Metabolic dysregulation induced in plasmodium falciparum by dihydroartemisinin and other front-line antimalarial drugs

Journal of Infectious Diseases

Volumn 213, Issue 2, 2016, Pages 276-286

  Cobbold, Simon A ^a   Chua, Hwa H ^a   Nijagal, Brunda ^a   Creek, Darren J ^a,b   Ralph, Stuart A ^a   McConville, Malcolm J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

antimalarial; artemisinin; atovaquone; chloroquine; drug screening; malaria; metabolite; metabolomics; Plasmodium; torin

Indexed keywords

ANTIMALARIAL AGENT; ATOVAQUONE; CARBON 13; CHLOROQUINE; CYCLOGUANIL; DIHYDROARTEMISININ; FOSMIDOMYCIN; GLUCOSE; HEMOGLOBIN; METHYLENE BLUE; PROGUANIL; TORIN 2; UNCLASSIFIED DRUG; 9-(6-AMINOPYRIDIN-3-YL)-1-(3-(TRIFLUOROMETHYL)PHENYL)BENZO(H)(1,6)NAPHTHYRIDIN-2(1H)-ONE; ARTEMISININ DERIVATIVE; FOSFOMYCIN; NAPHTHYRIDINE DERIVATIVE; TRIAZINE DERIVATIVE;

ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; BIOSYNTHESIS; CATABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ERYTHROCYTE; INCUBATION TIME; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; DRUG EFFECTS; IC50; METABOLISM;

ANTIMALARIALS; ARTEMISININS; ATOVAQUONE; CHLOROQUINE; FOSFOMYCIN; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; INHIBITORY CONCENTRATION 50; METHYLENE BLUE; NAPHTHYRIDINES; PLASMODIUM FALCIPARUM; PROGUANIL; TRIAZINES;

EID: 84959860038     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv372     Document Type: Article

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