메뉴 건너뛰기




Volumn 37, Issue 2, 2016, Pages 321-331

Metabolism, Metabolomics, and Nutritional Support of Patients with Sepsis

Author keywords

Biomarker; ICU outcomes; Metabolism; Metabolomics; Nutrition; Sepsis

Indexed keywords

2 OXOISOVALERIC ACID; AMINO ACID; ANTIOXIDANT; ARGININE; CARNITINE; CATECHOLAMINE; CYTOKINE; GLUCOSE; GLUTAMINE; GLYCOGEN; HYDROCORTISONE; INOTROPIC AGENT; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LACTIC ACID; LIPOPROTEIN; MANNOSE; METHIONINE; OMEGA 3 FATTY ACID; OXYGEN; PLACEBO; REACTIVE OXYGEN METABOLITE; SELENIUM; SUCROSE; TRACE ELEMENT; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; BIOLOGICAL MARKER;

EID: 84960335738     PISSN: 02725231     EISSN: 15578216     Source Type: Journal    
DOI: 10.1016/j.ccm.2016.01.011     Document Type: Review
Times cited : (73)

References (78)
  • 1
    • 0029932696 scopus 로고    scopus 로고
    • Metabolism of sepsis and multiple organ failure
    • Michie H.R. Metabolism of sepsis and multiple organ failure. World J Surg 1996, 20(4):460-464.
    • (1996) World J Surg , vol.20 , Issue.4 , pp. 460-464
    • Michie, H.R.1
  • 2
    • 72449168374 scopus 로고    scopus 로고
    • The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study
    • Alberda C., Gramlich L., Jones N., et al. The relationship between nutritional intake and clinical outcomes in critically ill patients: results of an international multicenter observational study. Intensive Care Med 2009, 35(10):1728-1737.
    • (2009) Intensive Care Med , vol.35 , Issue.10 , pp. 1728-1737
    • Alberda, C.1    Gramlich, L.2    Jones, N.3
  • 3
    • 84902587332 scopus 로고    scopus 로고
    • Nutrition in the acute phase of critical illness
    • Casaer M.P., Van den Berghe G. Nutrition in the acute phase of critical illness. N Engl J Med 2014, 370(25):2450-2451.
    • (2014) N Engl J Med , vol.370 , Issue.25 , pp. 2450-2451
    • Casaer, M.P.1    Van den Berghe, G.2
  • 4
    • 84868131871 scopus 로고    scopus 로고
    • Endocrine and metabolic changes during sepsis: an update
    • Khardori R., Castillo D. Endocrine and metabolic changes during sepsis: an update. Med Clin North Am 2012, 96(6):1095-1105.
    • (2012) Med Clin North Am , vol.96 , Issue.6 , pp. 1095-1105
    • Khardori, R.1    Castillo, D.2
  • 5
    • 0037456430 scopus 로고    scopus 로고
    • Corticosteroid insufficiency in acutely ill patients
    • Cooper M.S., Stewart P.M. Corticosteroid insufficiency in acutely ill patients. N Engl J Med 2003, 348(8):727-734.
    • (2003) N Engl J Med , vol.348 , Issue.8 , pp. 727-734
    • Cooper, M.S.1    Stewart, P.M.2
  • 6
    • 0021322361 scopus 로고
    • Mechanisms of adrenocortical depression during Escherichia coli shock
    • Catalano R.D., Parameswaran V., Ramachandran J., et al. Mechanisms of adrenocortical depression during Escherichia coli shock. Arch Surg 1984, 119(2):145-150.
    • (1984) Arch Surg , vol.119 , Issue.2 , pp. 145-150
    • Catalano, R.D.1    Parameswaran, V.2    Ramachandran, J.3
  • 7
    • 38049110809 scopus 로고    scopus 로고
    • Hydrocortisone therapy for patients with septic shock
    • Sprung C.L., Annane D., Keh D., et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008, 358(2):111-124.
    • (2008) N Engl J Med , vol.358 , Issue.2 , pp. 111-124
    • Sprung, C.L.1    Annane, D.2    Keh, D.3
  • 8
    • 79953653217 scopus 로고    scopus 로고
    • Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?
