.
-
(2015)
Science
, vol.347
, Issue.6220
, pp. 428-431
-
-
Straimer, J.1
-
16
-
-
84892372929
-
A molecular marker of artemisinin-resistant plasmodium falciparum malaria
-
Ariey F, et al. A molecular marker of artemisinin-resistant plasmodium falciparum malaria. Nature. 2014;505(7481):50-5.
-
(2014)
Nature
, vol.505
, Issue.7481
, pp. 50-55
-
-
Ariey, F.1
-
17
-
-
84921528358
-
Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype
-
Brown TS, et al. Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype. Infection, Genetics and Evolution: J Mol Epidemiol Evol Genet Infect Dis. 2015;30:318-22.
-
(2015)
Infection, Genetics and Evolution: J Mol Epidemiol Evol Genet Infect Dis
, vol.30
, pp. 318-322
-
-
Brown, T.S.1
-
18
-
-
84873559086
-
Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy? International Journal for parasitology
-
Cheng Q, Kyle DE, Gatton ML. Artemisinin resistance in Plasmodium falciparum: A process linked to dormancy? International Journal for parasitology. Drugs and Drug Resist. 2012;2:249-55.
-
(2012)
Drugs and Drug Resist
, vol.2
, pp. 249-255
-
-
Cheng, Q.1
Kyle, D.E.2
Gatton, M.L.3
-
19
-
-
79952355825
-
Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure
-
Codd A, et al. Artemisinin-induced parasite dormancy: a plausible mechanism for treatment failure. Malar J. 2011;10
-
(2011)
Malar J.
, pp. 10
-
-
Codd, A.1
-
20
-
-
84921719133
-
Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
-
Straimer J, et al. Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Sci. 2015;347(6220):428-31.
-
(2015)
Sci
, vol.347
, Issue.6220
, pp. 428-431
-
-
Straimer, J.1
-
21
-
-
84928814749
-
A molecular mechanism of artemisinin resistance in plasmodium falciparum malaria
-
Mbengue A, et al. A molecular mechanism of artemisinin resistance in plasmodium falciparum malaria. Nat. 2015;520(7549):683-7.
-
(2015)
Nat
, vol.520
, Issue.7549
, pp. 683-687
-
-
Mbengue, A.1
-
22
-
-
0027935551
-
Alkylation of proteins by artemisinin: effects of heme, pH, and drug structure
-
Ying-Zi Y, Little B, Meshnick SR. Alkylation of proteins by artemisinin: effects of heme, pH, and drug structure. Biochem Pharmacol. 1994;48(3):569-73.
-
(1994)
Biochem Pharmacol
, vol.48
, Issue.3
, pp. 569-573
-
-
Ying-Zi, Y.1
Little, B.2
Meshnick, S.R.3
-
23
-
-
84939173145
-
Amino acid efflux by asexual blood-stage plasmodium falciparum and its utility in interrogating the kinetics of hemoglobin endocytosis and catabolism in vivo
-
Dalal S, Klemba M. Amino acid efflux by asexual blood-stage plasmodium falciparum and its utility in interrogating the kinetics of hemoglobin endocytosis and catabolism in vivo. Mol Biochem Parasitol. 2015;201(2):116-22.
-
(2015)
Mol Biochem Parasitol
, vol.201
, Issue.2
, pp. 116-122
-
-
Dalal, S.1
Klemba, M.2
-
24
-
-
79960992639
-
Artemisinin activity against plasmodium falciparum requires hemoglobin uptake and digestion
-
Klonis N, et al. Artemisinin activity against plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci U S A. 2011;108(28):11405-10.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, Issue.28
, pp. 11405-11410
-
-
Klonis, N.1
-
25
-
-
77949661216
-
Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation
-
Wang J, et al. Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation. PLoS One. 2010;5(3):e9582.
-
(2010)
PLoS One.
, vol.5
, Issue.3
-
-
Wang, J.1
-
26
-
-
84905386385
-
Fatty acid synthesis and pyruvate metabolism pathways remain active in Dihydroartemisinin-induced dormant ring stages of plasmodium falciparum
-
Chen N, et al. Fatty acid synthesis and pyruvate metabolism pathways remain active in Dihydroartemisinin-induced dormant ring stages of plasmodium falciparum. Antimicrob Agents Chemother. 2014;58(8):4773-81.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, Issue.8
, pp. 4773-4781
-
-
Chen, N.1
-
27
-
-
84930225999
-
Implications of glutathione levels in the plasmodium berghei response to chloroquine and artemisinin
-
Vega-Rodríguez J, et al. Implications of glutathione levels in the plasmodium berghei response to chloroquine and artemisinin. PLoS One. 2015;10(5):e0128212.
-
(2015)
PLoS One.
, vol.10
, Issue.5
-
-
Vega-Rodríguez, J.1
-
28
-
-
84959860038
-
Metabolic dysregulation induced in plasmodium falciparum by Dihydroartemisinin and other front-line antimalarial drugs
-
Cobbold SA, et al. Metabolic dysregulation induced in plasmodium falciparum by Dihydroartemisinin and other front-line antimalarial drugs. J Infect Dis. 2016;213(2):276-86.
-
(2016)
J Infect Dis
, vol.213
, Issue.2
, pp. 276-286
-
-
Cobbold, S.A.1
-
29
-
-
84939540007
-
Mitochondrial membrane potential in a small subset of artemisinin-induced dormant plasmodium falciparum parasites in vitro
-
Peatey CL, et al. Mitochondrial membrane potential in a small subset of artemisinin-induced dormant plasmodium falciparum parasites in vitro. J Infect Dis. 2015;212(3):426-34.
-
(2015)
J Infect Dis
, vol.212
, Issue.3
, pp. 426-434
-
-
Peatey, C.L.1
-
30
-
-
0037021405
-
Artemisinin: mechanisms of action, resistance and toxicity
-
Meshnick SR. Artemisinin: mechanisms of action, resistance and toxicity. Int J Parasitol. 2002;32(13):1655-60.
-
(2002)
Int J Parasitol
, vol.32
, Issue.13
, pp. 1655-1660
-
-
Meshnick, S.R.1
-
31
-
-
0042860063
-
Artemisinins target the SERCA of plasmodium falciparum
-
Eckstein-Ludwig U, et al. Artemisinins target the SERCA of plasmodium falciparum. Nature. 2003;424(6951):957-61.
-
(2003)
Nature
, vol.424
, Issue.6951
, pp. 957-961
-
-
Eckstein-Ludwig, U.1
-
32
-
-
33751006146
-
Current perspectives on the mechanism of action of artemisinins
-
Golenser J, et al. Current perspectives on the mechanism of action of artemisinins. Int J Parasitol. 2006;36(14):1427-41.
