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Volumn 35, Issue , 2017, Pages 85-96

Glucocorticoid resistance as a major drive in sepsis pathology

Author keywords

Glucocorticoid resistance; Inflammation; Metabolism; Sepsis

Indexed keywords

CORTICOSTERONE; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR BETA; HEAT SHOCK PROTEIN 90; HISTONE DEACETYLASE 4; HYDROCORTISONE; INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LACTIC ACID; LIVER X RECEPTOR; METHYLPREDNISOLONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PREDNISOLONE; PYRUVATE DEHYDROGENASE KINASE 4; TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENT;

EID: 85018985478     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2017.04.002     Document Type: Review
Times cited : (66)

References (216)
  • 1
    • 84958107344 scopus 로고
    • The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis, Proceedings of the staff meetings
    • Hench, P.S., Kendall, E.C., The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis, Proceedings of the staff meetings. Mayo Clin. 24:8 (1949), 181–197.
    • (1949) Mayo Clin. , vol.24 , Issue.8 , pp. 181-197
    • Hench, P.S.1    Kendall, E.C.2
  • 2
    • 84994834198 scopus 로고    scopus 로고
    • The role of ACTH and corticosteroids for sepsis and septic shock: an update
    • Annane, D., The role of ACTH and corticosteroids for sepsis and septic shock: an update. Front. Endocrinol., 7, 2016, 70.
    • (2016) Front. Endocrinol. , vol.7 , pp. 70
    • Annane, D.1
  • 3
    • 0036949072 scopus 로고    scopus 로고
    • The use of corticosteroids in severe sepsis and acute respiratory distress syndrome
    • Chadda, K., Annane, D., The use of corticosteroids in severe sepsis and acute respiratory distress syndrome. Ann. Med. 34:7–8 (2002), 582–589.
    • (2002) Ann. Med. , vol.34 , Issue.7-8 , pp. 582-589
    • Chadda, K.1    Annane, D.2
  • 4
    • 0023194967 scopus 로고
    • A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: clinical effects
    • Milligan, N.M., Newcombe, R., Compston, D.A., A double-blind controlled trial of high dose methylprednisolone in patients with multiple sclerosis: clinical effects. J. Neurol. Neurosurg. Psychiatry 50:5 (1987), 511–516.
    • (1987) J. Neurol. Neurosurg. Psychiatry , vol.50 , Issue.5 , pp. 511-516
    • Milligan, N.M.1    Newcombe, R.2    Compston, D.A.3
  • 5
    • 0035490913 scopus 로고    scopus 로고
    • Molecular mechanisms of corticosteroids in allergic diseases
    • Barnes, P.J., Molecular mechanisms of corticosteroids in allergic diseases. Allergy 56:10 (2001), 928–936.
    • (2001) Allergy , vol.56 , Issue.10 , pp. 928-936
    • Barnes, P.J.1
  • 6
    • 84873206093 scopus 로고    scopus 로고
    • Prevalence of oral glucocorticoid usage in the United States: a general population perspective
    • Overman, R.A., Yeh, J.-Y.Y., Deal, C.L., Prevalence of oral glucocorticoid usage in the United States: a general population perspective. Arthritis Care Res. 65:2 (2013), 294–298.
    • (2013) Arthritis Care Res. , vol.65 , Issue.2 , pp. 294-298
    • Overman, R.A.1    Yeh, J.-Y.Y.2    Deal, C.L.3
  • 7
    • 0036135774 scopus 로고    scopus 로고
    • Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
    • Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells. FASEB J., 2002.
    • (2002) FASEB J.
    • Galon, J.1    Franchimont, D.2    Hiroi, N.3    Frey, G.4    Boettner, A.5
  • 8
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United Statesfrom 1979 through 2000
    • Martin, G.S., Mannino, D.M., Eaton, S., The epidemiology of sepsis in the United Statesfrom 1979 through 2000. N. Engl. J. Med., 2003.
    • (2003) N. Engl. J. Med.
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3
  • 9
    • 84941013338 scopus 로고    scopus 로고
    • The burden of sepsis in the Emergency Department: an observational snapshot
    • Cowan, S.L., Holland, J.A.A., Kane, A.D., Frost, I., Boyle, A.A., The burden of sepsis in the Emergency Department: an observational snapshot. Eur. J. Emerg. Med. 22:5 (2015), 363–365.
    • (2015) Eur. J. Emerg. Med. , vol.22 , Issue.5 , pp. 363-365
    • Cowan, S.L.1    Holland, J.A.A.2    Kane, A.D.3    Frost, I.4    Boyle, A.A.5
  • 10
    • 84862669323 scopus 로고    scopus 로고
    • A historical perspective on sepsis
    • Ward, P.A., Bosmann, M., A historical perspective on sepsis. Am. J. Pathol. 181:1 (2012), 2–7.
    • (2012) Am. J. Pathol. , vol.181 , Issue.1 , pp. 2-7
    • Ward, P.A.1    Bosmann, M.2
  • 11
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • Angus, D.C., Linde-Zwirble, W.T., Lidicker, J., Clermont, G., Carcillo, J., Pinsky, M.R., Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29:7 (2001), 1303–1310.
    • (2001) Crit. Care Med. , vol.29 , Issue.7 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 12
    • 34547652674 scopus 로고    scopus 로고
    • National estimates of severe sepsis in United States emergency departments
    • Wang, H.E., Shapiro, N.I., Angus, D.C., Yealy, D.M., National estimates of severe sepsis in United States emergency departments. Crit. Care Med. 35:8 (2007), 1928–1936.
    • (2007) Crit. Care Med. , vol.35 , Issue.8 , pp. 1928-1936
    • Wang, H.E.1    Shapiro, N.I.2    Angus, D.C.3    Yealy, D.M.4
  • 13
    • 0036878761 scopus 로고    scopus 로고
    • Guidance on patient identification and administration of recombinant human activated protein C for the treatment of severe sepsis
    • Garber, G., Gibney, R.N., Light, B., Martin, C., Cunningham, K., Guimond, J.-G.G., Magder, S., Russell, J., Guidance on patient identification and administration of recombinant human activated protein C for the treatment of severe sepsis. Can. J. Infect. Dis. 13:6 (2002), 361–372.
    • (2002) Can. J. Infect. Dis. , vol.13 , Issue.6 , pp. 361-372
    • Garber, G.1    Gibney, R.N.2    Light, B.3    Martin, C.4    Cunningham, K.5    Guimond, J.-G.G.6    Magder, S.7    Russell, J.8
  • 15
    • 0025342735 scopus 로고
    • Mechanisms of serotonin receptor agonist-induced activation of the hypothalamic-pituitary-adrenal axis in the rat
    • Calogero, A.E., Bagdy, G., Szemeredi, K., Tartaglia, M.E., Gold, P.W., Chrousos, G.P., Mechanisms of serotonin receptor agonist-induced activation of the hypothalamic-pituitary-adrenal axis in the rat. Endocrinology 126:4 (1990), 1888–1894.
    • (1990) Endocrinology , vol.126 , Issue.4 , pp. 1888-1894
    • Calogero, A.E.1    Bagdy, G.2    Szemeredi, K.3    Tartaglia, M.E.4    Gold, P.W.5    Chrousos, G.P.6
  • 16
    • 0027788036 scopus 로고
    • Involvement of GABAB receptors in the regulation of the hypothalamo-pituitary-adrenocortical (HPA) axis in rats
    • Häusler, A., Monnet, G., Peter, O., Involvement of GABAB receptors in the regulation of the hypothalamo-pituitary-adrenocortical (HPA) axis in rats. J. Steroid Biochem. Mol. Biol. 46:6 (1993), 767–771.
    • (1993) J. Steroid Biochem. Mol. Biol. , vol.46 , Issue.6 , pp. 767-771
    • Häusler, A.1    Monnet, G.2    Peter, O.3
  • 17
    • 0026081754 scopus 로고
    • Interleukins-1 and −6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway
    • Navarra, P., Tsagarakis, S., Faria, M.S., Rees, L.H., Besser, G.M., Grossman, A.B., Interleukins-1 and −6 stimulate the release of corticotropin-releasing hormone-41 from rat hypothalamus in vitro via the eicosanoid cyclooxygenase pathway. Endocrinology 128:1 (1991), 37–44.
    • (1991) Endocrinology , vol.128 , Issue.1 , pp. 37-44
    • Navarra, P.1    Tsagarakis, S.2    Faria, M.S.3    Rees, L.H.4    Besser, G.M.5    Grossman, A.B.6
  • 19
    • 79951665862 scopus 로고    scopus 로고
    • The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders
    • Miller, W.L., Auchus, R.J., The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocr. Rev. 32:1 (2011), 81–151.
    • (2011) Endocr. Rev. , vol.32 , Issue.1 , pp. 81-151
    • Miller, W.L.1    Auchus, R.J.2
  • 20
    • 84964313676 scopus 로고    scopus 로고
    • Rapid intra-adrenal feedback regulation of glucocorticoid synthesis
    • 20140875
    • Walker, J.J., Spiga, F., Gupta, R., Rapid intra-adrenal feedback regulation of glucocorticoid synthesis. J. R. Soc. Interface, 12(102), 2015 20140875.
    • (2015) J. R. Soc. Interface , vol.12 , Issue.102
    • Walker, J.J.1    Spiga, F.2    Gupta, R.3
  • 21
    • 0036801275 scopus 로고    scopus 로고
    • Plasma binding proteins as mediators of corticosteroid action in vertebrates
    • Breuner, C.W., Orchinik, M., Plasma binding proteins as mediators of corticosteroid action in vertebrates. J. Endocrinol. 175:1 (2002), 99–112.
    • (2002) J. Endocrinol. , vol.175 , Issue.1 , pp. 99-112
    • Breuner, C.W.1    Orchinik, M.2
  • 22
    • 4043077286 scopus 로고    scopus 로고
    • 11β-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response
    • Tomlinson, J.W., Walker, E.A., Bujalska, I.J., 11β-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr. Rev. 25:5 (2004), 831–866.
