Heterogeneity of glucocorticoid resistance in patients with bronchial asthma

International Journal of Biomedical Science

Volumn 6, Issue 3, 2010, Pages 158-166

  Matsumura, Yasuhiro ^a  

^a Akishima Hospital   (Japan)

Author keywords

Activator protein 1 (Ap 1); Bronchial asthma; c jun n terminal kinase (JNK); Glucocorticoid (GC); Glucocorticoid receptor (GR); Glucocorticoid resistant (GC R) asthma; Histone deacetylase (HDAC); Map kinase (MAPK); Nuclear factor kappa b (Nf B)

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CD38 ANTIGEN; DEXAMETHASONE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR BETA; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; NUCLEAR RECEPTOR COACTIVATOR 2; PHOSPHATIDYLINOSITOL 3 KINASE; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA 3;

ASTHMA; BINDING AFFINITY; BODY MASS; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYTOKINE PRODUCTION; DRUG RESPONSE; ENZYME ACTIVATION; ENZYME INHIBITION; EOSINOPHIL; GENETIC HETEROGENEITY; HELPER CELL; HUMAN; INFLAMMATION; INNATE IMMUNITY; PATHOPHYSIOLOGY; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REGULATORY T LYMPHOCYTE; REVIEW; SMOKING; TH2 CELL; TRANSCRIPTION INITIATION; UPREGULATION;

EID: 77957331607     PISSN: 15509702     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (93)

