Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 28, 2011, Pages 11405-11410

  Klonis, Nectarios ^a,b   Crespo Ortiz, Maria P ^a   Bottova, Iveta ^a   Abu Bakar, Nurhidanatasha ^a   Kenny, Shannon ^a   Rosenthal, Philip J ^c   Tilley, Leann ^a,b,d  

^a LA TROBE UNIVERSITY   (Australia)

^b LA TROBE UNIVERSITY   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Endoperoxide; Erythrocyte

Indexed keywords

ARTEMISININ DERIVATIVE; ASPARTIC PROTEINASE; CYSTEINE PROTEASE INHIBITOR; CYSTEINE PROTEINASE; DEOXYARTEMISININ; ENZYME INHIBITOR; HEMOGLOBIN; HEMOGLOBIN HYDROXYLASE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CELL LYSATE; CONTROLLED STUDY; CYTOPLASM; DIGESTION; DRUG HALF LIFE; ENZYME ACTIVITY; ENZYME INHIBITION; ERYTHROCYTE; GENE DELETION; KNOCKOUT GENE; NONHUMAN; OXIDATIVE STRESS; PARASITE; PARASITE SURVIVAL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN TRANSPORT; TROPHOZOITE;

ANIMALS; ANTIMALARIALS; ARTEMISININS; BIOLOGICAL TRANSPORT, ACTIVE; CYSTEINE ENDOPEPTIDASES; ENDOCYTOSIS; ERYTHROCYTES; GENE DELETION; GENES, PROTOZOAN; HEMOGLOBINS; HOST-PARASITE INTERACTIONS; HUMANS; MALARIA, FALCIPARUM; PARASITEMIA; PLASMODIUM FALCIPARUM;

PLASMODIUM FALCIPARUM;

EID: 79960992639     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104063108     Document Type: Article

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