    • (2004) Endocr. Rev. , vol.25 , Issue.5 , pp. 831-866
    • Tomlinson, J.W.1    Walker, E.A.2    Bujalska, I.J.3
  • 23
    • 0034129679 scopus 로고    scopus 로고
    • Steroid hormone receptors: an update
    • Beato, M., Klug, J., Steroid hormone receptors: an update. Hum. Reprod. Update 6:3 (2000), 225–236.
    • (2000) Hum. Reprod. Update , vol.6 , Issue.3 , pp. 225-236
    • Beato, M.1    Klug, J.2
  • 24
    • 0027433763 scopus 로고
    • Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates
    • Boumpas, D.T., Chrousos, G.P., Wilder, R.L., Cupps, T.R., Balow, J.E., Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates. Ann. Intern. Med. 119:12 (1993), 1198–1208.
    • (1993) Ann. Intern. Med. , vol.119 , Issue.12 , pp. 1198-1208
    • Boumpas, D.T.1    Chrousos, G.P.2    Wilder, R.L.3    Cupps, T.R.4    Balow, J.E.5
  • 25
    • 0029096371 scopus 로고
    • Molecular genetic analysis of glucocorticoid signalling in development
    • Schmid, W., Cole, T.J., Blendy, J.A., Schütz, G., Molecular genetic analysis of glucocorticoid signalling in development. J. Steroid Biochem. Mol. Biol. 53:1–6 (1995), 33–35.
    • (1995) J. Steroid Biochem. Mol. Biol. , vol.53 , Issue.1-6 , pp. 33-35
    • Schmid, W.1    Cole, T.J.2    Blendy, J.A.3    Schütz, G.4
  • 26
    • 0028857830 scopus 로고
    • The nuclear hormone-receptor family in the brain: classics and orphans
    • Lopes da Silva, S., Burbach, J.P., The nuclear hormone-receptor family in the brain: classics and orphans. Trends Neurosci. 18:12 (1995), 542–548.
    • (1995) Trends Neurosci. , vol.18 , Issue.12 , pp. 542-548
    • Lopes da Silva, S.1    Burbach, J.P.2
  • 28
    • 79952799756 scopus 로고    scopus 로고
    • Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids
    • Oakley, R.H., Cidlowski, J.A., Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids. J. Biol. Chem. 286:5 (2011), 3177–3184.
    • (2011) J. Biol. Chem. , vol.286 , Issue.5 , pp. 3177-3184
    • Oakley, R.H.1    Cidlowski, J.A.2
  • 29
    • 0029056558 scopus 로고
    • Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans
    • Bamberger, C.M., Bamberger, A.M., de Castro, M., Chrousos, G.P., Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J. Clin. Invest. 95:6 (1995), 2435–2441.
    • (1995) J. Clin. Invest. , vol.95 , Issue.6 , pp. 2435-2441
    • Bamberger, C.M.1    Bamberger, A.M.2    de Castro, M.3    Chrousos, G.P.4
  • 30
    • 70349881524 scopus 로고    scopus 로고
    • Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology
    • Kino, T., Su, Y.A., Chrousos, G.P., Human glucocorticoid receptor isoform beta: recent understanding of its potential implications in physiology and pathophysiology. Cell. Mol. Life Sci.: CMLS 66:21 (2009), 3435–3448.
    • (2009) Cell. Mol. Life Sci.: CMLS , vol.66 , Issue.21 , pp. 3435-3448
    • Kino, T.1    Su, Y.A.2    Chrousos, G.P.3
  • 31
    • 0036240969 scopus 로고    scopus 로고
    • AUUUA motifs in the 3′UTR of human glucocorticoid receptor α and β mRNA destabilize mRNA and decrease receptor protein expression
    • Schaaf, M.J.M., Cidlowski, J.A., AUUUA motifs in the 3′UTR of human glucocorticoid receptor α and β mRNA destabilize mRNA and decrease receptor protein expression. Steroids 67:7 (2002), 627–636.
    • (2002) Steroids , vol.67 , Issue.7 , pp. 627-636
    • Schaaf, M.J.M.1    Cidlowski, J.A.2
  • 35
    • 84455191490 scopus 로고    scopus 로고
    • ACTH-dependent regulation of microRNA as endogenous modulators of glucocorticoid receptor expression in the adrenal gland
    • Riester, A., Issler, O., Spyroglou, A., Rodrig, S.H., Chen, A., Beuschlein, F., ACTH-dependent regulation of microRNA as endogenous modulators of glucocorticoid receptor expression in the adrenal gland. Endocrinology 153:1 (2012), 212–222.
    • (2012) Endocrinology , vol.153 , Issue.1 , pp. 212-222
    • Riester, A.1    Issler, O.2    Spyroglou, A.3    Rodrig, S.H.4    Chen, A.5    Beuschlein, F.6
  • 36
    • 20844437424 scopus 로고    scopus 로고
    • Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes
    • Lu, N.Z., Cidlowski, J.A., Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol. Cell, 2005.
    • (2005) Mol. Cell
    • Lu, N.Z.1    Cidlowski, J.A.2
  • 37
    • 33751000477 scopus 로고    scopus 로고
    • Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification
    • Duma, D., Jewell, C.M., Cidlowski, J.A., Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification. J. Steroid Biochem. Mol. Biol. 102:1–5 (2006), 11–21.
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.102 , Issue.1-5 , pp. 11-21
    • Duma, D.1    Jewell, C.M.2    Cidlowski, J.A.3
  • 39
    • 71849112377 scopus 로고    scopus 로고
    • The human glucocorticoid receptor: molecular basis of biologic function
    • Nicolaides, N.C., Galata, Z., Kino, T., Chrousos, G.P., Charmandari, E., The human glucocorticoid receptor: molecular basis of biologic function. Steroids 75:1 (2009), 1–12.
    • (2009) Steroids , vol.75 , Issue.1 , pp. 1-12
    • Nicolaides, N.C.1    Galata, Z.2    Kino, T.3    Chrousos, G.P.4    Charmandari, E.5
  • 40
    • 84905034984 scopus 로고    scopus 로고
    • Comprehensive overview of the structure and regulation of the glucocorticoid receptor
    • Vandevyver, S., Dejager, L., Libert, C., Comprehensive overview of the structure and regulation of the glucocorticoid receptor. Endocr. Rev. 35:4 (2014), 671–693.
    • (2014) Endocr. Rev. , vol.35 , Issue.4 , pp. 671-693
    • Vandevyver, S.1    Dejager, L.2    Libert, C.3
  • 41
    • 0030024586 scopus 로고    scopus 로고
    • Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination
    • Zhang, S., Liang, X., Danielsen, M., Role of the C terminus of the glucocorticoid receptor in hormone binding and agonist/antagonist discrimination. Mol. Endocrinol. 10:1 (1996), 24–34.
    • (1996) Mol. Endocrinol. , vol.10 , Issue.1 , pp. 24-34
    • Zhang, S.1    Liang, X.2    Danielsen, M.3
  • 42
    • 33748297516 scopus 로고    scopus 로고
    • Functional analysis of the LXXLL motifs of the human glucocorticoid receptor: association with altered ligand affinity
    • Dong, D.D., Jewell, C.M., Bienstock, R.J., Cidlowski, J.A., Functional analysis of the LXXLL motifs of the human glucocorticoid receptor: association with altered ligand affinity. J. Steroid Biochem. Mol. Biol. 101:2–3 (2006), 106–117.
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.101 , Issue.2-3 , pp. 106-117
    • Dong, D.D.1    Jewell, C.M.2    Bienstock, R.J.3    Cidlowski, J.A.4
  • 43
    • 34547872322 scopus 로고    scopus 로고
    • The glucocorticoid responses are shaped by molecular chaperones, The glucocorticoid responses are shaped by molecular chaperones
    • (1-2)
    • Grad, I., Picard, D., The glucocorticoid responses are shaped by molecular chaperones, The glucocorticoid responses are shaped by molecular chaperones. Mol. Cell. Endocrinol. 275 (2007), 2–12 (1-2).
    • (2007) Mol. Cell. Endocrinol. , vol.275 , pp. 2-12
    • Grad, I.1    Picard, D.2
  • 44
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones 1
    • Pratt, W.B., Toft, D.O., Steroid receptor interactions with heat shock protein and immunophilin chaperones 1. Endocr. Rev. 18:3 (1997), 306–360.
    • (1997) Endocr. Rev. , vol.18 , Issue.3 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 45
    • 84856790766 scopus 로고    scopus 로고
    • On the trail of the glucocorticoid receptor: into the nucleus and back
    • Vandevyver, L., On the trail of the glucocorticoid receptor: into the nucleus and back. Traffic (Copenhagen, Denmark) 13:3 (2012), 364–374.
    • (2012) Traffic (Copenhagen, Denmark) , vol.13 , Issue.3 , pp. 364-374
    • Vandevyver, L.1
  • 47
    • 84906979408 scopus 로고    scopus 로고
    • Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA
    • Hudson, W.H., Youn, C., Ortlund, E.A., Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA. PLoS One, 9(9), 2014.
    • (2014) PLoS One , vol.9 , Issue.9
    • Hudson, W.H.1    Youn, C.2    Ortlund, E.A.3
  • 48
    • 73249130316 scopus 로고    scopus 로고
    • Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation
    • Reddy, T.E., Pauli, F., Sprouse, R.O., Neff, N.F., Newberry, K.M., Garabedian, M.J., Myers, R.M., Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. Genome Res. 19:12 (2009), 2163–2171.
    • (2009) Genome Res. , vol.19 , Issue.12 , pp. 2163-2171
    • Reddy, T.E.1    Pauli, F.2    Sprouse, R.O.3    Neff, N.F.4    Newberry, K.M.5    Garabedian, M.J.6    Myers, R.M.7
  • 50
    • 84878547373 scopus 로고    scopus 로고
    • C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements
    • Grøntved, L., John, S., Baek, S., Liu, Y., Buckley, J.R., Vinson, C., Aguilera, G., Hager, G.L., C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements. EMBO J. 32:11 (2013), 1568–1583.
