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Volumn 408, Issue 27, 2016, Pages 7641-7649

Application of LC-MS-based metabolomics method in differentiating septic survivors from non-survivors

Author keywords

Catabolism; Early mortality; Liquid chromatography mass spectrometry; Metabolomics; Septic shock

Indexed keywords

AMINO ACIDS; BIOMOLECULES; DIAGNOSIS; FATTY ACIDS; INTENSIVE CARE UNITS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PATIENT TREATMENT; UREA;

EID: 84986278057     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-016-9845-9     Document Type: Article
Times cited : (39)

References (48)
  • 1
    • 84893509575 scopus 로고    scopus 로고
    • Proteomics reveals age-related differences in the host immune response to sepsis
    • COI: 1:CAS:528:DC%2BC3sXhvVCis7fJ
    • Cao Z, Yende S, Kellum JA, Angus DC, Robinson RA. Proteomics reveals age-related differences in the host immune response to sepsis. J Proteome Res. 2014;13(2):422–32.
    • (2014) J Proteome Res , vol.13 , Issue.2 , pp. 422-432
    • Cao, Z.1    Yende, S.2    Kellum, J.A.3    Angus, D.C.4    Robinson, R.A.5
  • 2
    • 0018964280 scopus 로고
    • Sepsis and septic shock—a review of laboratory models and a prospal
    • COI: 1:STN:280:DyaL3M%2FhtVyisA%3D%3D
    • Wichterman KA, Baue AE, Chaudry IH. Sepsis and septic shock—a review of laboratory models and a prospal. J Surg Res. 1980;29(2):189–201.
    • (1980) J Surg Res , vol.29 , Issue.2 , pp. 189-201
    • Wichterman, K.A.1    Baue, A.E.2    Chaudry, I.H.3
  • 3
    • 0023837751 scopus 로고
    • Antibiotic-lock technique—a new approach to optimal therapy for catheter-related sepsis in home - parenteral nutrition patients
    • COI: 1:STN:280:DyaL1c3gtVGjug%3D%3D
    • Messing B, Peitracohen S, Debure A, Beliah M, Bernier JJ. Antibiotic-lock technique—a new approach to optimal therapy for catheter-related sepsis in home - parenteral nutrition patients. Jpen-Parenter Enter. 1988;12(2):185–9.
    • (1988) Jpen-Parenter Enter , vol.12 , Issue.2 , pp. 185-189
    • Messing, B.1    Peitracohen, S.2    Debure, A.3    Beliah, M.4    Bernier, J.J.5
  • 4
    • 0031467108 scopus 로고    scopus 로고
    • New therapies in sepsis
    • COI: 1:STN:280:DyaK1c%2Fmt1Sksg%3D%3D
    • Vincent F-L. New therapies in sepsis. Chest. 1997;112(6):330S–8.
    • (1997) Chest , vol.112 , Issue.6 , pp. 330S-338S
    • Vincent, F.-L.1
  • 5
    • 84893437825 scopus 로고    scopus 로고
    • The role of proteomics in understanding biological mechanisms of sepsis
    • COI: 1:CAS:528:DC%2BC2cXhsl2jtro%3D
    • Cao Z, Robinson RA. The role of proteomics in understanding biological mechanisms of sepsis. Proteomics Clin Appl. 2014;8(1–2):35–52.
    • (2014) Proteomics Clin Appl , vol.8 , Issue.1-2 , pp. 35-52
    • Cao, Z.1    Robinson, R.A.2
  • 6
    • 84923092222 scopus 로고    scopus 로고
    • Predictive value of the complement system for sepsis-induced disseminated intravascular coagulation in septic patients in emergency department
    • Zhao X, Chen YX, Li CS. Predictive value of the complement system for sepsis-induced disseminated intravascular coagulation in septic patients in emergency department. J Crit Care. 2015;30(2):290–5.