-
(2006)
Int J Parasitol
, vol.36
, Issue.14
, pp. 1427-1441
-
-
Golenser, J.1
-
33
-
-
2942624053
-
Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines
-
Efferth T, Oesch F. Oxidative stress response of tumor cells: microarray-based comparison between artemisinins and anthracyclines. Biochem Pharmacol. 2004;68(1):3-10.
-
(2004)
Biochem Pharmacol
, vol.68
, Issue.1
, pp. 3-10
-
-
Efferth, T.1
Oesch, F.2
-
34
-
-
84896485226
-
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential
-
Antoine T, et al. Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. J Antimicrob Chemother. 2014;69(4):1005-16.
-
(2014)
J Antimicrob Chemother
, vol.69
, Issue.4
, pp. 1005-1016
-
-
Antoine, T.1
-
35
-
-
84947026465
-
Two distinct and competitive pathways confer the cellcidal actions of artemisinins
-
Sun C, et al. Two distinct and competitive pathways confer the cellcidal actions of artemisinins. Microbial Cell. 2015;2(1):14-25.
-
(2015)
Microbial Cell
, vol.2
, Issue.1
, pp. 14-25
-
-
Sun, C.1
-
36
-
-
55449124885
-
Yeast model uncovers dual roles of mitochondria in the action of artemisinin
-
Li, W., et al., Yeast model uncovers dual roles of mitochondria in the action of artemisinin. PLoS Genet, 2005. 1(3): p. e36.
-
(2005)
PLoS Genet
, vol.1
, Issue.3
-
-
Li, W.1
-
37
-
-
84926625655
-
K13-propeller polymorphisms in plasmodium falciparum parasites from sub-Saharan Africa
-
Kamau E, et al. K13-propeller polymorphisms in plasmodium falciparum parasites from sub-Saharan Africa. J Infect Dis. 2015;211(8):1352-5.
-
(2015)
J Infect Dis
, vol.211
, Issue.8
, pp. 1352-1355
-
-
Kamau, E.1
-
38
-
-
84923120760
-
Novel mutations in K13 propeller Gene of artemisinin-resistant plasmodium falciparum
-
Isozumi R, et al. Novel mutations in K13 propeller Gene of artemisinin-resistant plasmodium falciparum. Emerg Infect Dis. 2015;21(3):490-2.
-
(2015)
Emerg Infect Dis
, vol.21
, Issue.3
, pp. 490-492
-
-
Isozumi, R.1
-
39
-
-
84875498942
-
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
-
Klonis N, et al. Altered temporal response of malaria parasites determines differential sensitivity to artemisinin. Proc Natl Acad Sci U S A. 2013;110(13):5157-62.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.13
, pp. 5157-5162
-
-
Klonis, N.1
-
40
-
-
79961008996
-
Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription
-
Mok S, et al. Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription. BMC Genomics. 2011:12(1).
-
(2011)
BMC Genomics.
, vol.12
, Issue.1
-
-
Mok, S.1
-
41
-
-
77958086412
-
Artemisinin-induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure
-
Teuscher F, et al. Artemisinin-induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failure. J Infect Dis. 2010;202(9):1362-8.
-
(2010)
J Infect Dis
, vol.202
, Issue.9
, pp. 1362-1368
-
-
Teuscher, F.1
-
42
-
-
77951220629
-
Increased tolerance to artemisinin in plasmodium falciparum is mediated by a quiescence mechanism
-
Witkowski B, et al. Increased tolerance to artemisinin in plasmodium falciparum is mediated by a quiescence mechanism. Antimicrob Agents Chemother. 2010;54(5):1872-7.
-
(2010)
Antimicrob Agents Chemother
, vol.54
, Issue.5
, pp. 1872-1877
-
-
Witkowski, B.1
-
43
-
-
0035174389
-
An integrative database of the Plasmodium falciparum genome. Tools for accessing and analyzing finished and unfinished sequence data
-
Collaborativea TPGD, PlasmoDB: An integrative database of the Plasmodium falciparum genome. Tools for accessing and analyzing finished and unfinished sequence data. Nucleic Acids Res. 2001;29(1):66-9.
-
(2001)
Nucleic Acids Res.
, vol.29
, Issue.1
, pp. 66-69
-
-
Collaborativea, T.P.G.D.1
Plasmo, D.B.2
-
44
-
-
0033636607
-
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance
-
Fidock DA, et al. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell. 2000:6.
-
(2000)
Mol Cell.
, pp. 6
-
-
Fidock, D.A.1
-
45
-
-
0000841123
-
Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria
-
Peterson DS, Walliker D, Wellems TE. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci U S A. 1988;85(23):9114-9118.
-
(1988)
Proc Natl Acad Sci U S A.
, vol.85
, Issue.23
, pp. 9114-9118
-
-
Peterson, D.S.1
Walliker, D.2
Wellems, T.E.3
-
46
-
-
84924404654
-
Direct evidence for the atovaquone action on the plasmodium cytochrome bc1 complex
-
Siregar JE, et al. Direct evidence for the atovaquone action on the plasmodium cytochrome bc1 complex. Parasitol Int. 2015;64(3):295-300.
-
(2015)
Parasitol Int
, vol.64
, Issue.3
, pp. 295-300
-
-
Siregar, J.E.1
-
47
-
-
77953773127
-
Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy
-
Phillips MA, Rathod PK. Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy. Infect Disord Drug Targets. 2010;10(3):226-39.
-
(2010)
Infect Disord Drug Targets
, vol.10
, Issue.3
, pp. 226-239
-
-
Phillips, M.A.1
Rathod, P.K.2
-
48
-
-
85010842085
-
Genomewide landscape of gene-metabolome associations in Escherichia coli
-
Fuhrer T, et al. Genomewide landscape of gene-metabolome associations in Escherichia coli. Mol Syst Biol. 2017;13(1):907.
-
(2017)
Mol Syst Biol.
, vol.13
, Issue.1
, pp. 907
-
-
Fuhrer, T.1
-
49
-
-
84921785363
-
Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
-
Mok S, et al. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance. Science. 2015;347(6220):431-5.
-
(2015)
Science
, vol.347
, Issue.6220
, pp. 431-435
-
-
Mok, S.1
-
50
-
-
85025113408
-
Reconstruction and flux-balance analysis of the plasmodium falciparum metabolic network
-
Plata G, et al. Reconstruction and flux-balance analysis of the plasmodium falciparum metabolic network. Mol Syst Biol. 2010;6
-
(2010)
Mol Syst Biol.
, pp. 6
-
-
Plata, G.1
-
51
-
-
33847398001
-
Specific role of mitochondrial electron transport in blood-stage plasmodium falciparum
-
Painter HJ, et al. Specific role of mitochondrial electron transport in blood-stage plasmodium falciparum. Nature. 2007;446(7131):88-91.
