The genome of the kinetoplastid parasite, Leishmania major

Science

Volumn 309, Issue 5733, 2005, Pages 436-442

  Ivens, Alasdair C ^a   Peacock, Christopher S ^a   Worthey, Elizabeth A ^b   Murphy, Lee ^a   Aggarwal, Gautam ^b   Berriman, Matthew ^a   Sisk, Ellen ^b   Rajandream, Marie Adele ^a   Adlem, Ellen ^a   Aert, Rita ^c   Anupama, Atashi ^b   Apostolou, Zina ^d   Attipoe, Philip ^b   Bason, Nathalie ^a   Bauser, Christopher ^e   Beck, Alfred ^f   Beverley, Stephen M ^g   Bianchettin, Gabriella ^h   Borzym, Katja ^f   Bothe, Gordana ^e   Bruschi, Carlo V ^h,i   Collins, Matt ^a   Cadag, Eithon ^b   Ciarloni, Laura ^h   Clayton, Christine ^j   Coulson, Richard M R ^k   Cronin, Ann ^a   Cruz, Angela K ^l   Davies, Robert M ^a   De Gaudenzi, Javier ^m   Dobson, Deborah E ^g   Duesterhoeft, Andreas ⁿ   Fazelina, Gholam ^b   Fosker, Nigel ^a   Frasch, Alberto Carlos ^m   Fraser, Audrey ^a   Fuchs, Monika ^d   Gabel, Claudia ^d   Goble, Arlette ^a   Goffeau, André ^o   Harris, David ^a   Hertz Fowler, Christiane ^a   Hilbert, Helmut ⁿ   Horn, David ^p   Huang, Yiting ^b   Klages, Sven ^f   Knights, Andrew ^a   Kube, Michael ^f   Larke, Natasha ^a   Litvin, Lyudmila ^b   Lord, Angela ^a   Louie, Tin ^b   Marra, Marco ^q   Masuy, David ^o   Matthews, Keith ^r   Michaeli, Shulamit ^s   Mottram, Jeremy C ^t   Müller Auer, Silke ^d   Munden, Heather ^b   Nelson, Siri ^b   Norbertczak, Halina ^a   Oliver, Karen ^a   O'Neil, Susan ^a   Pentony, Martin ^b   Pohl, Thomas M ^e   Price, Claire ^a   Purnelle, Bénédicte ^o   Quail, Michael A ^a   Rabbinowitsch, Ester ^a   Reinhardt, Richard ^f   Rieger, Michael ^d   Rinta, Joel ^b   Robben, Johan ^c   Robertson, Laura ^b   Ruiz, Jeronimo C ^l   Rutter, Simon ^a   Saunders, David ^a   Schäfer, Melanie ^d   Schein, Jacquie ^q   Schwartz, David C ^u   Seeger, Kathy ^a   Seyler, Amber ^b   Sharp, Sarah ^a   Shin, Heesun ^q   Sivam, Dhileep ^b   Squares, Rob ^a   Squares, Steve ^a   Tosato, Valentina ^h   Vogt, Christy ^b   Volckaert, Guido ^c   Wambutt, Rolf ^v   Warren, Tim ^a   Wedler, Holger ⁿ   Woodward, John ^a   Zhou, Shiguo ^u   Zimmermann, Wolfgang ^v   Smith, Deborah F ^w   Blackwell, Jenefer M ^k   Stuart, Kenneth D ^b,x   Barrell, Bart ^a   Myler, Peter J ^b,x   more..

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c LABORATORY OF GENE TECHNOLOGY   (Belgium)

^d Genotype GmbH   (Germany)

^e GATC Biotech AG   (Germany)

^f MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^g WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h UNIVERSITY OF TRIESTE   (Italy)

ⁱ INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^j UNIVERSITY OF HEIDELBERG   (Germany)

^k WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^l UNIVERSITY OF SÃO PAULO   (Brazil)

^m INSTITUTO DE INVESTIGACIONES BIOTECNOLÓGICAS   (Argentina)

ⁿ QIAGEN GMBH   (Germany)

^o UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^p LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^q BRITISH COLUMBIA CANCER AGENCY   (Canada)