    • (2013) EMBO J. , vol.32 , Issue.11 , pp. 1568-1583
    • Grøntved, L.1    John, S.2    Baek, S.3    Liu, Y.4    Buckley, J.R.5    Vinson, C.6    Aguilera, G.7    Hager, G.L.8
  • 52
    • 84884530913 scopus 로고    scopus 로고
    • Chromatin architecture defines the glucocorticoid response
    • Burd, C.J., Archer, T.K., Chromatin architecture defines the glucocorticoid response. Mol. Cell. Endocrinol. 380:1 (2013), 25–31.
    • (2013) Mol. Cell. Endocrinol. , vol.380 , Issue.1 , pp. 25-31
    • Burd, C.J.1    Archer, T.K.2
  • 55
    • 14644401720 scopus 로고    scopus 로고
    • Role of activation function domain-1, DNA binding, and coactivator GRIP1 in the expression of partial agonist activity of glucocorticoid receptor-antagonist complexes
    • Cho, S., Blackford, J.A., Simons, S.S., Role of activation function domain-1, DNA binding, and coactivator GRIP1 in the expression of partial agonist activity of glucocorticoid receptor-antagonist complexes. Biochemistry 44:9 (2005), 3547–3561.
    • (2005) Biochemistry , vol.44 , Issue.9 , pp. 3547-3561
    • Cho, S.1    Blackford, J.A.2    Simons, S.S.3
  • 56
    • 0035320538 scopus 로고    scopus 로고
    • Novel glucocorticoid receptor coactivator effector mechanisms
    • Jenkins, B.D., Pullen, C.B., Darimont, B.D., Novel glucocorticoid receptor coactivator effector mechanisms. Trends Endocrinol. Metab. 12:3 (2001), 122–126.
    • (2001) Trends Endocrinol. Metab. , vol.12 , Issue.3 , pp. 122-126
    • Jenkins, B.D.1    Pullen, C.B.2    Darimont, B.D.3
  • 57
    • 33746539852 scopus 로고    scopus 로고
    • Role of steroid receptor coactivators in glucocorticoid and transforming growth factor beta regulation of plasminogen activator inhibitor gene expression
    • Li, G., Heaton, J.H., Gelehrter, T.D., Role of steroid receptor coactivators in glucocorticoid and transforming growth factor beta regulation of plasminogen activator inhibitor gene expression. Mol. Endocrinol. (Baltimore, Md.) 20:5 (2006), 1025–1034.
    • (2006) Mol. Endocrinol. (Baltimore, Md.) , vol.20 , Issue.5 , pp. 1025-1034
    • Li, G.1    Heaton, J.H.2    Gelehrter, T.D.3
  • 59
    • 0033920259 scopus 로고    scopus 로고
    • A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein
    • Mahajan, M.A., Samuels, H.H., A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. Mol. Cell. Biol. 20:14 (2000), 5048–5063.
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.14 , pp. 5048-5063
    • Mahajan, M.A.1    Samuels, H.H.2
  • 60
    • 79953871100 scopus 로고    scopus 로고
    • Widespread negative response elements mediate direct repression by agonist- liganded glucocorticoid receptor
    • Surjit, M., Ganti, K., Mukherji, A., Ye, T., Hua, G., Metzger, D., Li, M., Chambon, P., Widespread negative response elements mediate direct repression by agonist- liganded glucocorticoid receptor. Cell, 145(2), 2010.
    • (2010) Cell , vol.145 , Issue.2
    • Surjit, M.1    Ganti, K.2    Mukherji, A.3    Ye, T.4    Hua, G.5    Metzger, D.6    Li, M.7    Chambon, P.8
  • 61
    • 34547884315 scopus 로고    scopus 로고
    • Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects
    • Kassel, O., Herrlich, P., Crosstalk between the glucocorticoid receptor and other transcription factors: molecular aspects. Mol. Cell. Endocrinol., 275(1-2), 2007.
    • (2007) Mol. Cell. Endocrinol. , vol.275 , Issue.1-2
    • Kassel, O.1    Herrlich, P.2
  • 63
    • 84955661658 scopus 로고    scopus 로고
    • Why we need to revise the definition and diagnostic criteria for sepsis
    • Lin, H.-Y.Y., Why we need to revise the definition and diagnostic criteria for sepsis. Chin. J. Traumatol. 18:5 (2015), 249–250.
    • (2015) Chin. J. Traumatol. , vol.18 , Issue.5 , pp. 249-250
    • Lin, H.-Y.Y.1
  • 64
    • 84978775150 scopus 로고    scopus 로고
    • Sepsis-3. What is the meaning of a definition?
    • Marshall, J.C., Sepsis-3. What is the meaning of a definition?. Crit. Care Med. 44:8 (2016), 1459–1460.
    • (2016) Crit. Care Med. , vol.44 , Issue.8 , pp. 1459-1460
    • Marshall, J.C.1
  • 66
    • 43349108280 scopus 로고    scopus 로고
    • Sepsis: rethinking the approach to clinical research
    • Marshall, J.C., Sepsis: rethinking the approach to clinical research. J. Leukoc. Biol. 83:3 (2008), 471–482.
    • (2008) J. Leukoc. Biol. , vol.83 , Issue.3 , pp. 471-482
    • Marshall, J.C.1
  • 67
    • 0037090339 scopus 로고    scopus 로고
    • Clinical trials of immunomodulatory therapies in severe sepsis and septic shock
    • Vincent, J.-L.L., Sun, Q., Dubois, M.-J.J., Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin. Infect. Dis. 34:8 (2002), 1084–1093.
    • (2002) Clin. Infect. Dis. , vol.34 , Issue.8 , pp. 1084-1093
    • Vincent, J.-L.L.1    Sun, Q.2    Dubois, M.-J.J.3
  • 68
    • 84889859020 scopus 로고    scopus 로고
    • Severe sepsis and septic shock
    • Angus, D.C., van der Poll, T., Severe sepsis and septic shock. N. Engl. J. Med. 369:21 (2013), 2062–2063.
    • (2013) N. Engl. J. Med. , vol.369 , Issue.21 , pp. 2062-2063
    • Angus, D.C.1    van der Poll, T.2
  • 72
    • 84956474298 scopus 로고    scopus 로고
    • Balance between hyperinflammation and immunosuppression in sepsis
    • Yadav, H., Cartin-Ceba, R., Balance between hyperinflammation and immunosuppression in sepsis. Semin. Respir. Crit. Care Med. 37:1 (2016), 42–50.
    • (2016) Semin. Respir. Crit. Care Med. , vol.37 , Issue.1 , pp. 42-50
    • Yadav, H.1    Cartin-Ceba, R.2
  • 73
    • 33747502519 scopus 로고    scopus 로고
    • Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis
    • Rice, T.W., Wheeler, A.P., Morris, P.E., Paz, H.L., Russell, J.A., Edens, T.R., Bernard, G.R., Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis. Crit. Care Med. 34:9 (2006), 2271–2281.
    • (2006) Crit. Care Med. , vol.34 , Issue.9 , pp. 2271-2281
    • Rice, T.W.1    Wheeler, A.P.2    Morris, P.E.3    Paz, H.L.4    Russell, J.A.5    Edens, T.R.6    Bernard, G.R.7
  • 74
    • 80053957554 scopus 로고    scopus 로고
    • The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death
    • Qiu, P., Cui, X., Barochia, A., Li, Y., Natanson, C., Eichacker, P.Q., The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death. Expert Opin. Investig. Drugs 20:11 (2011), 1555–1564.
    • (2011) Expert Opin. Investig. Drugs , vol.20 , Issue.11 , pp. 1555-1564
    • Qiu, P.1    Cui, X.2    Barochia, A.3    Li, Y.4    Natanson, C.5    Eichacker, P.Q.6
  • 75
    • 84954310841 scopus 로고    scopus 로고
    • Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial
    • Shakoory, B., Carcillo, J.A., Chatham, W.W., Amdur, R.L., Zhao, H., Dinarello, C.A., Cron, R.Q., Opal, S.M., Interleukin-1 receptor blockade is associated with reduced mortality in sepsis patients with features of macrophage activation syndrome: reanalysis of a prior phase III trial. Crit. Care Med. 44:2 (2016), 275–281.
    • (2016) Crit. Care Med. , vol.44 , Issue.2 , pp. 275-281
    • Shakoory, B.1    Carcillo, J.A.2    Chatham, W.W.3    Amdur, R.L.4    Zhao, H.5    Dinarello, C.A.6    Cron, R.Q.7    Opal, S.M.8
  • 76
    • 84995959525 scopus 로고    scopus 로고
    • Coagulation and sepsis
    • Levi, M., van der Poll, T., Coagulation and sepsis. Thromb. Res. 149 (2017), 38–44.
    • (2017) Thromb. Res. , vol.149 , pp. 38-44
    • Levi, M.1    van der Poll, T.2
  • 77
    • 84963812445 scopus 로고    scopus 로고
    • In sepsis, complement is alive and well
    • Ward, P.A., In sepsis, complement is alive and well. Crit. Care Med. 44:5 (2016), 1026–1027.
    • (2016) Crit. Care Med. , vol.44 , Issue.5 , pp. 1026-1027
    • Ward, P.A.1
  • 78
    • 84941695605 scopus 로고    scopus 로고
    • Activated complement factors as disease markers for sepsis
    • Charchaflieh, J., Rushbrook, J., Worah, S., Zhang, M., Activated complement factors as disease markers for sepsis. Dis. Markers, 2015, 2015, 382463.
    • (2015) Dis. Markers , vol.2015 , pp. 382463
    • Charchaflieh, J.1    Rushbrook, J.2    Worah, S.3    Zhang, M.4
  • 79
    • 84858202338 scopus 로고    scopus 로고
    • Temperature variability analysis using wavelets and multiscale entropy in patients with systemic inflammatory response syndrome, sepsis, and septic shock
    • Papaioannou, V.E., Chouvarda, I.G., Maglaveras, N.K., Pneumatikos, I.A., Temperature variability analysis using wavelets and multiscale entropy in patients with systemic inflammatory response syndrome, sepsis, and septic shock. Crit. Care (London, England), 16(2), 2012.
