Differential regulation and function of 5 ′untranslated GR-exon 1 transcripts

Molecular Endocrinology

Volumn 25, Issue 7, 2011, Pages 1100-1110

  Bockühl, Yvonne ^a   Murgatroyd, Christopher A ^a   Kuczynska, Arleta ^a   Adcock, Ian M ^b   Almeida, Osborne F X ^a   Spengler, Dietmar ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID RECEPTOR; GROWTH FACTOR; RNA;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; EXON; GENE EXPRESSION; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; POSTTRANSCRIPTIONAL GENE SILENCING; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; RNA STABILITY; RNA TRANSLATION; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

5' UNTRANSLATED REGIONS; ADRENAL GLANDS; ANIMALS; BASE SEQUENCE; BRAIN; CELL LINE; EXONS; GENE EXPRESSION REGULATION; HUMANS; KIDNEY; LIVER; MALE; MICE; NUCLEIC ACID CONFORMATION; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; PROTEIN BIOSYNTHESIS; RATS; RECEPTORS, GLUCOCORTICOID; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPLEEN; THYMUS GLAND;

RATTUS;

EID: 79959836377     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0436     Document Type: Article

References (50)

1. Ayoubi TA, Van De Ven WJ 1996 Regulation of gene expression by alternative promoters. FASEB J 10:453-460
2. Hirata S, Shoda T, Kato J, Hoshi K 2001 The multiple untranslated first exons system of the human estrogen receptor β (ER β) gene. J Steroid Biochem Mol Biol 78:33-40
3. Iwamoto H, Hirata S, Shoda T, Kato J, Hoshi K 2003 The novel 5́-untranslated first exon, exon 0H, of the rat estrogen receptor β gene. Endocr Res 29:157-168
4. Kos M, Reid G, Denger S, Gannon F 2001 Minireview: genomic organization of the human ERα gene promoter region. Mol Endocrinol 15:2057-2063
5. Kwak SP, Patel PD, Thompson RC, Akil H, Watson SJ 1993 5́- Heterogeneity of the mineralocorticoid receptor messenger ribonucleic acid: differential expression and regulation of splice variants within the rat hippocampus. Endocrinology 133:2344-2350
6. Zennaro MC, Le Menuet D, Lombés M 1996 Characterization of the human mineralocorticoid receptor gene 5́-regulatory region: evidence for differential hormonal regulation of two alternative promoters via nonclassical mechanisms. Mol Endocrinol 10:1549-1560
7. Turner JD, Muller CP 2005 Structure of the glucocorticoid receptor (NR3C1) gene 5́ untranslated region: identification, and tissue distribution of multiple new human exon 1. J Mol Endocrinol 35:283-292
8. Strähle U, Schmidt A, Kelsey G, Stewart AF, Cole TJ, Schmid W, Schütz G 1992 At least three promoters direct expression of the mouse glucocorticoid receptor gene. Proc Natl Acad Sci USA 89: 6731-6735
9. Mc Cormick JA, Lyons V, Jacobson MD, Noble J, Diorio J, Nyirenda M, Weaver S, Ester W, Yau JL, Meaney MJ, Seckl JR, Chapman KE, 2000 5́-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events. Mol Endocrinol 14:506-517
10. Breslin MB, Geng CD, Vedeckis WV 2001 Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids. Mol Endocrinol 15:1381-1395
11. Presul E, Schmidt S, Kofler R, Helmberg A 2007 Identification, tissue expression, and glucocorticoid responsiveness of alternative first exons of the human glucocorticoid receptor. J Mol Endocrinol 38:79-90
12. Chen F, Watson CS, Gametchu B 1999 Multiple glucocorticoid receptor transcripts in membrane glucocorticoid receptor-enriched S-49 mouse lymphoma cells. J Cell Biochem 74:418-429
13. Babendure JR, Babendure JL, Ding JH, Tsien RY 2006 Control of mammalian translation by mRNA structure near caps. RNA 12: 851-861
14. Pickering BM, Willis AE 2005 The implications of structured 5́ untranslated regions on translation and disease. Semin Cell Dev Biol 16:39-47
15. Turner JD, Schote AB, Macedo JA, Pelascini LP, Muller CP 2006 Tissue specific glucocorticoid receptor expression, a role for alternative first usage? Biochem Pharmacol 72:1529-1537
16. Turner JD, Alt SR, Cao L, Vernocchi S, Trifonova S, Battello N, Muller CP 2010 Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more. Biochem Pharmacol 80:1860-1868
17. Cao-Lei L, Leija SC, Kumsta R, Wust S, Meyer J, Turner JD, Muller CP 2011 Transcriptional control of the human glucocorticoid receptor: identification and analysis of alternative promoter regions. Hum Genet 129:533-543
18. van Wijk PA, van Neck JW, Rijnberk A, Croughs RJ, Mol JA 1995 Proliferation of the murine corticotropic tumour cell line AtT20 is affected by hypophysiotrophic hormones, growth factors and glucocorticoids. Mol Cell Endocrinol 111:13-19
19. Flavell SW, Greenberg ME 2008 Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system. Annu Rev Neurosci 31:563-590
20. Kochetov AV, Ischenko IV, Vorobiev DG, Kel AE, Babenko VN, Kisselev LL, Kolchanov NA 1998 Eukaryotic mRNAs encoding abundant and scarce proteins are statistically dissimilar in many structural features. FEBS Lett 440:351-355
