-
1
-
-
34249290789
-
Sepsis in the 21st century: recent definitions and therapeutic advances
-
Nguyen H.B., Smith D. Sepsis in the 21st century: recent definitions and therapeutic advances. Am. J. Emerg. Med. 2007, 25:564-571.
-
(2007)
Am. J. Emerg. Med.
, vol.25
, pp. 564-571
-
-
Nguyen, H.B.1
Smith, D.2
-
3
-
-
77955551852
-
Molecular diagnostics of sepsis - where are we today?
-
Bauer M., Reinhart K. Molecular diagnostics of sepsis - where are we today?. Int. J. Med. Microbiol. 2010, 300:411-413.
-
(2010)
Int. J. Med. Microbiol.
, vol.300
, pp. 411-413
-
-
Bauer, M.1
Reinhart, K.2
-
4
-
-
67650486328
-
Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis
-
Osuchowski M.F., et al. Stratification is the key: inflammatory biomarkers accurately direct immunomodulatory therapy in experimental sepsis. Crit. Care Med. 2009, 37:1567-1573.
-
(2009)
Crit. Care Med.
, vol.37
, pp. 1567-1573
-
-
Osuchowski, M.F.1
-
5
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
-
Angus D.C., et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit.Care Med. 2001, 29:1303-1310.
-
(2001)
Crit.Care Med.
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
-
6
-
-
35348858067
-
Drotrecogin alfa (activated) in the treatment of severe sepsis
-
Vincent J.L. Drotrecogin alfa (activated) in the treatment of severe sepsis. Curr. Drug Saf. 2007, 2:227-231.
-
(2007)
Curr. Drug Saf.
, vol.2
, pp. 227-231
-
-
Vincent, J.L.1
-
7
-
-
0018964280
-
Sepsis and septic shock - a review of laboratory models and a proposal
-
Wichterman K.A., et al. Sepsis and septic shock - a review of laboratory models and a proposal. J. Surg. Res. 1980, 29:189-201.
-
(1980)
J. Surg. Res.
, vol.29
, pp. 189-201
-
-
Wichterman, K.A.1
-
8
-
-
33646759609
-
Cecal ligation and puncture
-
Hubbard W.J., et al. Cecal ligation and puncture. Shock (Augusta, Ga) 2005, 24(Suppl. 1):52-57.
-
(2005)
Shock (Augusta, Ga)
, vol.24
, Issue.SUPPL. 1
, pp. 52-57
-
-
Hubbard, W.J.1
-
9
-
-
16644385124
-
Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis
-
Maier S., et al. Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock (Augusta, Ga) 2004, 21:505-511.
-
(2004)
Shock (Augusta, Ga)
, vol.21
, pp. 505-511
-
-
Maier, S.1
-
10
-
-
0034132796
-
Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture
-
Remick D.G., et al. Comparison of the mortality and inflammatory response of two models of sepsis: lipopolysaccharide vs. cecal ligation and puncture. Shock (Augusta, Ga) 2000, 13:110-116.
-
(2000)
Shock (Augusta, Ga)
, vol.13
, pp. 110-116
-
-
Remick, D.G.1
-
11
-
-
33749528005
-
Type I IFN modulates host defense and late hyperinflammation in septic peritonitis
-
Weighardt H., et al. Type I IFN modulates host defense and late hyperinflammation in septic peritonitis. J. Immunol. 2006, 177:5623-5630.
-
(2006)
J. Immunol.
, vol.177
, pp. 5623-5630
-
-
Weighardt, H.1
-
12
-
-
77149144182
-
Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10
-
Kelly-Scumpia K.M., et al. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J. Exp. Med. 2010, 207:319-326.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 319-326
-
-
Kelly-Scumpia, K.M.1
-
13
-
-
0033485754
-
Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4
-
Matsukawa A., et al. Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. J. Immunol. 1999, 163:6148-6154.
-
(1999)
J. Immunol.
, vol.163
, pp. 6148-6154
-
-
Matsukawa, A.1
-
15
-
-
0037218519
-
Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression
-
Riedemann N.C., et al. Protective effects of IL-6 blockade in sepsis are linked to reduced C5a receptor expression. J. Immunol. 2003, 170:503-507.