1. Gibson PG. Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest. 2001; 119(5): 1329.
2. Anderson GP. Endotyping asthma: new insight into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet. 2008; 372(9643): 1107.
3. Barrett NA, Austen KF. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity. 2009; 31(3): 425.
4. Holgate ST, Davies DE. Rethinking the pathogenesis of asthma. Immunity. 2009; 31(3):362.
5. Woolcock AJ. Corticosteroid-resistant asthma: definitions. Am. J. Respir. Crit. Care Med. 1996; 154(2 Pt 2): S45.
6. Hakonarson H, Bjornsdottir US, Halapi E, Bradfield J, et al. Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc. Natl. Acad. Sci. U. S. A. 2005; 102(41):14789.
7. Ito K, Chung KF, Adcock IM. Update on glucocorticoid action and resistance. J. Allergy Clin. Immunol. 2006; 117(3): 522.
8. Adcock IM, Barnes PJ. Molecular mechanisms of corticosteroid resistance. Chest. 2008; 134(2): 394.
9. Barnes PJ. Glucocorticoid resistance in inflammatory disease. Lancet. 2009; 373(9678): 1905.
10. Barnes PJ, Chung KF, Page CP. Inflammatory mediators of asthma: an update. Pharmacol. Rev. 1998; 50(4): 515.
11. Newton R, Hart LA, Stevens DA, Bergmann M, et al. Effect of dexamethasone on interleukin-1beta-(IL-1beta)-induced nuclear factorkappaB (NF-kappaB) and kappaB-dependent transcription in epithelial cells. Eur. J. Biochem. 1998; 254(1): 8.
12. Hall SE, Lim S, Witherden IR, Tetley TD, et al. Lung type II cell and macrophage annexin I release: differential effects of two glucocorticoids. Am. J. Physiol. 1999; 276(1 Pt 1): L114.
13. Jalonen U, Lahti A, Korhonen R, Kankaanranta H, Moilanen E. Inhibition of tristetraprolin expression by dexamethasone in activated macrophages. Biochem. Pharmacol. 2005; 69(5): 733.
14. Ito K, Barnes PJ, Adcock IM. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol. Cell Biol. 2000; 20(18): 6891.
15. Cosío BG, Mann B, Ito K, Jazrawi E, Barnes PJ, Chung KF, Adcock IM Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma. Am. J. Respir. Crit. Care Med. 2004; 170(2): 141.
16. Bhavsar P, Ahmad T, Adcock IM. The role of histone deacetylases in asthma and allergic diseases. J. Allergy Clin. Immunol. 2008; 121(3): 580.
17. Ito K, Herbert C, Siegle JS, Vuppusetty C, et al. Steroid-resistant neutrophilic inflammation in a mouse model of an acute exacerbation of asthma. Am. J. Respir. Cell Mol. Biol. 2008; 39(5): 543.
18. Löwenberg M, Verhaar AP, van den Brink GR, Hommes DW. Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression. Trends Mol. Med. 2007; 13(4):158
19. Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, et al. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science. 2008; 321(5889): 663.
20. Bruna A, Nicolàs M, Muñoz A, Kyriakis JM, Caelles C. Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids. EMBO J. 2003; 22(22): 6035.
21. Bergmann M, Barnes PJ, Newton R. Molecular regulation of granulocyte macrophage colony-stimulating factor in human lung epithelial cells by interleukin (IL)-1beta, IL-4, and IL-13 involves both transcriptional and post-transcriptional mechanisms. Am. J. Respir. Cell Mol. Biol. 2000; 22 (5): 582.
22. Newton R, Staples KJ, Hart L, Barnes PJ, Bergmann MW. GM-CSF expression in pulmonary epithelial cells is regulated negatively by posttranscriptional mechanisms. Biochem. Biophys. Res. Commun. 2001; 287(1): 249.
23. Clark AR. MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids? J. Endocrinol. 2003; 178(1): 5.
24. Abraham SM, Lawrence T, Kleiman A, Warden P, et al. Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. J. Exp. Med. 2006; 203(8): 1883.
25. Dean JL, Sully G, Clark AR, Saklatvala J. The involvement of AUrich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell Signal. 2004; 16(10): 1113.
26. Bhavsar P, Hew M, Khorasani N, Torrego A, et al. Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared to non-severe asthma. Thorax. 2008; 63(9): 784.
27. Ismaili N, Garabedian MJ. Modulation of glucocorticoid receptor function via phosphorylation. Ann NY Acad Sci. 2004; 1024:86.
28. Ito K, Caramori G, Adcock IM. Therapeutic potential of phosphatidylinositol 3-kinase inhibitors in inflammatory respiratory disease. J. Pharmacol. Exp. Ther. 2007; 321(1): 1.
29. Marwick JA, Caramori G, Stevenson CS, Casolari P, et al. Inhibition of PI3Kdelta restores glucocorticoid function in smoking induced airway inflammation in mice. Am. J. Respir. Crit. Care Med. 2009; 179(7):542.
30. Hamid QA, Wenzel SE, Hauk PJ, Tsicopoulos A, et al. Increased glucocorticoid receptor beta in airway cells of glucocorticoid insensitive asthma. Am. J. Respir. Crit. Care Med. 1999; 159(5 Pt 1):1600.
31. Sousa AR, Lane SJ, Cidlowski JA, Staynov DZ, Lee TH. Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform. J. Allergy Clin. Immunol. 2000; 105(5): 943.
32. Pujols L, Mullol J, Pérez M, Roca-Ferrer J, et al. Expression of the human glucocorticoid receptor alpha and beta isoforms in human respiratory epithelial cells and their regulation by dexamethasone. Am. J. Respir. Cell Mol. Biol. 2001; 24(1):49.