    • (2012) Crit. Care (London, England) , vol.16 , Issue.2
    • Papaioannou, V.E.1    Chouvarda, I.G.2    Maglaveras, N.K.3    Pneumatikos, I.A.4
  • 80
    • 84877927802 scopus 로고    scopus 로고
    • Sepsis-induced morbidity in mice: effects on body temperature, body weight, cage activity, social behavior and cytokines in brain
    • Granger, J.I., Ratti, P.-L.L., Datta, S.C., Raymond, R.M., Opp, M.R., Sepsis-induced morbidity in mice: effects on body temperature, body weight, cage activity, social behavior and cytokines in brain. Psychoneuroendocrinology 38:7 (2013), 1047–1057.
    • (2013) Psychoneuroendocrinology , vol.38 , Issue.7 , pp. 1047-1057
    • Granger, J.I.1    Ratti, P.-L.L.2    Datta, S.C.3    Raymond, R.M.4    Opp, M.R.5
  • 81
    • 84959294104 scopus 로고    scopus 로고
    • Dysglycemia and glucose control during sepsis
    • Plummer, M.P., Deane, A.M., Dysglycemia and glucose control during sepsis. Clin. Chest Med. 37:2 (2016), 309–319.
    • (2016) Clin. Chest Med. , vol.37 , Issue.2 , pp. 309-319
    • Plummer, M.P.1    Deane, A.M.2
  • 83
    • 85013640719 scopus 로고    scopus 로고
    • Hyperglycemia and glycemic variability are associated with the severity of sepsis in nondiabetic subjects
    • Preechasuk, L., Suwansaksri, N., Ipichart, N., Vannasaeng, S., Permpikul, C., Sriwijitkamol, A., Hyperglycemia and glycemic variability are associated with the severity of sepsis in nondiabetic subjects. J. Crit. Care 38 (2016), 319–323.
    • (2016) J. Crit. Care , vol.38 , pp. 319-323
    • Preechasuk, L.1    Suwansaksri, N.2    Ipichart, N.3    Vannasaeng, S.4    Permpikul, C.5    Sriwijitkamol, A.6
  • 84
    • 84960335738 scopus 로고    scopus 로고
    • Metabolism, metabolomics, and nutritional support of patients with sepsis
    • Englert, J.A., Rogers, A.J., Metabolism, metabolomics, and nutritional support of patients with sepsis. Clin. Chest Med. 37:2 (2016), 321–331.
    • (2016) Clin. Chest Med. , vol.37 , Issue.2 , pp. 321-331
    • Englert, J.A.1    Rogers, A.J.2
  • 85
    • 85009827084 scopus 로고    scopus 로고
    • Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis
    • Alverdy, J.C., Krezalek, M.A., Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis. Crit. Care Med. 45:2 (2017), 337–347.
    • (2017) Crit. Care Med. , vol.45 , Issue.2 , pp. 337-347
    • Alverdy, J.C.1    Krezalek, M.A.2
  • 86
    • 84992089305 scopus 로고    scopus 로고
    • Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis
    • Wei, Y., Yang, J., Wang, J., Yang, Y., Huang, J., Gong, H., Cui, H., Chen, D., Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis. Crit. Care (London, England), 20(1), 2016, 332.
    • (2016) Crit. Care (London, England) , vol.20 , Issue.1 , pp. 332
    • Wei, Y.1    Yang, J.2    Wang, J.3    Yang, Y.4    Huang, J.5    Gong, H.6    Cui, H.7    Chen, D.8
  • 87
    • 84867427226 scopus 로고    scopus 로고
    • Long-lasting effects of sepsis on circadian rhythms in the mouse
    • O'Callaghan, E.K., Anderson, S.T., Moynagh, P.N., Coogan, A.N., Long-lasting effects of sepsis on circadian rhythms in the mouse. PLoS One, 7(10), 2012.
    • (2012) PLoS One , vol.7 , Issue.10
    • O'Callaghan, E.K.1    Anderson, S.T.2    Moynagh, P.N.3    Coogan, A.N.4
  • 88
    • 53049091405 scopus 로고    scopus 로고
    • Animal models of sepsis and its complications
    • Fink, M.P., Animal models of sepsis and its complications. Kidney Int. 74:8 (2008), 991–993.
    • (2008) Kidney Int. , vol.74 , Issue.8 , pp. 991-993
    • Fink, M.P.1
  • 89
    • 27644577000 scopus 로고    scopus 로고
    • Animal models of sepsis: setting the stage, Nature reviews
    • Buras, J.A., Holzmann, B., Sitkovsky, M., Animal models of sepsis: setting the stage, Nature reviews. Drug Discov. 4:10 (2005), 854–865.
    • (2005) Drug Discov. , vol.4 , Issue.10 , pp. 854-865
    • Buras, J.A.1    Holzmann, B.2    Sitkovsky, M.3
  • 91
    • 84875798446 scopus 로고    scopus 로고
    • Endotoxins and other sepsis triggers
    • Opal, S.M., Endotoxins and other sepsis triggers. Contrib. Nephrol. 167 (2010), 14–24.
    • (2010) Contrib. Nephrol. , vol.167 , pp. 14-24
    • Opal, S.M.1
  • 92
    • 79953292076 scopus 로고    scopus 로고
    • Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?
    • Dejager, L., Pinheiro, I., Dejonckheere, E., Libert, C., Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?. Trends Microbiol. 19:4 (2011), 198–208.
    • (2011) Trends Microbiol. , vol.19 , Issue.4 , pp. 198-208
    • Dejager, L.1    Pinheiro, I.2    Dejonckheere, E.3    Libert, C.4
  • 93
    • 0036810356 scopus 로고    scopus 로고
    • Mechanisms involved in the side effects of glucocorticoids
    • Schäcke, H., Döcke, W.-D., Asadullah, K., Mechanisms involved in the side effects of glucocorticoids. Pharmacol. Ther. 96:1 (2002), 23–43.
    • (2002) Pharmacol. Ther. , vol.96 , Issue.1 , pp. 23-43
    • Schäcke, H.1    Döcke, W.-D.2    Asadullah, K.3
  • 94
    • 65849427529 scopus 로고    scopus 로고
    • Glucocorticoid resistance in inflammatory diseases
    • Barnes, P.J., Adcock, I.M., Glucocorticoid resistance in inflammatory diseases. Lancet (London, England) 373:9678 (2009), 1905–1917.
    • (2009) Lancet (London, England) , vol.373 , Issue.9678 , pp. 1905-1917
    • Barnes, P.J.1    Adcock, I.M.2
  • 98
    • 57349189398 scopus 로고    scopus 로고
    • A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression
    • Charmandari, E., Ichijo, T., Jubiz, W., Baid, S., Zachman, K., Chrousos, G.P., Kino, T., A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. J. Clin. Endocrinol. Metab. 93:12 (2008), 4963–4968.
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , Issue.12 , pp. 4963-4968
    • Charmandari, E.1    Ichijo, T.2    Jubiz, W.3    Baid, S.4    Zachman, K.5    Chrousos, G.P.6    Kino, T.7
  • 99
    • 84899991790 scopus 로고    scopus 로고
    • A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities
    • Nicolaides, N.C., Roberts, M.L., Kino, T., Braatvedt, G., Hurt, D.E., Katsantoni, E., Sertedaki, A., Chrousos, G.P., Charmandari, E., A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities. J. Clin. Endocrinol. Metab., 99(5), 2014, 7.
    • (2014) J. Clin. Endocrinol. Metab. , vol.99 , Issue.5 , pp. 7
    • Nicolaides, N.C.1    Roberts, M.L.2    Kino, T.3    Braatvedt, G.4    Hurt, D.E.5    Katsantoni, E.6    Sertedaki, A.7    Chrousos, G.P.8    Charmandari, E.9
  • 100
    • 80054720474 scopus 로고    scopus 로고
    • Primary generalized glucocorticoid resistance and hypersensitivity
    • Charmandari, E., Primary generalized glucocorticoid resistance and hypersensitivity. Horm. Res. Paediatr. 76:3 (2011), 145–155.
    • (2011) Horm. Res. Paediatr. , vol.76 , Issue.3 , pp. 145-155
    • Charmandari, E.1
  • 101
    • 3042754450 scopus 로고    scopus 로고
    • Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms
    • Charmandari, E., Kino, T., Chrousos, G.P., Familial/sporadic glucocorticoid resistance: clinical phenotype and molecular mechanisms. Ann. N. Y. Acad. Sci. 1024:1 (2004), 168–181.
    • (2004) Ann. N. Y. Acad. Sci. , vol.1024 , Issue.1 , pp. 168-181
    • Charmandari, E.1    Kino, T.2    Chrousos, G.P.3
  • 102
    • 84978522059 scopus 로고    scopus 로고
    • GR gene polymorphism is associated with inter-subject variability in response to glucocorticoids in patients with myasthenia gravis
    • Xie, Y., Meng, Y., Li, H.F.F., Hong, Y., Sun, L., Zhu, X., Yue, Y.X.X., Gao, X., Wang, S., Li, Y., Kusner, L.L., Kaminski, H.J., GR gene polymorphism is associated with inter-subject variability in response to glucocorticoids in patients with myasthenia gravis. Eur. J. Neurol. 23:8 (2016), 1372–1379.
    • (2016) Eur. J. Neurol. , vol.23 , Issue.8 , pp. 1372-1379
    • Xie, Y.1    Meng, Y.2    Li, H.F.F.3    Hong, Y.4    Sun, L.5    Zhu, X.6    Yue, Y.X.X.7    Gao, X.8    Wang, S.9    Li, Y.10    Kusner, L.L.11    Kaminski, H.J.12
  • 103
    • 84895814467 scopus 로고    scopus 로고
    • Dominance of the strongest: inflammatory cytokines versus glucocorticoids
    • Dejager, L., Vandevyver, S., Petta, I., Libert, C., Dominance of the strongest: inflammatory cytokines versus glucocorticoids. Cytokine Growth Factor Rev. 25:1 (2014), 21–33.
    • (2014) Cytokine Growth Factor Rev. , vol.25 , Issue.1 , pp. 21-33
    • Dejager, L.1    Vandevyver, S.2    Petta, I.3    Libert, C.4
  • 104
    • 77956401656 scopus 로고    scopus 로고
    • Crosstalk between TNF and glucocorticoid receptor signaling pathways
    • Van Bogaert, T., De Bosscher, K., Libert, C., Crosstalk between TNF and glucocorticoid receptor signaling pathways. Cytokine Growth Factor Rev. 21:4 (2010), 275–286.