    • (2015) J Crit Care , vol.30 , Issue.2 , pp. 290-295
    • Zhao, X.1    Chen, Y.X.2    Li, C.S.3
  • 8
    • 84901689664 scopus 로고    scopus 로고
    • The beginning of personalized medicine in sepsis: small steps to a bright future
    • COI: 1:STN:280:DC%2BC2cvovFyjsg%3D%3D
    • Christaki E, Giamarellos-Bourboulis EJ. The beginning of personalized medicine in sepsis: small steps to a bright future. Clin Genet. 2014;86(1):56–61.
    • (2014) Clin Genet , vol.86 , Issue.1 , pp. 56-61
    • Christaki, E.1    Giamarellos-Bourboulis, E.J.2
  • 9
    • 84889648452 scopus 로고    scopus 로고
    • Neonatal sepsis: progress towards improved outcomes
    • Shane AL, Stoll BJ. Neonatal sepsis: progress towards improved outcomes. J Infect. 2014;68 Suppl 1:S24–32.
    • (2014) J Infect , vol.68 , pp. S24-S32
    • Shane, A.L.1    Stoll, B.J.2
  • 10
    • 0035829842 scopus 로고    scopus 로고
    • Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • COI: 1:STN:280:DC%2BD38%2FmsFGjtA%3D%3D
    • Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. New Engl J Med. 2001;345(19):1368–77.
    • (2001) New Engl J Med , vol.345 , Issue.19 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3    Ressler, J.4    Muzzin, A.5    Knoblich, B.6
  • 11
    • 84875794940 scopus 로고    scopus 로고
    • Septic shock: the initial moments and beyond
    • Lam SW, Bauer SR, Guzman JA. Septic shock: the initial moments and beyond. Cleve Clin J Med. 2013;80(3):175–84.
    • (2013) Cleve Clin J Med , vol.80 , Issue.3 , pp. 175-184
    • Lam, S.W.1    Bauer, S.R.2    Guzman, J.A.3
  • 12
    • 84874523025 scopus 로고    scopus 로고
    • Metabolic profiling for detection of Staphylococcus aureus infection and antibiotic resistance
    • COI: 1:CAS:528:DC%2BC3sXjslyksrc%3D
    • Antti H, Fahlgren A, Nasstrom E, Kouremenos K, Sunden-Cullberg J, Guo Y, et al. Metabolic profiling for detection of Staphylococcus aureus infection and antibiotic resistance. PLoS One. 2013;8(2):e56971.
    • (2013) PLoS One , vol.8 , Issue.2
    • Antti, H.1    Fahlgren, A.2    Nasstrom, E.3    Kouremenos, K.4    Sunden-Cullberg, J.5    Guo, Y.6
  • 13
    • 84899485865 scopus 로고    scopus 로고
    • Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock
    • COI: 1:CAS:528:DC%2BC2cXmtFaisbw%3D
    • Mickiewicz B, Duggan GE, Winston BW, Doig C, Kubes P, Vogel HJ, et al. Metabolic profiling of serum samples by 1H nuclear magnetic resonance spectroscopy as a potential diagnostic approach for septic shock. Crit Care Med. 2014;42(5):1140–9.
    • (2014) Crit Care Med , vol.42 , Issue.5 , pp. 1140-1149
    • Mickiewicz, B.1    Duggan, G.E.2    Winston, B.W.3    Doig, C.4    Kubes, P.5    Vogel, H.J.6
  • 14
    • 84897045525 scopus 로고    scopus 로고
    • Biomarkers of sepsis
    • COI: 1:CAS:528:DC%2BC2cXpsVSrtrc%3D
    • Cho SY, Choi JH. Biomarkers of sepsis. Infect Chemother. 2014;46(1):1–12.
    • (2014) Infect Chemother , vol.46 , Issue.1 , pp. 1-12
    • Cho, S.Y.1    Choi, J.H.2
  • 16
    • 77949951419 scopus 로고    scopus 로고
    • Proteome and metabolome alterations in heart and liver indicate compromised energy production during sepsis
    • COI: 1:CAS:528:DC%2BC3cXisVKgtb8%3D
    • Hinkelbein J, Kalenka A, Schubert C, Peterka A, Feldmann Jr RE. Proteome and metabolome alterations in heart and liver indicate compromised energy production during sepsis. Protein Peptide Lett. 2010;17(1):18–31.
