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Volumn 12, Issue 4, 2013, Pages 316-327

Functional genomics of plasmodium falciparum using metabolic modelling and analysis

Author keywords

Central carbon metabolism; Constraint based modelling; Flux balance analysis; In silico gene essentiality; Plasmodium falciparum; Systems biology

Indexed keywords

ARTICLE; BIOMICS; COMPUTER MODEL; FLUXOMICS; FUNCTIONAL GENOMICS; GENOMICS; MALARIA; METABOLOMICS; NONHUMAN; PLASMODIUM FALCIPARUM; PROTEOMICS; SYSTEMS BIOLOGY; TRANSCRIPTOMICS;

EID: 84882619498     PISSN: 20412649     EISSN: 20412657     Source Type: Journal    
DOI: 10.1093/bfgp/elt017     Document Type: Article
Times cited : (14)

References (87)
  • 2
    • 0037015614 scopus 로고    scopus 로고
    • Genome sequence of the human malaria parasite Plasmodium falciparum
    • Gardner MJ, Hall N, Fung E, et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature
    • (2002) Nature , vol.419 , pp. 498-511
    • Gardner, M.J.1    Hall, N.2    Fung, E.3
  • 3
    • 79957577925 scopus 로고    scopus 로고
    • Functional genetics in Apicomplexa: potentials and limits
    • Limenitakis J, Soldati-Favre D. Functional genetics in Apicomplexa: potentials and limits. FEBS Lett 2011;585: 1579-88.
    • (2011) FEBS Lett , vol.585 , pp. 1579-1588
    • Limenitakis, J.1    Soldati-Favre, D.2
  • 4
    • 67649882048 scopus 로고    scopus 로고
    • Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites
    • Baum J, Papenfuss AT, Mair GR, et al. Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Res 2009;37:3788-98.
    • (2009) Nucleic Acids Res , vol.37 , pp. 3788-3798
    • Baum, J.1    Papenfuss, A.T.2    Mair, G.R.3
  • 6
    • 84862282934 scopus 로고    scopus 로고
    • Moving ''forward'' in Plasmodium genetics through a transposon-based approach
    • Balu B. Moving ''forward'' in Plasmodium genetics through a transposon-based approach. JTropMed 2012;2012:829210.
    • (2012) JTropMed , vol.2012 , pp. 829210
    • Balu, B.1
  • 7
    • 84860004871 scopus 로고    scopus 로고
    • Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum
    • Augagneur Y, Wesolowski D, Tae HS, et al. Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. ProcNatl Acad SciUSA 2012;109:6235-40.
    • (2012) ProcNatl Acad SciUSA , vol.109 , pp. 6235-6240
    • Augagneur, Y.1    Wesolowski, D.2    Tae, H.S.3
  • 8
    • 84863230581 scopus 로고    scopus 로고
    • Metabolic network modeling and simulation for drug targeting and discovery
    • Kim HU, Sohn SB, Lee SY. Metabolic network modeling and simulation for drug targeting and discovery. BiotechnolJ 2012;7:330-42.
    • (2012) BiotechnolJ , vol.7 , pp. 330-342
    • Kim, H.U.1    Sohn, S.B.2    Lee, S.Y.3
  • 9
    • 35649002488 scopus 로고    scopus 로고
    • Metabolic reconstruction and analysis for parasite genomes
    • Pinney JW, Papp B, Hyland C, et al. Metabolic reconstruction and analysis for parasite genomes. Trends Parasitol 2007; 23:548-54.
    • (2007) Trends Parasitol , vol.23 , pp. 548-554
    • Pinney, J.W.1    Papp, B.2    Hyland, C.3
  • 10
    • 84865535722 scopus 로고    scopus 로고
    • Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism
    • Bazzani S, Hoppe A, Holzhutter HG. Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism. BMCSyst Biol 2012;6:118.
    • (2012) BMCSyst Biol , vol.6 , pp. 118
    • Bazzani, S.1    Hoppe, A.2    Holzhutter, H.G.3
  • 11
    • 64549142857 scopus 로고    scopus 로고
    • Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico
    • Fatumo S, Plaimas K, Mallm JP, et al. Estimating novel potential drug targets of Plasmodium falciparum by analysing the metabolic network of knock-out strains in silico. Infect Genet Evol 2009;9:351-8.
