Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

PLoS Computational Biology

Volumn 13, Issue 3, 2017, Pages

  Chiappino Pepe, Anush ^a   Tymoshenko, Stepan ^a,b   Ataman, Meriç ^a   Soldati Favre, Dominique ^b   Hatzimanikatis, Vassily ^a  

^a EPFL   (Switzerland)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; DISEASES; METABOLISM; PHYSIOLOGY; THERMODYNAMICS;

ANTIMALARIAL THERAPY; BASED MODELLING; ESSENTIAL GENE; FLUX ANALYSIS; INFECTED CELLS; MALARIA PARASITE; METABOLIC CAPABILITIES; PARASITE-; PLASMODIUM FALCIPARUM; SUBSTRATE CHANNELINGS;

GENES;

ANALYTIC METHOD; ARTICLE; BIOENERGY; CELL METABOLISM; ESSENTIAL GENE; GENE IDENTIFICATION; MEASUREMENT ACCURACY; METABOLOMICS; NONHUMAN; NUTRITIONAL REQUIREMENT; PLASMODIUM FALCIPARUM; PREDICTION; SENSITIVITY ANALYSIS; THERMODYNAMICS BASED FLUX ANALYSIS; BIOLOGICAL MODEL; COMPUTER SIMULATION; ENERGY METABOLISM; METABOLIC FLUX ANALYSIS; METABOLISM; METABOLOME; PHYSIOLOGY; PROCEDURES; THERMODYNAMICS;

PROTOZOAL PROTEIN;

COMPUTER SIMULATION; ENERGY METABOLISM; GENES, ESSENTIAL; METABOLIC FLUX ANALYSIS; METABOLOME; MODELS, BIOLOGICAL; NUTRITIONAL REQUIREMENTS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; THERMODYNAMICS;

EID: 85016725723     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1005397     Document Type: Article

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