    • (2010) Protein Peptide Lett , vol.17 , Issue.1 , pp. 18-31
    • Hinkelbein, J.1    Kalenka, A.2    Schubert, C.3    Peterka, A.4    Feldmann, R.E.5
  • 17
    • 33745361258 scopus 로고    scopus 로고
    • Metabonomics techniques and applications to pharmaceutical research & development
    • COI: 1:CAS:528:DC%2BD28XmtFCnsL0%3D
    • Lindon JC, Holmes E, Nicholson JK. Metabonomics techniques and applications to pharmaceutical research & development. Pharm Res. 2006;23(6):1075–88.
    • (2006) Pharm Res , vol.23 , Issue.6 , pp. 1075-1088
    • Lindon, J.C.1    Holmes, E.2    Nicholson, J.K.3
  • 18
    • 70049118476 scopus 로고    scopus 로고
    • A metabonomic approach to early prognostic evaluation of experimental sepsis by (1)H NMR and pattern recognition
    • COI: 1:CAS:528:DC%2BD1MXhtVSnurrK
    • Lin ZY, Xu PB, Yan SK, Meng HB, Yang GJ, Dai WX, et al. A metabonomic approach to early prognostic evaluation of experimental sepsis by (1)H NMR and pattern recognition. NMR Biomed. 2009;22(6):601–8.
    • (2009) NMR Biomed , vol.22 , Issue.6 , pp. 601-608
    • Lin, Z.Y.1    Xu, P.B.2    Yan, S.K.3    Meng, H.B.4    Yang, G.J.5    Dai, W.X.6
  • 20
    • 44649112396 scopus 로고    scopus 로고
    • A metabonomic approach to early prognostic evaluation of experimental sepsis
    • Xu PB, Lin ZY, Meng HB, Yan SK, Yang Y, Liu XR, et al. A metabonomic approach to early prognostic evaluation of experimental sepsis. J Infect. 2008;56(6):474–81.
    • (2008) J Infect , vol.56 , Issue.6 , pp. 474-481
    • Xu, P.B.1    Lin, Z.Y.2    Meng, H.B.3    Yan, S.K.4    Yang, Y.5    Liu, X.R.6
  • 21
    • 84897529055 scopus 로고    scopus 로고
    • Urinary 1H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis
    • COI: 1:CAS:528:DC%2BC2cXns1Wrt7g%3D
    • Fanos V, Caboni P, Corsello G, Stronati M, Gazzolo D, Noto A, et al. Urinary 1H-NMR and GC-MS metabolomics predicts early and late onset neonatal sepsis. Early Hum Dev. 2014;90:S78–83.
    • (2014) Early Hum Dev , vol.90 , pp. S78-S83
    • Fanos, V.1    Caboni, P.2    Corsello, G.3    Stronati, M.4    Gazzolo, D.5    Noto, A.6
  • 22
    • 37549020378 scopus 로고    scopus 로고
    • Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008
    • Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36(1):296–327.
    • (2008) Crit Care Med , vol.36 , Issue.1 , pp. 296-327
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3    Bion, J.4    Parker, M.M.5    Jaeschke, R.6
  • 23
    • 60849102446 scopus 로고    scopus 로고
    • Evaluation of SOFA-based models for predicting mortality in the ICU: a systematic review
    • Minne L, Abu-Hanna A, de Jonge E. Evaluation of SOFA-based models for predicting mortality in the ICU: a systematic review. Crit Care. 2008;12(6):R161.
    • (2008) Crit Care , vol.12 , Issue.6 , pp. R161
    • Minne, L.1    Abu-Hanna, A.2    de Jonge, E.3
  • 24
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure
    • COI: 1:STN:280:DyaK2s%2FgtFantQ%3D%3D
    • Vincent JL, Moreno R, Takala J, Willatts S, DeMendonca A, Bruining H, et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. Intens Care Med. 1996;22(7):707–10.
    • (1996) Intens Care Med , vol.22 , Issue.7 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3    Willatts, S.4    DeMendonca, A.5    Bruining, H.6
  • 26
    • 39449129263 scopus 로고    scopus 로고
    • Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information
    • COI: 1:CAS:528:DC%2BD1cXlsl2hug%3D%3D
    • Chen J, Zhao X, Fritsche J, Yin P, Schmitt-Kopplin P, Wang W, et al. Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information. Anal Chem. 2008;80(4):1280–9.