-
(2003)
J. Immunol.
, vol.170
, pp. 503-507
-
-
Riedemann, N.C.1
-
16
-
-
46749158250
-
Adverse functions of IL-17A in experimental sepsis
-
Flierl M.A., et al. Adverse functions of IL-17A in experimental sepsis. FASEB J. 2008, 22:2198-2205.
-
(2008)
FASEB J.
, vol.22
, pp. 2198-2205
-
-
Flierl, M.A.1
-
17
-
-
67649216116
-
IL-17 receptor signaling is required to control polymicrobial sepsis
-
Freitas A., et al. IL-17 receptor signaling is required to control polymicrobial sepsis. J. Immunol. 2009, 182:7846-7854.
-
(2009)
J. Immunol.
, vol.182
, pp. 7846-7854
-
-
Freitas, A.1
-
18
-
-
78649418643
-
Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models
-
Hammer M., et al. Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology 2010, 131:395-404.
-
(2010)
Immunology
, vol.131
, pp. 395-404
-
-
Hammer, M.1
-
19
-
-
33750288937
-
Apoptosis and caspases regulate death and inflammation in sepsis
-
Hotchkiss R.S., Nicholson D.W. Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 2006, 6:813-822.
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 813-822
-
-
Hotchkiss, R.S.1
Nicholson, D.W.2
-
20
-
-
77950208700
-
Characterization and modulation of the immunosuppressive phase of sepsis
-
Muenzer J.T., et al. Characterization and modulation of the immunosuppressive phase of sepsis. Infect. Immun. 2010, 78:1582-1592.
-
(2010)
Infect. Immun.
, vol.78
, pp. 1582-1592
-
-
Muenzer, J.T.1
-
21
-
-
66749164669
-
The sepsis seesaw: tilting toward immunosuppression
-
Hotchkiss R.S., et al. The sepsis seesaw: tilting toward immunosuppression. Nat. Med. 2009, 15:496-497.
-
(2009)
Nat. Med.
, vol.15
, pp. 496-497
-
-
Hotchkiss, R.S.1
-
22
-
-
55949084597
-
Sepsis, apoptosis and complement
-
Ward P.A. Sepsis, apoptosis and complement. Biochem. Pharmacol. 2008, 76:1383-1388.
-
(2008)
Biochem. Pharmacol.
, vol.76
, pp. 1383-1388
-
-
Ward, P.A.1
-
23
-
-
0036152735
-
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice
-
Coopersmith C.M., et al. Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit. Care Med. 2002, 30:195-201.
-
(2002)
Crit. Care Med.
, vol.30
, pp. 195-201
-
-
Coopersmith, C.M.1
-
24
-
-
72449148164
-
Toll-like receptors 2 and 4 contribute to sepsis-induced depletion of spleen dendritic cells
-
Pène F., et al. Toll-like receptors 2 and 4 contribute to sepsis-induced depletion of spleen dendritic cells. Infect. Immun. 2009, 77:5651-5658.
-
(2009)
Infect. Immun.
, vol.77
, pp. 5651-5658
-
-
Pène, F.1
-
25
-
-
77949317183
-
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
-
Inoue S., et al. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J. Immunol. 2010, 184:1401-1409.
-
(2010)
J. Immunol.
, vol.184
, pp. 1401-1409
-
-
Inoue, S.1
-
26
-
-
77956403940
-
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis
-
Brahmamdam P., et al. Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J. Leukoc. Biol. 2010, 88:233-240.
-
(2010)
J. Leukoc. Biol.
, vol.88
, pp. 233-240
-
-
Brahmamdam, P.1
-
27
-
-
33750276751
-
Peritoneal lavage with activated protein C alters compartmentalized coagulation and fibrinolysis and improves survival in polymicrobial peritonitis
-
van Veen S.Q., et al. Peritoneal lavage with activated protein C alters compartmentalized coagulation and fibrinolysis and improves survival in polymicrobial peritonitis. Crit. Care Med. 2006, 34:2799-2805.
