메뉴 건너뛰기




Volumn 11, Issue 5, 2015, Pages

Metabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental Analysis

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; ENZYMES; METABOLISM;

EID: 84930607857     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004261     Document Type: Article
Times cited : (81)

References (67)
  • 1
  • 2
    • 67349248861 scopus 로고    scopus 로고
    • Toxoplasmosis: A history of clinical observations
    • Weiss LM, Dubey JP, (2009) Toxoplasmosis: A history of clinical observations. Int J Parasitol 39: 895–901. doi: 10.1016/j.ijpara.2009.02.004 19217908
    • (2009) Int J Parasitol , vol.39 , pp. 895-901
    • Weiss, L.M.1    Dubey, J.P.2
  • 3
    • 84869167609 scopus 로고    scopus 로고
    • Macrae JI, Sheiner L, Nahid A, Tonkin C, Striepen B, et al. (2012) Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii. Cell Host Microbe. pp. 682–692.
  • 4
    • 77955346232 scopus 로고    scopus 로고
    • Versatility in the acquisition of energy and carbon sources by the Apicomplexa
    • Polonais V, Soldati-Favre D, (2010) Versatility in the acquisition of energy and carbon sources by the Apicomplexa. Biology of the Cell 102: 435–445. doi: 10.1042/BC20100005 20586726
    • (2010) Biology of the Cell , vol.102 , pp. 435-445
    • Polonais, V.1    Soldati-Favre, D.2
  • 5
    • 84863230581 scopus 로고    scopus 로고
    • Metabolic network modeling and simulation for drug targeting and discovery
    • Kim HU, Sohn SB, Lee SY, (2012) Metabolic network modeling and simulation for drug targeting and discovery. Biotechnol J 7: 330–342. doi: 10.1002/biot.201100159 22125297
    • (2012) Biotechnol J , vol.7 , pp. 330-342
    • Kim, H.U.1    Sohn, S.B.2    Lee, S.Y.3
  • 7
    • 77952767878 scopus 로고    scopus 로고
    • A genome-scale metabolic model of Cryptosporidium hominis
    • Vanee N, Roberts SB, Fong SS, Manque P, Buck GA, (2010) A genome-scale metabolic model of Cryptosporidium hominis. Chem Biodivers 7: 1026–1039. doi: 10.1002/cbdv.200900323 20491062
    • (2010) Chem Biodivers , vol.7 , pp. 1026-1039
    • Vanee, N.1    Roberts, S.B.2    Fong, S.S.3    Manque, P.4    Buck, G.A.5
  • 8
    • 77956419824 scopus 로고    scopus 로고
    • Plata G, Hsiao T-L, Olszewski KL, Llinás M, Vitkup D (2010) Reconstruction and flux-balance analysis of the Plasmodium falciparum metabolic network. Mol Syst Biol. pp. 408.
  • 9
    • 77956456621 scopus 로고    scopus 로고
    • Huthmacher C, Hoppe A, Bulik S, Holzhütter H-G (2010) Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis. BMC Syst Biol. pp. 120.
  • 10
    • 84888149629 scopus 로고    scopus 로고
    • Song C, Chiasson MA, Nursimulu N, Hung SS, Wasmuth J, et al. (2013) Metabolic reconstruction identifies strain-specific regulation of virulence in Toxoplasma gondii. Mol Syst Biol. pp. 708.
  • 11
    • 85135545230 scopus 로고    scopus 로고
    • Agren R, Liu L, Shoaie S, Vongsangnak W, Nookaew I, et al. (2013) The RAVEN Toolbox and Its Use for Generating a Genome-scale Metabolic Model for Penicillium chrysogenum. PLoS Comput Biol. pp. e1002980.
  • 12
    • 75149129569 scopus 로고    scopus 로고
    • A protocol for generating a high-quality genome-scale metabolic reconstruction
    • Thiele I, Palsson BO, (2010) A protocol for generating a high-quality genome-scale metabolic reconstruction. Nature Protocols 5: 93–121. doi: 10.1038/nprot.2009.203 20057383
    • (2010) Nature Protocols , vol.5 , pp. 93-121
    • Thiele, I.1    Palsson, B.O.2
  • 13
    • 84865535722 scopus 로고    scopus 로고
    • Bazzani S, Hoppe A, Holzhütter H-G (2012) Network-based assessment of the selectivity of metabolic drug targets in Plasmodium falciparum with respect to human liver metabolism. BMC Syst Biol. pp. 118.