    • Meyer S., Schuetz P., Wieland M., et al. Low triiodothyronine syndrome: a prognostic marker for outcome in sepsis?. Endocrine 2011, 39(2):167-174.
    • (2011) Endocrine , vol.39 , Issue.2 , pp. 167-174
    • Meyer, S.1    Schuetz, P.2    Wieland, M.3
  • 9
    • 34548157533 scopus 로고    scopus 로고
    • Metabolism modulators in sepsis: propranolol
    • Norbury W.B., Jeschke M.G., Herndon D.N. Metabolism modulators in sepsis: propranolol. Crit Care Med 2007, 35(9 Suppl):S616-S620.
    • (2007) Crit Care Med , vol.35 , Issue.9 , pp. S616-S620
    • Norbury, W.B.1    Jeschke, M.G.2    Herndon, D.N.3
  • 10
    • 0033858062 scopus 로고    scopus 로고
    • The direct effects of catecholamines on hepatic glucose production occur via alpha(1)- and beta(2)-receptors in the dog
    • Chu C.A., Sindelar D.K., Igawa K., et al. The direct effects of catecholamines on hepatic glucose production occur via alpha(1)- and beta(2)-receptors in the dog. Am J Physiol Endocrinol Metab 2000, 279(2):E463-E473.
    • (2000) Am J Physiol Endocrinol Metab , vol.279 , Issue.2 , pp. E463-E473
    • Chu, C.A.1    Sindelar, D.K.2    Igawa, K.3
  • 11
    • 0026792867 scopus 로고
    • Sepsis-induced insulin resistance in rats is mediated by a beta-adrenergic mechanism
    • Lang C.H. Sepsis-induced insulin resistance in rats is mediated by a beta-adrenergic mechanism. Am J Physiol 1992, 263(4 Pt 1):E703-E711.
    • (1992) Am J Physiol , vol.263 , Issue.4 , pp. E703-E711
    • Lang, C.H.1
  • 12
    • 0033638849 scopus 로고    scopus 로고
    • The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system
    • Elenkov I.J., Wilder R.L., Chrousos G.P., et al. The sympathetic nerve-an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000, 52(4):595-638.
    • (2000) Pharmacol Rev , vol.52 , Issue.4 , pp. 595-638
    • Elenkov, I.J.1    Wilder, R.L.2    Chrousos, G.P.3
  • 13
    • 3142558123 scopus 로고    scopus 로고
    • Therapeutic implications of immune-endocrine interactions in the critically ill patients
    • Oberbeck R. Therapeutic implications of immune-endocrine interactions in the critically ill patients. Curr Drug Targets Immune Endocr Metabol Disord 2004, 4(2):129-139.
    • (2004) Curr Drug Targets Immune Endocr Metabol Disord , vol.4 , Issue.2 , pp. 129-139
    • Oberbeck, R.1
  • 14
    • 0029944101 scopus 로고    scopus 로고
    • Sepsis and cytokines: current status
    • Blackwell T.S., Christman J.W. Sepsis and cytokines: current status. Br J Anaesth 1996, 77(1):110-117.
    • (1996) Br J Anaesth , vol.77 , Issue.1 , pp. 110-117
    • Blackwell, T.S.1    Christman, J.W.2
  • 15
    • 52949118458 scopus 로고    scopus 로고
    • Harmful molecular mechanisms in sepsis
    • Rittirsch D., Flierl M.A., Ward P.A. Harmful molecular mechanisms in sepsis. Nat Rev Immunol 2008, 8(10):776-787.
    • (2008) Nat Rev Immunol , vol.8 , Issue.10 , pp. 776-787
    • Rittirsch, D.1    Flierl, M.A.2    Ward, P.A.3
  • 16
    • 0023028369 scopus 로고
    • Shock and tissue injury induced by recombinant human cachectin
    • Tracey K.J., Beutler B., Lowry S.F., et al. Shock and tissue injury induced by recombinant human cachectin. Science 1986, 234(4775):470-474.
    • (1986) Science , vol.234 , Issue.4775 , pp. 470-474
    • Tracey, K.J.1    Beutler, B.2    Lowry, S.F.3
  • 17
    • 0027419926 scopus 로고
    • Cytokines, sepsis and immunomodulation
    • Molloy R.G., Mannick J.A., Rodrick M.L. Cytokines, sepsis and immunomodulation. Br J Surg 1993, 80(3):289-297.