    • (2009) Infect Genet Evol , vol.9 , pp. 351-358
    • Fatumo, S.1    Plaimas, K.2    Mallm, J.P.3
  • 12
    • 77956456621 scopus 로고    scopus 로고
    • Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
    • Huthmacher C, Hoppe A, Bulik S, et al. Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. BMCSyst Biol 2010;4:120.
    • (2010) BMCSyst Biol , vol.4 , pp. 120
    • Huthmacher, C.1    Hoppe, A.2    Bulik, S.3
  • 13
    • 77956419824 scopus 로고    scopus 로고
    • Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network
    • Plata G, Hsiao TL, Olszewski KL, et al. Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol 2010;6:408.
    • (2010) Mol Syst Biol , vol.6 , pp. 408
    • Plata, G.1    Hsiao, T.L.2    Olszewski, K.L.3
  • 14
    • 2442636351 scopus 로고    scopus 로고
    • Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery
    • Yeh I, Hanekamp T, Tsoka S, et al. Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery. Genome Res 2004; 14:917-24.
    • (2004) Genome Res , vol.14 , pp. 917-924
    • Yeh, I.1    Hanekamp, T.2    Tsoka, S.3
  • 15
    • 33747853193 scopus 로고    scopus 로고
    • Enlistment of omics technologies in the fight against malaria: Panacea or Pandora's Box?
    • Hayes CN, Wheelock AM, Normark J, et al. Enlistment of omics technologies in the fight against malaria: Panacea or Pandora's Box?. J Pestic Sci 2006;31:263-72.
    • (2006) J Pestic Sci , vol.31 , pp. 263-272
    • Hayes, C.N.1    Wheelock, A.M.2    Normark, J.3
  • 16
    • 0032919364 scopus 로고    scopus 로고
    • KEGG: Kyoto Encyclopedia of Genes and Genomes
    • Ogata H, Goto S, Sato K, et al. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res 1999;27:29-34.
    • (1999) Nucleic Acids Res , vol.27 , pp. 29-34
    • Ogata, H.1    Goto, S.2    Sato, K.3
  • 17
    • 33745006576 scopus 로고    scopus 로고
    • Progress in in silico functional genomics: the malaria Metabolic Pathways database
    • Ginsburg H. Progress in in silico functional genomics: the malaria Metabolic Pathways database. Trends Parasitol 2006; 22:238-40.
    • (2006) Trends Parasitol , vol.22 , pp. 238-240
    • Ginsburg, H.1
  • 18
    • 19344365153 scopus 로고    scopus 로고
    • Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes
    • Bozdech Z, Ginsburg H. Data mining of the transcriptome of Plasmodium falciparum: the pentose phosphate pathway and ancillary processes. MalarJ 2005;4:17.
    • (2005) MalarJ , vol.4 , pp. 17
    • Bozdech, Z.1    Ginsburg, H.2
  • 19
    • 4644268555 scopus 로고    scopus 로고
    • Mathematical models in microbial systems biology
    • Stelling J. Mathematical models in microbial systems biology. Curr OpinMicrobiol 2004;7:513-8.
    • (2004) Curr OpinMicrobiol , vol.7 , pp. 513-518
    • Stelling, J.1
  • 22
    • 84858439602 scopus 로고    scopus 로고
    • Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods
    • Lewis NE, Nagarajan H, Palsson BO. Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods. NatRevMicrobiol
    • (2012) NatRevMicrobiol , vol.10 , pp. 291-305
    • Lewis, N.E.1    Nagarajan, H.2    Palsson, B.O.3
  • 24
    • 34447523907 scopus 로고    scopus 로고
    • Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli
    • Schuetz R, Kuepfer L, Sauer U. Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli. Mol Syst Biol 2007;3:119.
    • (2007) Mol Syst Biol , vol.3 , pp. 119
    • Schuetz, R.1    Kuepfer, L.2    Sauer, U.3
  • 25
    • 75149129569 scopus 로고    scopus 로고
    • A protocol for generating a highquality genome-scale metabolic reconstruction
    • Thiele I, Palsson BO. A protocol for generating a highquality genome-scale metabolic reconstruction. Nature Protoc 2010;5:93-121.