  • 14
    • 84860521958 scopus 로고    scopus 로고
    • ApicoAP: the first computational model for identifying apicoplast-targeted proteins in multiple species of Apicomplexa
    • Cilingir G, Broschat SL, Lau AO, (2012) ApicoAP: the first computational model for identifying apicoplast-targeted proteins in multiple species of Apicomplexa. PLoS One 7: e36598. doi: 10.1371/journal.pone.0036598 22574192
    • (2012) PLoS One , vol.7 , pp. e36598
    • Cilingir, G.1    Broschat, S.L.2    Lau, A.O.3
  • 15
    • 0029915525 scopus 로고    scopus 로고
    • Computational method to predict mitochondrially imported proteins and their targeting sequences
    • Claros MG, Vincens P, (1996) Computational method to predict mitochondrially imported proteins and their targeting sequences. European Journal of Biochemistry 241: 779–786. 8944766
    • (1996) European Journal of Biochemistry , vol.241 , pp. 779-786
    • Claros, M.G.1    Vincens, P.2
  • 16
    • 34248531753 scopus 로고    scopus 로고
    • Locating proteins in the cell using TargetP, SignalP and related tools
    • Emanuelsson O, Brunak S, von Heijne G, Nielsen H, (2007) Locating proteins in the cell using TargetP, SignalP and related tools. Nat Protoc 2: 953–971. 17446895
    • (2007) Nat Protoc , vol.2 , pp. 953-971
    • Emanuelsson, O.1    Brunak, S.2    von Heijne, G.3    Nielsen, H.4
  • 18
    • 84876527534 scopus 로고    scopus 로고
    • Library of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasites
    • Shanmugasundram A, Gonzalez-Galarza FF, Wastling JM, Vasieva O, Jones AR (2012) Library of Apicomplexan Metabolic Pathways: a manually curated database for metabolic pathways of apicomplexan parasites. Nucleic Acids Res. pp. D706-D713.
    • (2012) Nucleic Acids Res , pp. D706-D713
    • Shanmugasundram, A.1    Gonzalez-Galarza, F.F.2    Wastling, J.M.3    Vasieva, O.4    Jones, A.R.5
  • 20
    • 41149169317 scopus 로고    scopus 로고
    • Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major
    • Chavali AK, Whittemore JD, Eddy JA, Williams KT, Papin JA, (2008) Systems analysis of metabolism in the pathogenic trypanosomatid Leishmania major. Mol Syst Biol 4: 177. doi: 10.1038/msb.2008.15 18364711
    • (2008) Mol Syst Biol , vol.4 , pp. 177
    • Chavali, A.K.1    Whittemore, J.D.2    Eddy, J.A.3    Williams, K.T.4    Papin, J.A.5
  • 22
    • 34548440314 scopus 로고    scopus 로고
    • Pino P, Foth BJ, Kwok L-Y, Sheiner L, Schepers R, et al. (2007) Dual targeting of antioxidant and metabolic enzymes to the mitochondrion and the apicoplast of Toxoplasma gondii. PLoS Pathog. pp. e115.