    • (2008) Anal Chem , vol.80 , Issue.4 , pp. 1280-1289
    • Chen, J.1    Zhao, X.2    Fritsche, J.3    Yin, P.4    Schmitt-Kopplin, P.5    Wang, W.6
  • 27
    • 0021111428 scopus 로고
    • Effect of tissue hypoxia and septic shock on human skeletal muscle mitochondria
    • Gasparetto A, Corbucci GG, Candiani A, Gohil K, Edwards RHT. Effect of tissue hypoxia and septic shock on human skeletal muscle mitochondria. Lancet. 1983;322(8365–8366):1386.
    • (1983) Lancet , vol.322 , Issue.8365-8366 , pp. 1386
    • Gasparetto, A.1    Corbucci, G.G.2    Candiani, A.3    Gohil, K.4    Edwards, R.H.T.5
  • 28
    • 0037142987 scopus 로고    scopus 로고
    • Association between mitochondrial dysfunction and severity and outcome of septic shock
    • COI: 1:CAS:528:DC%2BD38XlsVOmtL4%3D
    • Brealey D, Brand M, Hargreaves I, Heales S, Land J, Smolenski R, et al. Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet. 2002;360(9328):219–23.
    • (2002) Lancet , vol.360 , Issue.9328 , pp. 219-223
    • Brealey, D.1    Brand, M.2    Hargreaves, I.3    Heales, S.4    Land, J.5    Smolenski, R.6
  • 29
    • 84890115060 scopus 로고    scopus 로고
    • Polymicrobial sepsis is associated with decreased hepatic oxidative phosphorylation and an altered metabolic profile
    • COI: 1:CAS:528:DC%2BC3sXhsVOntbfP
    • Whelan SP, Carchman EH, Kautza B, Nassour I, Mollen K, Escobar D, et al. Polymicrobial sepsis is associated with decreased hepatic oxidative phosphorylation and an altered metabolic profile. J Surg Res. 2014;186(1):297–303.
    • (2014) J Surg Res , vol.186 , Issue.1 , pp. 297-303
    • Whelan, S.P.1    Carchman, E.H.2    Kautza, B.3    Nassour, I.4    Mollen, K.5    Escobar, D.6
  • 30
    • 0031933789 scopus 로고    scopus 로고
    • Sepsis: stimulation of energy-dependent protein breakdown resulting in protein loss in skeletal muscle
    • COI: 1:STN:280:DyaK1c7htl2iug%3D%3D
    • Hasselgren PO, Fischer JE. Sepsis: stimulation of energy-dependent protein breakdown resulting in protein loss in skeletal muscle. World J Surg. 1998;22:203–8.
    • (1998) World J Surg , vol.22 , pp. 203-208
    • Hasselgren, P.O.1    Fischer, J.E.2
  • 31
    • 0021024932 scopus 로고
    • Carnitine—metabolism and functions
    • COI: 1:CAS:528:DyaL2cXmsFGgsQ%3D%3D
    • Bremer J. Carnitine—metabolism and functions. Physiol Rev. 1983;63(4):1420–80.
    • (1983) Physiol Rev , vol.63 , Issue.4 , pp. 1420-1480
    • Bremer, J.1
  • 33
    • 84928584867 scopus 로고    scopus 로고
    • Impact of obesity on sepsis mortality: a systematic review
    • Trivedi V, Bavishi C, Jean R. Impact of obesity on sepsis mortality: a systematic review. J Crit Care. 2015;30(3):518–24.
    • (2015) J Crit Care , vol.30 , Issue.3 , pp. 518-524
    • Trivedi, V.1    Bavishi, C.2    Jean, R.3
  • 34
    • 33645229775 scopus 로고    scopus 로고
    • Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis
    • Forni LG, McKinnon W, Lord GA, Treacher DF, Peron JM, Hilton PJ. Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis. Crit Care. 2005;9(5):R591–5.