    • (1993) Br J Surg , vol.80 , Issue.3 , pp. 289-297
    • Molloy, R.G.1    Mannick, J.A.2    Rodrick, M.L.3
  • 18
    • 84897377065 scopus 로고    scopus 로고
    • Why have clinical trials in sepsis failed?
    • Marshall J.C. Why have clinical trials in sepsis failed?. Trends Mol Med 2014, 20(4):195-203.
    • (2014) Trends Mol Med , vol.20 , Issue.4 , pp. 195-203
    • Marshall, J.C.1
  • 19
    • 26444606369 scopus 로고    scopus 로고
    • The multiple organ dysfunction syndrome and late-phase mortality in sepsis
    • Englert J.A., Fink M.P. The multiple organ dysfunction syndrome and late-phase mortality in sepsis. Curr Infect Dis Rep 2005, 7(5):335-341.
    • (2005) Curr Infect Dis Rep , vol.7 , Issue.5 , pp. 335-341
    • Englert, J.A.1    Fink, M.P.2
  • 20
    • 3142716777 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in sepsis
    • Brealey D., Singer M. Mitochondrial dysfunction in sepsis. Curr Infect Dis Rep 2003, 5(5):365-371.
    • (2003) Curr Infect Dis Rep , vol.5 , Issue.5 , pp. 365-371
    • Brealey, D.1    Singer, M.2
  • 21
    • 0029041052 scopus 로고
    • Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock
    • VanderMeer T.J., Wang H., Fink M.P. Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 1995, 23(7):1217-1226.
    • (1995) Crit Care Med , vol.23 , Issue.7 , pp. 1217-1226
    • VanderMeer, T.J.1    Wang, H.2    Fink, M.P.3
  • 22
    • 0026012502 scopus 로고
    • Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: comparison to limited infection and cardiogenic shock
    • Boekstegers P., Weidenhofer S., Pilz G., et al. Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: comparison to limited infection and cardiogenic shock. Infection 1991, 19(5):317-323.
    • (1991) Infection , vol.19 , Issue.5 , pp. 317-323
    • Boekstegers, P.1    Weidenhofer, S.2    Pilz, G.3
  • 23
    • 0034948351 scopus 로고    scopus 로고
    • Tissue oxygenation and perfusion in patients with systemic sepsis
    • Sair M., Etherington P.J., Peter Winlove C., et al. Tissue oxygenation and perfusion in patients with systemic sepsis. Crit Care Med 2001, 29(7):1343-1349.
    • (2001) Crit Care Med , vol.29 , Issue.7 , pp. 1343-1349
    • Sair, M.1    Etherington, P.J.2    Peter Winlove, C.3
  • 24
    • 0036892452 scopus 로고    scopus 로고
    • Bench-to-bedside review: cytopathic hypoxia
    • Fink M.P. Bench-to-bedside review: cytopathic hypoxia. Crit Care 2002, 6(6):491-499.
    • (2002) Crit Care , vol.6 , Issue.6 , pp. 491-499
    • Fink, M.P.1
  • 25
    • 0014254191 scopus 로고
    • Hepatic changes produced by a single dose of endotoxin in the mouse. Electron microscopy
    • Levy E., Slusser R.J., Ruebner B.H. Hepatic changes produced by a single dose of endotoxin in the mouse. Electron microscopy. Am J Pathol 1968, 52(2):477-502.
    • (1968) Am J Pathol , vol.52 , Issue.2 , pp. 477-502
    • Levy, E.1    Slusser, R.J.2    Ruebner, B.H.3
  • 26
    • 0042267263 scopus 로고    scopus 로고
    • Metabolic alterations in sepsis and vasoactive drug-related metabolic effects
    • Trager K., DeBacker D., Radermacher P. Metabolic alterations in sepsis and vasoactive drug-related metabolic effects. Curr Opin Crit Care 2003, 9(4):271-278.