    • (2010) Cytokine Growth Factor Rev. , vol.21 , Issue.4 , pp. 275-286
    • Van Bogaert, T.1    De Bosscher, K.2    Libert, C.3
  • 105
    • 14744285888 scopus 로고    scopus 로고
    • Histone acetylation and deacetylation: importance in inflammatory lung diseases
    • Barnes, P.J., Adcock, I.M., Ito, K., Histone acetylation and deacetylation: importance in inflammatory lung diseases. Eur. Respir. J. 25:3 (2005), 552–563.
    • (2005) Eur. Respir. J. , vol.25 , Issue.3 , pp. 552-563
    • Barnes, P.J.1    Adcock, I.M.2    Ito, K.3
  • 106
    • 77952599246 scopus 로고    scopus 로고
    • Overcoming reduced glucocorticoid sensitivity in airway disease
    • Marwick, J.A., Adcock, I.M., Chung, K., Overcoming reduced glucocorticoid sensitivity in airway disease. Drugs 70:8 (2010), 929–948.
    • (2010) Drugs , vol.70 , Issue.8 , pp. 929-948
    • Marwick, J.A.1    Adcock, I.M.2    Chung, K.3
  • 107
    • 13244253907 scopus 로고    scopus 로고
    • Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response
    • Adcock, I.M., Cosio, B., Tsaprouni, L., Barnes, P.J., Ito, K., Redox regulation of histone deacetylases and glucocorticoid-mediated inhibition of the inflammatory response. Antioxid. Redox Signal. 7:1–2 (2005), 144–152.
    • (2005) Antioxid. Redox Signal. , vol.7 , Issue.1-2 , pp. 144-152
    • Adcock, I.M.1    Cosio, B.2    Tsaprouni, L.3    Barnes, P.J.4    Ito, K.5
  • 108
    • 0037173056 scopus 로고    scopus 로고
    • A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression
    • Ito, K., Lim, S., Caramori, G., Cosio, B., Chung, F.K., Adcock, I.M., Barnes, P.J., A molecular mechanism of action of theophylline: induction of histone deacetylase activity to decrease inflammatory gene expression. Proc. Natl. Acad. Sci. 99:13 (2002), 8921–8926.
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , Issue.13 , pp. 8921-8926
    • Ito, K.1    Lim, S.2    Caramori, G.3    Cosio, B.4    Chung, F.K.5    Adcock, I.M.6    Barnes, P.J.7
  • 109
    • 8544232153 scopus 로고    scopus 로고
    • Inhibition of glucocorticoid receptor binding by nitric oxide in endotoxemic rats
    • Duma, D., Silva-Santos, J.E.E., Assreuy, J., Inhibition of glucocorticoid receptor binding by nitric oxide in endotoxemic rats. Crit. Care Med. 32:11 (2004), 2304–2310.
    • (2004) Crit. Care Med. , vol.32 , Issue.11 , pp. 2304-2310
    • Duma, D.1    Silva-Santos, J.E.E.2    Assreuy, J.3
  • 110
    • 79955002992 scopus 로고    scopus 로고
    • Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ
    • Mercado, N., To, Y., Ito, K., Barnes, P.J., Nortriptyline reverses corticosteroid insensitivity by inhibition of phosphoinositide-3-kinase-δ. J. Pharmacol. Exp. Ther. 337:2 (2011), 465–470.
    • (2011) J. Pharmacol. Exp. Ther. , vol.337 , Issue.2 , pp. 465-470
    • Mercado, N.1    To, Y.2    Ito, K.3    Barnes, P.J.4
  • 111
    • 0036231010 scopus 로고    scopus 로고
    • p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma
    • Irusen, E., Matthews, J.G., Takahashi, A., Barnes, P.J., Chung, K.F., Adcock, I.M., p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J. Allergy Clin. Immunol. 109:4 (2002), 649–657.
    • (2002) J. Allergy Clin. Immunol. , vol.109 , Issue.4 , pp. 649-657
    • Irusen, E.1    Matthews, J.G.2    Takahashi, A.3    Barnes, P.J.4    Chung, K.F.5    Adcock, I.M.6
  • 114
    • 41449101856 scopus 로고    scopus 로고
    • Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1
    • Tliba, O., Damera, G., Banerjee, A., Gu, S., Baidouri, H., Keslacy, S., Amrani, Y., Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1. Am. J. Respir. Cell Mol. Biol. 38:4 (2008), 463–472.
    • (2008) Am. J. Respir. Cell Mol. Biol. , vol.38 , Issue.4 , pp. 463-472
    • Tliba, O.1    Damera, G.2    Banerjee, A.3    Gu, S.4    Baidouri, H.5    Keslacy, S.6    Amrani, Y.7
  • 117
    • 0034747215 scopus 로고    scopus 로고
    • Association between IL-1 β/TNF- α–induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle
    • Hakonarson, H., Halapi, E., Whelan, R., Gulcher, J., Stefansson, K., Grunstein, M.M., Association between IL-1 β/TNF- α–induced glucocorticoid-sensitive changes in multiple gene expression and altered responsiveness in airway smooth muscle. Am. J. Respir. Cell Mol. Biol. 25:6 (2001), 761–771.
    • (2001) Am. J. Respir. Cell Mol. Biol. , vol.25 , Issue.6 , pp. 761-771
    • Hakonarson, H.1    Halapi, E.2    Whelan, R.3    Gulcher, J.4    Stefansson, K.5    Grunstein, M.M.6
  • 118
    • 80052153018 scopus 로고    scopus 로고
    • Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists
    • Rider, C.F., King, E.M., Holden, N.S., Giembycz, M.A., Newton, R., Inflammatory stimuli inhibit glucocorticoid-dependent transactivation in human pulmonary epithelial cells: rescue by long-acting beta2-adrenoceptor agonists. J. Pharmacol. Exp. Ther. 338:3 (2011), 860–869.
    • (2011) J. Pharmacol. Exp. Ther. , vol.338 , Issue.3 , pp. 860-869
    • Rider, C.F.1    King, E.M.2    Holden, N.S.3    Giembycz, M.A.4    Newton, R.5
  • 120
    • 79251570253 scopus 로고    scopus 로고
    • IL-1 β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease
    • Pathak, S., Goldofsky, E., Vivas, E.X., Bonagura, V.R., Vambutas, A., IL-1 β is overexpressed and aberrantly regulated in corticosteroid nonresponders with autoimmune inner ear disease. J. Immunol. (Baltimore, Md.: 1950) 186:3 (2011), 1870–1879.
    • (2011) J. Immunol. (Baltimore, Md.: 1950) , vol.186 , Issue.3 , pp. 1870-1879
    • Pathak, S.1    Goldofsky, E.2    Vivas, E.X.3    Bonagura, V.R.4    Vambutas, A.5
  • 122
    • 0028944915 scopus 로고
    • Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma
    • Leung, D.Y., Martin, R.J., Szefler, S.J., Sher, E.R., Ying, S., Kay, A.B., Hamid, Q., Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. J. Exp. Med. 181:1 (1995), 33–40.
    • (1995) J. Exp. Med. , vol.181 , Issue.1 , pp. 33-40
    • Leung, D.Y.1    Martin, R.J.2    Szefler, S.J.3    Sher, E.R.4    Ying, S.5    Kay, A.B.6    Hamid, Q.7
  • 124
    • 38949112833 scopus 로고    scopus 로고
    • Mechanisms of disease: macrophage migration inhibitory factor in SLE, RA and atherosclerosis, Nature clinical practice
    • Ayoub, S., Hickey, M.J., Morand, E.F., Mechanisms of disease: macrophage migration inhibitory factor in SLE, RA and atherosclerosis, Nature clinical practice. Rheumatology 4:2 (2008), 98–105.
    • (2008) Rheumatology , vol.4 , Issue.2 , pp. 98-105
    • Ayoub, S.1    Hickey, M.J.2    Morand, E.F.3
  • 128
    • 84907009758 scopus 로고    scopus 로고
    • Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease
    • Vambutas, A., Lesser, M., Mullooly, V., Pathak, S., Zahtz, G., Rosen, L., Goldofsky, E., Early efficacy trial of anakinra in corticosteroid-resistant autoimmune inner ear disease. J. Clin. Invest. 124:9 (2014), 4115–4122.
    • (2014) J. Clin. Invest. , vol.124 , Issue.9 , pp. 4115-4122
    • Vambutas, A.1    Lesser, M.2    Mullooly, V.3    Pathak, S.4    Zahtz, G.5    Rosen, L.6    Goldofsky, E.7
  • 129
    • 77957331607 scopus 로고    scopus 로고
    • Heterogeneity of glucocorticoid resistance in patients with bronchial asthma
    • Matsumura, Y., Heterogeneity of glucocorticoid resistance in patients with bronchial asthma. Int. J. Biomed. Sci.: IJBS 6:3 (2010), 158–166.
    • (2010) Int. J. Biomed. Sci.: IJBS , vol.6 , Issue.3 , pp. 158-166
    • Matsumura, Y.1
  • 131
    • 0041669330 scopus 로고    scopus 로고
    • MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?
    • Clark, A.R., MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?. J. Endocrinol. 178:1 (2003), 5–12.
    • (2003) J. Endocrinol. , vol.178 , Issue.1 , pp. 5-12
    • Clark, A.R.1
  • 132
    • 51249109929 scopus 로고    scopus 로고
    • Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma
    • Bhavsar, P., Hew, M., Khorasani, N., Torrego, A., Barnes, P.J., Adcock, I., Chung, K.F., Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. Thorax 63:9 (2008), 784–790.
    • (2008) Thorax , vol.63 , Issue.9 , pp. 784-790
    • Bhavsar, P.1    Hew, M.2    Khorasani, N.3    Torrego, A.4    Barnes, P.J.5    Adcock, I.6    Chung, K.F.7
  • 133
    • 1542301591 scopus 로고    scopus 로고
    • Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase
    • Barnes, P.J., Ito, K., Adcock, I.M., Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet (London, England) 363:9410 (2004), 731–733.