-
(2007)
Nature
, vol.446
, Issue.7131
, pp. 88-91
-
-
Painter, H.J.1
-
52
-
-
0034979265
-
Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix
-
Langer RC, Vinetz JM. Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix. Trends Parasitol. 2001;17(6):269-72.
-
(2001)
Trends Parasitol.
, vol.17
, Issue.6
, pp. 269-272
-
-
Langer, R.C.1
Vinetz, J.M.2
-
53
-
-
75149129569
-
A protocol for generating a high-quality genome-scale metabolic reconstruction
-
Thiele I, Palsson BO. A protocol for generating a high-quality genome-scale metabolic reconstruction. Nat Protocols. 2010;5(1):93-121.
-
(2010)
Nat Protocols
, vol.5
, Issue.1
, pp. 93-121
-
-
Thiele, I.1
Palsson, B.O.2
-
54
-
-
84939806505
-
Mitochondrial ATP synthase is dispensable in blood-stage plasmodium berghei rodent malaria but essential in the mosquito phase
-
Sturm A, et al. Mitochondrial ATP synthase is dispensable in blood-stage plasmodium berghei rodent malaria but essential in the mosquito phase. Proc Natl Acad Sci. 2015;112(33):10216-23.
-
(2015)
Proc Natl Acad Sci
, vol.112
, Issue.33
, pp. 10216-10223
-
-
Sturm, A.1
-
55
-
-
0036861164
-
Abundant proton pumping in plasmodium, but why?
-
Ginsburg H. Abundant proton pumping in plasmodium, but why? Trends Parasitol. 2002;18(11):483-6.
-
(2002)
Trends Parasitol
, vol.18
, Issue.11
, pp. 483-486
-
-
Ginsburg, H.1
-
56
-
-
84941280668
-
Profiling the essential nature of lipid metabolism in asexual blood and gametocyte stages of plasmodium falciparum
-
Gulati S, et al. Profiling the essential nature of lipid metabolism in asexual blood and gametocyte stages of plasmodium falciparum. Cell Host Microbe. 2015;18(3):371-81.
-
(2015)
Cell Host Microbe
, vol.18
, Issue.3
, pp. 371-381
-
-
Gulati, S.1
-
57
-
-
60649112444
-
Host-parasite interactions revealed by plasmodium falciparum metabolomics
-
Olszewski KL, et al. Host-parasite interactions revealed by plasmodium falciparum metabolomics. Cell Host Microbe. 2009;5(2):191-9.
-
(2009)
Cell Host Microbe
, vol.5
, Issue.2
, pp. 191-199
-
-
Olszewski, K.L.1
-
58
-
-
84876060343
-
Global Mass Spectrometry Based Metabolomics Profiling of Erythrocytes Infected with Plasmodium falciparum
-
Sana TR, et al. Global Mass Spectrometry Based Metabolomics Profiling of Erythrocytes Infected with Plasmodium falciparum. PLoS One. 2013;8(4):e60840.
-
(2013)
PLoS One.
, vol.8
, Issue.4
-
-
Sana, T.R.1
-
60
-
-
84927697401
-
Genetic investigation of tricarboxylic acid metabolism during the plasmodium falciparum life cycle
-
Ke H, et al. Genetic investigation of tricarboxylic acid metabolism during the plasmodium falciparum life cycle. Cell Rep. 2015;11(1):164-74.
-
(2015)
Cell Rep
, vol.11
, Issue.1
, pp. 164-174
-
-
Ke, H.1
-
61
-
-
84878818779
-
Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite plasmodium falciparum
-
MacRae JI, et al. Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite plasmodium falciparum. BMC Biol. 2013;11(1):67.
-
(2013)
BMC Biol.
, vol.11
, Issue.1
, pp. 67
-
-
MacRae, J.I.1
-
62
-
-
2442636351
-
Computational analysis of plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery
-
Yeh I. Computational analysis of plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res. 2004;14(5):917-24.
-
(2004)
Genome Res
, vol.14
, Issue.5
, pp. 917-924
-
-
Yeh, I.1
-
63
-
-
33745041171
-
Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems
-
Liu J, et al. Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems. Proc Natl Acad Sci U S A. 2006;103(23):8840-5.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.23
, pp. 8840-8845
-
-
Liu, J.1
-
64
-
-
0036152532
-
Intraerythrocytic plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins
-
Krugliak M, Zhang J, Ginsburg H. Intraerythrocytic plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteins. Mol Biochem Parasitol. 2002;119(2):249-56.
-
(2002)
Mol Biochem Parasitol
, vol.119
, Issue.2
, pp. 249-256
-
-
Krugliak, M.1
Zhang, J.2
Ginsburg, H.3
-
65
-
-
0029984953
-
Hypoxanthine: a low molecular weight factor essential for growth of erythrocytic plasmodium falciparum in a serum-free medium
-
Asahi H, et al. Hypoxanthine: a low molecular weight factor essential for growth of erythrocytic plasmodium falciparum in a serum-free medium. Parasitol. 1996;113(01):19-23.
-
(1996)
Parasitol
, vol.113
, Issue.1
, pp. 19-23
-
-
Asahi, H.1
-
66
-
-
0022401698
-
Nutritional requirements of plasmodium falciparum in culture. III. Further observations on essential nutrients and antimetabolites
-
Geary TG, et al. Nutritional requirements of plasmodium falciparum in culture. III. Further observations on essential nutrients and antimetabolites. The J Protozool. 1985;32(4):608-13.
-
(1985)
The J Protozool
, vol.32
, Issue.4
, pp. 608-613
-
-
Geary, T.G.1
-
67
-
-
0037034017
-
The pathogenic basis of malaria
-
Miller LH, et al. The pathogenic basis of malaria. Nature. 2002;415(6872):673-9.
-
(2002)
Nature
, vol.415
, Issue.6872
, pp. 673-679
-
-
Miller, L.H.1
-
68
-
-
0021908682
-
Nutritional requirements of plasmodium falciparum in culture. II. Effects of antimetabolites in a semi defined medium
-
Geary TG, Divo AA, Jensen JB. Nutritional requirements of plasmodium falciparum in culture. II. Effects of antimetabolites in a semi defined medium. The J Protozool. 1985;32(1):65-9.
-
(1985)
The J Protozool
, vol.32
, Issue.1
, pp. 65-69
-
-
Geary, T.G.1
Divo, A.A.2
Jensen, J.B.3
-
69
-
-
79951536020
-
Functional integration of a metabolic network model and expression data without arbitrary thresholding
-
Jensen PA, Papin JA. Functional integration of a metabolic network model and expression data without arbitrary thresholding. Bioinform. 2011;27(4):541-7.