-
(2006)
Crit. Care Med.
, vol.34
, pp. 2799-2805
-
-
van Veen, S.Q.1
-
28
-
-
0029958832
-
Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome
-
Stove S., et al. Circulating complement proteins in patients with sepsis or systemic inflammatory response syndrome. Clin. Diagn. Lab. Immunol. 1996, 3:175-183.
-
(1996)
Clin. Diagn. Lab. Immunol.
, vol.3
, pp. 175-183
-
-
Stove, S.1
-
29
-
-
0036840236
-
Generation of C5a by phagocytic cells
-
Huber-Lang M., et al. Generation of C5a by phagocytic cells. Am. J. Pathol. 2002, 161:1849-1859.
-
(2002)
Am. J. Pathol.
, vol.161
, pp. 1849-1859
-
-
Huber-Lang, M.1
-
30
-
-
35748986432
-
C1 inhibitor-mediated protection from sepsis
-
Liu D., et al. C1 inhibitor-mediated protection from sepsis. J. Immunol. 2007, 179:3966-3972.
-
(2007)
J. Immunol.
, vol.179
, pp. 3966-3972
-
-
Liu, D.1
-
31
-
-
0036793526
-
Protection of innate immunity by C5aR antagonist in septic mice
-
Huber-Lang M.S., et al. Protection of innate immunity by C5aR antagonist in septic mice. FASEB J. 2002, 16:1567-1574.
-
(2002)
FASEB J.
, vol.16
, pp. 1567-1574
-
-
Huber-Lang, M.S.1
-
32
-
-
0033052453
-
Protective effects of C5a blockade in sepsis
-
Czermak B.J., et al. Protective effects of C5a blockade in sepsis. Nat. Med. 1999, 5:788-792.
-
(1999)
Nat. Med.
, vol.5
, pp. 788-792
-
-
Czermak, B.J.1
-
33
-
-
57949085998
-
The current management of septic shock
-
Russel J.A. The current management of septic shock. Minerva Med. 2008, 99:431-458.
-
(2008)
Minerva Med.
, vol.99
, pp. 431-458
-
-
Russel, J.A.1
-
34
-
-
4344618571
-
Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
-
Annane D., et al. Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis. BMJ 2004, 329:480.
-
(2004)
BMJ
, vol.329
, pp. 480
-
-
Annane, D.1
-
35
-
-
0026016470
-
Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group
-
Ziegler E.J., et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. A randomized, double-blind, placebo-controlled trial. The HA-1A Sepsis Study Group. N. Engl. J. Med. 1991, 324:429-436.
-
(1991)
N. Engl. J. Med.
, vol.324
, pp. 429-436
-
-
Ziegler, E.J.1
-
36
-
-
2442565752
-
CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14)
-
Reinhart K., et al. CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14). Crit. Care Med. 2004, 32:1100-1108.
-
(2004)
Crit. Care Med.
, vol.32
, pp. 1100-1108
-
-
Reinhart, K.1
-
37
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard G.R., et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 2001, 344:699-709.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 699-709
-
-
Bernard, G.R.1
-
38
-
-
58849120086
-
Adrenal insufficiency in septic shock
-
vii
-
Maxime V., et al. Adrenal insufficiency in septic shock. Clin. Chest Med. 2009, 30:17-27. vii.
-
(2009)
Clin. Chest Med.
, vol.30
, pp. 17-27
-
-
Maxime, V.1
-
39
-
-
54049158480
-
Experimental models of sepsis and their clinical relevance
-
Poli-de-Figueiredo L.F., et al. Experimental models of sepsis and their clinical relevance. Shock (Augusta, Ga) 2008, 30(Suppl. 1):53-59.
-
(2008)
Shock (Augusta, Ga)
, vol.30
, Issue.SUPPL. 1
, pp. 53-59
-
-
Poli-de-Figueiredo, L.F.1
-
40
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss R.S., Karl I.E. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 2003, 348:138-150.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
41
-
-
0025258906
-
Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis
-
Echtenacher B., et al. Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis. J. Immunol. 1990, 145:3762-3766.