  • 23
    • 0037738615 scopus 로고    scopus 로고
    • The apicoplast: a plastid in Plasmodium falciparum and other Apicomplexan parasites
    • Foth BJ, McFadden GI, (2003) The apicoplast: a plastid in Plasmodium falciparum and other Apicomplexan parasites. Int Rev Cytol 224: 57–110. 12722949
    • (2003) Int Rev Cytol , vol.224 , pp. 57-110
    • Foth, B.J.1    McFadden, G.I.2
  • 24
    • 74049118434 scopus 로고    scopus 로고
    • The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival
    • Brooks CF, Johnsen H, van Dooren GG, Muthalagi M, Lin SS, et al. (2010) The toxoplasma apicoplast phosphate translocator links cytosolic and apicoplast metabolism and is essential for parasite survival. Cell Host Microbe 7: 62–73. doi: 10.1016/j.chom.2009.12.002 20036630
    • (2010) Cell Host Microbe , vol.7 , pp. 62-73
    • Brooks, C.F.1    Johnsen, H.2    van Dooren, G.G.3    Muthalagi, M.4    Lin, S.S.5
  • 25
    • 80051674818 scopus 로고    scopus 로고
    • Isoprenoid Precursor Biosynthesis Offers Potential Targets for Drug Discovery Against Diseases Caused by Apicomplexan Parasites
    • Hunter WN, (2011) Isoprenoid Precursor Biosynthesis Offers Potential Targets for Drug Discovery Against Diseases Caused by Apicomplexan Parasites. Current Topics in Medicinal Chemistry 11: 2048–2059. 21619509
    • (2011) Current Topics in Medicinal Chemistry , vol.11 , pp. 2048-2059
    • Hunter, W.N.1
  • 26
    • 84855923559 scopus 로고    scopus 로고
    • Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance
    • Fritz HM, Bowyer PW, Bogyo M, Conrad PA, Boothroyd JC, (2012) Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance. PLoS One 7: e29955. doi: 10.1371/journal.pone.0029955 22279555
    • (2012) PLoS One , vol.7 , pp. e29955
    • Fritz, H.M.1    Bowyer, P.W.2    Bogyo, M.3    Conrad, P.A.4    Boothroyd, J.C.5
  • 27
    • 84905392255 scopus 로고    scopus 로고
    • BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei
    • Oppenheim RD, Creek DJ, Macrae JI, Modrzynska KK, Pino P, et al. (2014) BCKDH: the missing link in apicomplexan mitochondrial metabolism is required for full virulence of Toxoplasma gondii and Plasmodium berghei. PLoS Pathog 10: e1004263. doi: 10.1371/journal.ppat.1004263 25032958
    • (2014) PLoS Pathog , vol.10 , pp. e1004263
    • Oppenheim, R.D.1    Creek, D.J.2    Macrae, J.I.3    Modrzynska, K.K.4    Pino, P.5
  • 28
    • 84863539219 scopus 로고    scopus 로고
    • Cell biology. A mitochondrial mystery, solved
    • Divakaruni AS, Murphy AN, (2012) Cell biology. A mitochondrial mystery, solved. Science 337: 41–43. doi: 10.1126/science.1225601 22767917
    • (2012) Science , vol.337 , pp. 41-43
    • Divakaruni, A.S.1    Murphy, A.N.2
  • 29
    • 84863552418 scopus 로고    scopus 로고
    • Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, et al. (2012) A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans. Science. pp. 96–100.
  • 30
    • 84863553135 scopus 로고    scopus 로고
    • Identification and Functional Expression of the Mitochondrial Pyruvate Carrier
    • Herzig S, Raemy E, Montessuit S, Veuthey J-L, Zamboni N, et al. (2012) Identification and Functional Expression of the Mitochondrial Pyruvate Carrier. Science. pp. 93–96.
    • (2012) Science , pp. 93-96
    • Herzig, S.1    Raemy, E.2    Montessuit, S.3    Veuthey, J.-L.4    Zamboni, N.5
  • 31
    • 0036171419 scopus 로고    scopus 로고
    • Yardley V, Khan AA, Martin MB, Slifer TR, Araujo FG, et al. (2002) In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. pp. 929–931.
  • 32
    • 18244410156 scopus 로고    scopus 로고
    • Bisphosphonate inhibitors of Toxoplasma gondii growth: in vitro, QSAR, and in vivo investigations
    • Ling Y, Sahota G, Odeh S, Chan JM, Araujo FG, et al. (2005) Bisphosphonate inhibitors of Toxoplasma gondii growth: in vitro, QSAR, and in vivo investigations. J Med Chem 48: 3130–3140. 15857119
    • (2005) J Med Chem , vol.48 , pp. 3130-3140
    • Ling, Y.1    Sahota, G.2    Odeh, S.3    Chan, J.M.4    Araujo, F.G.5
  • 33
    • 44349095718 scopus 로고    scopus 로고
    • Fleige T, Pfaff N, Gross U, Bohne W (2008) Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii. International Journal for Parasitology. pp. 1121–1132.
  • 34
    • 33748353213 scopus 로고    scopus 로고
    • Mazumdar J, H Wilson E, Masek K, A Hunter C, Striepen B (2006) Apicoplast fatty acid synthesis is essential for organelle biogenesis and parasite survival in Toxoplasma gondii. Proc Natl Acad Sci USA. pp. 13192–13197.
