Effects of dexamethasone and L-canavanine on the intracellular calcium-contraction relation of the rat tail artery during septic shock

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 291, Issue 3, 2006, Pages

  Mansart, Arnaud ^a   Bollaert, Pierre Edouard ^b   Giummelly, Philippe ^a   Capdeville Atkinson, Christine ^a   Atkinson, Jeffrey ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

^b UNIVERSITY HOSPITAL OF NANCY   (France)

Author keywords

Glucocorticoid; Nitric oxide; Sepsis

Indexed keywords

ANTIINFLAMMATORY AGENT; CALCIUM; CANAVANINE; DEXAMETHASONE; DYE; FURA 2; GLUCOCORTICOID; NITRATE; NITRITE; NORADRENALIN; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTERY LIGATION; ARTERY PERFUSION; ARTERY PUNCTURE; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HEMODYNAMIC PARAMETERS; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PERFUSION PRESSURE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SEPTIC SHOCK; TAIL ARTERY;

ANIMALS; ARGININE; ARTERIES; CALCIUM; CANAVANINE; DEXAMETHASONE; GLUCOCORTICOIDS; HEMODYNAMIC PROCESSES; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; SHOCK, SEPTIC; TAIL; VASOCONSTRICTION;

EID: 33748424402     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00997.2005     Document Type: Article

References (37)

1. Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, Chaumet-Riffaut P, and Bellissant E. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 288: 862-871, 2002.
2. Archer SL, Huang JMC, Hampl V, Nelson DP, Shultz PJ, and Weir EK. Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase. Proc Natl Acad Sci USA 91: 7583-7587, 1994.
3. Atkinson J, Tatchum-Talom R, and Capdeville-Atkinson C. Reduction of endothelial function with age in the mesenteric arterial bed of the normotensive rat. Br J Pharmacol 111: 1184-1188, 1994.
4. Bellissant E and Annane D. Effect of hydrocortisone on phenylephrinemean arterial pressure dose-response relationship in septic shock. Clin Pharmacol Ther 68: 293-303, 2000.
5. Bollaert PE, Charpentier C, Levy B, Debouverie M, Audibert G, and Larcan A. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 26: 645-650, 1998.
6. Bolotina VM, Najibi S, Palacino JJ, Pagano PJ, and Cohen RA. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle. Nature 368: 850-853, 1994.
7. Briegel J, Forst H, Haller M, Schelling G, Kilger E, Kuprat G, Hemmer B, Hummel T, Lenhart A, Heyduck M, Stoll C, and Peter K. Stress doses of hydrocortisone reverse hyperdynamic septic shock: a prospective, randomised, double-blind single-center study. Crit Care Med 27: 723-732, 1999.
8. Callahan LA, Nethery D, Stofan D, DiMarco A, and Supinski G. Free radical-induced contractile protein dysfunction in endotoxin-induced sepsis. Am J Respir Cell Mol Biol 24: 210-217, 2001.
9. 2+ and vasoconstriction determined simultaneously in the perfused rat tail artery. Am J Physiol Cell Physiol 265: C1689-C1702, 1993.
10. Capdeville-Atkinson C, Oster L, Thorin-Trescases N, Robert A, Corman B, and Atkinson J. Effect of chronic ANG I-converting enzyme inhibition on aging processes. V. Intracellular calcium-vasoreactivity coupling. Am J Physiol Regul Integr Comp Physiol 268: R1394-R1400, 1995.
11. Caplan BA, Gerrity RG, and Schwartz CJ. Endothelial cell morphology in focal areas of in vivo Evans blue uptake in the young pig aorta. I. Quantitative light microscopic findings. Exp Mol Pathol 21: 102-117, 1974.
12. 2+ sensitivity and partially by repolarization. Am J Physiol Heart Circ Physiol 271: H962-H968, 1996.
13. 15N]nitrate in biological fluids. Anal Biochem 126: 131-138, 1982.
14. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
15. Knowles RG and Moncada S. Nitric oxide synthases in mammals. Biochem J 298: 249-258, 1994.
16. Landry DW and Oliver JA. The pathogenesis of vasodilatory shock. N Engl J Med 345: 588-595, 2001.
17. Levy B, Valtier M, De Chillou C, Bollaert PE, Canet D, and Mallié JP. Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high-energy phosphates during endotoxic shock in rats. Shock 11: 98-103, 1999.
18. Lopez A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, Brockway M, Anzueto A, Holzapfel L, Breen D, Silverman MS, Takala J, Donaldson J, Arneson C, Grove G, Grossman S, and Grover R. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32: 21-30, 2004.
19. Mansart A, Bollaert PE, Levy B, Nicolas MB, and Mallié JP. Comparative effects of dexamethasone and L-canavanine in experimental septic shock. Eur J Pharmacol 475: 61-67, 2003.
20. Martinez MC, Muller B, Stoclet JC, and Andrihantsitohaina R. Alteration by lipopolysaccharide of the relationship between intracellular calcium levels and contraction in rat mesenteric artery. Br J Pharmacol 118: 1218-1222, 1996.
21. ATP channel is an important molecular target for LPS-induced vascular hyporeactivity in vitro. Br J Pharmacol 144: 367-375, 2005.
22. Paik DC, Dillon J, Galicia E, and Tilson MD. The nitrite/collagen reaction: non-enzymatic nitration as a model system for age-related damage. Connect Tissue Res 42: 111-122, 2001.
23. Paya D, Gray GA, Fleming I, and Stoclet JC. Effect of dexamethasone on the onset and persistence of vascular hyporeactivity induced by E. coli lipopolysaccharide in rats. Circ Shock 41: 103-112, 1993.
24. Radomski MW, Palmer MRJ, and Moncada S. Glucocorticoids inhibit the expression of an inducible but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc Natl Acad Sci USA 87: 10043-10047, 1990.
25. 2+ measurement. J Biol Chem 262: 6308-6312, 1987.
26. Schlossmann J, Feil R, and Hofmann F. Signaling through NO- and cGMP-dependent protein kinases. Ann Med 35: 21-27, 2003.
27. Somlyo AV and Somlyo AP. Electromechanical and pharmacomechanical coupling in vascular smooth muscle. J Pharmacol Exp Ther 159: 129-145, 1968.
28. Stoclet JC, Fleming I, Gray GA, Julou-Schaeffer G, Schneider F, Scott CA, Schott C, and Parratt JR. Nitric oxide and endotoxemia. Circulation 87 Suppl V: 77-88, 1993.
29. Stoclet JC, Martinez MC, Ohlmann P, Schott C, Kleschyov AL, Schneider F, and Andriantsitohaina R. Induction of nitric oxide synthase and dual effects of nitric oxide and cyclooxygenase products in regulation of arterial contraction in human septic shock. Circulation 100: 107-112, 1999.
30. Tavernier B, Garrigue D, Boulle C, Vallet B, and Adnet P. Myofilament calcium is decreased in skinned cardiac fibres of endotoxin-treated rabbits. Cardiovasc Res 38: 472-479, 1998.
31. Tran NN, Spitzbarth E, Robert A, Giummelly P, Atkinson J, and Capdeville-Atkinson C. Nitric oxide lowers the calcium sensitivity of tension in the rat tail artery. J Physiol 15: 163-174, 1998.
32. Ullian ME. The role of corticosteroids in the regulation of vascular tone. Cardiovasc Res 41: 55-64, 1999.
33. G-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study. Crit Care Med 32: 13-20, 2004.
34. Wichterman KA, Baue AE, and Chaudry IH. Sepsis and septic shock - a review of laboratory models and a proposal. J Surg Res 29: 189-201, 1980.
35. Wu CC, Croxtall JD, Perretti M, Bryant CE, Thiemermann C, Flower RJ, and Vane JR. Lipocortin I mediates the inhibition by dexamethasone of the induction by endotoxin of nitric oxide synthase in the rat. Proc Natl Acad Sci USA 92: 3473-3477, 1995.
36. Wu LL, Tang C, and Liu MS. Altered phosphorylation and calcium sensitivity of cardiac myofibrillar proteins during sepsis. Am J Physiol Regul Integr Comp Physiol 281: R408-R416, 2001.
37. 2+ in cardiac myocytes. Circ Res 81: 1011-1020, 1997.