-
(1990)
J. Immunol.
, vol.145
, pp. 3762-3766
-
-
Echtenacher, B.1
-
42
-
-
0026585007
-
Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia
-
Eskandari M.K., et al. Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia. J. Immunol. 1992, 148:2724-2730.
-
(1992)
J. Immunol.
, vol.148
, pp. 2724-2730
-
-
Eskandari, M.K.1
-
43
-
-
0033136310
-
Multiple roles for IL-12 in a model of acute septic peritonitis
-
Steinhauser M.L., et al. Multiple roles for IL-12 in a model of acute septic peritonitis. J. Immunol. 1999, 162:5437-5443.
-
(1999)
J. Immunol.
, vol.162
, pp. 5437-5443
-
-
Steinhauser, M.L.1
-
44
-
-
33747753164
-
IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture
-
Moreno S.E., et al. IL-12, but not IL-18, is critical to neutrophil activation and resistance to polymicrobial sepsis induced by cecal ligation and puncture. J. Immunol. 2006, 177:3218-3224.
-
(2006)
J. Immunol.
, vol.177
, pp. 3218-3224
-
-
Moreno, S.E.1
-
45
-
-
0028970736
-
Endogenous IL-10 protects mice from death during septic peritonitis
-
van der Poll T., et al. Endogenous IL-10 protects mice from death during septic peritonitis. J. Immunol. 1995, 155:5397-5401.
-
(1995)
J. Immunol.
, vol.155
, pp. 5397-5401
-
-
van der Poll, T.1
-
46
-
-
0033134230
-
Splenic immune suppression in sepsis: A role for IL-10-induced changes in P38 MAPK signaling
-
Song G.Y., et al. Splenic immune suppression in sepsis: A role for IL-10-induced changes in P38 MAPK signaling. J. Surg. Res. 1999, 83:36-43.
-
(1999)
J. Surg. Res.
, vol.83
, pp. 36-43
-
-
Song, G.Y.1
-
47
-
-
33751231090
-
Pneumonia after cecal ligation and puncture: a clinically relevant 'two-hit' model of sepsis
-
Muenzer J.T., et al. Pneumonia after cecal ligation and puncture: a clinically relevant 'two-hit' model of sepsis. Shock (Augusta, Ga) 2006, 26:565-570.
-
(2006)
Shock (Augusta, Ga)
, vol.26
, pp. 565-570
-
-
Muenzer, J.T.1
-
48
-
-
0345275927
-
Septic mice are susceptible to pulmonary aspergillosis
-
Benjamim C.F., et al. Septic mice are susceptible to pulmonary aspergillosis. Am. J. Pathol. 2003, 163:2605-2617.
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 2605-2617
-
-
Benjamim, C.F.1
-
49
-
-
70349469854
-
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial
-
Meisel C., et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am. J. Respir. Crit. Care Med. 2009, 180:640-648.
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.180
, pp. 640-648
-
-
Meisel, C.1
-
50
-
-
62849119132
-
Effects of aging on the immunopathologic response to sepsis
-
Turnbull I.R., et al. Effects of aging on the immunopathologic response to sepsis. Crit. Care Med. 2009, 37:1018-1023.
-
(2009)
Crit. Care Med.
, vol.37
, pp. 1018-1023
-
-
Turnbull, I.R.1
-
51
-
-
11844267259
-
Genetic determinants influencing the response to injury, inflammation, and sepsis
-
De Maio A., et al. Genetic determinants influencing the response to injury, inflammation, and sepsis. Shock (Augusta, Ga) 2005, 23:11-17.
-
(2005)
Shock (Augusta, Ga)
, vol.23
, pp. 11-17
-
-
De Maio, A.1
-
52
-
-
77957697171
-
Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response
-
Osuchowski M.F., et al. Untreated type 1 diabetes increases sepsis-induced mortality without inducing a prelethal cytokine response. Shock (Augusta, Ga) 2010, 34:369-376.