    • (2010) Nature Protoc , vol.5 , pp. 93-121
    • Thiele, I.1    Palsson, B.O.2
  • 26
    • 41149169317 scopus 로고    scopus 로고
    • Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major
    • Chavali AK, Whittemore JD, Eddy JA, et al. Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major. Mol Syst Biol 2008;4:177.
    • (2008) Mol Syst Biol , vol.4 , pp. 177
    • Chavali, A.K.1    Whittemore, J.D.2    Eddy, J.A.3
  • 28
    • 78650188512 scopus 로고    scopus 로고
    • Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico
    • Fatumo S, Plaimas K, Adebiyi E, et al. Comparing metabolic network models based on genomic and automatically inferred enzyme information from Plasmodium and its human host to define drug targets in silico. Infect Genet Evol 2011;11:201-8.
    • (2011) Infect Genet Evol , vol.11 , pp. 201-208
    • Fatumo, S.1    Plaimas, K.2    Adebiyi, E.3
  • 29
    • 84857840354 scopus 로고    scopus 로고
    • SuperTarget goes quantitative: update on drug-target interactions
    • Hecker N, Ahmed J, Eichborn J, et al. SuperTarget goes quantitative: update on drug-target interactions. Nucleic Acids Res 2012;40:D1113-7.
    • (2012) Nucleic Acids Res , vol.40
    • Hecker, N.1    Ahmed, J.2    Eichborn, J.3
  • 30
    • 60649112444 scopus 로고    scopus 로고
    • Host-parasite interactions revealed by Plasmodiumfalciparum metabolomics
    • Olszewski KL, Morrisey JM, Wilinski D, et al. Host-parasite interactions revealed by Plasmodiumfalciparum metabolomics. CellHostMicrobe 2009;5:191-9.
    • (2009) CellHostMicrobe , vol.5 , pp. 191-199
    • Olszewski, K.L.1    Morrisey, J.M.2    Wilinski, D.3
  • 31
    • 77956407882 scopus 로고    scopus 로고
    • HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology
    • Gille C, Bolling C, Hoppe A, et al. HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol 2010;6:411.
    • (2010) Mol Syst Biol , vol.6 , pp. 411
    • Gille, C.1    Bolling, C.2    Hoppe, A.3
  • 33
    • 77952952952 scopus 로고    scopus 로고
    • Network thermodynamics in the post-genomic era
    • Soh KC, Hatzimanikatis V. Network thermodynamics in the post-genomic era. Curr OpinMicrobiol 2010;13:350-7.
    • (2010) Curr OpinMicrobiol , vol.13 , pp. 350-357
    • Soh, K.C.1    Hatzimanikatis, V.2
  • 34
    • 84857052437 scopus 로고    scopus 로고
    • From network models to network responses: integration of thermodynamic and kinetic properties of yeast genome-scale metabolic networks
    • Soh KC, Miskovic L, Hatzimanikatis V. From network models to network responses: integration of thermodynamic and kinetic properties of yeast genome-scale metabolic networks. FemsYeast Res 2012;12:129-43.
    • (2012) FemsYeast Res , vol.12 , pp. 129-143
    • Soh, K.C.1    Miskovic, L.2    Hatzimanikatis, V.3
  • 35
    • 79953649492 scopus 로고    scopus 로고
    • Reconciliation of genome-scale metabolic reconstructions for comparative systems analysis
    • Oberhardt MA, Puchalka J, dos Santos VAPM, et al. Reconciliation of genome-scale metabolic reconstructions for comparative systems analysis. PLoS Computat Biol 2011; 7:e1001116.
    • (2011) PLoS Computat Biol , vol.7
    • Oberhardt, M.A.1    Puchalka, J.2    dos Santos, V.A.P.M.3
  • 36
    • 84856314687 scopus 로고    scopus 로고
    • MetaMerge: scaling up genome-scale metabolic reconstructions with application to Mycobacterium tuberculosis
    • Chindelevitch L, Stanley S, Hung D, et al. MetaMerge: scaling up genome-scale metabolic reconstructions with application to Mycobacterium tuberculosis. Genome Biol 2012; 13:r6.
    • (2012) Genome Biol , vol.13
    • Chindelevitch, L.1    Stanley, S.2    Hung, D.3
  • 37
    • 14844349363 scopus 로고    scopus 로고
    • metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of Plasmodium falciparum and Eimeria tenella
    • Pinney JW, Shirley MW, McConkey GA, et al. metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of Plasmodium falciparum and Eimeria tenella. Nucleic Acids Res 2005;33:1399-409.