    • (2004) Lancet (London, England) , vol.363 , Issue.9410 , pp. 731-733
    • Barnes, P.J.1    Ito, K.2    Adcock, I.M.3
  • 134
    • 84883559178 scopus 로고    scopus 로고
    • The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia
    • Gruhn, B., Naumann, T., Gruner, D., Walther, M., Wittig, S., Becker, S., Beck, J.F., Sonnemann, J., The expression of histone deacetylase 4 is associated with prednisone poor-response in childhood acute lymphoblastic leukemia. Leuk. Res. 37:10 (2013), 1200–1207.
    • (2013) Leuk. Res. , vol.37 , Issue.10 , pp. 1200-1207
    • Gruhn, B.1    Naumann, T.2    Gruner, D.3    Walther, M.4    Wittig, S.5    Becker, S.6    Beck, J.F.7    Sonnemann, J.8
  • 137
    • 54449099014 scopus 로고    scopus 로고
    • Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex
    • Matysiak, M., Makosa, B., Walczak, A., Selmaj, K., Patients with multiple sclerosis resisted to glucocorticoid therapy: abnormal expression of heat-shock protein 90 in glucocorticoid receptor complex. Mult. Scler. (Houndmills, Basingstoke, England) 14:7 (2008), 919–926.
    • (2008) Mult. Scler. (Houndmills, Basingstoke, England) , vol.14 , Issue.7 , pp. 919-926
    • Matysiak, M.1    Makosa, B.2    Walczak, A.3    Selmaj, K.4
  • 139
    • 39549115677 scopus 로고    scopus 로고
    • Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis
    • Tsujimura, S., Saito, K., Nawata, M., Nakayamada, S., Tanaka, Y., Overcoming drug resistance induced by P-glycoprotein on lymphocytes in patients with refractory rheumatoid arthritis. Ann. Rheum. Dis. 67:3 (2008), 380–388.
    • (2008) Ann. Rheum. Dis. , vol.67 , Issue.3 , pp. 380-388
    • Tsujimura, S.1    Saito, K.2    Nawata, M.3    Nakayamada, S.4    Tanaka, Y.5
  • 140
    • 0024553710 scopus 로고
    • Regulation of glucocorticoid receptor protein and mRNA levels
    • Vedeckis, W.V., Ali, M., Allen, H.R., Regulation of glucocorticoid receptor protein and mRNA levels. Cancer Res., 49(8 Suppl), 1989.
    • (1989) Cancer Res. , vol.49 , Issue.8
    • Vedeckis, W.V.1    Ali, M.2    Allen, H.R.3
  • 141
    • 0024388773 scopus 로고
    • Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription
    • Drouin, J., Trifiro, M.A., Plante, R.K., Nemer, M., Eriksson, P., Wrange, O., Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Mol. Cell. Biol. 9:12 (1989), 5305–5314.
    • (1989) Mol. Cell. Biol. , vol.9 , Issue.12 , pp. 5305-5314
    • Drouin, J.1    Trifiro, M.A.2    Plante, R.K.3    Nemer, M.4    Eriksson, P.5    Wrange, O.6
  • 143
    • 0023058975 scopus 로고
    • A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation
    • Shaw, G., Kamen, R., A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:5 (1986), 659–667.
    • (1986) Cell , vol.46 , Issue.5 , pp. 659-667
    • Shaw, G.1    Kamen, R.2
  • 144
    • 0021946175 scopus 로고
    • Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form
    • McIntyre, W.R., Samuels, H.H., Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form. J. Biol. Chem. 260:1 (1985), 418–427.
    • (1985) J. Biol. Chem. , vol.260 , Issue.1 , pp. 418-427
    • McIntyre, W.R.1    Samuels, H.H.2
  • 145
    • 84988597054 scopus 로고    scopus 로고
    • A tri-nucleotide pattern in a 3' UTR segment affects the activity of a human glucocorticoid receptor isoform
    • Green, T.L., Leventhal, S.M., Lim, D., Cho, K., Greenhalgh, D.G., A tri-nucleotide pattern in a 3' UTR segment affects the activity of a human glucocorticoid receptor isoform. Shock (Augusta, Ga.) 47:2 (2017), 148–157.
    • (2017) Shock (Augusta, Ga.) , vol.47 , Issue.2 , pp. 148-157
    • Green, T.L.1    Leventhal, S.M.2    Lim, D.3    Cho, K.4    Greenhalgh, D.G.5
  • 146
    • 0035900780 scopus 로고    scopus 로고
    • Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids
    • Wallace, A.D., Cidlowski, J.A., Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids. J. Biol. Chem. 276:46 (2001), 42714–42721.
    • (2001) J. Biol. Chem. , vol.276 , Issue.46 , pp. 42714-42721
    • Wallace, A.D.1    Cidlowski, J.A.2
  • 147
    • 84866563441 scopus 로고    scopus 로고
    • Corticosteroid resistance in sepsis is influenced by microRNA-124–induced downregulation of glucocorticoid receptor-α
    • Ledderose, C., Möhnle, P., Limbeck, E., Schütz, S., Weis, F., Rink, J., Briegel, J., Kreth, S., Corticosteroid resistance in sepsis is influenced by microRNA-124–induced downregulation of glucocorticoid receptor-α. Crit. Care Med. 40:10 (2012), 2745–2753.
    • (2012) Crit. Care Med. , vol.40 , Issue.10 , pp. 2745-2753
    • Ledderose, C.1    Möhnle, P.2    Limbeck, E.3    Schütz, S.4    Weis, F.5    Rink, J.6    Briegel, J.7    Kreth, S.8
  • 148
    • 0030702823 scopus 로고    scopus 로고
    • Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta
    • Leung, D.Y., Hamid, Q., Vottero, A., Szefler, S.J., Surs, W., Minshall, E., Chrousos, G.P., Klemm, D.J., Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor beta. J. Exp. Med. 186:9 (1997), 1567–1574.
    • (1997) J. Exp. Med. , vol.186 , Issue.9 , pp. 1567-1574
    • Leung, D.Y.1    Hamid, Q.2    Vottero, A.3    Szefler, S.J.4    Surs, W.5    Minshall, E.6    Chrousos, G.P.7    Klemm, D.J.8
  • 150
    • 0004815929 scopus 로고    scopus 로고
    • Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform
    • Sousa, A.R., Lane, S.J., Cidlowski, J.A., Staynov, D.Z., Lee, T.H., Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform. J. Allergy Clin. Immunol. 105:5 (2000), 943–950.
    • (2000) J. Allergy Clin. Immunol. , vol.105 , Issue.5 , pp. 943-950
    • Sousa, A.R.1    Lane, S.J.2    Cidlowski, J.A.3    Staynov, D.Z.4    Lee, T.H.5
  • 152
    • 33644834415 scopus 로고    scopus 로고
    • Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma
    • Goleva, E., Li, L.-B.B., Eves, P.T., Strand, M.J., Martin, R.J., Leung, D.Y., Increased glucocorticoid receptor beta alters steroid response in glucocorticoid-insensitive asthma. Am. J. Respir. Crit. Care Med. 173:6 (2006), 607–616.
    • (2006) Am. J. Respir. Crit. Care Med. , vol.173 , Issue.6 , pp. 607-616
    • Goleva, E.1    Li, L.-B.B.2    Eves, P.T.3    Strand, M.J.4    Martin, R.J.5    Leung, D.Y.6
  • 153
  • 154
    • 0034058875 scopus 로고    scopus 로고
    • Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis
    • Honda, M., Orii, F., Ayabe, T., Imai, S., Ashida, T., Obara, T., Kohgo, Y., Expression of glucocorticoid receptor beta in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology 118:5 (2000), 859–866.
    • (2000) Gastroenterology , vol.118 , Issue.5 , pp. 859-866
    • Honda, M.1    Orii, F.2    Ayabe, T.3    Imai, S.4    Ashida, T.5    Obara, T.6    Kohgo, Y.7
  • 155
    • 70349759349 scopus 로고    scopus 로고
    • The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients
    • Fujishima, S.-i., Takeda, H., Kawata, S., Yamakawa, M., The relationship between the expression of the glucocorticoid receptor in biopsied colonic mucosa and the glucocorticoid responsiveness of ulcerative colitis patients. Clin. Immunol. (Orlando, Fla.) 133:2 (2009), 208–217.
    • (2009) Clin. Immunol. (Orlando, Fla.) , vol.133 , Issue.2 , pp. 208-217
    • Fujishima, S.-I.1    Takeda, H.2    Kawata, S.3    Yamakawa, M.4
  • 156
    • 0034767551 scopus 로고    scopus 로고
    • A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis
    • Derijk, R.H., Schaaf, M.J., Turner, G., Datson, N.A., Vreugdenhil, E., Cidlowski, J., de Kloet, E.R., Emery, P., Sternberg, E.M., Detera-Wadleigh, S.D., A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. J. Rheumatol. 28:11 (2001), 2383–2388.
    • (2001) J. Rheumatol. , vol.28 , Issue.11 , pp. 2383-2388
    • Derijk, R.H.1    Schaaf, M.J.2    Turner, G.3    Datson, N.A.4    Vreugdenhil, E.5    Cidlowski, J.6    de Kloet, E.R.7    Emery, P.8    Sternberg, E.M.9    Detera-Wadleigh, S.D.10
  • 158
    • 84994472495 scopus 로고    scopus 로고
    • Cytokine-induced glucocorticoid resistance from eosinophil activation: protein phosphatase 5 modulation of glucocorticoid receptor phosphorylation and signaling
    • Pazdrak, K., Straub, C., Maroto, R., Stafford, S., White, W.I., Calhoun, W.J., Kurosky, A., Cytokine-induced glucocorticoid resistance from eosinophil activation: protein phosphatase 5 modulation of glucocorticoid receptor phosphorylation and signaling. J. Immunol. (Baltimore, Md.: 1950) 197:10 (2016), 3782–3791.