-
(2010)
Shock (Augusta, Ga)
, vol.34
, pp. 369-376
-
-
Osuchowski, M.F.1
-
53
-
-
77957719801
-
Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes
-
Jacob A., et al. Sepsis-induced inflammation is exacerbated in an animal model of type 2 diabetes. Int. J. Clin. Exp. Med. 2008, 1:22-31.
-
(2008)
Int. J. Clin. Exp. Med.
, vol.1
, pp. 22-31
-
-
Jacob, A.1
-
54
-
-
53049090662
-
Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome
-
Doi K., et al. Pre-existing renal disease promotes sepsis-induced acute kidney injury and worsens outcome. Kidney Int. 2008, 74:1017-1025.
-
(2008)
Kidney Int.
, vol.74
, pp. 1017-1025
-
-
Doi, K.1
-
55
-
-
77957865301
-
The role of interferon-gamma in the pathogenesis of acute intra-abdominal sepsis
-
Romero C.R., et al. The role of interferon-gamma in the pathogenesis of acute intra-abdominal sepsis. J. Leukoc. Biol. 2010, 88:725-735.
-
(2010)
J. Leukoc. Biol.
, vol.88
, pp. 725-735
-
-
Romero, C.R.1
-
56
-
-
0035177937
-
Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis
-
Echtenacher B., et al. Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis. Infect. Immun. 2001, 69:7271-7276.
-
(2001)
Infect. Immun.
, vol.69
, pp. 7271-7276
-
-
Echtenacher, B.1
-
57
-
-
62949201482
-
Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis
-
Zanotti-Cavazzoni S.L., et al. Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis. Intensive Care Med. 2009, 35:748-754.
-
(2009)
Intensive Care Med.
, vol.35
, pp. 748-754
-
-
Zanotti-Cavazzoni, S.L.1
-
58
-
-
33746190736
-
Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
-
Osuchowski M.F., et al. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol. 2006, 177:1967-1974.
-
(2006)
J. Immunol.
, vol.177
, pp. 1967-1974
-
-
Osuchowski, M.F.1
-
59
-
-
0001611329
-
Protection from septic shock by neutralization of macrophage migration inhibitory factor
-
Calandra T., et al. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat. Med. 2000, 6:164-170.
-
(2000)
Nat. Med.
, vol.6
, pp. 164-170
-
-
Calandra, T.1
-
60
-
-
33745854493
-
Role of HMGB1 in apoptosis-mediated sepsis lethality
-
Qin S., et al. Role of HMGB1 in apoptosis-mediated sepsis lethality. J. Exp. Med. 2006, 203:1637-1642.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1637-1642
-
-
Qin, S.1
-
61
-
-
0020520054
-
Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model
-
Baker C.C., et al. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 1983, 94:331-335.
-
(1983)
Surgery
, vol.94
, pp. 331-335
-
-
Baker, C.C.1
-
62
-
-
61449154547
-
Immunodesign of experimental sepsis by cecal ligation and puncture
-
Rittirsch D., et al. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat. Protoc. 2009, 4:31-36.
-
(2009)
Nat. Protoc.
, vol.4
, pp. 31-36
-
-
Rittirsch, D.1
-
63
-
-
0033838948
-
Immune depression in polymicrobial sepsis: the role of necrotic (injured) tissue and endotoxin
-
Ayala A., et al. Immune depression in polymicrobial sepsis: the role of necrotic (injured) tissue and endotoxin. Crit. Care Med. 2000, 28:2949-2955.
-
(2000)
Crit. Care Med.
, vol.28
, pp. 2949-2955
-
-
Ayala, A.1
-
64
-
-
0242383209
-
Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and interleukin-6 expression following cecal ligation and puncture in the rat
-
Singleton K.D., Wischmeyer P.E. Distance of cecum ligated influences mortality, tumor necrosis factor-alpha and interleukin-6 expression following cecal ligation and puncture in the rat. Eur. Surg. Res. 2003, 35:486-491.
-
(2003)
Eur. Surg. Res.
