Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype

Infection, Genetics and Evolution

Volumn 30, Issue , 2015, Pages 318-322

  Brown, Tyler S ^d,m   Jacob, Christopher G ^d   Silva, Joana C ^f   Takala Harrison, Shannon ^d   Djimdé, Abdoulaye ^a   Dondorp, Arjen M ^b,c   Fukuda, Mark ⁱ   Noedl, Harald ^e   Nyunt, Myaing Myaing ^d   Kyaw, Myat Phone ^k   Mayxay, Mayfong ^g,h   Hien, Tran Tinh ^l   Plowe, Christopher V ^d   Cummings, Michael P ^j  

^a UNIVERSITY OF BAMAKO   (Mali)

^b MAHIDOL UNIVERSITY   (Thailand)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d University of Maryland School of Medicine Center for Vaccine Development   (United States)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^g MAHOSOT HOSPITAL   (Laos)

^h UNIVERSITY OF HEALTH SCIENCES   (Laos)

ⁱ ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^j University of Maryland   (United States)

^k Centre for Tropical Medicine Oxford University Clinical Research Unit Vietnam ^*  (Myanmar)

^l OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

^m JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

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Author keywords

Artemisinin; Drug resistance; Molecular evolution; Mutation rate; Plasmodium falciparum

Indexed keywords

ARTEMISININ; CHLOROQUINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; PROTOZOAL DNA;

AFRICA; ARTICLE; BANGLADESH; CAMBODIA; CONTROLLED STUDY; EFFECT SIZE; GENE MUTATION; GENE SEQUENCE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; LAOS; MALARIA FALCIPARUM; MALI; MOLECULAR EVOLUTION; MYANMAR; NUCLEIC ACID BASE SUBSTITUTION; PARASITE ISOLATION; PHENOTYPE; PLASMODIUM FALCIPARUM; SEQUENCE ALIGNMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTHEAST ASIA; THAILAND; VIET NAM; DNA SEQUENCE; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; MALARIA, FALCIPARUM; MUTATION RATE; PARASITOLOGY;

PLASMODIUM FALCIPARUM;

ANTIMALARIALS; ARTEMISININS; ASIA, SOUTHEASTERN; DNA, PROTOZOAN; DRUG RESISTANCE; HUMANS; MALARIA, FALCIPARUM; MUTATION RATE; PHENOTYPE; PLASMODIUM FALCIPARUM; SEQUENCE ANALYSIS, DNA;

EID: 84921528358     PISSN: 15671348     EISSN: 15677257     Source Type: Journal    
DOI: 10.1016/j.meegid.2014.12.010     Document Type: Article

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