-
(2011)
Bioinform
, vol.27
, Issue.4
, pp. 541-547
-
-
Jensen, P.A.1
Papin, J.A.2
-
70
-
-
84907030956
-
Modeling metabolism and stage-specific growth of plasmodium falciparum HB3 during the intraerythrocytic developmental cycle
-
Fang X, Reifman J, Wallqvist A. Modeling metabolism and stage-specific growth of plasmodium falciparum HB3 during the intraerythrocytic developmental cycle. Mol BioSyst. 2014;10(10):2526-37.
-
(2014)
Mol BioSyst
, vol.10
, Issue.10
, pp. 2526-2537
-
-
Fang, X.1
Reifman, J.2
Wallqvist, A.3
-
71
-
-
85016725723
-
Bioenergetics-based modeling of plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks
-
Chiappino-Pepe A, et al. Bioenergetics-based modeling of plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks. PLoS Comput Biol. 2017;13(3):e1005397.
-
(2017)
PLoS Comput Biol
, vol.13
, Issue.3
-
-
Chiappino-Pepe, A.1
-
72
-
-
84984814937
-
Metabolic host responses to malarial infection during the intraerythrocytic developmental cycle
-
Wallqvist A, et al. Metabolic host responses to malarial infection during the intraerythrocytic developmental cycle. BMC Syst Biol. 2016;10(1):58.
-
(2016)
BMC Syst Biol
, vol.10
, Issue.1
, pp. 58
-
-
Wallqvist, A.1
-
73
-
-
84882619498
-
Functional genomics of plasmodium falciparum using metabolic modelling and analysis
-
Tymoshenko S, et al. Functional genomics of plasmodium falciparum using metabolic modelling and analysis. Briefings in Functional Genomics. 2013;12(4):316-27.
-
(2013)
Briefings in Functional Genomics
, vol.12
, Issue.4
, pp. 316-327
-
-
Tymoshenko, S.1
-
74
-
-
84865535722
-
Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism
-
Bazzani S, Hoppe A, Holzhütter H-G. Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism. BMC Syst Biol. 2012:6(1).
-
(2012)
BMC Syst Biol.
, vol.6
, Issue.1
-
-
Bazzani, S.1
Hoppe, A.2
Holzhütter, H.-G.3
-
75
-
-
85016138705
-
EuPathDB: the eukaryotic pathogen genomics database resource
-
Aurrecoechea, C., et al., EuPathDB: the eukaryotic pathogen genomics database resource. Nucleic Acids Res, 2017: 45:D581-D591.
-
(2017)
Nucleic Acids Res
, vol.45
, pp. D581-D591
-
-
Aurrecoechea, C.1
-
76
-
-
0037015614
-
Genome sequence of the human malaria parasite plasmodium falciparum
-
Gardner MJ, et al. Genome sequence of the human malaria parasite plasmodium falciparum. Nat. 2002;419(6906):498-511.
-
(2002)
Nat
, vol.419
, Issue.6906
, pp. 498-511
-
-
Gardner, M.J.1
-
77
-
-
38549128700
-
ToxoDB: an integrated Toxoplasma gondii database resource
-
Gajria B, et al. ToxoDB: an integrated Toxoplasma gondii database resource. Nucleic Acids Res. 2008;36(Database issue):D553-6.
-
(2008)
Nucleic Acids Res
, vol.36
, Issue.DATABASE ISSUE
, pp. D553-D556
-
-
Gajria, B.1
-
78
-
-
49249124561
-
The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation
-
Xia D, et al. The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation. Genome Biol. 2008;9(7):R116.
-
(2008)
Genome Biol
, vol.9
, Issue.7
, pp. R116
-
-
Xia, D.1
-
79
-
-
84930607857
-
Metabolic needs and capabilities of Toxoplasma gondii through combined Computational and experimental analysis
-
Tymoshenko S, et al. Metabolic needs and capabilities of Toxoplasma gondii through combined Computational and experimental analysis. PLoS Comput Biol. 2015;11(5):e1004261.
-
(2015)
PLoS Comput Biol
, vol.11
, Issue.5
-
-
Tymoshenko, S.1
-
80
-
-
22244437571
-
The genome of the Kinetoplastid parasite, Leishmania major
-
Ivens AC, et al. The genome of the Kinetoplastid parasite, Leishmania major. Sci. 2005;309(5733):436.
-
(2005)
Sci
, vol.309
, Issue.5733
, pp. 436
-
-
Ivens, A.C.1
-
81
-
-
41149169317
-
Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major
-
Chavali AK, et al. Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major. Mol Syst Biol. 2008;4(1):177.
-
(2008)
Mol Syst Biol
, vol.4
, Issue.1
, pp. 177
-
-
Chavali, A.K.1
-
82
-
-
80054069179
-
A comprehensive genome-scale reconstruction of Escherichia coli metabolism-2011
-
Orth, J.D., et al., A comprehensive genome-scale reconstruction of Escherichia coli metabolism-2011. Mol Syst Biol, 2011. 7: p. 535-535.
-
(2011)
Mol Syst Biol
, vol.7
, pp. 535-535
-
-
Orth, J.D.1
-
83
-
-
84949239513
-
Comparative analysis of yeast metabolic network models highlights progress, opportunities for metabolic reconstruction
-
Heavner BD, Price ND. Comparative analysis of yeast metabolic network models highlights progress, opportunities for metabolic reconstruction. PLoS Comput Biol. 2015;11(11):e1004530.
-
(2015)
PLoS Comput Biol
, vol.11
, Issue.11
-
-
Heavner, B.D.1
Price, N.D.2
-
84
-
-
84899141796
-
Open questions: microbes, metabolism and host-pathogen interactions
-
McConville M. Open questions: microbes, metabolism and host-pathogen interactions. BMC Biol. 2014;12(1):18.
-
(2014)
BMC Biol.
, vol.12
, Issue.1
, pp. 18
-
-
McConville, M.1
-
85
-
-
84857782095
-
An evolving picture of the interactions between malaria parasites and their host erythrocytes
-
Wellems TE, Fairhurst RM. An evolving picture of the interactions between malaria parasites and their host erythrocytes. Cell Res. 2012;22(3):453-6.
-
(2012)
Cell Res
, vol.22
, Issue.3
, pp. 453-456
-
-
Wellems, T.E.1
Fairhurst, R.M.2
-
87
-
-
35348837375
-
Make it or take it: fatty acid metabolism of apicomplexan parasites
-
Mazumdar J, Striepen B. Make it or take it: fatty acid metabolism of apicomplexan parasites. Eukaryot Cell. 2007;6(10):1727-35.