    • (2005) Nucleic Acids Res , vol.33 , pp. 1399-1409
    • Pinney, J.W.1    Shirley, M.W.2    McConkey, G.A.3
  • 38
    • 77954469267 scopus 로고    scopus 로고
    • DETECT-a density estimation tool for enzyme classification and its application to Plasmodium falciparum
    • Hung SS, Wasmuth J, Sanford C, et al. DETECT-a density estimation tool for enzyme classification and its application to Plasmodium falciparum. Bioinformatics 2010;26: 1690-8.
    • (2010) Bioinformatics , vol.26 , pp. 1690-1698
    • Hung, S.S.1    Wasmuth, J.2    Sanford, C.3
  • 39
    • 63549108441 scopus 로고    scopus 로고
    • GrowMatch: an automated method for reconciling in silico/in vivo growth predictions
    • Kumar VS, Maranas CD. GrowMatch: an automated method for reconciling in silico/in vivo growth predictions. PLoSComput Biol 2009;5:e1000308.
    • (2009) PLoSComput Biol , vol.5
    • Kumar, V.S.1    Maranas, C.D.2
  • 40
    • 4243071596 scopus 로고    scopus 로고
    • The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum
    • Bozdech Z, Llinas M, Pulliam BL, et al. The transcriptome of the intraerythrocytic developmental cycle of Plasmodium falciparum. PLoS Biol 2003;1:85-100.
    • (2003) PLoS Biol , vol.1 , pp. 85-100
    • Bozdech, Z.1    Llinas, M.2    Pulliam, B.L.3
  • 41
    • 0141633042 scopus 로고    scopus 로고
    • Discovery of gene function by expression profiling of the malaria parasite life cycle
    • Le Roch KG, Zhou YY, Blair PL, et al. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science 2003;301:1503-8.
    • (2003) Science , vol.301 , pp. 1503-1508
    • Le Roch, K.G.1    Zhou, Y.Y.2    Blair, P.L.3
  • 42
    • 37249026903 scopus 로고    scopus 로고
    • Distinct physiological states of Plasmodium falciparum in malaria-infected patients
    • Daily JP, Scanfeld D, Pochet N, et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature 2007;450:1091-5.
    • (2007) Nature , vol.450 , pp. 1091-1095
    • Daily, J.P.1    Scanfeld, D.2    Pochet, N.3
  • 43
    • 77950265905 scopus 로고    scopus 로고
    • New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq
    • Otto TD, Wilinski D, Assefa S, et al. New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. MolMicrobiol 2010;76:12-24.
    • (2010) MolMicrobiol , vol.76 , pp. 12-24
    • Otto, T.D.1    Wilinski, D.2    Assefa, S.3
  • 44
    • 84866487453 scopus 로고    scopus 로고
    • Integration of expression data in genome-scale metabolic network reconstructions
    • Blazier AS, Papin JA. Integration of expression data in genome-scale metabolic network reconstructions. Front Physiol 2012;3:299.
    • (2012) Front Physiol , vol.3 , pp. 299
    • Blazier, A.S.1    Papin, J.A.2
  • 45
    • 0037015602 scopus 로고    scopus 로고
    • A proteomic view of the Plasmodium falciparum life cycle
    • Florens L, Washburn MP, Raine JD, et al. A proteomic view of the Plasmodium falciparum life cycle. Nature 2002;419: 520-6.
    • (2002) Nature , vol.419 , pp. 520-526
    • Florens, L.1    Washburn, M.P.2    Raine, J.D.3
  • 46
    • 0037015610 scopus 로고    scopus 로고
    • Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry
    • Lasonder E, Ishihama Y, Andersen JS, et al. Analysis of the Plasmodium falciparum proteome by high-accuracy mass spectrometry. Nature 2002;419:537-42.
    • (2002) Nature , vol.419 , pp. 537-542
    • Lasonder, E.1    Ishihama, Y.2    Andersen, J.S.3
  • 47
    • 67649908740 scopus 로고    scopus 로고
    • Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi
    • Roberts SB, Robichaux JL, Chavali AK, et al. Proteomic and network analysis characterize stage-specific metabolism in Trypanosoma cruzi. BMCSyst Biol 2009;3:52.