    • (2003) Curr Opin Crit Care , vol.9 , Issue.4 , pp. 271-278
    • Trager, K.1    DeBacker, D.2    Radermacher, P.3
  • 27
    • 0037142987 scopus 로고    scopus 로고
    • Association between mitochondrial dysfunction and severity and outcome of septic shock
    • Brealey D., Brand M., Hargreaves I., et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002, 360(9328):219-223.
    • (2002) Lancet , vol.360 , Issue.9328 , pp. 219-223
    • Brealey, D.1    Brand, M.2    Hargreaves, I.3
  • 28
    • 2442468054 scopus 로고    scopus 로고
    • Stress-hyperglycemia, insulin and immunomodulation in sepsis
    • Marik P.E., Raghavan M. Stress-hyperglycemia, insulin and immunomodulation in sepsis. Intensive Care Med 2004, 30(5):748-756.
    • (2004) Intensive Care Med , vol.30 , Issue.5 , pp. 748-756
    • Marik, P.E.1    Raghavan, M.2
  • 29
    • 70449704239 scopus 로고    scopus 로고
    • Blood glucose control in patients with severe sepsis and septic shock
    • Hirasawa H., Oda S., Nakamura M. Blood glucose control in patients with severe sepsis and septic shock. World J Gastroenterol 2009, 15(33):4132-4136.
    • (2009) World J Gastroenterol , vol.15 , Issue.33 , pp. 4132-4136
    • Hirasawa, H.1    Oda, S.2    Nakamura, M.3
  • 30
    • 22144434453 scopus 로고    scopus 로고
    • Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects
    • Turina M., Fry D.E., Polk H.C. Acute hyperglycemia and the innate immune system: clinical, cellular, and molecular aspects. Crit Care Med 2005, 33(7):1624-1633.
    • (2005) Crit Care Med , vol.33 , Issue.7 , pp. 1624-1633
    • Turina, M.1    Fry, D.E.2    Polk, H.C.3
  • 31
    • 25844465324 scopus 로고    scopus 로고
    • Hyperglycemia in the intensive care unit: no longer just a marker of illness severity
    • Taylor J.H., Beilman G.J. Hyperglycemia in the intensive care unit: no longer just a marker of illness severity. Surg Infect (Larchmt) 2005, 6(2):233-245.
    • (2005) Surg Infect (Larchmt) , vol.6 , Issue.2 , pp. 233-245
    • Taylor, J.H.1    Beilman, G.J.2
  • 32
    • 0035046942 scopus 로고    scopus 로고
    • Amino acid kinetics in patients with sepsis
    • Druml W., Heinzel G., Kleinberger G. Amino acid kinetics in patients with sepsis. Am J Clin Nutr 2001, 73(5):908-913.
    • (2001) Am J Clin Nutr , vol.73 , Issue.5 , pp. 908-913
    • Druml, W.1    Heinzel, G.2    Kleinberger, G.3
  • 33
    • 84928974327 scopus 로고    scopus 로고
    • Dynamic changes in amino acid concentration profiles in patients with sepsis
    • Su L., Li H., Xie A., et al. Dynamic changes in amino acid concentration profiles in patients with sepsis. PLoS One 2015, 10(4):e0121933.
    • (2015) PLoS One , vol.10 , Issue.4 , pp. e0121933
    • Su, L.1    Li, H.2    Xie, A.3
  • 34
    • 33846266165 scopus 로고    scopus 로고
    • Lipoproteins in inflammation and sepsis. II. Clinical aspects
    • Wendel M., Paul R., Heller A.R. Lipoproteins in inflammation and sepsis. II. Clinical aspects. Intensive Care Med 2007, 33(1):25-35.
    • (2007) Intensive Care Med , vol.33 , Issue.1 , pp. 25-35
    • Wendel, M.1    Paul, R.2    Heller, A.R.3
  • 35
    • 79958066269 scopus 로고    scopus 로고
    • Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT study
    • Pontes-Arruda A., Martins L.F., de Lima S.M., et al. Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid and antioxidants in the early treatment of sepsis: results from a multicenter, prospective, randomized, double-blinded, controlled study: the INTERSEPT study. Crit Care 2011, 15(3):R144.
    • (2011) Crit Care , vol.15 , Issue.3 , pp. R144
    • Pontes-Arruda, A.1    Martins, L.F.2    de Lima, S.M.3
  • 37
    • 0031657210 scopus 로고    scopus 로고
    • Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients
    • Forceville X., Vitoux D., Gauzit R., et al. Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients. Crit Care Med 1998, 26(9):1536-1544.