    • (2016) J. Immunol. (Baltimore, Md.: 1950) , vol.197 , Issue.10 , pp. 3782-3791
    • Pazdrak, K.1    Straub, C.2    Maroto, R.3    Stafford, S.4    White, W.I.5    Calhoun, W.J.6    Kurosky, A.7
  • 159
    • 33746674992 scopus 로고    scopus 로고
    • Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients
    • Loke, T.-K., Mallett, K.H., Ratoff, J., O'Connor, B.J., Ying, S., Meng, Q., Soh, C., Lee, T.H., Corrigan, C.J., Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients. J. Allergy Clin. Immunol. 118:2 (2006), 368–375.
    • (2006) J. Allergy Clin. Immunol. , vol.118 , Issue.2 , pp. 368-375
    • Loke, T.-K.1    Mallett, K.H.2    Ratoff, J.3    O'Connor, B.J.4    Ying, S.5    Meng, Q.6    Soh, C.7    Lee, T.H.8    Corrigan, C.J.9
  • 160
    • 41649097975 scopus 로고    scopus 로고
    • Is there a future for small molecule drugs in the treatment of rheumatic diseases?
    • Stanczyk, J., Ospelt, C., Gay, S., Is there a future for small molecule drugs in the treatment of rheumatic diseases?. Curr. Opin. Rheumatol. 20:3 (2008), 257–262.
    • (2008) Curr. Opin. Rheumatol. , vol.20 , Issue.3 , pp. 257-262
    • Stanczyk, J.1    Ospelt, C.2    Gay, S.3
  • 161
    • 0025880739 scopus 로고
    • The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice
    • Libert, C., Van Bladel, S., Brouckaert, P., Fiers, W., The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice. J. Immunother. 10:4 (1991), 227–235.
    • (1991) J. Immunother. , vol.10 , Issue.4 , pp. 227-235
    • Libert, C.1    Van Bladel, S.2    Brouckaert, P.3    Fiers, W.4
  • 162
    • 0007547876 scopus 로고
    • Effects of cortisone and antibiotics on lethal action of endotoxins in mice, Proceedings of the Society for Experimental Biology and Medicine
    • Geller, P., Merrill, E.R., Jawetz, E., Effects of cortisone and antibiotics on lethal action of endotoxins in mice, Proceedings of the Society for Experimental Biology and Medicine. Soc. Exp. Biol. Med. (New York, N.Y.) 86:4 (1954), 716–719.
    • (1954) Soc. Exp. Biol. Med. (New York, N.Y.) , vol.86 , Issue.4 , pp. 716-719
    • Geller, P.1    Merrill, E.R.2    Jawetz, E.3
  • 163
    • 15344351568 scopus 로고
    • The role of adrenocortical steroids in infection, immunity and hypersensitivity
    • Germuth, F.G., The role of adrenocortical steroids in infection, immunity and hypersensitivity. Pharmacol. Rev. 8:1 (1956), 1–24.
    • (1956) Pharmacol. Rev. , vol.8 , Issue.1 , pp. 1-24
    • Germuth, F.G.1
  • 165
    • 0023922510 scopus 로고
    • Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor
    • Bertini, R., Bianchi, M., Ghezzi, P., Adrenalectomy sensitizes mice to the lethal effects of interleukin 1 and tumor necrosis factor. J. Exp. Med. 167:5 (1988), 1708–1712.
    • (1988) J. Exp. Med. , vol.167 , Issue.5 , pp. 1708-1712
    • Bertini, R.1    Bianchi, M.2    Ghezzi, P.3
  • 166
    • 0026605079 scopus 로고
    • The glucocorticoid antagonist RU38486 mimics interleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor necrosis factor
    • Brouckaert, P., Everaerdt, B., Fiers, W., The glucocorticoid antagonist RU38486 mimics interleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor necrosis factor. Eur. J. Immunol. 22:4 (1992), 981–986.
    • (1992) Eur. J. Immunol. , vol.22 , Issue.4 , pp. 981-986
    • Brouckaert, P.1    Everaerdt, B.2    Fiers, W.3
  • 167
    • 0026607654 scopus 로고
    • Modification of septic shock in mice by the antiglucocorticoid RU 38486
    • Lazar, G., Lazar, G., Agarwal, M.K., Modification of septic shock in mice by the antiglucocorticoid RU 38486. Circ. Shock 36:3 (1992), 180–184.
    • (1992) Circ. Shock , vol.36 , Issue.3 , pp. 180-184
    • Lazar, G.1    Lazar, G.2    Agarwal, M.K.3
  • 169
  • 171
    • 84961244976 scopus 로고    scopus 로고
    • Comparison of prednisolone, etoricoxib, and indomethacin in treatment of acute gouty arthritis: an open-label randomized, controlled trial
    • Xu, L., Liu, S., Guan, M., Xue, Y., Comparison of prednisolone, etoricoxib, and indomethacin in treatment of acute gouty arthritis: an open-label randomized, controlled trial. Med. Sci. Monit. 22 (2016), 810–817.
    • (2016) Med. Sci. Monit. , vol.22 , pp. 810-817
    • Xu, L.1    Liu, S.2    Guan, M.3    Xue, Y.4
  • 172
    • 3342979528 scopus 로고    scopus 로고
    • Glucocorticoid regulation of the inflammatory response to injury
    • Yeager, M.P., Guyre, P.M., Munck, A.U., Glucocorticoid regulation of the inflammatory response to injury. Acta Anaesthesiol. Scand. 48:7 (2004), 799–813.
    • (2004) Acta Anaesthesiol. Scand. , vol.48 , Issue.7 , pp. 799-813
    • Yeager, M.P.1    Guyre, P.M.2    Munck, A.U.3
  • 173
    • 33748424402 scopus 로고    scopus 로고
    • Effects of dexamethasone and L-canavanine on the intracellular calcium-contraction relation of the rat tail artery during septic shock, American journal of physiology
    • Mansart, A., Bollaert, P.-E.E., Giummelly, P., Capdeville-Atkinson, C., Atkinson, J., Effects of dexamethasone and L-canavanine on the intracellular calcium-contraction relation of the rat tail artery during septic shock, American journal of physiology. Heart Circ. Physiol., 291(3), 2006, 82.
    • (2006) Heart Circ. Physiol. , vol.291 , Issue.3 , pp. 82
    • Mansart, A.1    Bollaert, P.-E.E.2    Giummelly, P.3    Capdeville-Atkinson, C.4    Atkinson, J.5
  • 174
    • 84943311782 scopus 로고    scopus 로고
    • Glucocorticoids offer protection against myocardial injury in a murine model of sepsis
    • Lu, Z.-Q.Q., Lu, J.-X.X., Deng, Y.-J.J., Glucocorticoids offer protection against myocardial injury in a murine model of sepsis. Int. J. Clin. Exp. Med. 8:8 (2015), 12211–12218.
    • (2015) Int. J. Clin. Exp. Med. , vol.8 , Issue.8 , pp. 12211-12218
    • Lu, Z.-Q.Q.1    Lu, J.-X.X.2    Deng, Y.-J.J.3
  • 176
    • 67651113860 scopus 로고    scopus 로고
    • Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology
    • Dhabhar, F.S., Enhancing versus suppressive effects of stress on immune function: implications for immunoprotection and immunopathology. Neuroimmunomodulation 16:5 (2009), 300–317.
    • (2009) Neuroimmunomodulation , vol.16 , Issue.5 , pp. 300-317
    • Dhabhar, F.S.1
  • 178
    • 8444223102 scopus 로고    scopus 로고
    • Use of corticosteroid therapy in patients with sepsis and septic shock: an evidence-based review
    • Keh, D., Sprung, C.L., Use of corticosteroid therapy in patients with sepsis and septic shock: an evidence-based review. Crit. Care Med., 32(11 Suppl), 2004, 33.
    • (2004) Crit. Care Med. , vol.32 , Issue.11 , pp. 33
    • Keh, D.1    Sprung, C.L.2
  • 179
    • 3042858950 scopus 로고    scopus 로고
    • Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose
    • Minneci, P.C., Deans, K.J., Banks, S.M., Eichacker, P.Q., Natanson, C., Meta-analysis: the effect of steroids on survival and shock during sepsis depends on the dose. Ann. Intern. Med. 141:1 (2004), 47–56.
    • (2004) Ann. Intern. Med. , vol.141 , Issue.1 , pp. 47-56
    • Minneci, P.C.1    Deans, K.J.2    Banks, S.M.3    Eichacker, P.Q.4    Natanson, C.5
  • 181
    • 0033398206 scopus 로고    scopus 로고
    • New rationale for glucocorticoid treatment in septic shock
    • Meduri, G.U., New rationale for glucocorticoid treatment in septic shock. J. Chemother. (Florence, Italy 11:6 (1999), 541–550.
    • (1999) J. Chemother. (Florence, Italy , vol.11 , Issue.6 , pp. 541-550
    • Meduri, G.U.1
  • 182
    • 0347054095 scopus 로고    scopus 로고
    • Corticosteroids in sepsis: from bench to bedside?
    • Annane, D., Cavaillon, J.-M.M., Corticosteroids in sepsis: from bench to bedside?. Shock (Augusta, Ga) 20:3 (2003), 197–207.
    • (2003) Shock (Augusta, Ga) , vol.20 , Issue.3 , pp. 197-207
    • Annane, D.1    Cavaillon, J.-M.M.2
  • 183
    • 84979502267 scopus 로고    scopus 로고
    • Corticosteroids in severe sepsis and septic shock: a concise review
    • Salluh, J.I., Póvoa, P., Corticosteroids in severe sepsis and septic shock: a concise review. Shock (Augusta, Ga.) 1 (2017), 47–51.
    • (2017) Shock (Augusta, Ga.) , vol.1 , pp. 47-51
    • Salluh, J.I.1    Póvoa, P.2
  • 185
    • 34547174678 scopus 로고    scopus 로고
    • TNF-alpha and glucocorticoid receptor interaction in L6 muscle cells: a cooperative downregulation of myosin heavy chain
    • Dekelbab, B.H., Witchel, S.F., DeFranco, D.B., TNF-alpha and glucocorticoid receptor interaction in L6 muscle cells: a cooperative downregulation of myosin heavy chain. Steroids 72:9–10 (2007), 705–712.