^r UNIVERSITY OF EDINBURGH   (United Kingdom)

^s BAR ILAN UNIVERSITY   (Israel)

^t UNIVERSITY OF GLASGOW   (United Kingdom)

^u UNIVERSITY OF WISCONSIN MADISON   (United States)

^v AGOWA GmbH   (Germany)

^w UNIVERSITY OF YORK   (United Kingdom)

^x UNIVERSITY OF WASHINGTON   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; POLYMERS; PROTEINS; RNA;

HAPLOID GENOME; LEISHMANIA SPECIES; PROTEIN-CODING GENES; TRYPANOSOMATIDS;

GENES;

GENE PRODUCT; GLYCOCONJUGATE; PROTEINASE; RNA; RNA BINDING PROTEIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR;

GENOME;

ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOME ANALYSIS; CISTRON; EUKARYOTE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENOME ANALYSIS; HAPLOIDY; HOST PATHOGEN INTERACTION; LEISHMANIA MAJOR; NONHUMAN; PRIORITY JOURNAL; PSEUDOGENE; TRANSCRIPTION REGULATION; TROPICS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; CHROMATIN; GENE EXPRESSION REGULATION; GENES, PROTOZOAN; GENES, RRNA; GENOME, PROTOZOAN; GLYCOCONJUGATES; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LIPID METABOLISM; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTOZOAN PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA SPLICING; RNA, PROTOZOAN; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION, GENETIC;

EUKARYOTA; KINETOPLASTIDA; LEISHMANIA (PROPER); LEISHMANIA (SUBGENUS); LEISHMANIA MAJOR; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPANOSOMATIDAE;

EID: 22244437571     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1112680     Document Type: Article

References (54)

