NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

Nature Genetics

Volumn 47, Issue 6, 2015, Pages 607-614

  Paugh, Steven W ^a   Bonten, Erik J ^a   Savic, Daniel ^b   Ramsey, Laura B ^a   Thierfelder, William E ^a   Gurung, Prajwal ^a   Malireddi, R K Subbarao ^a   Actis, Marcelo ^a   Mayasundari, Anand ^a   Min, Jaeki ^a   Coss, David R ^a   Laudermilk, Lucas T ^a   Panetta, John C ^a   McCorkle, J Robert ^a   Fan, Yiping ^a   Crews, Kristine R ^a   Stocco, Gabriele ^a,g   Wilkinson, Mark R ^a   Ferreira, Antonio M ^a   Cheng, Cheng ^a   Yang, Wenjian ^a   Karol, Seth E ^a   Fernandez, Christian A ^a   Diouf, Barthelemy ^a   Smith, Colton ^a   Hicks, J Kevin ^a   Zanut, Alessandra ^a   Giordanengo, Audrey ^a   Crona, Daniel ^a   Bianchi, Joy J ^a   Holmfeldt, Linda ^a   Mullighan, Charles G ^a   Den Boer, Monique L ^c   Pieters, Rob ^c,d   Jeha, Sima ^a   Dunwell, Thomas L ^e   Latif, Farida ^e   Bhojwani, Deepa ^a   Carroll, William L ^f   Pui, Ching Hon ^a   Myers, Richard M ^b   Guy, R Kiplin ^a   Kanneganti, Thirumala Devi ^a   Relling, Mary V ^a   Evans, William E ^a   more..

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY   (United States)

^c SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^d University Medical Center Utrecht Princess Máxima Center for Pediatric Oncology   (Netherlands)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^f NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF TRIESTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CRYOPYRIN; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; PREDNISOLONE; TETRAPEPTIDE; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; CARRIER PROTEIN; INFLAMMASOME; NLRP3 PROTEIN, HUMAN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BINDING SITE; CHILD; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; ENZYMATIC ASSAY; ENZYME INHIBITION; ENZYME REGULATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; LC50; LEUKEMIA CELL LINE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN INDUCTION; PROTEIN METHYLATION; RECEPTOR BINDING; RECURRENT DISEASE; SITE DIRECTED MUTAGENESIS; TRANSACTIVATION; UPREGULATION; ADOLESCENT; DNA METHYLATION; DRUG RESISTANCE; DRUG SCREENING; ENZYMOLOGY; GENE EXPRESSION REGULATION; HEK293 CELL LINE; INFANT; METABOLISM; NEWBORN; NUCLEOTIDE SEQUENCE; PATHOLOGY; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRESCHOOL CHILD; PROTEIN DEGRADATION; TUMOR CELL CULTURE; TUMOR RECURRENCE;

ADOLESCENT; ANTINEOPLASTIC AGENTS, HORMONAL; BASE SEQUENCE; CARRIER PROTEINS; CASPASE 1; CHILD; CHILD, PRESCHOOL; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION REGULATION, LEUKEMIC; HEK293 CELLS; HUMANS; INFANT; INFANT, NEWBORN; INFLAMMASOMES; NEOPLASM RECURRENCE, LOCAL; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREDNISOLONE; PROTEOLYSIS; RECEPTORS, GLUCOCORTICOID; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84930088053     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng.3283     Document Type: Article

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