Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27045-27056

  Pastrana Mena, Rebecca ^a   Dinglasan, Rhoel R ^b   Franke Fayard, Blandine ^c   Vega Rodríguez, Joel ^a,b   Fuentes Caraballo, Mariela ^a   Baerga Ortiz, Abel ^a   Coppens, Isabelle ^b   Jacobs Lorena, Marcelo ^b   Janse, Chris J ^c   Serrano, Adelfa E ^a  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL DRUG; GLUTAMYLCYSTEINE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; GLUTATHIONES; MALARIA PARASITE; METHYLENE BLUE; NULL MUTANT; PARASITE-; REDOX SYSTEMS; SYNTHETASES; TARGET MOLECULE; WILD TYPES;

METABOLISM;

BLOOD;

EOSINE BLUE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE REDUCTASE; METHYLENE BLUE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOPHELES STEPHENSI; ARTICLE; CONTROLLED STUDY; CYTOPLASM; DEVELOPMENTAL STAGE; ENDOPLASMIC RETICULUM; FEMALE; GAMETOCYTE; GENE DISRUPTION; GLUTATHIONE METABOLISM; GROWTH RATE; MITOCHONDRION; MOUSE; MUTANT; NONHUMAN; NUCLEAR SIZE; OOCYST; PARASITE DEVELOPMENT; PARASITE SURVIVAL; PARASITEMIA; PHENOTYPE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPOROZOITE; WILD TYPE;

ANIMALS; DRUG DESIGN; ENZYME INHIBITORS; FEMALE; FLUORESCEINS; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE DISULFIDE; GLUTATHIONE REDUCTASE; MALARIA; METHYLENE BLUE; MICE; OOCYSTS; PLASMODIUM BERGHEI; PROTOZOAN PROTEINS;

PLASMODIUM BERGHEI; RODENTIA;

EID: 77956245794     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.122275     Document Type: Article

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