Developing artemisinin based drug combinations for the treatment of drug resistant falciparum malaria: A review

Journal of Postgraduate Medicine

Volumn 50, Issue 1, 2004, Pages 40-44

  Olliaro, P L ^a   Taylor, W R J ^a  

^a WORLD BANK   (United States)

Author keywords

Drug combination; Drug resistance; Malaria; Treatment

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; ARTEKIN; ARTEMETHER; ARTEMETHER PLUS BENFLUMETOL; ARTEMISININ DERIVATIVE; ARTESUNATE; ATOVAQUONE PLUS PROGUANIL; BENFLUMETOL; CHLOROQUINE; CHLORPROGUANIL PLUS DAPSONE; CLINDAMYCIN; DIHYDROARTEMISININ DERIVATIVE; FANSIDAR; FANSIMEF; FOLIC ACID ANTAGONIST; FOSMIDOMYCIN; ISOPRENOID; MEFLOQUINE; PIPERAQUINE; PLACEBO; PYRIMETHAMINE; PYRONARIDINE; QUININE DERIVATIVE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULFADOXINE;

CHILD; CLINICAL RESEARCH; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG PACKAGING; DRUG POTENTIATION; DRUG SAFETY; DRUG SYNTHESIS; DRUG TOLERABILITY; HUMAN; MALARIA CONTROL; MALARIA FALCIPARUM; PLASMODIUM FALCIPARUM; REVIEW; SIDE EFFECT; SOUTHEAST ASIA; VECTOR CONTROL;

ANIMALS; ANTIMALARIALS; ARTEMISININS; DRUG RESISTANCE, MICROBIAL; DRUG THERAPY, COMBINATION; HUMANS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; SESQUITERPENES;

EID: 1942504778     PISSN: 00223859     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (40)