, vol.35
, pp. 486-491
-
-
Singleton, K.D.1
Wischmeyer, P.E.2
-
65
-
-
0036533584
-
Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells
-
Oberholzer A., et al. Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells. J. Immunol. 2002, 168:3412-3418.
-
(2002)
J. Immunol.
, vol.168
, pp. 3412-3418
-
-
Oberholzer, A.1
-
66
-
-
0031868366
-
Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice
-
Leon L.R., et al. Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice. Am. J. Physiol. 1998, 275:R269-277.
-
(1998)
Am. J. Physiol.
, vol.275
-
-
Leon, L.R.1
-
67
-
-
0034830633
-
Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice
-
Wang Q., et al. Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2001, 281:R1013-1023.
-
(2001)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.281
-
-
Wang, Q.1
-
68
-
-
25844500877
-
Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels
-
Vyas D., et al. Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 289:R1048-1053.
-
(2005)
Am. J. Physiol. Regul. Integr. Comp. Physiol.
, vol.289
-
-
Vyas, D.1
-
69
-
-
55349143535
-
Endogenous IL-10 regulates sepsis-induced thymic apoptosis and improves survival in septic IL-10 null mice
-
Tschoeke S.K., et al. Endogenous IL-10 regulates sepsis-induced thymic apoptosis and improves survival in septic IL-10 null mice. Scand. J. Immunol. 2008, 68:565-571.
-
(2008)
Scand. J. Immunol.
, vol.68
, pp. 565-571
-
-
Tschoeke, S.K.1
-
70
-
-
0034162550
-
Expression and contribution of endogenous IL-13 in an experimental model of sepsis
-
Matsukawa A., et al. Expression and contribution of endogenous IL-13 in an experimental model of sepsis. J. Immunol. 2000, 164:2738-2744.
-
(2000)
J. Immunol.
, vol.164
, pp. 2738-2744
-
-
Matsukawa, A.1
-
71
-
-
33746931178
-
Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27
-
Wirtz S., et al. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J. Exp. Med. 2006, 203:1875-1881.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1875-1881
-
-
Wirtz, S.1
-
72
-
-
26244456123
-
Interferon-gamma inhibition attenuates lethality after cecal ligation and puncture in rats: implication of high mobility group box-1
-
Yin K., et al. Interferon-gamma inhibition attenuates lethality after cecal ligation and puncture in rats: implication of high mobility group box-1. Shock (Augusta, Ga) 2005, 24:396-401.
-
(2005)
Shock (Augusta, Ga)
, vol.24
, pp. 396-401
-
-
Yin, K.1
-
73
-
-
0037408295
-
Inhibition of gamma interferon decreases bacterial load in peritonitis by accelerating peritoneal fibrin deposition and tissue repair
-
Qiu G., et al. Inhibition of gamma interferon decreases bacterial load in peritonitis by accelerating peritoneal fibrin deposition and tissue repair. Infect. Immun. 2003, 71:2766-2774.
-
(2003)
Infect. Immun.
, vol.71
, pp. 2766-2774
-
-
Qiu, G.1
-
74
-
-
16244414906
-
Opposing effects of tumor necrosis factor receptor 1 and 2 in sepsis due to cecal ligation and puncture
-
Ebach D.R., et al. Opposing effects of tumor necrosis factor receptor 1 and 2 in sepsis due to cecal ligation and puncture. Shock (Augusta, Ga) 2005, 23:311-318.
-
(2005)
Shock (Augusta, Ga)
, vol.23
, pp. 311-318
-
-
Ebach, D.R.1
-
75
-
-
67649201746
-
Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis
-
Secher T., et al. Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. J. Immunol. 2009, 182:7855-7864.
-
(2009)
J. Immunol.
, vol.182
, pp. 7855-7864
-
-
Secher, T.1
-
76
-
-
0029348036
-
Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture
-
Remick D., et al. Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture. Shock (Augusta, Ga) 1995, 4:89-95.
