Corticosteroid resistance in sepsis is influenced by microRNA-124-induced downregulation of glucocorticoid receptor-α

Critical Care Medicine

Volumn 40, Issue 10, 2012, Pages 2745-2753

  Ledderose, Carola ^b   Möhnle, Patrick ^a   Limbeck, Elisabeth ^a   Schütz, Stefanie ^a   Weis, Florian ^a   Rink, Jessica ^a   Briegel, Josef ^a   Kreth, Simone ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

critical illness related corticosteroid insufficiency; glucocorticoid resistance; microRNA regulation; miR 124

Indexed keywords

CD28 ANTIGEN; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; HYDROCORTISONE; INTERLEUKIN 2; MICRORNA 124; SMALL INTERFERING RNA;

3' UNTRANSLATED REGION; ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD3+ T LYMPHOCYTE; CELL CULTURE; CELL STRAIN HEK293; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG RESISTANCE; EMBRYO; EXPRESSION VECTOR; FEMALE; GENE CONSTRUCT; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; GLUCOCORTICOID RESISTANCE; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LEUKEMIA CELL LINE; MALE; MOLECULAR CLONING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REPORTER GENE; SEPSIS; T LYMPHOCYTE; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; DOWN-REGULATION; DRUG TOLERANCE; FEMALE; GLUCOCORTICOIDS; HUMANS; MALE; MICRORNAS; MIDDLE AGED; PROTEIN ISOFORMS; RECEPTORS, GLUCOCORTICOID; RNA, SMALL INTERFERING; SEPSIS; T-LYMPHOCYTES;

EID: 84866563441     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31825b8ebc     Document Type: Article

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