-
(2007)
Eukaryot Cell
, vol.6
, Issue.10
, pp. 1727-1735
-
-
Mazumdar, J.1
Striepen, B.2
-
88
-
-
30044443910
-
Maurer's clefts: a novel multi-functional organelle in the cytoplasm of plasmodium falciparum-infected erythrocytes
-
Lanzer M, et al. Maurer's clefts: a novel multi-functional organelle in the cytoplasm of plasmodium falciparum-infected erythrocytes. Int J Parasitol. 2006;36(1):23-36.
-
(2006)
Int J Parasitol
, vol.36
, Issue.1
, pp. 23-36
-
-
Lanzer, M.1
-
89
-
-
0034307484
-
A brief illustrated guide to the ultrastructure of plasmodium falciparum asexual blood stages
-
Bannister LH, et al. A brief illustrated guide to the ultrastructure of plasmodium falciparum asexual blood stages. Parasitol Today. 2000;16(10):427-33.
-
(2000)
Parasitol Today
, vol.16
, Issue.10
, pp. 427-433
-
-
Bannister, L.H.1
-
90
-
-
33645285279
-
Evidence for the involvement of plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane
-
Baumeister S, et al. Evidence for the involvement of plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane. Mol Microbiol. 2006;60(2):493-504.
-
(2006)
Mol Microbiol
, vol.60
, Issue.2
, pp. 493-504
-
-
Baumeister, S.1
-
91
-
-
0020630101
-
New permeability pathways induced in membranes of plasmodium falciparum infected erythrocytes
-
Ginsburg H, et al. New permeability pathways induced in membranes of plasmodium falciparum infected erythrocytes. Mol Biochem Parasitol. 1983;8(2):177-90.
-
(1983)
Mol Biochem Parasitol
, vol.8
, Issue.2
, pp. 177-190
-
-
Ginsburg, H.1
-
92
-
-
33751167422
-
Solute transport via the new permeability pathways in plasmodium falciparum-infected human red blood cells is not consistent with a simple single-channel model
-
Staines HM, et al. Solute transport via the new permeability pathways in plasmodium falciparum-infected human red blood cells is not consistent with a simple single-channel model. Blood. 2006;108(9):3187-94.
-
(2006)
Blood
, vol.108
, Issue.9
, pp. 3187-3194
-
-
Staines, H.M.1
-
93
-
-
0021909963
-
Nutritional requirements of plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth
-
Divo AA, et al. Nutritional requirements of plasmodium falciparum in culture. I. Exogenously supplied dialyzable components necessary for continuous growth. J Protozool. 1985;32(1):59-64.
-
(1985)
J Protozool
, vol.32
, Issue.1
, pp. 59-64
-
-
Divo, A.A.1
-
94
-
-
84949495194
-
In silico multiple-targets identification for heme detoxification in the human malaria parasite plasmodium falciparum
-
Phaiphinit S, et al. In silico multiple-targets identification for heme detoxification in the human malaria parasite plasmodium falciparum. Infect Genet Evol. 2016;37:237-44.
-
(2016)
Infect Genet Evol
, vol.37
, pp. 237-244
-
-
Phaiphinit, S.1
-
95
-
-
84905746811
-
Genome editing in the human malaria parasite plasmodium falciparum using the CRISPR-Cas9 system
-
Ghorbal M, et al. Genome editing in the human malaria parasite plasmodium falciparum using the CRISPR-Cas9 system. Nat Biotech. 2014;32(8):819-21.
-
(2014)
Nat Biotech
, vol.32
, Issue.8
, pp. 819-821
-
-
Ghorbal, M.1
-
96
-
-
84906840855
-
CRISPR-mediated genome editing of plasmodium falciparum malaria parasites
-
Lee MCS, Fidock DA. CRISPR-mediated genome editing of plasmodium falciparum malaria parasites. Genome Med. 2014;6(8):63.
-
(2014)
Genome Med
, vol.6
, Issue.8
, pp. 63
-
-
Lee, M.C.S.1
Fidock, D.A.2
-
97
-
-
84921644699
-
Efficient CRISPR-Cas9-mediated genome editing in plasmodium falciparum
-
Wagner JC, et al. Efficient CRISPR-Cas9-mediated genome editing in plasmodium falciparum. Nat Meth. 2014;11(9):915-8.
-
(2014)
Nat Meth
, vol.11
, Issue.9
, pp. 915-918
-
-
Wagner, J.C.1
-
98
-
-
84963853553
-
A redesigned CRISPR/Cas9 system for marker-free genome editing in plasmodium falciparum
-
Lu J, et al. A redesigned CRISPR/Cas9 system for marker-free genome editing in plasmodium falciparum. Parasit Vectors. 2016;9(1):1.
-
(2016)
Parasit Vectors
, vol.9
, Issue.1
, pp. 1
-
-
Lu, J.1
-
99
-
-
33846026771
-
Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in plasmodium falciparum
-
Ramya TNC, et al. Inhibitors of nonhousekeeping functions of the apicoplast defy delayed death in plasmodium falciparum. Antimicrob Agents Chemother. 2007;51(1):307-16.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, Issue.1
, pp. 307-316
-
-
Ramya, T.N.C.1
-
100
-
-
84918580707
-
The heme biosynthesis pathway is essential for plasmodium falciparum development in mosquito stage but not in blood stages
-
Ke H, et al. The heme biosynthesis pathway is essential for plasmodium falciparum development in mosquito stage but not in blood stages. J Biol Chem. 2014;289(50):34827-37.
-
(2014)
J Biol Chem
, vol.289
, Issue.50
, pp. 34827-34837
-
-
Ke, H.1
-
101
-
-
84883378968
-
Malaria parasite-synthesized Heme is essential in the mosquito and liver stages and complements host Heme in the blood stages of infection
-
Nagaraj VA, et al. Malaria parasite-synthesized Heme is essential in the mosquito and liver stages and complements host Heme in the blood stages of infection. PLoS Pathog. 2013;9(8):e1003522.
-
(2013)
PLoS Pathog
, vol.9
, Issue.8
-
-
Nagaraj, V.A.1
-
102
-
-
70350077269
-
Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases
-
Ho M-C, et al. Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases. Biochemistry. 2009;48(40):9618-26.
-
(2009)
Biochemistry
, vol.48
, Issue.40
, pp. 9618-9626
-
-
Ho, M.-C.1
-
103
-
-
84966326711
-
Profiling of multiple targets of artemisinin activated by hemin in cancer cell proteome
-
Zhou Y, Li W, Xiao Y. Profiling of multiple targets of artemisinin activated by hemin in cancer cell proteome. ACS Chem Biol. 2016;11(4):882-8.
-
(2016)
ACS Chem Biol
, vol.11
, Issue.4
, pp. 882-888
-
-
Zhou, Y.1
Li, W.2
Xiao, Y.3
-
104
-
-
84959253636
-
Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites plasmodium falciparum 3D7
-
Ismail HM, et al. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites plasmodium falciparum 3D7. Proc Natl Acad Sci. 2016;113(8):2080-5.
