The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages

Journal of Biological Chemistry

Volumn 289, Issue 50, 2014, Pages 34827-34837

  Ke, Hangjun ^a   Sigala, Paul A ^b   Miura, Kazutoyo ^c   Morrisey, Joanne M ^a   Mather, Michael W ^a   Crowley, Jan R ^b   Henderson, Jeffrey P ^b   Goldberg, Daniel E ^b   Long, Carole A ^b   Vaidya, Akhil B ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; DISEASES; DRUG THERAPY; GENES; ISOTOPES; PORPHYRINS;

5-AMINOLEVULINIC ACID; ANTIMALARIAL THERAPY; BIOLOGICAL FUNCTIONS; BIOSYNTHETIC PATHWAY; HUMAN MALARIA PARASITE; INFECTED ERYTHROCYTES; PLASMODIUM FALCIPARUM; POTENTIAL DRUG TARGETS;

BLOOD;

5 AMINOLEVULINATE SYNTHASE; ARTEMISININ; ATOVAQUONE; CARBON 13; CHLOROQUINE; FERROCHELATASE; HEMOPROTEIN; PORPHYRIN; STABLE ISOTOPE; HEME;

ANIMAL CELL; ANOPHELES STEPHENSI; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; ASEXUAL REPRODUCTION; CELL MATURATION; CONTROLLED STUDY; EC50; ERYTHROCYTE; FC GENE; FEMALE; GAMETE; GENE DISRUPTION; GENE INACTIVATION; HEME SYNTHESIS; HUMAN; HUMAN CELL; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MALARIA FALCIPARUM; MALE; MASS SPECTROMETRY; NONHUMAN; OOCYST; PARASITE CULTIVATION; PARASITE DEVELOPMENT; PARASITE TRANSMISSION; PARASITE VECTOR; PLASMODIUM (LIFE CYCLE STAGE); PLASMODIUM FALCIPARUM; QUANTITATIVE ANALYSIS; ANIMAL; ANOPHELES; BIOSYNTHESIS; DEFICIENCY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PARASITOLOGY; PHYSIOLOGY; TANDEM MASS SPECTROMETRY;

ANOPHELES STEPHENSI; PLASMODIUM FALCIPARUM;

5-AMINOLEVULINATE SYNTHETASE; ANIMALS; ANOPHELES; ERYTHROCYTES; FEMALE; FERROCHELATASE; GENE KNOCKOUT TECHNIQUES; HEME; HUMANS; MALE; PLASMODIUM FALCIPARUM; TANDEM MASS SPECTROMETRY;

EID: 84918580707     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.615831     Document Type: Article

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