1. World malaria situation in 1994. Part I. Population at risk. Wkl Epidemiol Rec 1997;72:269-76.
2. Snow RN, Craig M, Deichmann U, Marsh K. Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population. Bull World Health Organ 1999;77:624-40.
3. Remme JH, Binka F, Nabarro D. Toward a framework and indicators for monitoring Roll Back Malaria. Am J Trop Med Hyg 2001;64:76-84.
4. White NJ. Antimalarial drug resistance:the pace quickens. J Antimicob Chemother 1992;30:571-85.
5. Wongsrichanalai C, Pickard AL, Wernsdorfer WH, Meshnick SR. Epidemiology of drug-resistant malaria. Lancet Infect Dis 2002;2:209-18.
6. Pukrittayakamee S, Supanaranond W, Looareesuwan S, Vanijanonta S, White NJ. Quinine in severe falciparum malaria: evidence of declining efficacy in Thailand. Trans R Soc Trop Med Hyg 1994;88:324-7.
7. Garg M, Gopinathan N, Bodhe P, Kshirsagar NA. Vivax malaria resistant to chloroquine:case reports from Bombay. Trans R Soc Trop Med Hyg 1995:89:656-7.
8. Myat-Phone-Kyaw, Myint-Oo, Myint-Lwin, Thaw-Zin, Kyin-Hla-Aye, Nwe-Nwe-Yin. Emergence of chloroquine-resistant Plasmodium vivax in Myanmar (Burma). Trans R Soc Trop Med Hyg 1993;87:687.
9. Murphy GS, Purnomo HB, Andersen EM, Bangs MJ, Mount DL, Gorden J, et al. Vivax malaria resistant to treatment and prophylaxis with chloroquine. Lancet 1993:341:96-100.
10. Schuurkamp GJ, Spicer PE, Kereu RK, Bulungol PK, Rieckmann KH. Chloroquine-resistant Plasmodium vivax in Papua New Guinea. Trans R Soc Trop Med Hyg 1992;86:121-2.
11. Alecrim MD, Alecrim W, Macedo V. Plasmodium vivax resistance to chloroquine (R2) and mefloquine (R3) in Brazilian Amazon region. Rev Soc Bras Med Trop 1999;32:67-8.
12. Phillips EJ, Keystone JS, Kain KC. Failure of combined chloroquine and high dose primaquine therapy for Plasmodium vivax malaria acquired in Guyana, South America. Clin Infect Dis 1996;23:1171-3.
13. Soto J, Toledo J, Guthierrez P, Luzz M, Llinas N, Cedeno N, et al. Plasmodium vivax clinically resistant to chloroquine in Colombia. Am J Trop Med Hyg 2001;65:90-3.
14. Taylor WR, Widjaja H, Richie TL, Basri H, Ohrt C, Tjitra, et al. Chloroquine/doxycycline combination versus chloroquine alone, and doxycycline alone for the treatment of Plasmodium falciparum and Plasmodium vivax malaria in northeastern Irian Jaya, Indonesia. Am J Trop Med Hyg 2001;64:223-8.
15. Maguire JD, Sumawinata IW, Masbar S, Laksana B, Prodjodipuro P, Susanti I, et al. Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. Lancet 2002;360:58-60.
16. Price RN, Nosten F. Drug resistant falciparum malaria: clinical consequences and strategies for prevention. Drug Resist Updat 2001;4:187-96.
17. Trape JF, Pison G, Preziosi MP, Enel C, Desgrees du Lou A, Delaunay V, et al. Impact of chloroquine resistance on malaria mortality. Comptes Rendus Aced Sci III 1998;321:689-97.
18. Murphy SC, Breman JG. Gaps in the childhood malaria burden in Africa:cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia, and complications of pregnancy. Am J Trop Med Hyg 2001;64:57-67.
19. Zucker JR, Lackritz EM, Ruebush TK, Hightower AW, Adungosi JE, Were JB, et al. Childhood mortality during and after hospitalization in Western Kenya:Effect of malaria treatment regimens. Am J Trop Med Hyg 1996;55:655-60.
20. Bloland PB, Ettling M. Making malaria-treatment policy in the face of drug resistance. Ann Trop Med Parasitol 1999;93:5-23.
21. White NJ. Pongtavornpinyo W. The de novo selection of drug-resistant malaria parasites. Proc R Soc Lond B Biol Sci 2003;270:545-54.
22. Nzila AM, Nduati E, Mberu EK, Hopkins Sibley C, Monks SA, Winstanley PA, et al. Molecular evidence of greater selective pressure for drug resistance exerted by the long-acting antifolate Pyrimethamine/Sulfadoxine compared with the shorter-acting chlorproguanil/dapsone on Kenyan Plasmodium falciparum. J Infect Dis 2000;181:2023-8.
23. Peters W. The prevention of antimalarial drug resistance. Pharmacol Ther 1990;47:499-508.
24. Nosten F, Luxemburger C, ter Kuile FO, Woodrow C, Eh JP, Chongsuphajaisiddhi T et al. Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination. J Infect Dis 1994;170:971-7.
25. Nosten F, van Vugt M, Price R, Luxemburger C, Thway KL, Brockman A, et al. Effects of artesunate-mefloquine combination on incidence of Plasmodium falciparum malaria and mefloquine resistance in western Thailand: a prospective study. Lancet 2000;356:297-302.
26. White NJ. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob Agents Chemother 1997;41:1413-22.
27. Meshnick SR. Artemisinin: mechanisms of action, resistance and toxicity. Int J Parasitol. 2002;32:1655-60.
28. Olliaro P, Taylor WR, Rigal J. Controlling malaria: challenges and solutions. Trop Med Int Health 2001;6:922-7.
29. von Seidlein L. Milligan P, Pinder M, Bojang K, Anyalebechi C, Gosling R, et al. Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children:a double-blind, randomised, controlled trial. Lancet 2000;355:352-7.
30. Adjuik M, Agnamey P, Babiker A, Borrmann S, Brasseur P, Cisse M, et al. Amodiaquine-artesunate versus amodiaquine for uncomplicated Plasmodium falciparum malaria in African children: a randomised, multicentre trial. Lancet 2002;359:1365-72.
31. International Artemesinin Study group. In press Artesunate combinations for the treatment of malaria. Lancet 2004.
32. WHO. Antimalarial drug combination therapy. WHO/CDS/RBM/2001.35
33. Lang T, Greenwood B. The development of Lapdap, an affordable new treatment for malaria. Lancet Infect Dis 2003;3:162-8.
34. Mutabingwa T, Nzila A, Mberu E, Nduati E, Winstanley P, Hills E, et al. Chlorproguanildapsone for treatment of drug-resistant falciparum malaria in Tanzania. Lancet 2001;358:1218-23.
35. Vugt MV, Wilairatana P, Gemperli B, Gathmann I, Phaipun L, Brockman A, et al. Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant Plasmodium falciparum malaria. Am J Trop Med Hyg 1999;60:936-42.
36. Denis MB, Davis TM, Hewitt S, Incardona S, Nimol K, Fandeur T, et al. Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria. Clin Infect Dis 2002;35:1469-76.
37. Ringwald P, Bickii J, Basco L. Randomised trial of pyronaridine versus chloroquine for acute uncomplicated falciparum malaria in Africa. Lancet 1996;347:24-8.
38. Looareesuwan S, Kyle DE, Viravan C, Vanijanonta S, Wilairatana P, Wernsdorfer WH. Clinical study of pyronaridine for the treatment of acute uncomplicated falciparum malaria in Thailand. Am J Trop Med Hyg 1996;54:205-9.
39. Lell B, Ruangweerayut R, Wiesner J, Missinou MA, Schindler A, Baranek T, et al. Fosmidomycin, a novel chemotherapeutic agent for malaria. Antimicrob Agents Chemother 2003;47:735-8.
40. Missinou MA, Borrmann S, Schindler A, Issifou S, Adegnika AA, Matsiegui PB, et al. Fosmidomycin for malaria. Lancet 2002;360:1941-2.