    • (2009) BMCSyst Biol , vol.3 , pp. 52
    • Roberts, S.B.1    Robichaux, J.L.2    Chavali, A.K.3
  • 48
    • 84863993448 scopus 로고    scopus 로고
    • A quantitative liquid chromatography tandem mass spectrometry method for metabolomic analysis of Plasmodium falciparum lipid related metabolites
    • Duy SV, Besteiro S, Berry L, et al. A quantitative liquid chromatography tandem mass spectrometry method for metabolomic analysis of Plasmodium falciparum lipid related metabolites. Analy Chim Acta 2012; 739:47-55.
    • (2012) Analy Chim Acta , vol.739 , pp. 47-55
    • Duy, S.V.1    Besteiro, S.2    Berry, L.3
  • 49
    • 64949105863 scopus 로고    scopus 로고
    • Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by H-1 NMR spectroscopy
    • Teng RW, Junankar PR, Bubb WA, et al. Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by H-1 NMR spectroscopy. NMR Biomed 2009; 22:292-302.
    • (2009) NMR Biomed , vol.22 , pp. 292-302
    • Teng, R.W.1    Junankar, P.R.2    Bubb, W.A.3
  • 50
    • 27544438209 scopus 로고    scopus 로고
    • Malaria parasiteinfected erythrocytes inhibit glucose utilization in uninfected red cells
    • Mehta M, Sonawat HM, Sharma S. Malaria parasiteinfected erythrocytes inhibit glucose utilization in uninfected red cells. FEBS Lett 2005;579:6151-8.
    • (2005) FEBS Lett , vol.579 , pp. 6151-6158
    • Mehta, M.1    Sonawat, H.M.2    Sharma, S.3
  • 51
    • 33749483184 scopus 로고    scopus 로고
    • Glycolysis in Plasmodium falciparum results in modulation of host enzyme activities
    • Mehta M, Sonawat HM, Sharma S. Glycolysis in Plasmodium falciparum results in modulation of host enzyme activities. JVector Borne Dis 2006;43:95-103.
    • (2006) JVector Borne Dis , vol.43 , pp. 95-103
    • Mehta, M.1    Sonawat, H.M.2    Sharma, S.3
  • 52
    • 0035947587 scopus 로고    scopus 로고
    • H+-coupled pantothenate transport in the intracellular malaria parasite
    • Saliba KJ, Kirk K. H+-coupled pantothenate transport in the intracellular malaria parasite. J Biol Chem 2001;276: 18115-21.
    • (2001) J Biol Chem , vol.276 , pp. 18115-21
    • Saliba, K.J.1    Kirk, K.2
  • 53
    • 65549087156 scopus 로고    scopus 로고
    • Advances in analysis of microbial metabolic fluxes via C-13 isotopic labeling
    • Tang YJ, Martin HG, Myers S, et al. Advances in analysis of microbial metabolic fluxes via C-13 isotopic labeling. Mass Spectrom Rev 2009;28:362-75.
    • (2009) Mass Spectrom Rev , vol.28 , pp. 362-375
    • Tang, Y.J.1    Martin, H.G.2    Myers, S.3
  • 54
    • 84880044091 scopus 로고    scopus 로고
    • Fluxomics-connecting 'omics analysis and phenotypes
    • doi 10.1111/1462-2920. (Advance Access publication 6 December 2012)
    • Winter G, Kromer JO. Fluxomics-connecting 'omics analysis and phenotypes. EnvironMicrobiol 2012; doi: 10.1111/1462-2920.12064 (Advance Access publication 6 December 2012).
    • (2012) EnvironMicrobiol , pp. 12064
    • Winter, G.1    Kromer, J.O.2
  • 55
    • 33846120023 scopus 로고    scopus 로고
    • ApiDB: integrated resources for the apicomplexan bioinformatics resource center
    • Aurrecoechea C, Heiges M, Wang H, et al. ApiDB: integrated resources for the apicomplexan bioinformatics resource center. Nucleic Acids Res 2007;35:D427-30.