  • 35
    • 18144365490 scopus 로고    scopus 로고
    • Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth
    • Gupta N, Zahn MM, Coppens I, Joiner KA, Voelker DR, (2005) Selective disruption of phosphatidylcholine metabolism of the intracellular parasite Toxoplasma gondii arrests its growth. J Biol Chem 280: 16345–16353. 15708856
    • (2005) J Biol Chem , vol.280 , pp. 16345-16353
    • Gupta, N.1    Zahn, M.M.2    Coppens, I.3    Joiner, K.A.4    Voelker, D.R.5
  • 36
    • 84930597998 scopus 로고    scopus 로고
    • Sampels V (2012) Plasticity of the phosphatidylcholine biogenesis in the obligate intracellular Parasite Toxoplasma gondii: Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, PhD thesis, Available: http://edoc.hu-berlin.de/dissertationen/sampels-vera-2012-03-27/PDF/sampels.pdf
  • 37
    • 13844298790 scopus 로고    scopus 로고
    • Targeting DHFR in parasitic protozoa
    • Anderson AC, (2005) Targeting DHFR in parasitic protozoa. Drug Discov Today 10: 121–128. 15718161
    • (2005) Drug Discov Today , vol.10 , pp. 121-128
    • Anderson, A.C.1
  • 38
    • 84882619498 scopus 로고    scopus 로고
    • Tymoshenko S, Oppenheim RD, Soldati-Favre D, Hatzimanikatis V (2013) Functional genomics of Plasmodium falciparum using metabolic modelling and analysis. Briefings in functional genomics. pp. 316–327.
  • 39
  • 40
    • 77956905091 scopus 로고    scopus 로고
    • AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability
    • Jonas MC, Pehar M, Puglielli L, (2010) AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability. Journal of Cell Science 123: 3378–3388. doi: 10.1242/jcs.068841 20826464
    • (2010) Journal of Cell Science , vol.123 , pp. 3378-3388
    • Jonas, M.C.1    Pehar, M.2    Puglielli, L.3
  • 41
    • 84930598000 scopus 로고    scopus 로고
    • Pieperhoff MS, Pall GS, Jimenez-Ruis E, Das S, Wong EH, et al. (2014) Conditional U1 Gene Silencing in Toxoplasma gondii, Preprint, Available: http://biorxiv.org/biorxiv/early/2014/09/01/008649.full.pdf. Accessed 01.11.2014
  • 42
    • 84903975411 scopus 로고    scopus 로고
    • Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9
    • Shen B, Brown KM, Lee TD, Sibley LD, (2014) Efficient Gene Disruption in Diverse Strains of Toxoplasma gondii Using CRISPR/CAS9. Mbio 5: e01114–01114. doi: 10.1128/mBio.01114-14 24825012
    • (2014) Mbio , vol.5 , pp. e01114-01114
    • Shen, B.1    Brown, K.M.2    Lee, T.D.3    Sibley, L.D.4
  • 43
    • 38349164135 scopus 로고    scopus 로고
    • Impact of systems biology on metabolic engineering of Saccharomyces cerevisiae
    • Nielsen J, Jewett MC, (2008) Impact of systems biology on metabolic engineering of Saccharomyces cerevisiae. FEMS Yeast Res 8: 122–131. 17727659
    • (2008) FEMS Yeast Res , vol.8 , pp. 122-131
    • Nielsen, J.1    Jewett, M.C.2
  • 44
    • 84930598001 scopus 로고    scopus 로고
    • Forth T (2012) Metabolic systems biology of the malaria parasite: reconstruction, visualisation and analysis of an experimentally parameterised metabolic model of the human acute malaria parasite Plasmodium falciparum, PhD thesis, University of Leeds, Available: http://etheses.whiterose.ac.uk/3739/
  • 45
    • 68049135099 scopus 로고    scopus 로고
    • Blume M, Rodriguez-Contreras D (2009) Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis. PNAS. pp. 12998–13003.
