The pathogenic basis of malaria

Nature

Volumn 415, Issue 6872, 2002, Pages 673-679

  Miller, Louis H ^a   Baruch, Dror I ^a   Marsh, Kevin ^a   Doumbo, Ogobara K ^a  

^a KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

ECONOMIC AND SOCIAL EFFECTS; RURAL AREAS; VACCINES;

PATHOGENESIS;

MALARIA CONTROL;

ANTIMALARIAL AGENT; MALARIA VACCINE;

DISEASE CONTROL; MALARIA; PATHOGENICITY; RESEARCH AND DEVELOPMENT;

AFRICA; DEVELOPING COUNTRY; HEALTH CARE ACCESS; HUMAN; MALARIA; MALARIA CONTROL; MEDICAL RESEARCH; MORTALITY; PATHOGENESIS; PLASMODIUM; POVERTY; PRIORITY JOURNAL; REVIEW;

ANIMALS; ENDOTHELIUM, VASCULAR; ERYTHROCYTES; HUMANS; LIFE CYCLE STAGES; MALARIA, FALCIPARUM; PLACENTA; PLASMODIUM FALCIPARUM;

AFRICA;

PROTOZOA;

EID: 0037034017     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/415673a     Document Type: Review

References (82)

1. Estimating mortality, morbidity and disability due to malaria among Africa's non-pregnant population
2. Indicators of life-threatening malaria in African children
3. Acid-base status in paediatric Plasmodium falciparum malaria
4. Deep breathing in children with severe malaria: Indicator of metabolic acidosis and poor outcome
5. Acidosis in severe childhood malaria
6. Alteration in the rheologic properties of Plasmodium knowlesi infected red cells. A possible mechanism of cerebral malaria
7. Abnormal blood flow and red blood cell deformability in severe malaria
8. Hyponatraemia and dehydration in severe malaria
9. Severe anaemia in children living in a malaria endemic area of Kenya
10. Bacteraemia complicating severe malaria in children
11. Bacterial strains isolated from blood cultures of Nigerian children with cerebral malaria
12. Transfusion for respiratory distress in life-threatening childhood malaria
13. Seizures and status epilepticus in childhood cerebral malaria
14. The neglected burden of Plasmodium vivax malaria
15. Migration of Plasmodium sporozoites through cells before infection
16. Malaria circumsporozoite protein binds to heparan sulfate proteoglycans associated with the surface membrane of hepatocytes
17. Molecular insights into receptors used by malaria parasites for erythrocyte invasion
18. Invasion of erythrocytes by malaria merozoites
19. Johnson Erythrocyte entry by malarial parasites. A moving junction between erythrocyte and parasite
20. The Duffy receptor family of Plasmodium knowlesi is located within the micronemes of invasive malaria merozoites
21. Conservation of a gliding motility and cell invasion machinery in Apicomplexan parasites
22. Parasite multiplication potential and the severity of falciparum malaria
23. The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype, FyFy
24. null in a Plasmodium vivax-endemic region of Papua New Guinea
25. A family of erythrocyte binding proteins of malaria parasites
26. A reticulocyte-binding protein complex of Plasmodium vivax merozoites
27. A Plasmodium falciparum homologue of Plasmodium vivax reticulocyte binding protein (PvRBP1) defines a trypsin-resistant erythocyte invasion pathway
28. A gene coding for a high-molecular mass rhoptry protein of Plasmodium yoelii
29. A rhoptry-protein-associated mechanism of clonal phenotypic variation in rodent malaria
30. Plasmodium falciparum field isolates commonly use erythrocyte invasion pathways that are independent of sialic acid residues of glycophorin A
31. Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum
32. Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum
33. Characterization of a Plasmodium falciparum erythrocyte-binding protein paralogous to EBA-175
34. The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea
35. Antibodies that inhibit malaria merozoite surface protein- 1 processing and erythrocyte invasion are blocked by naturally acquired human antibodies
36. The disulfide bond structure of Plasmodium apical membrane antigen-1
37. Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species
38. Plasmodium chabaudi p68 serine protease activity required for merozoite entry into mouse erythrocytes
39. Adhesive receptors on malaria-parasitized red cells
40. Molecular aspects of severe malaria
41. Cytoadherence, pathogenesis and the infected red cell surface in Plasmodium falciparum