    • (2007) Nucleic Acids Res , vol.35
    • Aurrecoechea, C.1    Heiges, M.2    Wang, H.3
  • 56
    • 78149440251 scopus 로고    scopus 로고
    • A genetic screen for attenuated growth identifies genes crucial for intraerythrocytic development of Plasmodiumfalciparum
    • Balu B, Singh N, Maher SP, et al. A genetic screen for attenuated growth identifies genes crucial for intraerythrocytic development of Plasmodiumfalciparum. PLoSOne 2010; 5:e13282.
    • (2010) PLoSOne , vol.5
    • Balu, B.1    Singh, N.2    Maher, S.P.3
  • 57
    • 79955602637 scopus 로고    scopus 로고
    • High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome
    • Alsford S, Turner DJ, Obado SO, et al. High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome. Genome Res 2011;21: 915-24.
    • (2011) Genome Res , vol.21 , pp. 915-924
    • Alsford, S.1    Turner, D.J.2    Obado, S.O.3
  • 58
    • 20644450109 scopus 로고    scopus 로고
    • Transcriptional analysis of invivoPlasmodiumyoelii liver stage gene expression
    • Sacci JB, Ribeiro JMC, Huang FY, et al. Transcriptional analysis of invivoPlasmodiumyoelii liver stage gene expression. Mol Biochem Parasitol 2005;142:177-83.
    • (2005) Mol Biochem Parasitol , vol.142 , pp. 177-183
    • Sacci, J.B.1    Ribeiro, J.M..C.2    Huang, F.Y.3
  • 59
    • 38349159563 scopus 로고    scopus 로고
    • A combined transcriptome and proteome survey of malaria parasite liver stages
    • Tarun AS, Peng X, Dumpit RF, et al. A combined transcriptome and proteome survey of malaria parasite liver stages. Proc Natl Acad Sci USA 2008;105:305-10.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 305-310
    • Tarun, A.S.1    Peng, X.2    Dumpit, R.F.3
  • 60
    • 8744234024 scopus 로고    scopus 로고
    • Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
    • Le Roch KG, Johnson JR, Florens L, et al. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Res 2004;14:2308-18.
    • (2004) Genome Res , vol.14 , pp. 2308-2318
    • Le Roch, K.G.1    Johnson, J.R.2    Florens, L.3
  • 61
    • 33644854445 scopus 로고    scopus 로고
    • Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains
    • Llinas M, Bozdech Z, Wong ED, et al. Comparative whole genome transcriptome analysis of three Plasmodium falciparum strains. Nucleic Acids Res 2006;34: 1166-73.
    • (2006) Nucleic Acids Res , vol.34 , pp. 1166-1173
    • Llinas, M.1    Bozdech, Z.2    Wong, E.D.3
  • 62
    • 57549116120 scopus 로고    scopus 로고
    • Proteomes and transcriptomes of the Apicomplexa-where's the message?
    • Wastling JM, Xia D, Sohal A, et al. Proteomes and transcriptomes of the Apicomplexa-where's the message? Int J Parasitol 2009;39:135-43.
    • (2009) Int J Parasitol , vol.39 , pp. 135-143
    • Wastling, J.M.1    Xia, D.2    Sohal, A.3
  • 63
    • 3142671580 scopus 로고    scopus 로고
    • Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition
    • Nirmalan N, Sims PFG, Hyde JE. Quantitative proteomics of the human malaria parasite Plasmodium falciparum and its application to studies of development and inhibition. MolMicrobiol 2004;52:1187-99. 326 Tymoshenko et al.
    • (2004) MolMicrobiol , vol.52
    • Nirmalan, N.1    Sims, P.F.G.2    Hyde, J.E.3
  • 64
    • 58149339918 scopus 로고    scopus 로고
    • Large-scale differential proteome analysis in Plasmodiumfalciparum under drug treatment
    • Prieto JH, Koncarevic S, Park SK, et al. Large-scale differential proteome analysis in Plasmodiumfalciparum under drug treatment. PLoS One 2008;3:e4098.
    • (2008) PLoS One , vol.3
    • Prieto, J.H.1    Koncarevic, S.2    Park, S.K.3
  • 65
    • 80054866274 scopus 로고    scopus 로고
    • A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance
    • Southworth PM, Hyde JE, Sims PFG. A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance. MalariaJ 2011;10:315.