  • 46
    • 84907841896 scopus 로고    scopus 로고
    • Toxoplasma gondii Is Dependent on Glutamine and Alters Migratory Profile of Infected Host Bone Marrow Derived Immune Cells through SNAT2 and CXCR4 Pathways
    • Lee IP, Evans AK, Yang C, Works MG, Kumar V, et al. (2014) Toxoplasma gondii Is Dependent on Glutamine and Alters Migratory Profile of Infected Host Bone Marrow Derived Immune Cells through SNAT2 and CXCR4 Pathways. Plos One 9: e109803. doi: 10.1371/journal.pone.0109803 25299045
    • (2014) Plos One , vol.9 , pp. e109803
    • Lee, I.P.1    Evans, A.K.2    Yang, C.3    Works, M.G.4    Kumar, V.5
  • 47
    • 77956407882 scopus 로고    scopus 로고
    • HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology
    • Gille C, Bölling C, Hoppe A, Bulik S, Hoffmann S, et al. (2010) HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol Syst Biol. pp. 411.
    • (2010) Mol Syst Biol , pp. 411
    • Gille, C.1    Bölling, C.2    Hoppe, A.3    Bulik, S.4    Hoffmann, S.5
  • 48
    • 84898011025 scopus 로고    scopus 로고
    • Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease
    • Mardinoglu A, Agren R, Kampf C, Asplund A, Uhlen M, et al. (2014) Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease. Nat Commun 5: 3083. doi: 10.1038/ncomms4083 24419221
    • (2014) Nat Commun , vol.5 , pp. 3083
    • Mardinoglu, A.1    Agren, R.2    Kampf, C.3    Asplund, A.4    Uhlen, M.5
  • 49
    • 0033920138 scopus 로고    scopus 로고
    • Dispensable and indispensable amino acids for humans
    • Reeds PJ, (2000) Dispensable and indispensable amino acids for humans. J Nutr 130: 1835S–1840S. 10867060
    • (2000) J Nutr , vol.130 , pp. 1835S-1840S
    • Reeds, P.J.1
  • 50
    • 84874945066 scopus 로고    scopus 로고
    • Global proteomic analysis of the oocyst/sporozoite of Toxoplasma gondii reveals commitment to a host-independent lifestyle
    • Possenti A, Fratini F, Fantozzi L, Pozio E, Dubey JP, et al. (2013) Global proteomic analysis of the oocyst/sporozoite of Toxoplasma gondii reveals commitment to a host-independent lifestyle. BMC Genomics 14: 183. doi: 10.1186/1471-2164-14-183 23496850
    • (2013) BMC Genomics , vol.14 , pp. 183
    • Possenti, A.1    Fratini, F.2    Fantozzi, L.3    Pozio, E.4    Dubey, J.P.5
  • 51
    • 84880936636 scopus 로고    scopus 로고
    • Toxoplasma oocysts as a public health problem
    • Torrey EF, Yolken RH, (2013) Toxoplasma oocysts as a public health problem. Trends in Parasitology 29: 380–384. doi: 10.1016/j.pt.2013.06.001 23849140
    • (2013) Trends in Parasitology , vol.29 , pp. 380-384
    • Torrey, E.F.1    Yolken, R.H.2
  • 52
    • 77956646014 scopus 로고    scopus 로고
    • Fox BA, Bzik DJ (2010) Avirulent Uracil Auxotrophs Based on Disruption of Orotidine-5'-Monophosphate Decarboxylase Elicit Protective Immunity to Toxoplasma gondii. Infection and Immunity. pp. 3744–3752.
  • 53
    • 84883236965 scopus 로고    scopus 로고
    • Metabolic pathway analysis and molecular docking analysis for identification of putative drug targets in Toxoplasma gondii: novel approach
    • Gautam B, Singh G, Wadhwa G, Farmer R, Singh S, et al. (2012) Metabolic pathway analysis and molecular docking analysis for identification of putative drug targets in Toxoplasma gondii: novel approach. Bioinformation 8: 134–141. 22368385
    • (2012) Bioinformation , vol.8 , pp. 134-141
    • Gautam, B.1    Singh, G.2    Wadhwa, G.3    Farmer, R.4    Singh, S.5
  • 54
    • 53749085229 scopus 로고    scopus 로고
    • A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology
    • Herrgard MJ, Swainston N, Dobson P, Dunn WB, Arga KY, et al. (2008) A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology. Nature Biotechnology 26: 1155–1160. doi: 10.1038/nbt1492 18846089
    • (2008) Nature Biotechnology , vol.26 , pp. 1155-1160
    • Herrgard, M.J.1    Swainston, N.2    Dobson, P.3    Dunn, W.B.4    Arga, K.Y.5
  • 55
    • 84856861276 scopus 로고    scopus 로고
    • Ramakrishnan S, Docampo MD, MacRae JI, Pujol FM, Brooks CF, et al. (2012) Apicoplast and Endoplasmic Reticulum Cooperate in Fatty Acid Biosynthesis in Apicomplexan Parasite Toxoplasma gondii. Journal of Biological Chemistry. pp. 4957–4971.