    • (2007) Steroids , vol.72 , Issue.9-10 , pp. 705-712
    • Dekelbab, B.H.1    Witchel, S.F.2    DeFranco, D.B.3
  • 186
    • 84878818465 scopus 로고    scopus 로고
    • Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay
    • Guerrero, J., Gatica, H.A.A., Rodríguez, M., Estay, R., Goecke, I.A., Septic serum induces glucocorticoid resistance and modifies the expression of glucocorticoid isoforms receptors: a prospective cohort study and in vitro experimental assay. Crit. Care (London, England), 17(3), 2013.
    • (2013) Crit. Care (London, England) , vol.17 , Issue.3
    • Guerrero, J.1    Gatica, H.A.A.2    Rodríguez, M.3    Estay, R.4    Goecke, I.A.5
  • 188
    • 84954110681 scopus 로고    scopus 로고
    • Lactic acidosis in sepsis: it's not all anaerobic implications for diagnosis and management
    • Suetrong, B., Walley, K.R., Lactic acidosis in sepsis: it's not all anaerobic implications for diagnosis and management. Chest 149:1 (2016), 252–261.
    • (2016) Chest , vol.149 , Issue.1 , pp. 252-261
    • Suetrong, B.1    Walley, K.R.2
  • 190
    • 0026527574 scopus 로고
    • Lactic acidosis in critical illness
    • Mizock, B.A., Falk, J.L., Lactic acidosis in critical illness. Crit. Care Med. 20:1 (1992), 80–93.
    • (1992) Crit. Care Med. , vol.20 , Issue.1 , pp. 80-93
    • Mizock, B.A.1    Falk, J.L.2
  • 191
    • 79959412738 scopus 로고    scopus 로고
    • Oxidative stress and mitochondrial dysfunction in sepsis
    • Galley, H.F., Oxidative stress and mitochondrial dysfunction in sepsis. Br. J. Anaesth. 107:1 (2011), 57–64.
    • (2011) Br. J. Anaesth. , vol.107 , Issue.1 , pp. 57-64
    • Galley, H.F.1
  • 194
    • 0032699670 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting
    • Kersten, S., Seydoux, J., Peters, J.M., Gonzalez, F.J., Desvergne, B., Wahli, W., Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J. Clin. Invest. 103:11 (1999), 1489–1498.
    • (1999) J. Clin. Invest. , vol.103 , Issue.11 , pp. 1489-1498
    • Kersten, S.1    Seydoux, J.2    Peters, J.M.3    Gonzalez, F.J.4    Desvergne, B.5    Wahli, W.6
  • 195
    • 0033594980 scopus 로고    scopus 로고
    • A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders
    • Leone, T.C., Weinheimer, C.J., Kelly, D.P., A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. Proc. Natl. Acad. Sci. U. S. A. 96:13 (1999), 7473–7478.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , Issue.13 , pp. 7473-7478
    • Leone, T.C.1    Weinheimer, C.J.2    Kelly, D.P.3
  • 197
    • 70449134237 scopus 로고    scopus 로고
    • Potential dysregulation of the pyruvate dehydrogenase complex by bacterial toxins and insulin
    • Thomas, G.W., Mains, C.W., Slone, D.S., Craun, M.L., Bar-Or, D., Potential dysregulation of the pyruvate dehydrogenase complex by bacterial toxins and insulin. J. Trauma 67:3 (2009), 628–633.
    • (2009) J. Trauma , vol.67 , Issue.3 , pp. 628-633
    • Thomas, G.W.1    Mains, C.W.2    Slone, D.S.3    Craun, M.L.4    Bar-Or, D.5
  • 198
    • 4143097091 scopus 로고    scopus 로고
    • The biochemistry of the pyruvate dehydrogenase complex
    • Patel, M.S., Korotchkina, L.G., The biochemistry of the pyruvate dehydrogenase complex. Biochem. Mol. Biol. Educ. 31:1 (2003), 5–15.
    • (2003) Biochem. Mol. Biol. Educ. , vol.31 , Issue.1 , pp. 5-15
    • Patel, M.S.1    Korotchkina, L.G.2
  • 199
    • 84902530496 scopus 로고    scopus 로고
    • The pyruvate dehydrogenase complexes: structure-based function and regulation
    • Patel, M.S., Nemeria, N.S., Furey, W., Jordan, F., The pyruvate dehydrogenase complexes: structure-based function and regulation. J. Biol. Chem. 289:24 (2014), 16615–16623.
    • (2014) J. Biol. Chem. , vol.289 , Issue.24 , pp. 16615-16623
    • Patel, M.S.1    Nemeria, N.S.2    Furey, W.3    Jordan, F.4
  • 203
    • 70049118476 scopus 로고    scopus 로고
    • A metabonomic approach to early prognostic evaluation of experimental sepsis by 1H NMR and pattern recognition
    • Lin, Z.y., Xu, P.b., Yan, S.k., Meng, H.b., Yang, G.j., Dai, W.x., Liu, X.r., Li, J.b., Deng, X.m., Zhang, W.d., A metabonomic approach to early prognostic evaluation of experimental sepsis by 1H NMR and pattern recognition. NMR Biomed. 22:6 (2009), 601–608.
    • (2009) NMR Biomed. , vol.22 , Issue.6 , pp. 601-608
    • Lin, Z.Y.1    Xu, P.B.2    Yan, S.K.3    Meng, H.B.4    Yang, G.J.5    Dai, W.X.6    Liu, X.R.7    Li, J.B.8    Deng, X.M.9    Zhang, W.D.10
  • 204
    • 84986278057 scopus 로고    scopus 로고
    • Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors
    • Liu, Z., Yin, P., Amathieu, R., Savarin, P., Xu, G., Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors. Anal. Bioanal. Chem. 408:27 (2016), 7641–7649.
    • (2016) Anal. Bioanal. Chem. , vol.408 , Issue.27 , pp. 7641-7649
    • Liu, Z.1    Yin, P.2    Amathieu, R.3    Savarin, P.4    Xu, G.5
  • 205
    • 0030203145 scopus 로고    scopus 로고
    • Sepsis-induced alterations in pyruvate dehydrogenase complex activity in rat skeletal muscle: effects on plasma lactate
    • Vary, T.C., Sepsis-induced alterations in pyruvate dehydrogenase complex activity in rat skeletal muscle: effects on plasma lactate. Shock (Augusta, Ga.) 6:2 (1996), 89–94.
    • (1996) Shock (Augusta, Ga.) , vol.6 , Issue.2 , pp. 89-94
    • Vary, T.C.1
  • 206
    • 40949133248 scopus 로고    scopus 로고
    • Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats
    • Alamdari, N., Constantin-Teodosiu, D., Murton, A.J., Gardiner, S.M., Bennett, T., Layfield, R., Greenhaff, P.L., Temporal changes in the involvement of pyruvate dehydrogenase complex in muscle lactate accumulation during lipopolysaccharide infusion in rats. J. Physiol. 586:6 (2008), 1767–1775.
    • (2008) J. Physiol. , vol.586 , Issue.6 , pp. 1767-1775
    • Alamdari, N.1    Constantin-Teodosiu, D.2    Murton, A.J.3    Gardiner, S.M.4    Bennett, T.5    Layfield, R.6    Greenhaff, P.L.7
  • 208
    • 73149116031 scopus 로고    scopus 로고
    • In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice
    • Chichelnitskiy, E., Vegiopoulos, A., Berriel Diaz, M., Ziegler, A., Kleiman, A., Rauch, A., Tuckermann, J., Herzig, S., In vivo phosphoenolpyruvate carboxykinase promoter mapping identifies disrupted hormonal synergism as a target of inflammation during sepsis in mice. Hepatology (Baltimore, Md.) 50:6 (2009), 1963–1971.
    • (2009) Hepatology (Baltimore, Md.) , vol.50 , Issue.6 , pp. 1963-1971
    • Chichelnitskiy, E.1    Vegiopoulos, A.2    Berriel Diaz, M.3    Ziegler, A.4    Kleiman, A.5    Rauch, A.6    Tuckermann, J.7    Herzig, S.8
  • 209
    • 0035955654 scopus 로고    scopus 로고
    • Accessory factors facilitate the binding of glucocorticoid receptor to the phosphoenolpyruvate carboxykinase gene promoter
    • Stafford, J.M., Wilkinson, J.C., Beechem, J.M., Accessory factors facilitate the binding of glucocorticoid receptor to the phosphoenolpyruvate carboxykinase gene promoter. J. Biol. Chem. 43 (2001), 39885–39891.
    • (2001) J. Biol. Chem. , vol.43 , pp. 39885-39891
    • Stafford, J.M.1    Wilkinson, J.C.2    Beechem, J.M.3
  • 210
    • 84863373226 scopus 로고    scopus 로고
    • Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism
    • Nader, N., Ng, S.S., Wang, Y., Abel, B.S., Chrousos, G.P., Kino, T., Liver x receptors regulate the transcriptional activity of the glucocorticoid receptor: implications for the carbohydrate metabolism. PLoS One, 7(3), 2012.
    • (2012) PLoS One , vol.7 , Issue.3
    • Nader, N.1    Ng, S.S.2    Wang, Y.3    Abel, B.S.4    Chrousos, G.P.5    Kino, T.6
  • 214
    • 0039849217 scopus 로고    scopus 로고
    • Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats
    • Kim, P.K., Chen, J., Andrejko, K.M., Deutschman, C.S., Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats. Shock (Augusta, Ga.) 14:2 (2000), 176–181.
    • (2000) Shock (Augusta, Ga.) , vol.14 , Issue.2 , pp. 176-181
    • Kim, P.K.1    Chen, J.2    Andrejko, K.M.3    Deutschman, C.S.4
  • 215
    • 33745370013 scopus 로고    scopus 로고
    • Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis
    • Moseley, R.H., Wang, W., Takeda, H., Lown, K., Shick, L., Ananthanarayanan, M., Suchy, F.J., Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis. Am. J. Physiol., 271(1 Pt 1), 1996, 46.
    • (1996) Am. J. Physiol. , vol.271 , Issue.1 , pp. 46
    • Moseley, R.H.1    Wang, W.2    Takeda, H.3    Lown, K.4    Shick, L.5    Ananthanarayanan, M.6    Suchy, F.J.7


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