    • (1998) Crit Care Med , vol.26 , Issue.9 , pp. 1536-1544
    • Forceville, X.1    Vitoux, D.2    Gauzit, R.3
  • 38
    • 33845954738 scopus 로고    scopus 로고
    • Selenium in intensive care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock
    • Angstwurm M.W., Engelmann L., Zimmermann T., et al. Selenium in intensive care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Crit Care Med 2007, 35(1):118-126.
    • (2007) Crit Care Med , vol.35 , Issue.1 , pp. 118-126
    • Angstwurm, M.W.1    Engelmann, L.2    Zimmermann, T.3
  • 39
    • 84860196333 scopus 로고    scopus 로고
    • Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis
    • Manzanares W., Dhaliwal R., Jiang X., et al. Antioxidant micronutrients in the critically ill: a systematic review and meta-analysis. Crit Care 2012, 16(2):R66.
    • (2012) Crit Care , vol.16 , Issue.2 , pp. R66
    • Manzanares, W.1    Dhaliwal, R.2    Jiang, X.3
  • 41
    • 59849093433 scopus 로고    scopus 로고
    • Functional significance of zinc-related signaling pathways in immune cells
    • Haase H., Rink L. Functional significance of zinc-related signaling pathways in immune cells. Annu Rev Nutr 2009, 29:133-152.
    • (2009) Annu Rev Nutr , vol.29 , pp. 133-152
    • Haase, H.1    Rink, L.2
  • 42
    • 67650507043 scopus 로고    scopus 로고
    • Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis
    • Knoell D.L., Julian M.W., Bao S., et al. Zinc deficiency increases organ damage and mortality in a murine model of polymicrobial sepsis. Crit Care Med 2009, 37(4):1380-1388.
    • (2009) Crit Care Med , vol.37 , Issue.4 , pp. 1380-1388
    • Knoell, D.L.1    Julian, M.W.2    Bao, S.3
  • 43
    • 79956314867 scopus 로고    scopus 로고
    • A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission
    • Besecker B.Y., Exline M.C., Hollyfield J., et al. A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission. Am J Clin Nutr 2011, 93(6):1356-1364.
    • (2011) Am J Clin Nutr , vol.93 , Issue.6 , pp. 1356-1364
    • Besecker, B.Y.1    Exline, M.C.2    Hollyfield, J.3
  • 44
    • 70349695920 scopus 로고    scopus 로고
    • Blood lactate monitoring in critically ill patients: a systematic health technology assessment
    • Jansen T.C., van Bommel J., Bakker J. Blood lactate monitoring in critically ill patients: a systematic health technology assessment. Crit Care Med 2009, 37(10):2827-2839.
    • (2009) Crit Care Med , vol.37 , Issue.10 , pp. 2827-2839
    • Jansen, T.C.1    van Bommel, J.2    Bakker, J.3
  • 45
    • 0031968240 scopus 로고    scopus 로고
    • Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction
    • Levraut J., Ciebiera J.P., Chave S., et al. Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction. Am J Respir Crit Care Med 1998, 157(4 Pt 1):1021-1026.
    • (1998) Am J Respir Crit Care Med , vol.157 , Issue.4 , pp. 1021-1026
    • Levraut, J.1    Ciebiera, J.P.2    Chave, S.3
  • 47
    • 84873339299 scopus 로고    scopus 로고
    • Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
    • Dellinger R.P., Levy M.M., Rhodes A., et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013, 41(2):580-637.
    • (2013) Crit Care Med , vol.41 , Issue.2 , pp. 580-637
    • Dellinger, R.P.1    Levy, M.M.2    Rhodes, A.3
  • 48
    • 0035829842 scopus 로고    scopus 로고
    • Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • Rivers E., Nguyen B., Havstad S., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345(19):1368-1377.
    • (2001) N Engl J Med , vol.345 , Issue.19 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3
  • 49
    • 84904559933 scopus 로고    scopus 로고
    • Protocol-based care for early septic shock
    • Angus D.C., Yealy D.M., Kellum J.A., et al. Protocol-based care for early septic shock. N Engl J Med 2014, 371(4):386.