21. Kozak M 1991 An analysis of vertebrate mRNA sequences: intimations of translational control. J Cell Biol 115:887-903
22. Gray NK, Wickens M 1998 Control of translation initiation in animals. Annu Rev Cell Dev Biol 14:399-458
23. Zuker M 2003 Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res 31:3406-3415
24. Mathews DH, Sabina J, Zuker M, Turner DH 1999 Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J Mol Biol 288:911-940
25. Kozak M 2005 Regulation of translation via mRNA structure in prokaryotes and eukaryotes. Gene 361:13-37
26. Wang G, Guo X, Floros J 2005 Differences in the translation efficiency and mRNA stability mediated by 5́-UTR splice variants of human SP-A1 and SP-A2 genes. AmJ Physiol Lung Cell Mol Physiol 289:L497-L508
27. De Moor CH, Jansen M, Bonte EJ, Thomas AA, Sussenbach JS, Van den Brande JL 1994 Influence of the four leader sequences of the human insulin-like-growth-factor-2 on the expression of reporter genes. Eur J Biochem 226:1039-1047
28. Gauss KA, Bunger PL, Crawford MA, McDermott BE, Swearingen R, Nelson-Overton LK, Siemsen DW, Kobayashi SD, Deleo FR, Quinn MT 2006 Variants of the 5́-untranslated region of human NCF2: expression and translational efficiency. Gene 366:169-179
29. Kudo K, Xi Y, Wang Y, Song B, Chu E, Ju J, Russo JJ, Ju J 2010 Translational control analysis by translationally active RNA capture/microarray analysis (TrIP-Chip). Nucleic Acids Res 38:e104
30. Eggers DK, Welch WJ, Hansen WJ 1997 Complexes between nascent polypeptides and their molecular chaperones in the cytosol of mammalian cells. Mol Biol Cell 8:1559-1573
31. Azzam ME, Algranati ID 1973 Mechanism of puromycin action: fate of ribosomes after release of nascent protein chains from polysomes. Proc Natl Acad Sci USA 70:3866-3869
32. Alt SR, Turner JD, Klok MD, Meijer OC, Lakke EA, Derijk RH, Muller CP 2010 Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed. Psychoneuroendocrinology 35:544-556
33. Pavithra L, Sreenath K, Singh S, Chattopadhyay S 2010 Heat-shock protein 70 binds to a novel sequence in 5́ UTR of tumor suppressor SMAR1 and regulates its mRNA stability upon prostaglandin A2 treatment. FEBS Lett 584:1187-1192
34. Zhao X, Chen J, Lei L, Hu G, Xiong Y, Xu J, Li Q, Yang X, Chang CC, Song B, Chang T, Li B 2009 The optional long 5́-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay. Acta Biochim Biophys Sin (Shanghai) 41:30-41
35. Payton SG, Haska CL, Flatley RM, Ge Y, Matherly LH 2007 Effects of 5́ untranslated region diversity on the posttranscriptional regulation of the human reduced folate carrier. Biochim Biophys Acta 1769:131-138
36. Vilela C, Ramirez CV, Linz B, Rodrigues-Pousada C, McCarthy JE 1999 Post-termination ribosome interactions with the 5́UTR modulate yeast mRNA stability. EMBO J 18:3139-3152
37. Capri M, Santoni MJ, Thomas-Delaage M, Aït-Ahmed O 1997 Implication of a 5́ coding sequence in targeting maternal mRNA to the Drosophila oocyte. Mech Dev 68:91-100
38. Saunders C, Cohen RS 1999 The role of oocyte transcription, the 5́UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization. Mol Cell 3:43-54
39. Thio GL, Ray RP, Barcelo G, Schüpbach T 2000 Localization of gurken RNA in Drosophila oogenesis requires elements in the 5́ and 3́ regions of the transcript. Dev Biol 221:435-446
40. Chatterjee S, Pal JK 2009 Role of 5́- and 3́-untranslated regions of mRNAs in human diseases. Biol Cell 101:251-262
41. Morris DR, Geballe AP 2000 Upstream open reading frames as regulators of mRNA translation. Mol Cell Biol 20:8635-8642
42. Kos M, Denger S, Reid G, Gannon F 2002 Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor α J Biol Chem 277:37131-37138
43. Kozak M 1987 Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes. Mol Cell Biol 7:3438-3445
44. Imataka H, Nakayama K, Yasumoto K, Mizuno A, Fujii-Kuriyama Y, Hayami M1 1994 Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5́-untranslated region. J Biol Chem 269:20668-20673
45. Hill JR, Morris DR 1992 Cell-specific translation of S-adenosylmethionine decarboxylase mRNA. Regulation by the 5́ transcript leader. J Biol Chem 267:21886-21893
46. Belsham DD, Cai F, Cui H, Smukler SR, Salapatek AM, Shkreta L 2004 Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders. Endocrinology 145:393-400
47. Baj A, Bettaccini A, Nishimura T, Onodera T, Toniolo A 2005 Poliovirus type 1 infection of murine PRNP-knockout neuronal cells. J Neurovirol 11:237-246
48. Ross J 1995 mRNA stability in mammalian cells. Microbiol Rev 59:423-450
49. Shu W, Bo X, Liu R, Zhao D, Zheng Z, Wang S 2006 RDMAS: a web server for RNA deleterious mutation analysis. BMC Bioinformatics 7:404
50. Churkin A, Barash D 2006 RNAmute: RNA secondary structure mutation analysis tool. BMC Bioinformatics 7:221