Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

FASEB Journal

Volumn 26, Issue 2, 2012, Pages 722-729

  Kleiman, Anna ^a   Hübner, Sabine ^a   Rodriguez Parkitna, Jan M ^b,h   Neumann, Anita ^a   Hofer, Stefan ^c   Weigand, Markus A ^d   Bauer, Michael ^e   Schmid, Wolfgang ^b   Schütz, Günter ^b   Libert, Claude ^f   Reichardt, Holger M ^g   Tuckermann, Jan P ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d JUSTUS LIEBIG UNIVERSITY   (Germany)

^e JENA UNIVERSITY HOSPITAL   (Germany)

^f GHENT UNIVERSITY   (Belgium)

^g UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^h INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

CLP; GR; IL 1

Indexed keywords

GLUCOCORTICOID RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; DISEASE PREDISPOSITION; DOWN REGULATION; DRUG MECHANISM; IN VITRO STUDY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; SEPTIC SHOCK; SURVIVAL RATE;

ANIMALS; DEXAMETHASONE; DIMERIZATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PROTEIN STRUCTURE, QUATERNARY; RECEPTORS, GLUCOCORTICOID; RECEPTORS, INTERLEUKIN-1; RNA; RNA, MESSENGER; SHOCK, SEPTIC; SIGNAL TRANSDUCTION; TRANSCRIPTOME; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 84856544361     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.11-192112     Document Type: Article

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