33. Goleva E, Li LB, Eves PT, Strand MJ, et al. Increased glucocorticoid receptor beta alters steroid response in glucocorticoid insensitive asthma. Am. J. Respir. Crit. Care Med. 2006; 173(6): 607.
34. Kelly A, Bowen H, Jee YK, Mahfiche N, et al. The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylases. J. Allergy Clin. Immunol. 2008; 121(1):203.
35. Demoly P, Basset-Seguin N, Chanez P, Campbell AM, et al. c-fos proto-oncogene expression in bronchial biopsies of asthmatics. Am. J. Respir. Cell Mol. Biol. 1992; 7(2): 128.
36. Adcock IM, Lane SJ, Brown CR, Lee TH, Barnes PJ. Abnormal glucocorticoid receptor-activator protein 1 interaction in steroid resistant asthma. J. Exp. Med. 1995; 182(6): 1951.
37. Sousa AR, Lane SJ, Soh C, Lee TH. In vivo resistance to corticoste roids in bronchial asthma is associated with enhanced phosphorylation of JUN N-terminal kinase and failure of prednisolone to inhibit JUN N-terminal kinase phosphorylation. J. Allergy Clin. Immunol. 1999; 104(3 Pt 1): 565.
38. Loke TK, Mallett KH, Ratoff J, O'Connor BJ, et al. Systemic glucocorticoid reduces bronchial mucosal activation of activator protein 1 components in glucocorticoid-sensitive but not glucocorticoid-resistant asthmatic patients. J. Allergy Clin. Immunol. 2006; 118(2): 368.
39. Hart LA, Krishnan VL, Adcock IM, Barnes PJ, Chung KF. Activation and localization of transcription factor, nuclear factor kappaB, in asthma. Am. J. Respir. Crit. Care Med. 1998; 158(5 Pt 1): 1585.
40. Vignola AM, Chiappara G, Siena L, Bruno A, et al. Proliferation and activation of bronchial epithelial cells in corticosteroid dependent asthma. J. Allergy Clin. Immunol. 2001; 108(5): 738.
41. Caramori G, Oates T, Nicholson AG, Casolari P, et al. Activation of NF-kappaB transcription factor in asthma death. Histopathology. 2009; 54(4): 507.
42. Gagliardo R, Chanez P, Mathieu M, Bruno A, et al. Persistent activation of nuclear factor-kappaB signaling pathway in severe uncontrolled asthma. Am. J. Respir. Crit. Care Med. 2003; 168(10): 1190.
43. Zhu Z, Tang W, Ray A, Wu Y, et al. Rhinovirus stimulation of interleukin- 6 in vivo and in vitro. Evidence for nuclear factor kappa B-dependent transcriptional activation. J. Clin. Invest. 1996; 97(2): 421.
44. Zhu Z, Tang W, Gwaltney JM Jr, Wu Y, Elias JA. Rhinovirus stimulation of interleukin-8 in vivo and in vitro: role of NF-kappaB. Am. J. Physiol. 1997; 273(4 Pt 1): L814.
45. Papi A, Johnston SL. Respiratory epithelial cell expression of vascular cell adhesion molecule-1 and its up-regulation by rhinovirus infection via NF-kappaB and GATA transcription factors. J. Biol. Chem. 1999; 274(42): 30041.
46. Ray A, Cohn L. Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J. Clin. Invest. 1999; 104(8): 985.
47. Zhu J, Yamane H, Cote-Sierra J, Guo L, Paul WE. GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors. Cell Res. 2006; 16(1): 3.
48. Barnes PJ. Role of GATA-3 in allergic diseases. Curr. Mol. Med. 2008; 8(5): 330.
49. Schleimer R. Glucocorticoids suppress inflammation but spare immune response in airway epithelium. Proc. Am. Thorac. Soc. 2004; 1(3): 222.
50. Zhang N, Truong-Tran QA, Tancowny B, Harris KE, Schleimer RP. Glucocorticoids enhance or spare innate immunity: effects in airway epithelium are mediated by CCAAT/enhancer binding proteins. J. Immunol. 2007; 179(1): 578.
51. Black JL, Oliver BG, Roth M. Molecular mechanisms of combination therapy with inhaled corticosteroids and long-acting beta agonists. Chest. 2009; 136(4):1095.
52. Roth M, Johnson PR, Borger P, Bihl MP, et al. Dysfunctional interaction of C/EBPalpha and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells. N. Engl. J. Med. 2004; 351(6): 560.
53. Kröger A, Köster M, Schroeder K, Hauser H, Mueller PP. Activities of IRF-1. J. Interferon Cytokine Res. 2002; 22(1): 5.
54. Vianna EO, Westcott J, Martin RJ. The effects of upper respiratory infection on T-cell proliferation and steroid sensitivity of asthmatics. J. Allergy Clin. Immunol. 1998; 102(4 Pt 1): 592.
55. Yamada K, Elliott WM, Hayashi S, Brattsand R, et al. Latent adenoviral infection modifies the steroid response in allergic lung inflammation. J. Allergy Clin. Immunol. 2000; 106(5): 844.
56. Gally F, Hartney JM, Janssen WJ, Perraud AL. CD38 plays a dual role in allergen-induced airway hyperresponsiveness. Am. J. Respir. Cell Mol. Biol. 2009; 40(4): 433.
57. Tliba O, Cidlowski JA, Amrani Y. CD38 expression is insensitive to steroid action in cells treated with tumor necrosis factor-alpha and interferon-gamma by a mechanism involving the up-regulation of the glucocorticoid receptor beta isoform. Mol. Pharmacol. 2006; 69(2): 588.
58. Tliba O, Damera G, Banerjee A, Gu S, et al. Cytokines induce an early steroid resistance in airway smooth muscle cells: novel role of interferon regulatory factor-1. Am. J. Respir. Cell Mol. Biol. 2008; 38(4): 463.
59. Bhandare R, Damera G, Banerjee A, Flammer JR, et al. Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells. Am. J. Respir. Cell Mol. Biol. 2010; 42(1): 9.
60. Kam JC, Szefler SJ, Surs W, Sher ER, Leung DY. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J. Immunol. 1993; 151(7): 3460.
