Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 8, 2016, Pages 2080-2085

  Ismail, Hanafy M ^a   Barton, Victoria ^b   Phanchana, Matthew ^a   Charoensutthivarakul, Sitthivut ^b   Wong, Michael H L ^a   Hemingway, Janet ^a   Biagini, Giancarlo A ^a   O'Neill, Paul M ^b   Ward, Stephen A ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Antimalarial; Artemisinin; Bioactivation; Chemical proteomics; Molecular targets

Indexed keywords

ANTIOXIDANT; ARTEMISIN ACTIVITY BASED PROTEIN PROFILING PROBE; ARTEMISININ DERIVATIVE; CARRIER PROTEIN; CHAPERONE; CYTOCHROME P450; DYE; HEMOGLOBIN; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; ARTEMISIN; LACTONE; MOLECULAR PROBE; PROTOZOAL PROTEIN;

ALKYLATION; ANTIMALARIAL ACTIVITY; ARTICLE; CLICK CHEMISTRY; CONTROLLED STUDY; CYTOSKELETON; GLYCOLYSIS; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; PARASITE SURVIVAL; PLASMODIUM (LIFE CYCLE STAGE); PLASMODIUM FALCIPARUM 3D7; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; PROTEOMICS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; HUMAN; LIFE CYCLE STAGE; METABOLISM; MOLECULAR PROBE; PHARMACOLOGY; PLASMODIUM FALCIPARUM; SYNTHESIS;

ANTIMALARIALS; ARTEMISININS; CLICK CHEMISTRY; HUMANS; LACTONES; LIFE CYCLE STAGES; MOLECULAR PROBES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 84959253636     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1600459113     Document Type: Article

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