    • (2005) Crit Care , vol.9 , Issue.5 , pp. R591-R595
    • Forni, L.G.1    McKinnon, W.2    Lord, G.A.3    Treacher, D.F.4    Peron, J.M.5    Hilton, P.J.6
  • 35
    • 0036205361 scopus 로고    scopus 로고
    • Fatty acid oxidation in neonatal hepatocytes: effects of sepsis and glutamine
    • COI: 1:CAS:528:DC%2BD38XisV2kur4%3D
    • Kim SC, Pierro A, Zamparelli M, Spitz L, Eaton S. Fatty acid oxidation in neonatal hepatocytes: effects of sepsis and glutamine. Nutrition. 2002;18(4):298–300.
    • (2002) Nutrition , vol.18 , Issue.4 , pp. 298-300
    • Kim, S.C.1    Pierro, A.2    Zamparelli, M.3    Spitz, L.4    Eaton, S.5
  • 36
    • 84900821711 scopus 로고    scopus 로고
    • Serum metabolomics identifies citrulline as a predictor of adverse outcomes in an equine model of gut-derived sepsis
    • COI: 1:CAS:528:DC%2BC2cXhsF2qsbfP
    • Steelman SM, Johnson P, Jackson A, Schulze J, Chowdhary BP. Serum metabolomics identifies citrulline as a predictor of adverse outcomes in an equine model of gut-derived sepsis. Physiol Genomics. 2014;46(10):339–47.
    • (2014) Physiol Genomics , vol.46 , Issue.10 , pp. 339-347
    • Steelman, S.M.1    Johnson, P.2    Jackson, A.3    Schulze, J.4    Chowdhary, B.P.5
  • 37
    • 77957571558 scopus 로고    scopus 로고
    • Metabolomic analysis of thermally injured and/or septic rats
    • Liu XR, Zheng XF, Ji SZ, Lv YH, Zheng DY, Xia ZF, et al. Metabolomic analysis of thermally injured and/or septic rats. Burns. 2010;36(7):992–8.
    • (2010) Burns , vol.36 , Issue.7 , pp. 992-998
    • Liu, X.R.1    Zheng, X.F.2    Ji, S.Z.3    Lv, Y.H.4    Zheng, D.Y.5    Xia, Z.F.6
  • 38
    • 84891343087 scopus 로고    scopus 로고
    • Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents
    • COI: 1:CAS:528:DC%2BC2cXkslCm
    • Luo L, Schomaker S, Houle C, Aubrecht J, Colangelo JL. Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents. Toxicol Sci. 2014;137(1):12–25.
    • (2014) Toxicol Sci , vol.137 , Issue.1 , pp. 12-25
    • Luo, L.1    Schomaker, S.2    Houle, C.3    Aubrecht, J.4    Colangelo, J.L.5
  • 39
    • 84877128328 scopus 로고    scopus 로고
    • Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality
    • COI: 1:CAS:528:DC%2BC3sXot1emtrw%3D
    • Mickiewicz B, Vogel HJ, Wong HR, Winston BW. Metabolomics as a novel approach for early diagnosis of pediatric septic shock and its mortality. Am J Respir Crit Care Med. 2013;187(9):967–76.
    • (2013) Am J Respir Crit Care Med , vol.187 , Issue.9 , pp. 967-976
    • Mickiewicz, B.1    Vogel, H.J.2    Wong, H.R.3    Winston, B.W.4
  • 40
    • 84924778239 scopus 로고    scopus 로고
    • A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma
    • COI: 1:CAS:528:DC%2BC2MXhtFKku7zO
    • Zhang W, Zhou L, Yin P, Wang J, Lu X, Wang X, et al. A weighted relative difference accumulation algorithm for dynamic metabolomics data: long-term elevated bile acids are risk factors for hepatocellular carcinoma. Sci Rep. 2015;5:8984.
    • (2015) Sci Rep , vol.5 , pp. 8984
    • Zhang, W.1    Zhou, L.2    Yin, P.3    Wang, J.4    Lu, X.5    Wang, X.6
  • 41
    • 84868323261 scopus 로고    scopus 로고
    • Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry
    • COI: 1:CAS:528:DC%2BC38Xht12ju7%2FN
    • Zhou L, Ding L, Yin P, Lu X, Wang X, Niu J, et al. Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry. J Proteome Res. 2012;11(11):5433–42.
