Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model

Journal of Biological Chemistry

Volumn 289, Issue 30, 2014, Pages 20502-20515

  Jones, Courtney L ^a   Bhatla, Teena ^a   Blum, Roy ^a   Wang, Jinhua ^a   Paugh, Steven W ^b   Wen, Xin ^a   Bourgeois, Wallace ^a   Bitterman, Danielle S ^a   Raetz, Elizabeth A ^c   Morrison, Debra J ^a   Teachey, David T ^d   Evans, William E ^b   Garabedian, Michael J ^a   Carroll, William L ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL RECEPTOR; CHROMATIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HISTONE DEACETYLASE; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE INHIBITOR; NUCLEAR PROTEIN; REPRESSOR PROTEIN; TBL1XR1 PROTEIN, HUMAN; TUMOR PROTEIN;

ADOLESCENT; BIOLOGICAL MODEL; CHILD; CHROMATIN; CLINICAL TRIAL; DRUG RESISTANCE; FEMALE; GENE SILENCING; GENETICS; HUMAN; MALE; METABOLISM; PATHOLOGY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRESCHOOL CHILD; TUMOR CELL LINE;

ADOLESCENT; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; CHROMATIN; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE KNOCKDOWN TECHNIQUES; GLUCOCORTICOIDS; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; MALE; MODELS, BIOLOGICAL; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, GLUCOCORTICOID; REPRESSOR PROTEINS;

EID: 84905386025     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.569889     Document Type: Article

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