-
(2016)
Proc Natl Acad Sci
, vol.113
, Issue.8
, pp. 2080-2085
-
-
Ismail, H.M.1
-
105
-
-
58149339918
-
Large-Scale Differential Proteome Analysis in Plasmodium falciparum under Drug Treatment
-
Prieto JH, et al. Large-Scale Differential Proteome Analysis in Plasmodium falciparum under Drug Treatment. PLoS One. 2008;3(12):e4098.
-
(2008)
PLoS One.
, vol.3
, Issue.12
-
-
Prieto, J.H.1
-
106
-
-
84994716301
-
Metabolomics-based screening of the malaria box reveals both novel and established mechanisms of action
-
Creek DJ, et al. Metabolomics-based screening of the malaria box reveals both novel and established mechanisms of action. Antimicrob Agents Chemother. 2016;60(11):6650-63.
-
(2016)
Antimicrob Agents Chemother
, vol.60
, Issue.11
, pp. 6650-6663
-
-
Creek, D.J.1
-
107
-
-
85014574032
-
Characterization and redox regulation of plasmodium falciparum methionine adenosyltransferase
-
Pretzel J, et al. Characterization and redox regulation of plasmodium falciparum methionine adenosyltransferase. J Biochem. 2016;160(6):355-67.
-
(2016)
J Biochem
, vol.160
, Issue.6
, pp. 355-367
-
-
Pretzel, J.1
-
108
-
-
84455169978
-
The molecular basis of folate salvage in plasmodium falciparum characterization of two folate transporters
-
Salcedo-Sora JE, et al. The molecular basis of folate salvage in plasmodium falciparum characterization of two folate transporters. J Biol Chem. 2011;286(52):44659-68.
-
(2011)
J Biol Chem
, vol.286
, Issue.52
, pp. 44659-44668
-
-
Salcedo-Sora, J.E.1
-
109
-
-
33846088138
-
HMDB: the human metabolome database
-
Wishart DS, et al. HMDB: the human metabolome database. Nucleic Acids Res. 2007;35(suppl 1):D521-6.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. D521-D526
-
-
Wishart, D.S.1
-
110
-
-
84951850850
-
Haem-activated promiscuous targeting of artemisinin in plasmodium falciparum
-
Wang J, et al. Haem-activated promiscuous targeting of artemisinin in plasmodium falciparum. Nat Commun. 2015;6:10111.
-
(2015)
Nat Commun
, vol.6
, pp. 10111
-
-
Wang, J.1
-
111
-
-
0030985218
-
Characterization of Simian malarial parasite (plasmodium knowlesi)-induced putrescine transport in rhesus monkey erythrocytes a NOVEL PUTRESCINE CONJUGATE ARRESTS IN VITRO GROWTH OF SIMIAN MALARIAL PARASITE (PLASMODIUM KNOWLESI) AND CURES MULTIDRUG RESISTANT MURINE MALARIA (Plasmodium YOELII) INFECTION IN VIVO
-
Singh S, et al. Characterization of Simian malarial parasite (plasmodium knowlesi)-induced putrescine transport in rhesus monkey erythrocytes a NOVEL PUTRESCINE CONJUGATE ARRESTS IN VITRO GROWTH OF SIMIAN MALARIAL PARASITE (PLASMODIUM KNOWLESI) AND CURES MULTIDRUG RESISTANT MURINE MALARIA (Plasmodium YOELII) INFECTION IN VIVO. J Biol Chem. 1997;272(21):13506-11.
-
(1997)
J Biol Chem
, vol.272
, Issue.21
, pp. 13506-13511
-
-
Singh, S.1
-
112
-
-
0023125604
-
Effect of polyamine depletion on macromolecular synthesis of the malarial parasite, plasmodium falciparum, cultured in human erythrocytes
-
Assaraf YG, et al. Effect of polyamine depletion on macromolecular synthesis of the malarial parasite, plasmodium falciparum, cultured in human erythrocytes. Biochem J. 1987;242(1):221-6.
-
(1987)
Biochem J
, vol.242
, Issue.1
, pp. 221-226
-
-
Assaraf, Y.G.1
-
113
-
-
0014740770
-
The biochemical role of naturally occurring polyamines in nucleic acid synthesis
-
Stevens L. The biochemical role of naturally occurring polyamines in nucleic acid synthesis. Biol Rev. 1970;45(1):1-25.
-
(1970)
Biol Rev
, vol.45
, Issue.1
, pp. 1-25
-
-
Stevens, L.1
-
114
-
-
84873328169
-
Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells
-
Mandal S, et al. Depletion of cellular polyamines, spermidine and spermine, causes a total arrest in translation and growth in mammalian cells. Proc Natl Acad Sci. 2013;110(6):2169-74.
-
(2013)
Proc Natl Acad Sci
, vol.110
, Issue.6
, pp. 2169-2174
-
-
Mandal, S.1
-
115
-
-
84455170079
-
Phenotypic changes in artemisinin-resistant plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition
-
Teuscher F, et al. Phenotypic changes in artemisinin-resistant plasmodium falciparum lines in vitro: evidence for decreased sensitivity to dormancy and growth inhibition. Antimicrob Agents Chemother. 2012;56(1):428-31.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, Issue.1
, pp. 428-431
-
-
Teuscher, F.1
-
116
-
-
85008205759
-
Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments
-
Srivastava A, et al. Stage-specific changes in plasmodium metabolism required for differentiation and adaptation to different host and vector environments. PLoS Pathog. 2016;12(12):e1006094.
-
(2016)
PLoS Pathog
, vol.12
, Issue.12
-
-
Srivastava, A.1
-
117
-
-
33847055382
-
Vitamin and cofactor biosynthesis pathways in plasmodium and other apicomplexan parasites
-
Müller S, Kappes B. Vitamin and cofactor biosynthesis pathways in plasmodium and other apicomplexan parasites. Trends Parasitol. 2007;23(3):112-21.
-
(2007)
Trends Parasitol
, vol.23
, Issue.3
, pp. 112-121
-
-
Müller, S.1
Kappes, B.2
-
118
-
-
68949187841
-
Characterization of plasmodium falciparum serine hydroxymethyltransferase-a potential antimalarial target
-
Maenpuen S, et al. Characterization of plasmodium falciparum serine hydroxymethyltransferase-a potential antimalarial target. Mol Biochem Parasitol. 2009;168(1):63-73.