    • (2014) N Engl J Med , vol.371 , Issue.4 , pp. 386
    • Angus, D.C.1    Yealy, D.M.2    Kellum, J.A.3
  • 50
    • 84942950608 scopus 로고
    • The use and clinical importance of a substrate-specific electrode for rapid determination of blood lactate concentrations
    • Aduen J., Bernstein W.K., Khastgir T., et al. The use and clinical importance of a substrate-specific electrode for rapid determination of blood lactate concentrations. JAMA 1994, 272(21):1678-1685.
    • (1994) JAMA , vol.272 , Issue.21 , pp. 1678-1685
    • Aduen, J.1    Bernstein, W.K.2    Khastgir, T.3
  • 51
    • 17844398255 scopus 로고    scopus 로고
    • Serum lactate as a predictor of mortality in emergency department patients with infection
    • Shapiro N.I., Howell M.D., Talmor D., et al. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med 2005, 45(5):524-528.
    • (2005) Ann Emerg Med , vol.45 , Issue.5 , pp. 524-528
    • Shapiro, N.I.1    Howell, M.D.2    Talmor, D.3
  • 52
    • 67650489580 scopus 로고    scopus 로고
    • Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
    • Mikkelsen M.E., Miltiades A.N., Gaieski D.F., et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med 2009, 37(5):1670-1677.
    • (2009) Crit Care Med , vol.37 , Issue.5 , pp. 1670-1677
    • Mikkelsen, M.E.1    Miltiades, A.N.2    Gaieski, D.F.3
  • 53
    • 35448971112 scopus 로고    scopus 로고
    • Occult hypoperfusion and mortality in patients with suspected infection
    • Howell M.D., Donnino M., Clardy P., et al. Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med 2007, 33(11):1892-1899.
    • (2007) Intensive Care Med , vol.33 , Issue.11 , pp. 1892-1899
    • Howell, M.D.1    Donnino, M.2    Clardy, P.3
  • 54
    • 3943052086 scopus 로고    scopus 로고
    • Early lactate clearance is associated with improved outcome in severe sepsis and septic shock
    • Nguyen H.B., Rivers E.P., Knoblich B.P., et al. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock. Crit Care Med 2004, 32(8):1637-1642.
    • (2004) Crit Care Med , vol.32 , Issue.8 , pp. 1637-1642
    • Nguyen, H.B.1    Rivers, E.P.2    Knoblich, B.P.3
  • 55
    • 77249162677 scopus 로고    scopus 로고
    • Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial
    • Jones A.E., Shapiro N.I., Trzeciak S., et al. Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial. JAMA 2010, 303(8):739-746.
    • (2010) JAMA , vol.303 , Issue.8 , pp. 739-746
    • Jones, A.E.1    Shapiro, N.I.2    Trzeciak, S.3
  • 56
    • 77954930936 scopus 로고    scopus 로고
    • Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial
    • Jansen T.C., van Bommel J., Schoonderbeek F.J., et al. Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial. Am J Respir Crit Care Med 2010, 182(6):752-761.
    • (2010) Am J Respir Crit Care Med , vol.182 , Issue.6 , pp. 752-761
    • Jansen, T.C.1    van Bommel, J.2    Schoonderbeek, F.J.3
  • 57
    • 84876148784 scopus 로고    scopus 로고
    • HMDB 3.0-the human metabolome database in 2013
    • Wishart D.S., Jewison T., Guo A.C., et al. HMDB 3.0-the human metabolome database in 2013. Nucleic Acids Res 2013, 41(Database issue):D801-D807.
    • (2013) Nucleic Acids Res , vol.41 , Issue.DATABASE ISSUE , pp. D801-D807
    • Wishart, D.S.1    Jewison, T.2    Guo, A.C.3
  • 59
    • 16244402990 scopus 로고    scopus 로고
    • Metabolomics: current analytical platforms and methodologies
    • Dunn W.B., Ellis D.I. Metabolomics: current analytical platforms and methodologies. Trends Analyt Chem 2005, 24(4):285-294.