  • 56
    • 34250873343 scopus 로고    scopus 로고
    • Fleige T, Fischer K, Ferguson DJP, Gross U, Bohne W (2007) Carbohydrate Metabolism in the Toxoplasma gondii Apicoplast: Localization of Three Glycolytic Isoenzymes, the Single Pyruvate Dehydrogenase Complex, and a Plastid Phosphate Translocator. Eukaryotic Cell. pp. 984–996.
  • 57
    • 38549128700 scopus 로고    scopus 로고
    • Gajria B, Bahl A, Brestelli J, Dommer J (2008) ToxoDB: an integrated Toxoplasma gondii database resource. Nucleic Acids Res. pp. D553-D556.
  • 59
    • 0028115808 scopus 로고    scopus 로고
    • Schwab JC, Beckers CJ, Joiner KA (1994) The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve. Proc Natl Acad Sci USA. pp. 509–513.
  • 60
    • 77749320898 scopus 로고    scopus 로고
    • What is flux balance analysis?
    • Orth JD, Thiele I, Palsson BO, (2010) What is flux balance analysis? Nat Biotechnol 28: 245–248. doi: 10.1038/nbt.1614 20212490
    • (2010) Nat Biotechnol , vol.28 , pp. 245-248
    • Orth, J.D.1    Thiele, I.2    Palsson, B.O.3
  • 63
    • 0027310836 scopus 로고    scopus 로고
    • Soldati D, Boothroyd JC (1993) Transient transfection and expression in the obligate intracellular parasite Toxoplasma gondii. Science. pp. 349–352.
  • 64
    • 0029895115 scopus 로고    scopus 로고
    • Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene—Use as a selectable marker for stable transformation
    • Donald RGK, Carter D, Ullman B, Roos DS, (1996) Insertional tagging, cloning, and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene—Use as a selectable marker for stable transformation. Journal of Biological Chemistry 271: 14010–14019. 8662859
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 14010-14019
    • Donald, R.G.K.1    Carter, D.2    Ullman, B.3    Roos, D.S.4
  • 65
    • 38849095132 scopus 로고    scopus 로고
    • Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response
    • Plattner F, Yarovinsky F, Romero S, Didry D, Carlier MF, et al. (2008) Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. Cell Host & Microbe 3: 77–87.
    • (2008) Cell Host & Microbe , vol.3 , pp. 77-87
    • Plattner, F.1    Yarovinsky, F.2    Romero, S.3    Didry, D.4    Carlier, M.F.5
  • 66
    • 51649116051 scopus 로고    scopus 로고
    • A thioredoxin family protein of the apicoplast periphery identifies abundant candidate transport vesicles in Toxoplasma gondii
    • DeRocher AE, Coppens I, Karnataki A, Gilbert LA, Rome ME, et al. (2008) A thioredoxin family protein of the apicoplast periphery identifies abundant candidate transport vesicles in Toxoplasma gondii. Eukaryotic Cell 7: 1518–1529. doi: 10.1128/EC.00081-08 18586952
    • (2008) Eukaryotic Cell , vol.7 , pp. 1518-1529
    • DeRocher, A.E.1    Coppens, I.2    Karnataki, A.3    Gilbert, L.A.4    Rome, M.E.5
  • 67
    • 0034111791 scopus 로고    scopus 로고
    • A dibasic motif in the tail of a class XIV apicomplexan myosin is an essential determinant of plasma membrane localization
    • Hettmann C, Herm A, Geiter A, Frank B, Schwarz E, et al. (2000) A dibasic motif in the tail of a class XIV apicomplexan myosin is an essential determinant of plasma membrane localization. Molecular Biology of the Cell 11: 1385–1400. 10749937
    • (2000) Molecular Biology of the Cell , vol.11 , pp. 1385-1400
    • Hettmann, C.1    Herm, A.2    Geiter, A.3    Frank, B.4    Schwarz, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.