    • (2011) MalariaJ , vol.10 , pp. 315
    • Southworth, P.M.1    Hyde, J.E.2    Sims, P.F.G.3
  • 66
    • 80051654221 scopus 로고    scopus 로고
    • Quantitative timecourse profiling of parasite and host cell proteins in the human malaria parasite Plasmodium falciparum
    • Foth BJ, Zhang N, Chaal BK, et al. Quantitative timecourse profiling of parasite and host cell proteins in the human malaria parasite Plasmodium falciparum. Mol Cell Proteomics 2011;10: M110.006411.
    • (2011) Mol Cell Proteomics , vol.10
    • Foth, B.J.1    Zhang, N.2    Chaal, B.K.3
  • 67
    • 33746875960 scopus 로고    scopus 로고
    • Regulation of sexual development of Plasmodium by translational repression
    • Mair GR, Braks JAM, Garver LS, et al. Regulation of sexual development of Plasmodium by translational repression. Science 2006;313:667-669.
    • (2006) Science , vol.313 , pp. 667-669
    • Mair, G.R.1    Braks, J.A.M.2    Garver, L.S.3
  • 68
    • 84860451927 scopus 로고    scopus 로고
    • Metabolomics: the final frontier?
    • Veenstra TD. Metabolomics: the final frontier? GenomeMed 2012;4:40.
    • (2012) GenomeMed , vol.4 , pp. 40
    • Veenstra, T.D.1
  • 69
    • 84867350029 scopus 로고    scopus 로고
    • Realising the potential of metabolomics
    • Nicholls AW. Realising the potential of metabolomics. Bioanalysis 2012;4:2195-7.
    • (2012) Bioanalysis , vol.4 , pp. 2195-2197
    • Nicholls, A.W.1
  • 70
    • 75649113424 scopus 로고    scopus 로고
    • Computational approaches to metabolomics
    • Wishart DS. Computational approaches to metabolomics. MethodsMol Biol 2010;593:283-313.
    • (2010) MethodsMol Biol , vol.593 , pp. 283-313
    • Wishart, D.S.1
  • 72
    • 78049351897 scopus 로고    scopus 로고
    • Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis
    • t'Kindt R, Jankevics A, Scheltema RA, et al. Towards an unbiased metabolic profiling of protozoan parasites: optimisation of a Leishmania sampling protocol for HILIC-orbitrap analysis. Anal Bioanal Chem 2010;398:2059-69.
    • (2010) Anal Bioanal Chem , vol.398 , pp. 2059-2069
    • T'Kindt, R.1    Jankevics, A.2    Scheltema, R.A.3
  • 73
    • 84856231790 scopus 로고    scopus 로고
    • Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole- time of flight mass spectrometry (UPLC-Q-ToFMS)
    • Paglia G, Hrafnsdottir S, Magnusdottir M, et al. Monitoring metabolites consumption and secretion in cultured cells using ultra-performance liquid chromatography quadrupole- time of flight mass spectrometry (UPLC-Q-ToFMS). Anal Bioanal Chem 2012;402:1183-98.
    • (2012) Anal Bioanal Chem , vol.402 , pp. 1183-1198
    • Paglia, G.1    Hrafnsdottir, S.2    Magnusdottir, M.3
  • 74
    • 63149174170 scopus 로고    scopus 로고
    • Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite
    • Lian LY, Al-Helal M, Roslaini AM, et al. Glycerol: an unexpected major metabolite of energy metabolism by the human malaria parasite. MalarJ 2009;8:38.
    • (2009) MalarJ , vol.8 , pp. 38
    • Lian, L.Y.1    Al-Helal, M.2    Roslaini, A.M.3
  • 75
    • 80053584823 scopus 로고    scopus 로고
    • Metabolomics of a single vacuole reveals metabolic dynamism in an alga Chara australis
    • Oikawa A, Matsuda F, Kikuyama M, et al. Metabolomics of a single vacuole reveals metabolic dynamism in an alga Chara australis. Plant Physiol 2011;157:544-51.
    • (2011) Plant Physiol , vol.157 , pp. 544-551
    • Oikawa, A.1    Matsuda, F.2    Kikuyama, M.3
  • 76
    • 33847413750 scopus 로고    scopus 로고
    • Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum
    • Martin RE, Kirk K. Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum. Blood 2007;109:2217-24.