    • (2005) Trends Analyt Chem , vol.24 , Issue.4 , pp. 285-294
    • Dunn, W.B.1    Ellis, D.I.2
  • 60
    • 84860190790 scopus 로고    scopus 로고
    • Statistical methods in metabolomics
    • Humana Press, New York
    • Korman A., Oh A., Raskind A., et al. Statistical methods in metabolomics. Evolutionary genomics 2012, 856:381-413. Humana Press, New York.
    • (2012) Evolutionary genomics , vol.856 , pp. 381-413
    • Korman, A.1    Oh, A.2    Raskind, A.3
  • 61
    • 84939547213 scopus 로고    scopus 로고
    • Whole blood reveals more metabolic detail of the human metabolome than serum as measured by 1H-NMR spectroscopy: implications for sepsis metabolomics
    • Stringer K.A., Younger J.G., McHugh C., et al. Whole blood reveals more metabolic detail of the human metabolome than serum as measured by 1H-NMR spectroscopy: implications for sepsis metabolomics. Shock 2015, 44(3):200-208.
    • (2015) Shock , vol.44 , Issue.3 , pp. 200-208
    • Stringer, K.A.1    Younger, J.G.2    McHugh, C.3
  • 62
    • 84885615124 scopus 로고    scopus 로고
    • Acute skeletal muscle wasting in critical illness
    • Puthucheary Z.A., Rawal J., McPhail M., et al. Acute skeletal muscle wasting in critical illness. JAMA 2013, 310(15):1591-1600.
    • (2013) JAMA , vol.310 , Issue.15 , pp. 1591-1600
    • Puthucheary, Z.A.1    Rawal, J.2    McPhail, M.3
  • 63
    • 0034884032 scopus 로고    scopus 로고
    • Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients
    • Garnacho-Montero J., Madrazo-Osuna J., Garcia-Garmendia J.L., et al. Critical illness polyneuropathy: risk factors and clinical consequences. A cohort study in septic patients. Intensive Care Med 2001, 27(8):1288-1296.
    • (2001) Intensive Care Med , vol.27 , Issue.8 , pp. 1288-1296
    • Garnacho-Montero, J.1    Madrazo-Osuna, J.2    Garcia-Garmendia, J.L.3
  • 64
    • 84896953177 scopus 로고    scopus 로고
    • Nutrition in the acute phase of critical illness
    • Casaer M.P., van den Berghe G. Nutrition in the acute phase of critical illness. N Engl J Med 2014, 370(13):1227-1236.
    • (2014) N Engl J Med , vol.370 , Issue.13 , pp. 1227-1236
    • Casaer, M.P.1    van den Berghe, G.2
  • 65
    • 67650470214 scopus 로고    scopus 로고
    • Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: executive summary
    • Martindale R.G., McClave S.A., Vanek V.W., et al. Guidelines for the provision and assessment of nutrition support therapy in the adult critically ill patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition: executive summary. Crit Care Med 2009, 37(5):1757-1761.
    • (2009) Crit Care Med , vol.37 , Issue.5 , pp. 1757-1761
    • Martindale, R.G.1    McClave, S.A.2    Vanek, V.W.3
  • 66
    • 70949099097 scopus 로고    scopus 로고
    • Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta-analysis of randomised controlled trials
    • Doig G.S., Heighes P.T., Simpson F., et al. Early enteral nutrition, provided within 24 h of injury or intensive care unit admission, significantly reduces mortality in critically ill patients: a meta-analysis of randomised controlled trials. Intensive Care Med 2009, 35(12):2018-2027.
    • (2009) Intensive Care Med , vol.35 , Issue.12 , pp. 2018-2027
    • Doig, G.S.1    Heighes, P.T.2    Simpson, F.3
  • 67
    • 84876158749 scopus 로고    scopus 로고
    • One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial
    • Needham D.M., Dinglas V.D., Bienvenu O.J., et al. One year outcomes in patients with acute lung injury randomised to initial trophic or full enteral feeding: prospective follow-up of EDEN randomised trial. BMJ 2013, 346:f1532.
    • (2013) BMJ , vol.346 , pp. f1532
    • Needham, D.M.1    Dinglas, V.D.2    Bienvenu, O.J.3
  • 68
    • 84857427752 scopus 로고    scopus 로고
    • Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial
    • National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network, Rice T.W., Wheeler A.P., et al. Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA 2012, 307(8):795-803.