    • (2012) J Proteome Res , vol.11 , Issue.11 , pp. 5433-5442
    • Zhou, L.1    Ding, L.2    Yin, P.3    Lu, X.4    Wang, X.5    Niu, J.6
  • 42
    • 84855206110 scopus 로고    scopus 로고
    • Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma
    • M110.004945
    • Chen T, Xie G, Wang X, Fan J, Qiu Y, Zheng X, et al. Serum and urine metabolite profiling reveals potential biomarkers of human hepatocellular carcinoma. Mol Cell Proteomics. 2011;10(7):M110.004945.
    • (2011) Mol Cell Proteomics , vol.10 , Issue.7
    • Chen, T.1    Xie, G.2    Wang, X.3    Fan, J.4    Qiu, Y.5    Zheng, X.6
  • 43
    • 84880289108 scopus 로고    scopus 로고
    • Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study
    • COI: 1:CAS:528:DC%2BC3sXhtFajtb7K
    • Seymour CW, Yende S, Scott MJ, Pribis J, Mohney RP, Bell LN, et al. Metabolomics in pneumonia and sepsis: an analysis of the GenIMS cohort study. Intensive Care Med. 2013;39(8):1423–34.
    • (2013) Intensive Care Med , vol.39 , Issue.8 , pp. 1423-1434
    • Seymour, C.W.1    Yende, S.2    Scott, M.J.3    Pribis, J.4    Mohney, R.P.5    Bell, L.N.6
  • 44
    • 84874526125 scopus 로고    scopus 로고
    • Serum creatinine as a marker of muscle mass in chronic kidney disease: results of a cross-sectional study and review of literature
    • Patel SS, Molnar MZ, Tayek JA, Ix JH, Noori N, Benner D, et al. Serum creatinine as a marker of muscle mass in chronic kidney disease: results of a cross-sectional study and review of literature. J Cachex Sarcopenia Muscle. 2013;4(1):19–29.
    • (2013) J Cachex Sarcopenia Muscle , vol.4 , Issue.1 , pp. 19-29
    • Patel, S.S.1    Molnar, M.Z.2    Tayek, J.A.3    Ix, J.H.4    Noori, N.5    Benner, D.6
  • 46
    • 0024501051 scopus 로고
    • Phosphatidylethanolamine levels and regulation of phosphatidylethanolamine N-methyltransferase
    • COI: 1:CAS:528:DyaL1MXlsFSquw%3D%3D
    • Ridgway ND, Yao Z, Vance DE. Phosphatidylethanolamine levels and regulation of phosphatidylethanolamine N-methyltransferase. J Biol Chem. 1989;264(2):1203–7.
    • (1989) J Biol Chem , vol.264 , Issue.2 , pp. 1203-1207
    • Ridgway, N.D.1    Yao, Z.2    Vance, D.E.3
  • 47
    • 84921950738 scopus 로고    scopus 로고
    • Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
    • COI: 1:CAS:528:DC%2BC2cXhs1ehsr3E
    • Mayers JR, Wu C, Clish CB, Kraft P, Torrence ME, Fiske BP, et al. Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med. 2014;20(10):1193–8.
    • (2014) Nat Med , vol.20 , Issue.10 , pp. 1193-1198
    • Mayers, J.R.1    Wu, C.2    Clish, C.B.3    Kraft, P.4    Torrence, M.E.5    Fiske, B.P.6
  • 48
    • 84936890278 scopus 로고    scopus 로고
    • Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet
    • COI: 1:CAS:528:DC%2BC2MXhtFWmt73I
    • Xu L, Huang D, Hu Q, Wu J, Wang Y, Feng J. Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet. Br J Nutr. 2015;113(12):1835–43.
    • (2015) Br J Nutr , vol.113 , Issue.12 , pp. 1835-1843
    • Xu, L.1    Huang, D.2    Hu, Q.3    Wu, J.4    Wang, Y.5    Feng, J.6


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