Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 3, 2015, Pages 628-637.e4

  Chambers, Emma S ^a   Nanzer, Alexandra M ^a,b   Pfeffer, Paul E ^a   Richards, David F ^a   Timms, Peter M ^c   Martineau, Adrian R ^b   Griffiths, Christopher J ^a,b   Corrigan, Christopher J ^a   Hawrylowicz, Catherine M ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c HOMERTON UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Asthma; glucocorticoids; IL 17A; steroid resistant; steroid sensitive; Vitamin D

Indexed keywords

CALCITRIOL; CD8 ANTIGEN; CORTICOSTEROID; DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; PLACEBO; PREDNISOLONE; VITAMIN D; CD3 ANTIGEN; IL10 PROTEIN, HUMAN; IL17A PROTEIN, HUMAN; IMMUNOLOGIC FACTOR; INTERLEUKIN 10;

ADULT; ARTICLE; ASTHMA; CELL CULTURE; CELL ISOLATION; CLINICAL ARTICLE; CYTOKINE PRODUCTION; DRUG RESPONSE; FEMALE; HUMAN; IMMUNOPHENOTYPING; IN VITRO STUDY; MALE; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SUPERNATANT; BIOSYNTHESIS; CONTROLLED STUDY; DRUG EFFECTS; DRUG RESISTANCE; IMMUNOLOGY; MONONUCLEAR CELL; PATHOLOGY; PRIMARY CELL CULTURE; SEVERITY OF ILLNESS INDEX;

ADRENAL CORTEX HORMONES; ADULT; ANTIGENS, CD3; ASTHMA; CALCITRIOL; DEXAMETHASONE; DRUG RESISTANCE; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; IMMUNOPHENOTYPING; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-17; INTERLEUKIN-2; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PREDNISOLONE; PRIMARY CELL CULTURE; SEVERITY OF ILLNESS INDEX;

EID: 84941189146     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.01.026     Document Type: Article

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