    • (2012) JAMA , vol.307 , Issue.8 , pp. 795-803
    • Rice, T.W.1    Wheeler, A.P.2
  • 69
    • 80051648934 scopus 로고    scopus 로고
    • Early versus late parenteral nutrition in critically ill adults
    • Casaer M.P., Mesotten D., Hermans G., et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med 2011, 365(6):506-517.
    • (2011) N Engl J Med , vol.365 , Issue.6 , pp. 506-517
    • Casaer, M.P.1    Mesotten, D.2    Hermans, G.3
  • 70
    • 84877996857 scopus 로고    scopus 로고
    • Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial
    • Doig G.S., Simpson F., Sweetman E.A., et al. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA 2013, 309(20):2130-2138.
    • (2013) JAMA , vol.309 , Issue.20 , pp. 2130-2138
    • Doig, G.S.1    Simpson, F.2    Sweetman, E.A.3
  • 71
    • 84873108218 scopus 로고    scopus 로고
    • Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial
    • Heidegger C.P., Berger M.M., Graf S., et al. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet 2013, 381(9864):385-393.
    • (2013) Lancet , vol.381 , Issue.9864 , pp. 385-393
    • Heidegger, C.P.1    Berger, M.M.2    Graf, S.3
  • 72
    • 84876336998 scopus 로고    scopus 로고
    • A randomized trial of glutamine and antioxidants in critically ill patients
    • Heyland D., Muscedere J., Wischmeyer P.E., et al. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med 2013, 368(16):1489-1497.
    • (2013) N Engl J Med , vol.368 , Issue.16 , pp. 1489-1497
    • Heyland, D.1    Muscedere, J.2    Wischmeyer, P.E.3
  • 73
    • 79953200838 scopus 로고    scopus 로고
    • Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients
    • Andrews P.J., Avenell A., Noble D.W., et al. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ 2011, 342:d1542.
    • (2011) BMJ , vol.342 , pp. d1542
    • Andrews, P.J.1    Avenell, A.2    Noble, D.W.3
  • 74
    • 80054003232 scopus 로고    scopus 로고
    • Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury
    • Rice T.W., Wheeler A.P., Thompson B.T., et al. Enteral omega-3 fatty acid, gamma-linolenic acid, and antioxidant supplementation in acute lung injury. JAMA 2011, 306(14):1574-1581.
    • (2011) JAMA , vol.306 , Issue.14 , pp. 1574-1581
    • Rice, T.W.1    Wheeler, A.P.2    Thompson, B.T.3
  • 75
    • 84877128328 scopus 로고    scopus 로고
    • Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality
    • Mickiewicz B., Vogel H.J., Wong H.R., et al. Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med 2013, 187(9):967-976.
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.9 , pp. 967-976
    • Mickiewicz, B.1    Vogel, H.J.2    Wong, H.R.3
  • 76
    • 84882977493 scopus 로고    scopus 로고
    • An integrated clinico-metabolomic model improves prediction of death in sepsis
    • Langley R.J., Tsalik E.L., Velkinburgh J.C., et al. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med 2013, 5(195):195ra95.
    • (2013) Sci Transl Med , vol.5 , Issue.195 , pp. 195-295
    • Langley, R.J.1    Tsalik, E.L.2    Velkinburgh, J.C.3
  • 77
    • 84900401311 scopus 로고    scopus 로고
    • Metabolomic derangements are associated with mortality in critically ill adult patients
    • Rogers A.J., McGeachie M., Baron R.M., et al. Metabolomic derangements are associated with mortality in critically ill adult patients. PLoS One 2014, 9(1):e87538.
    • (2014) PLoS One , vol.9 , Issue.1 , pp. e87538
    • Rogers, A.J.1    McGeachie, M.2    Baron, R.M.3
  • 78
    • 84899485865 scopus 로고    scopus 로고
    • Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock
    • Mickiewicz B., Duggan G.E., Winston B.W., et al. Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock. Crit Care Med 2014, 42(5):1140-1149.
    • (2014) Crit Care Med , vol.42 , Issue.5 , pp. 1140-1149
    • Mickiewicz, B.1    Duggan, G.E.2    Winston, B.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.