-
(2009)
Mol Biochem Parasitol
, vol.168
, Issue.1
, pp. 63-73
-
-
Maenpuen, S.1
-
119
-
-
23644440247
-
A glycine-cleavage complex as part of the folate one-carbon metabolism of plasmodium falciparum
-
Salcedo E, Sims PFG, Hyde JE. A glycine-cleavage complex as part of the folate one-carbon metabolism of plasmodium falciparum. Trends Parasitol. 2005;21(9):406-11.
-
(2005)
Trends Parasitol
, vol.21
, Issue.9
, pp. 406-411
-
-
Salcedo, E.1
Sims, P.F.G.2
Hyde, J.E.3
-
120
-
-
84869886096
-
Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization
-
Pornthanakasem W, et al. Plasmodium serine hydroxymethyltransferase: indispensability and display of distinct localization. Malar J. 2012;11(1):387.
-
(2012)
Malar J
, vol.11
, Issue.1
, pp. 387
-
-
Pornthanakasem, W.1
-
121
-
-
17444427080
-
A three-dimensional structure of plasmodium falciparum serine hydroxymethyltransferase in complex with glycine and 5-formyl-tetrahydrofolate. Homology modeling and molecular dynamics
-
França TCC, Pascutti PG, Ramalho TC. A three-dimensional structure of plasmodium falciparum serine hydroxymethyltransferase in complex with glycine and 5-formyl-tetrahydrofolate. Homology modeling and molecular dynamics. Biophys Chem. 2005;115(1):1-10.
-
(2005)
Biophys Chem
, vol.115
, Issue.1
, pp. 1-10
-
-
França, T.C.C.1
Pascutti, P.G.2
Ramalho, T.C.3
-
122
-
-
0033899208
-
Glutathione, oxidative stress and neurodegeneration
-
Schulz JB, et al. Glutathione, oxidative stress and neurodegeneration. Eur J Biochem. 2000;267(16):4904-11.
-
(2000)
Eur J Biochem
, vol.267
, Issue.16
, pp. 4904-4911
-
-
Schulz, J.B.1
-
123
-
-
0036728244
-
Oxidative stress, antioxidants and stress tolerance
-
Mittler R. Oxidative stress, antioxidants and stress tolerance. Trends Plant Sci. 2002;7(9):405-10.
-
(2002)
Trends Plant Sci
, vol.7
, Issue.9
, pp. 405-410
-
-
Mittler, R.1
-
124
-
-
1242316941
-
Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions
-
Becker K, et al. Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactions. Int J Parasitol. 2004;34(2):163-89.
-
(2004)
Int J Parasitol
, vol.34
, Issue.2
, pp. 163-189
-
-
Becker, K.1
-
125
-
-
0029908565
-
Molecular cloning and characterization of a putative glutathione reductase gene, the PfGR2 gene, from plasmodium falciparum
-
Färber PM, et al. Molecular cloning and characterization of a putative glutathione reductase gene, the PfGR2 gene, from plasmodium falciparum. Eur J Biochem. 1996;239(3):655-61.
-
(1996)
Eur J Biochem
, vol.239
, Issue.3
, pp. 655-661
-
-
Färber, P.M.1
-
126
-
-
78651262197
-
Compartmentation of redox metabolism in malaria parasites
-
Kehr S, et al. Compartmentation of redox metabolism in malaria parasites. PLoS Pathog. 2010;6(12):e1001242.
-
(2010)
PLoS Pathog
, vol.6
, Issue.12
-
-
Kehr, S.1
-
127
-
-
84926507971
-
Limma powers differential expression analyses for RNA-sequencing and microarray studies
-
Ritchie, M.E., et al., Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res, 2015. 43(7): p. e47-e47.
-
(2015)
Nucleic Acids Res
, vol.43
, Issue.7
-
-
Ritchie, M.E.1
-
128
-
-
84930526538
-
Defining the In Vivo Phenotype of Artemisinin-Resistant Falciparum Malaria: A Modelling Approach
-
White LJ, et al. Defining the In Vivo Phenotype of Artemisinin-Resistant Falciparum Malaria: A Modelling Approach. PLoS Med. 2015;12(4):e1001823.
-
(2015)
PLoS Med.
, vol.12
, Issue.4
-
-
White, L.J.1
-
129
-
-
0345040873
-
Classification and regression by randomForest
-
Liaw A, Wiener M. Classification and regression by randomForest. R News. 2002;2(3):18-22.
-
(2002)
R News
, vol.2
, Issue.3
, pp. 18-22
-
-
Liaw, A.1
Wiener, M.2
-
130
-
-
0001677717
-
Controlling the false discovery rate: a practical and powerful approach to multiple testing
-
Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc. Series B (Methodological). 1995:289-300.
-
(1995)
J R Stat Soc. Series B (Methodological).
, pp. 289-300
-
-
Benjamini, Y.1
Hochberg, Y.2
-
131
-
-
0035733108
-
The control of the false discovery rate in multiple testing under dependency
-
Benjamini Y, Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Ann Stat. 2001:1165-88.
-
(2001)
Ann Stat.
, pp. 1165-1188
-
-
Benjamini, Y.1
Yekutieli, D.2
-
132
-
-
34347258175
-
Quantitative prediction of cellular metabolism with constraint-based models: the COBRA toolbox
-
Becker SA, et al. Quantitative prediction of cellular metabolism with constraint-based models: the COBRA toolbox. Nat Protoc. 2007;2
-
(2007)
Nat Protoc.
, pp. 2
-
-
Becker, S.A.1
-
134
-
-
77957837882
-
Metabolic network analysis of Pseudomonas Aeruginosa during chronic cystic fibrosis lung infection
-
Oberhardt MA, et al. Metabolic network analysis of Pseudomonas Aeruginosa during chronic cystic fibrosis lung infection. J Bacteriol. 2010;192
-
(2010)
J Bacteriol.
, pp. 192
-
-
Oberhardt, M.A.1
-
135
-
-
77957117220
-
Computationally efficient flux variability analysis
-
Gudmundsson S, Thiele I. Computationally efficient flux variability analysis. BMC Bioinform. 2010;11(1):489.
-
(2010)
BMC Bioinform
, vol.11
, Issue.1
, pp. 489
-
-
Gudmundsson, S.1
Thiele, I.2
-
136
-
-
84976907502
-
KEGG as a reference resource for gene and protein annotation
-
Kanehisa M, et al. KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 2016;44(D1):D457-62.
-
(2016)
Nucleic Acids Res
, vol.44
, Issue.D1
, pp. D457-D462
-
-
Kanehisa, M.1
-
137
-
-
0043122944
-
ExPASy: the proteomics server for in-depth protein knowledge and analysis
-
Gasteiger E, et al. ExPASy: the proteomics server for in-depth protein knowledge and analysis. Nucleic Acids Res. 2003;31(13):3784-8.