1. WHO/TDR (World Health Organization-The Special Programme for Research and Training in Tropical Diseases) Web site on leishmaniasis, www.who.int/tdr/ diseases/leish
2. J. Alexander, D. G. Russell, Adv. Parasitol. 31, 175 (1992).
3. P. Wincker et al., Nucleic Acids Res. 24, 1688 (1996).
4. C. Britto et al., Gene 222, 107 (1998).
5. C. Ravel et al., Nucleic Acids Res. 27, 2473 (1999).
6. M. Berriman et al., Science 309, 416 (2005).
7. N. M. El-Sayed et al., Science 309, 409 (2005).
8. S. Zhou et al., Mol. Biochem. Parasitol. 138, 97 (2004).
9. S. M. Sunkin, P. Kiser, P. J. Myler, K. D. Stuart, Mol. Biochem. Parasitol. 109, 1 (2000).
10. Materials and methods are available as supporting material on Science Online.
11. N. M. El-Sayed et al., Science 309, 404 (2005).
12. M. A. Chiurillo et al., Exp. Parasitol. 94, 248 (2000).
13. S. Juttner et al., J. Immunol. 161, 2383 (1998).
14. F. H. Falcone et al., J. Immunol. 167, 5348 (2001).
15. L. Liu et al., J. Biol. Chem. 278, 18271 (2003).
16. F. Van Leeuwen, D. E. Gottschling, Cell 112, 591 (2003).
17. S. O. Obado, M. C. Taylor, S. R. Wilkinson, E. V. Bromley, J. M. Kelly, Genome Res. 15, 36 (2005).
18. A. K. Ingram, D. Horn, Mol. Microbiol. 45, 89 (2002).
19. C. E. Clayton, EMBO J. 21, 1881 (2002).
20. P. J. Myler et al., Proc. Natl. Acad. Sci. U.S.A. 96, 2902 (1999).
21. E. Worthey et al., Nucleic Acids Res. 31, 4201 (2003).
22. N. Hall et al., Nucleic Acids Res. 31, 4864 (2003).
23. N. M. El-Sayed et al., Nucleic Acids Res. 31, 4856 (2003).
24. V. Tosato et al., Curr. Genet. 40, 186 (2001).
25. S. Martinez-Calvillo et al., Mol. Cell 11, 1291 (2003).
26. S. Martinez-Calvillo, D. T. Nguyen, K. D. Stuart, P. J. Myler, Eukaryot. Cell 3, 506 (2004).
27. E. P. Geiduschek, M. S. Bartlett, Nat. Struct. Biol. 7, 437 (2000).
28. Y. Huang, R. J. Maraia, Nucleic Acids Res. 29, 2675 (2001).
29. R. Evers et al., Cell 56, 585 (1989).
30. M. Zurita, C. Merino, Trends Genet. 19, 578 (2003).
31. J. P. Ruan, G. K. Arhin, E. Ullu, C. Tschudi, Mol. Cell. Biol. 24, 9610 (2004).
32. K. R. Matthews, C. Tschudi, E. Ullu, Genes Dev. 8, 491 (1994).
33. G. Mair et al., RNA 6, 163 (2000).
34. E. Ullu, personal communication.
35. X. H. Liang, A. Haritan, S. Uliel, S. Michaeli, Eukaryot. Cell 2, 830 (2003).
36. A. M. Estevez, T. Kempf, C. Clayton, EMBO J. 20, 3831 (2001).
37. O. Numata, Y. Kurasawa, K. Gonda, Y. Watanabe, J. Biochem. (Tokyo) 127, 51 (2000).
38. A. Garami, T. Ilg, EMBO J. 20, 3657 (2001).
39. T. J. Vickers, S. H. Wyllie, A. H. Fairlamb, J. Biol. Chem. 279, 49003 (2004).
40. D. E. Dobson et al., J. Biol. Chem. 278, 15523 (2003).
41. D. E. Dobson, L. D. Scholtes, P. J. Myler, S. J. Turco, S. M. Beverley, in preparation.
42. K. Zhang et al., Mol. Microbiol. 55, 1566 (2005).
43. P. W. Denny, D. Goulding, M. A. Ferguson, D. F. Smith, Mol. Microbiol. 52, 313 (2004).
44. C. Yao, J. E. Donelson, M. E. Wilson, Mol. Biochem. Parasitol. 132, 1 (2003).
45. S. M. Teixeira, D. G. Russell, L. V. Kirchhoff, J. E. Donelson, J. Biol. Chem. 269, 20509 (1994).
46. A. Rochette et al., Mol. Biochem. Parasitol. 140, 205 (2005).
47. N. D. Rawlings, D. P. Tolle, A. J. Barrett, Nucleic Acids Res. 32 (Database issue), D160 (2004).
48. C. C. Wang et al., J. Biol. Chem. 278, 15800 (2003).
49. B. Couvreur et al., Mol. Biol. Evol. 19, 2110 (2002).
50. H. Zangger, J. C. Mottram, N. Fasel, Cell Death Differ. 9, 1126 (2002).
51. B. A. Burleigh, A. M. Woolsey, Cell. Microbiol. 4, 701 (2002).
52. S. Besteiro, G. H. Coombs, J. C. Mottram, Mol. Microbiol. 54, 1224 (2004).
53. C. C. Santos et al., J. Cell Sci. 118, 901 (2005).
54. We thank our colleagues in the Leishmania Genome Network (LGN) for their support and encouragement. We thank the other members of the Tritryp Sequencing Consortium for their help with comparative genome annotation; special thanks to J. Donelson and S. Melville, who together have played a key driving role in the coordination, discussion, and collation of these manuscripts. Funding for this project was provided by grants from WHO TDR (T23/181/1 ID:940509), Burroughs Wellcome Fund (BWF) (APP#0500), and National Institute of Allergy and Infectious Diseases (NIAID) (RO1 AI040599) to SBRI; Wellcome Trust (WT) (054394/Z/98/Z, 060491/Z/00/Z, and 063272/Z/00/Z) to the Wellcome Trust Sanger Institute; the European Union (BIO4-CT98-0079) to the EULEISH consortium; NIAID (RO1 AI060645) to A.C.F.; and a Fundação de Amparo à Pesquisa do Estado de São Paulo fellowship (01/13461-9) to J.C.R. WHO TDR, WT, and NIAID also provided funds for several LGN meetings. Accession numbers: EMBL: CT005244 to CT005272, AL389894 and AL139794; GenBank: CP000078 to CP000081, AE001274, and NC_004916. All data are available in GeneDB (http://www.genedb.org).