    • (2007) Blood , vol.109 , pp. 2217-2224
    • Martin, R.E.1    Kirk, K.2
  • 77
    • 33749517548 scopus 로고    scopus 로고
    • Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite
    • Saliba KJ, Martin RE, Broer A, et al. Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite. Nature 2006;443:582-5.
    • (2006) Nature , vol.443 , pp. 582-585
    • Saliba, K.J.1    Martin, R.E.2    Broer, A.3
  • 78
    • 38349121328 scopus 로고    scopus 로고
    • Central carbon metabolism of Saccharomyces cerevisiae in anaerobic, oxygenlimited and fully aerobic steady-state conditions and following a shift to anaerobic conditions
    • Wiebe MG, Rintala E, Tamminen A, et al. Central carbon metabolism of Saccharomyces cerevisiae in anaerobic, oxygenlimited and fully aerobic steady-state conditions and following a shift to anaerobic conditions. FemsYeast Res 2008;8: 140-54.
    • (2008) FemsYeast Res , vol.8 , pp. 140-154
    • Wiebe, M.G.1    Rintala, E.2    Tamminen, A.3
  • 79
    • 10044224601 scopus 로고    scopus 로고
    • Metabolic control analysis under uncertainty: framework development and case studies
    • Wang LQ, Birol I, Hatzimanikatis V. Metabolic control analysis under uncertainty: framework development and case studies. BiophysJ 2004;87:3750-63.
    • (2004) BiophysJ , vol.87 , pp. 3750-3763
    • Wang, L.Q.1    Birol, I.2    Hatzimanikatis, V.3
  • 80
    • 84882565488 scopus 로고    scopus 로고
    • Integration of transcriptomic, proteomic, and metabolic flux information for understanding and redesigning metabolism
    • Wang LQ, Hatzimanikatis V. Integration of transcriptomic, proteomic, and metabolic flux information for understanding and redesigning metabolism. J Biotechnol 2005;118:S6.
    • (2005) J Biotechnol , vol.118
    • Wang, L.Q.1    Hatzimanikatis, V.2
  • 83
    • 0033977087 scopus 로고    scopus 로고
    • Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs
    • Bakker BM, WesterhoffHV, Opperdoes FR, et al. Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. Mol Biochem Parasitol 2000;106:1-10.
    • (2000) Mol Biochem Parasitol , vol.106 , pp. 1-10
    • Bakker, B.M.1    Westerhoff, H.V.2    Opperdoes, F.R.3
  • 84
    • 77955058605 scopus 로고    scopus 로고
    • Production of biofuels and biochemicals: in need of an ORACLE
    • Miskovic L, Hatzimanikatis V. Production of biofuels and biochemicals: in need of an ORACLE. Trends Biotechnol 2010;28:391-7.
    • (2010) Trends Biotechnol , vol.28 , pp. 391-397
    • Miskovic, L.1    Hatzimanikatis, V.2
  • 85
    • 78651330012 scopus 로고    scopus 로고
    • BRENDA, the enzyme information system in 2011
    • Scheer M, Grote A, Chang A, et al. BRENDA, the enzyme information system in 2011. Nucleic Acids Res 2011;39: D670-6.
    • (2011) Nucleic Acids Res , vol.39
    • Scheer, M.1    Grote, A.2    Chang, A.3
  • 86
    • 0037025146 scopus 로고    scopus 로고
    • Dynamic modeling of the central carbon metabolism of Escherichia coli
    • Chassagnole C, Noisommit-Rizzi N, Schmid JW, et al. Dynamic modeling of the central carbon metabolism of Escherichia coli. Biotechnol Bioeng 2002;79:53-73.
    • (2002) Biotechnol Bioeng , vol.79 , pp. 53-73
    • Chassagnole, C.1    Noisommit-Rizzi, N.2    Schmid, J.W.3
  • 87
    • 0033857139 scopus 로고    scopus 로고
    • Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry
    • Teusink B, Passarge J, Reijenga CA, et al. Can yeast glycolysis be understood in terms of in vitro kinetics of the constituent enzymes? Testing biochemistry. Eur J Biochem 2000;267:5313-29.
    • (2000) Eur J Biochem , vol.267 , pp. 5313-5329
    • Teusink, B.1    Passarge, J.2    Reijenga, C.A.3


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