-
(2003)
Nucleic Acids Res
, vol.31
, Issue.13
, pp. 3784-3788
-
-
Gasteiger, E.1
-
138
-
-
33745006576
-
Progress in in silico functional genomics: the malaria metabolic pathways database
-
Ginsburg H. Progress in in silico functional genomics: the malaria metabolic pathways database. Trends Parasitol. 2006;22(6):238-40.
-
(2006)
Trends Parasitol
, vol.22
, Issue.6
, pp. 238-240
-
-
Ginsburg, H.1
-
139
-
-
80052308799
-
Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum
-
Yeh E, DeRisi JL. Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum. PLoS Biol. 2011;9(8):e1001138.
-
(2011)
PLoS Biol.
, vol.9
, Issue.8
-
-
Yeh, E.1
DeRisi, J.L.2
-
140
-
-
0034730173
-
Hexose permeation pathways in plasmodium falciparum-infected erythrocytes
-
Woodrow CJ, Burchmore RJ, Krishna S. Hexose permeation pathways in plasmodium falciparum-infected erythrocytes. Proc Natl Acad Sci U S A. 2000;97(18):9931-6.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, Issue.18
, pp. 9931-9936
-
-
Woodrow, C.J.1
Burchmore, R.J.2
Krishna, S.3
-
141
-
-
84912948273
-
STUDIES ON MALARIAL PARASITES: VIII. FACTORS AFFECTING THE GROWTH OF PLASMODIUM KNOWLESI IN VITRO
-
Anfinsen CB, et al. STUDIES ON MALARIAL PARASITES: VIII. FACTORS AFFECTING THE GROWTH OF PLASMODIUM KNOWLESI IN VITRO. J Exp Med. 1946;84(6):607-21.
-
(1946)
J Exp Med
, vol.84
, Issue.6
, pp. 607-621
-
-
Anfinsen, C.B.1
-
142
-
-
0034019568
-
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against plasmodium falciparum
-
Jiang L, et al. Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against plasmodium falciparum. Antimicrob Agents Chemother. 2000;44(4):1047-50.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, Issue.4
, pp. 1047-1050
-
-
Jiang, L.1
-
143
-
-
57049187017
-
The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites
-
Yu M, et al. The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites. Cell Host Microbe. 2008;4(6):567-78.
-
(2008)
Cell Host Microbe
, vol.4
, Issue.6
, pp. 567-578
-
-
Yu, M.1
-
144
-
-
59849125892
-
Type II fatty acid synthesis is essential only for malaria parasite late liver stage development
-
Vaughan AM, et al. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol. 2009;11(3):506-20.
-
(2009)
Cell Microbiol
, vol.11
, Issue.3
, pp. 506-520
-
-
Vaughan, A.M.1
-
145
-
-
70350385202
-
Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
-
Deng X, et al. Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds. J Biol Chem. 2009;284(39):26999-7009.
-
(2009)
J Biol Chem
, vol.284
, Issue.39
, pp. 26999-27009
-
-
Deng, X.1
-
146
-
-
0036155407
-
RNA interference (RNAi) inhibits growth of plasmodium falciparum
-
McRobert L, McConkey GA. RNA interference (RNAi) inhibits growth of plasmodium falciparum. Mol Biochem Parasitol. 2002;119(2):273-8.
-
(2002)
Mol Biochem Parasitol
, vol.119
, Issue.2
, pp. 273-278
-
-
McRobert, L.1
McConkey, G.A.2
-
147
-
-
85025101468
-
Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target
-
(0022-2623 (Print)).
-
Nguyen, C., et al., Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. (0022-2623 (Print)).
-
-
-
Nguyen, C.1
-
148
-
-
85025077388
-
Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester
-
(0006-2952 (Print)).
-
Thornalley, P.J., R.J. Strath M Fau - Wilson, and R.J. Wilson, Antimalarial activity in vitro of the glyoxalase I inhibitor diester, S-p-bromobenzylglutathione diethyl ester. (0006-2952 (Print)).
-
-
-
Thornalley, P.J.1
Strath, R.J.2
Fau-Wilson, M.3
Wilson, R.J.4
-
149
-
-
0037033439
-
Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy
-
Hanada K, et al. Plasmodium falciparum phospholipase C hydrolyzing sphingomyelin and lysocholinephospholipids is a possible target for malaria chemotherapy. J Exp Med. 2002;195(1):23-34.
-
(2002)
J Exp Med
, vol.195
, Issue.1
, pp. 23-34
-
-
Hanada, K.1
-
150
-
-
85025101222
-
Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum
-
(0027-8424 (Print)).
-
Silva, A.M., et al., Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum. (0027-8424 (Print)).
-
-
-
Silva, A.M.1
-
151
-
-
84862286628
-
Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin
-
Hoepfner D, et al. Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host Microbe. 2012;11(6):654-63.
-
(2012)
Cell Host Microbe
, vol.11
, Issue.6
, pp. 654-663
-
-
Hoepfner, D.1
-
152
-
-
84855760118
-
Dissecting the role of glutathione biosynthesis in plasmodium falciparum
-
Patzewitz EM, Wong EH, Muller S. Dissecting the role of glutathione biosynthesis in plasmodium falciparum. Mol Microbiol. 2012;83(2):304-18.
-
(2012)
Mol Microbiol
, vol.83
, Issue.2
, pp. 304-318
-
-
Patzewitz, E.M.1
Wong, E.H.2
Muller, S.3
-
153
-
-
66349103376
-
Identification of proteins targeted by the thioredoxin superfamily in plasmodium falciparum
-
Sturm N, et al. Identification of proteins targeted by the thioredoxin superfamily in plasmodium falciparum. PLoS Pathog. 2009;5(4):e1000383.
-
(2009)
PLoS Pathog
, vol.5
, Issue.4
-
-
Sturm, N.1
-
154
-
-
84877793151
-
1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents
-
Belorgey D, Lanfranchi DA, Davioud-Charvet E. 1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents. Curr Pharm Des. 2013;19(14):2512-28.
-
(2013)
Curr Pharm Des
, vol.19
, Issue.14
, pp. 2512-2528
-
-
Belorgey, D.1
Lanfranchi, D.A.2
Davioud-Charvet, E.3
-
155
-
-
84938367995
-
Role and regulation of glutathione metabolism in plasmodium falciparum
-
Muller S. Role and regulation of glutathione metabolism in plasmodium falciparum. Mol. 2015;20(6):10511-34.
-
(2015)
Mol
, vol.20
, Issue.6
, pp. 10511-10534
-
-
Muller, S.1
-
156
-
-
77956245794
-
Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito
-
Pastrana-Mena R, et al. Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito. J Biol Chem. 2010;285(35):27045-56.
-
(2010)
J Biol Chem
, vol.285
, Issue.35
, pp. 27045-27056
-
-
Pastrana-Mena, R.1
|