Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

Nature Communications

Volumn 6, Issue , 2015, Pages

  Wang, Jigang ^a,b,c,d   Zhang, Chong Jing ^a   Chia, Wan Ni ^d   Loh, Cheryl C Y ^d   Li, Zhengjun ^a   Lee, Yew Mun ^a   He, Yingke ^e   Yuan, Li Xia ^f   Lim, Teck Kwang ^a   Liu, Min ^c   Liew, Chin Xia ^a   Lee, Yan Quan ^d   Zhang, Jianbin ^d   Lu, Nianci ^g   Lim, Chwee Teck ^a   Hua, Zi Chun ^b   Liu, Bin ^a   Shen, Han Ming ^d   Tan, Kevin S W ^d   Lin, Qingsong ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NANJING UNIVERSITY   (China)

^c SINGAPORE MIT ALLIANCE FOR RESEARCH AND TECHNOLOGY   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^e SINGAPORE GENERAL HOSPITAL   (Singapore)

^f SOUTHERN MEDICAL UNIVERSITY   (China)

^g BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; ARTEMISININ DERIVATIVE; BIOTIN; FERROUS ION; FLUORESCENT DYE; HEME; HEMOGLOBIN; ANTIMALARIAL AGENT; PROTOZOAL PROTEIN;

BIOCHEMICAL COMPOSITION; CAUSE OF DEATH; DRUG; HEMATOLOGY; ION; PARASITE; PROTEOMICS; PROTOZOAN;

ARTICLE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; COVALENT BOND; DRUG IDENTIFICATION; DRUG SPECIFICITY; DRUG SYNTHESIS; DRUG TARGETING; HUMAN; HUMAN CELL; NONHUMAN; PARASITE CLEARANCE; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN TARGETING; PROTEOMICS; CHEMICAL ENGINEERING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; METABOLISM; MOLECULAR MODEL; PROTEIN CONFORMATION;

PLASMODIUM FALCIPARUM;

ANTIMALARIALS; ARTEMISININS; CHEMICAL ENGINEERING; HEME; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; PROTOZOAN PROTEINS;

EID: 84951850850     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10111     Document Type: Article

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