61. Sher ER, Leung DY, Surs W, Kam JC, et al. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J. Clin. Invest. 1994; 93(1): 33.
62. Leung DY, Martin RJ, Szefler SJ, Sher ER, et al. Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. J. Exp. Med. 1995; 181(1): 33.
63. Leung DY, Spahn JD, Szefler SJ. Immunologic basis and management of steroid-resistant asthma. Allergy Asthma Proc. 1999; 20(1): 9.
64. Szefler SJ, Leung DY. Glucocorticoid-resistant asthma: pathogenesis and clinical implications for management. Eur. Respir. J. 1997; 10(7): 1640.
65. Irusen E, Matthews JG, Takahashi A, Barnes PJ, et al. p38 Mitogenactivated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J. Allergy Clin. Immunol. 2002;109(4): 649.
66. Berry MA, Hargadon B, Shelley M, Parker D, et al. Evidence of a role of tumor necrosis factor alpha in refractory asthma. N. Engl. J. Med. 2006; 354(7): 697.
67. Schmitz J, Owyang A, Oldham E, Song Y, et al. IL-33, an interleukin- 1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity. 2005; 23(5): 479.
68. Préfontaine D, Lajoie-Kadoch S, Foley S, Audusseau S, et al. Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells. J. Immunol. 2009; 183(8): 5094.
69. Hawrylowicz C, Richards D, Loke TK, Corrigan C, Lee T. A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients. J. Allergy Clin. Immunol. 2002; 109(2): 369.
70. Yang M, Kumar RK, Foster PS. Pathogenesis of steroid-resistant airway hyperresponsiveness: interaction between IFN-gamma and TLR4/MyD88 pathways. J. Immunol. 2009; 182(8): 5107.
71. Wenzel SE. Eosinophils in asthma - Closing the loop or opening the door? N. Engl. J. Med. 2009; 360(10): 1026.
72. Wenzel SE, Schwartz LB, Langmack EL, Halliday JL, et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am. J. Respir. Crit. Care Med. 1999; 160(3): 1001.
73. Douwes J, Gibson P, Pekkanen J, Pearce N. Non-eosinophilic asthma: importance and possible mechanisms. Thorax. 2002; 57(7): 643.
74. Puddicombe SM, Polosa R, Richter A, Krishna MT, et al. Involvement of the epidermal growth factor receptor in epithelial repair in asthma. FASEB J. 2000; 14(10): 1362.
75. Hamilton LM, Torres-Lozano C, Puddicombe SM, Richter A, et al. The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma. Clin. Exp. Allergy. 2003; 33(2): 233.
76. Simpson JL, Scott RJ, Boyle MJ, Gibson PG. Differential proteo lytic enzyme activity in eosinophilic and neutrophilic asthma. Am. J. Respir. Crit. Care Med. 2005; 172(5): 559.
77. Pavord ID. Non-eosinophilic asthma and the innate immune response. Thorax 2007; 62(3): 193.
78. Pavord ID, Brightling CE, Woltmann G, Wardlaw AJ. Non-eosinophilic corticosteroid unresponsive asthma. Lancet. 1999; 353(9171): 2213.
79. Green RH, Brightling CE, Woltmann G, Parker D, Wardlaw AJ, Pavord ID. Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids. Thorax. 2002; 57(10): 875.
80. McKinley L, Alcorn JF, Peterson A, Dupont RB, et al. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol. 2008; 181(6): 4089.
81. Pène J, Chevalier S, Preisser L, Vénéreau E, et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J. Immunol. 2008; 180(11): 7423.
82. Kawaguchi M, Kokubu F, Fujita J, Huang SK, Hizawa N. Role of interleukin- 17F in asthma. Inflamm. Allergy Drug Targets. 2009; 8(5): 383.
83. Okumura S, Sagara H, Fukuda T, Saito H, Okayama Y. FcepsilonRImediated amphiregulin production by human mast cells increases mucin gene expression in epithelial cells. J. Allergy Clin. Immunol. 2005; 115(2):272.
84. Goleva E, Hauk PJ, Hall CF, Liu AH, et al. Corticosteroid-resistant asthma is associated with classical antimicrobial activation of airway macrophages. J. Allergy Clin. Immunol. 2008; 122(3): 550.
85. Goleva E, Hauk PJ, Boguniewicz J, Martin RJ, Leung DY. Airway remodeling and lack of bronchodilator response in steroid resistant asthma. J. Allergy Clin. Immunol. 2007; 120(5): 1065.
86. Ito K, Lim S, Caramori G, Chung KF, et al. Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 2001; 15(6), 1110.
87. Chaudhuri R, Livingston E, McMahon AD, Lafferty J, et al. Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am. J. Respir. Crit. Care Med. 2006; 174(2): 127.
88. Adcock IM, Ford P, Ito K, Barnes PJ. Epigenetics and airways disease. Respir. Res. 2006; 7: 21.
89. Hansdottir S, Monick MM, Hinde SL, Lovan N, et al. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J. Immunol. 2008; 181(10): 7090.
90. Sutherland ER, Goleva E, Jackson LP, Stevens AD, Leung DY. Vitamin D levels, lung function and steroid response in adult asthma. Am. J. Respir. Crit. Care Med. 2010; 181(7): 699.
91. Xystrakis E, Kusumakar S, Boswell S, Peek E, et al. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid- resistant asthma patients. J. Clin. Invest. 2006; 116(1): 146.
92. Ginde AA, Mansbach JM, Camargo CA Jr. Vitamin D, respiratory infections, and asthma. Curr. Allergy Asthma Rep. 2009; 9(1): 81.
93. Sutherland ER, Goleva E, Strand M, Beuther DA, Leung DY. Body mass and glucocorticoid response in asthma. Am J Respir Crit Care Med. 2008; 178(7): 682.