-
(1995)
Shock (Augusta, Ga)
, vol.4
, pp. 89-95
-
-
Remick, D.1
-
77
-
-
54049119495
-
Granulocyte-macrophage-colony-stimulating factor-dependent peritoneal macrophage responses determine survival in experimentally induced peritonitis and sepsis in mice
-
Spight D., et al. Granulocyte-macrophage-colony-stimulating factor-dependent peritoneal macrophage responses determine survival in experimentally induced peritonitis and sepsis in mice. Shock (Augusta, Ga) 2008, 30:434-442.
-
(2008)
Shock (Augusta, Ga)
, vol.30
, pp. 434-442
-
-
Spight, D.1
-
78
-
-
9144241208
-
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
-
Yang H., et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:296-301.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 296-301
-
-
Yang, H.1
-
79
-
-
2942756123
-
Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
-
Liliensiek B., et al. Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. J. Clin. Invest. 2004, 113:1641-1650.
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1641-1650
-
-
Liliensiek, B.1
-
80
-
-
37749005803
-
Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
-
Lutterloh E.C., et al. Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection. Crit. Care 2007, 11:R122.
-
(2007)
Crit. Care
, vol.11
-
-
Lutterloh, E.C.1
-
81
-
-
45549107924
-
Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis
-
Bopp C., et al. Bench-to-bedside review: The inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis. Crit. Care 2008, 12:201.
-
(2008)
Crit. Care
, vol.12
, pp. 201
-
-
Bopp, C.1
-
82
-
-
9144265739
-
CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis
-
Ness T.L., et al. CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. J. Immunol. 2004, 173:6938-6948.
-
(2004)
J. Immunol.
, vol.173
, pp. 6938-6948
-
-
Ness, T.L.1
-
83
-
-
34548761490
-
The chemokine receptor CCR6 is an important component of the innate immune response
-
Wen H., et al. The chemokine receptor CCR6 is an important component of the innate immune response. Eur. J. Immunol. 2007, 37:2487-2498.
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 2487-2498
-
-
Wen, H.1
-
84
-
-
33644891877
-
Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis
-
Matsukawa A., et al. Absence of CC chemokine receptor 8 enhances innate immunity during septic peritonitis. FASEB J. 2006, 20:302-304.
-
(2006)
FASEB J.
, vol.20
, pp. 302-304
-
-
Matsukawa, A.1
-
85
-
-
56149116902
-
Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis
-
Ishida Y., et al. Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis. J. Immunol. 2008, 181:4208-4218.
-
(2008)
J. Immunol.
, vol.181
, pp. 4208-4218
-
-
Ishida, Y.1
-
86
-
-
0141886168
-
Immunomodulatory role of CXCR2 during experimental septic peritonitis
-
Ness T.L., et al. Immunomodulatory role of CXCR2 during experimental septic peritonitis. J. Immunol. 2003, 171:3775-3784.
-
(2003)
J. Immunol.
, vol.171
, pp. 3775-3784
-
-
Ness, T.L.1
-
87
-
-
0030921892
-
Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality
-
Walley K.R., et al. Elevated levels of macrophage inflammatory protein 2 in severe murine peritonitis increase neutrophil recruitment and mortality. Infect. Immun. 1997, 65:3847-3851.
-
(1997)
Infect. Immun.
, vol.65
, pp. 3847-3851
-
-
Walley, K.R.1
-
88
-
-
1942542884
-
Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis
-
Maitra S.R., et al. Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis. Shock (Augusta, Ga) 2003, 20:280-285.
-
(2003)
Shock (Augusta, Ga)
, vol.20
, pp. 280-285
-
-
Maitra, S.R.1
-
89
-
-
0037678914
-
Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats
-
Steinberg J., et al. Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats. J. Surg. Res. 2003, 111:185-195.
-
(2003)
J. Surg. Res.
, vol.111
, pp. 185-195
-
-
Steinberg, J.1
-
90
-
-
33751201520
-
Chemically modified tetracycline (COL-3) improves survival if given 12 but not 24hours after cecal ligation and puncture
-
Halter J.M., et al. Chemically modified tetracycline (COL-3) improves survival if given 12 but not 24hours after cecal ligation and puncture. Shock (Augusta, Ga) 2006, 26:587-591.