42. Plasmodium falciparum malaria. Ultrastructure of parasitized erythrocytes in cardiac vessels
43. Pathogenicity, stability, and immunogenicity of a knobless clone of Plasmodium falciparum in Colombian owl monkeys
44. Rolling and stationary cytoadhesion of red blood cells parasitized by Plasmodium falciparum: Separate roles for ICAM-1, CD36 and thrombospondin
45. Molecular mechanisms of cytoadherence in malaria
46. Plasmodium falciparum-infected erythrocytes adhere to the proteoglycan thrombomodulin in static and flow-based systems
47. Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelial cells under flow
48. Plasmodium falciparum isolates from infected pregnant women and children are associated with distinct adhesive and antigenic properties
49. Receptor-specific adhesion and clinical disease in Plasmodium falciparum
50. Cloning the P. falciparum gene encoding PfEMP 1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes
51. Switches in expression of Plasmodium falcifarum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
52. The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of Plasmodium falciparum-infected erythrocytes
53. Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family
54. Decoding the language of var genes and Plasmodium falciparum sequestration
55. Developmental selection of var gene expression in Plasmodium falciparum
56. Rapid switching to multiple antigenic and adhesive phenotypes in malaria
57. New insights into the epidemiology of malaria relevant for disease control
58. Adherence of Plasmodium falciparum to chondroitin sulfate A in the human placenta
59. Plasmodium falciparum domain mediating adhesion to chondroitin sulfate A: A receptor for human placental infection
60. Modifications in the CD 36 binding domain of the Plasmodium falciparum variant antigen are responsible for the inability of chondroitin sulfate A adherent parasites to bind CD36
61. Molecular basis of sequestration in severe and uncomplicated Plasmodium falciparum malaria: Differential adhesion of infected erythrocytes to CD36 and ICAM-1
62. An immunohistochemical study of the pathology of fatal malaria. Evidence for widespread endothelial activation and a potential role for intercellular adhesion molecule-1 in cerebral sequestration
63. A non-sense mutation in CD 36 gene is associated with protection from severe malaria
64. P. falciparum rosetting mediated by a parasitevariant erythrocyte membrane protein and complement-receptor 1
65. Fresh isolates from children with severe Plasmodium falciparum malaria bind to multiple receptors
66. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocyres is a common adhesive phenotype and is associated with severe malaria
67. Maternal antibodies block malaria
68. Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria
69. Antibody recognition of Plasmodium falciparum erythrocyte surface antigens in Kenya: Evidence for rare and prevalent variants
70. Plasmodium fulciparum-infected erythrocytes: Agglutination by diverse Kenyan plasma is associated with severe disease and young host age
71. Immunity to non-cerebral severe malaria is acquired after one or two in fections
72. Why is the pathology of falciparum worse than that of vivax malaria?
73. Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide
74. Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria
75. Cerebrospinal fluid studies in children with cerebral malaria: An excitotoxic mechanism?
76. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites
77. Glycosylphosphatidylinositol toxin of Plasmodium induces nitric oxide synthase expression in macrophages and vascular endothelial cells by a protein tyrosine kinase-dependent and protein kinase C-dependent signaling pathway
78. Glycosylphosphatidylinositol anchors of Plasmodium falciparum: Molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis
79. Plasmodium falciparum induces apoptosis in human mononuclear cells
80. + T cells adoptively transferred into recipient mice after challenge with homologous parasite
81. Different response to Plasmodium falciparum malaria in West African sympatric ethnic groups
82. Baseline immunity of the population and impact of insecticide-treated curtains on malaria infection