-
(2006)
Shock (Augusta, Ga)
, vol.26
, pp. 587-591
-
-
Halter, J.M.1
-
91
-
-
0345358579
-
Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
-
Martin E.L., et al. Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis. Am. J. Physiol. Lung. Cell. Mol. Physiol. 2003, 285:L1222-1232.
-
(2003)
Am. J. Physiol. Lung. Cell. Mol. Physiol.
, vol.285
-
-
Martin, E.L.1
-
92
-
-
22444432280
-
Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia
-
Martin E.L., et al. Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia. Am. J. Physiol. Lung. Cell. Mol. Physiol. 2005, 289:L244-251.
-
(2005)
Am. J. Physiol. Lung. Cell. Mol. Physiol.
, vol.289
-
-
Martin, E.L.1
-
93
-
-
35448937707
-
Neuronal nitric oxide synthase deficiency decreases survival in bacterial peritonitis and sepsis
-
Cui X., et al. Neuronal nitric oxide synthase deficiency decreases survival in bacterial peritonitis and sepsis. Intensive Care Med. 2007, 33:1993-2003.
-
(2007)
Intensive Care Med.
, vol.33
, pp. 1993-2003
-
-
Cui, X.1
-
94
-
-
0032863627
-
Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice
-
Cobb J.P., et al. Inducible nitric oxide synthase (iNOS) gene deficiency increases the mortality of sepsis in mice. Surgery 1999, 126:438-442.
-
(1999)
Surgery
, vol.126
, pp. 438-442
-
-
Cobb, J.P.1
-
95
-
-
0034828934
-
Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis
-
Reddy R.C., et al. Selective inhibition of COX-2 improves early survival in murine endotoxemia but not in bacterial peritonitis. Am. J. Physiol. Lung. Cell. Mol. Physiol. 2001, 281:L537-543.
-
(2001)
Am. J. Physiol. Lung. Cell. Mol. Physiol.
, vol.281
-
-
Reddy, R.C.1
-
96
-
-
31344481400
-
Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis
-
Alves-Filho J.C., et al. Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis. Crit. Care Med. 2006, 34:461-470.
-
(2006)
Crit. Care Med.
, vol.34
, pp. 461-470
-
-
Alves-Filho, J.C.1
-
97
-
-
45149129895
-
Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis
-
Plitas G., et al. Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis. J. Exp. Med. 2008, 205:1277-1283.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1277-1283
-
-
Plitas, G.1
-
98
-
-
43449087928
-
Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1
-
Chorny A., Delgado M. Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1. Am. J. Pathol. 2008, 172:1297-1307.
-
(2008)
Am. J. Pathol.
, vol.172
, pp. 1297-1307
-
-
Chorny, A.1
Delgado, M.2
-
99
-
-
36448948021
-
Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis
-
Huston J.M., et al. Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit. Care Med. 2007, 35:2762-2768.
-
(2007)
Crit. Care Med.
, vol.35
, pp. 2762-2768
-
-
Huston, J.M.1
-
100
-
-
34548040244
-
The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis
-
Wheeler D.S., et al. The green tea polyphenol epigallocatechin-3-gallate improves systemic hemodynamics and survival in rodent models of polymicrobial sepsis. Shock (Augusta, Ga) 2007, 28:353-359.
-
(2007)
Shock (Augusta, Ga)
, vol.28
, pp. 353-359
-
-
Wheeler, D.S.1
-
101
-
-
34247584500
-
Ethyl pyruvate: a novel treatment for sepsis
-
Fink M.P. Ethyl pyruvate: a novel treatment for sepsis. Curr. Drug Targets 2007, 8:515-518.
-
(2007)
Curr. Drug Targets
, vol.8
, pp. 515-518
-
-
Fink, M.P.1
-
102
-
-
77956057326
-
The harmful role of c5a on innate immunity in sepsis
-
Ward P.A. The harmful role of c5a on innate immunity in sepsis. J. Innate. Immun. 2010, 2:439-445.
-
(2010)
J. Innate. Immun.
, vol.2
, pp. 439-445
-
-
Ward, P.A.1
|